A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity by Da-yan Zhang, Zhi-hua Zhang, Wen-ting Liu, Wei-ming Zhou, Peng-fei Zhou, Juan-juan Wei, Xue-jing Dai, Xiao-li Zeng, Yu-qiong Zhou, Han-wang Li, Heng Zhang, Ao-lin Shen, Lian-sheng Cheng, Guo-dong Shen, Yi-fu He

“…In vivo antitumour activity was assessed by establishing humanized mice bearing human MSLN-expressing MC38 (MC38/hMSLN) or CT26 (CT26/hMSLN) cells, and safety was further evaluated in cynomolgus monkeys. …”
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Novel lncRNA LncMSTRG.11341.25 Promotes Osteogenic Differentiation of Human Bone Marrow Stem Cells via the miR-939-5p/PAX8 Axis by Feifei Ni, Jianjun Li, Qin Yin, Yangyang Chen, Zengwu Shao, Hong Wang

“…Human bone marrow stem cells (hBMSCs) play an important role during the fracture healing phase. …”
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Evaluation of the merit of ethanolic extract of Annona reticulata as an anti-cancer agent in human colon cancer cell lines (HCT-116) [version 2; peer review: 2 approved, 1 not approved] by Sri Pragnya Cheruku, Krishnananda Prabhu, Akshatha G Nayak, Vijetha Shenoy Belle, Vanishree Rao, Pooja Prakash Rao, Nitesh Kumar

“…This study was aimed to explore the anti-proliferative and anti-migratory activity of various fractions of Annona reticulata ethanolic leaf extract on human colon cancer cell lines (HCT-116) and to explore the potential molecular targets from the most potent plant extract fraction. …”
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Land-use and land-cover changes and emerging non-tuberculous and tuberculous infectious diseases in humans and animals: a mixed-methods review of research findings from global and spatio-temporal perspectives by Jean-François Guégan, Carlos A Vargas Campos, Christine Chevillon, Ahmadou Sylla, Magdalene Dogbe, Kayla M Fast, Jennifer Pechal, Alex Rakestraw, Matthew E Scott, Michael W Sandel, Heather Jordan, M Eric Benbow

Subjects: “…animal and human mycobacteria…”
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Design of a humanized CD40 agonist antibody with specific properties using AlphaFold2 and development of an anti-PD-L1/CD40 bispecific antibody for cancer immunotherapy by Kun Du, He Huang

“…Assisted by Alphafold2(AlphaFold-Multimer), we developed a humanized CD40 agonistic antibody that exhibits activation only in the presence of cross-linking. …”
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Potential antioxidant and cytoprotective effects of essential oil extracted from Cymbopogon citratus on OxLDL and H2O2 LDL induced Human Peripheral Blood Mononuclear Cells (PBMC) by Jamuna S., Sakeena Sadullah M.S., Ashokkumar R., Gokul Shanmuganathan, Senguttuvan Sivan Mozhi, Niranjali Devaraj S.

“…Food Science and Human Wellness…”
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High Human Immunodeficiency Virus (HIV) Viral Load and Coinfection with Viral Hepatitis Are Associated with Liver Enzyme Abnormalities among HIV Seropositive Patients on Antiretroviral Therapy in the Lake Victoria Zone, Tanzania by Shabani Iddi, Caroline A. Minja, Vitus Silago, Asteria Benjamin, Jastine Mpesha, Shimba Henerico, Benson R. Kidenya, Stephen E. Mshana, Mariam M. Mirambo

“…This study investigated factors associated with liver enzymes abnormalities among human immunodeficiency virus (HIV) infected individuals on ART from the Lake Victoria zone, Tanzania. …”
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CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody by Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang

“…Human CD200R1 (hCD200R1), an immune inhibitory receptor expressed predominantly on T cells and myeloid cells, was identified as a promising immuno-oncology target by the 23andMe database. …”
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Triptolide suppresses IL-1β-induced expression of interleukin-8 by inhibiting ROS-Mediated ERK, AP-1, and NF-κB molecules in human gastric cancer AGS cells by Shinan Li, Shinan Li, Dhiraj Kumar Sah, Archana Arjunan, Mohamed Yazeer Ameer, Bora Lee, Young-Do Jung

“…Here, we found that Triptolide has an inhibitory effect on IL-1β-induced IL-8 expression in human gastric cancer cells, via the suppression of reactive oxygen species (ROS) production, AP-1, and NF-κB activation, which in turn affects human endothelial cell angiogenetic activity in tumor microenvironments. …”
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Recombinant Human Brain Natriuretic Peptide Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting CD4+ T Cell Proliferation via PI3K/AKT/mTOR Pathway Activation by Kun-Peng Li, Hai-Yan Zhang, Xiao-Dong Xu, Ming-Yang, Tie-Jun Li, Shu-Tian Song

“…Inflammation plays a major role in the development of myocardial ischemia-reperfusion (IR) injury. Recombinant human brain natriuretic peptide (rhBNP), a man-made version of a peptide that is elevated in heart failure, exhibits anti-inflammatory effects in various tissues. …”
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Corrigendum: Refractory human cytomegalovirus infection without evidence of genetic resistance in the UL-54 and UL-97 genes in a pediatric hematopoietic stem cell transplant recipient: a case report by Alejandra Pando-Caciano, Ketty Adid Escudero-Ramirez, Jackeline Carol Rodríguez-Torres, Holger Maita-Malpartida, Holger Maita-Malpartida

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THE PROBLEM ОF HUMAN IDENTITY ІN POSTMODERN WORLD VIEW ПРОБЛЕМА ЧЕЛОВЕЧЕСКОЙ ИДЕНТИЧНОСТИ В ПОСТМОДЕРНИСТСКОЙ КАРТИНЕ МИРА ПРОБЛЕМА ЛЮДСЬКОЇ ІДЕНТИЧНОСТІ У ПОСТМОДЕРНІЙ КАРТИНІ СВІТУ by T. V. Danylova

“…The awareness of the pluralistic reality of postmodern transforms the very understanding of human identity: the human self is no longer something unified and indivisible but is rather composed of different, often conflicting, parts. …”
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Subarachnoid Transplant of the Human Neuronal hNT2.19 Serotonergic Cell Line Attenuates Behavioral Hypersensitivity without Affecting Motor Dysfunction after Severe Contusive Spinal Cord Injury by Mary J. Eaton, Eva Widerström-Noga, Stacey Quintero Wolfe

“…To address this need for clinically useful human cells, a unique neuronal cell line that synthesizes and secretes/releases the neurotransmitter serotonin (5HT) was isolated. …”
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Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes: In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer” by Rosenani A. Haque, Siti Fatimah Nasri, Muhammad Adnan Iqbal, Sawsan S. Al-Rawi, Seyedeh Fatemeh Jafari, Mohamed B. Khadeer Ahamed, A. M. S. Abdul Majid

“…All the compounds were tested for their cytotoxicity against human colorectal cancer (HCT 116) and breast cancer (MCF-7) cell lines. …”
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Modulatory Effect of 1,25-Dihydroxyvitamin D3 on IL1β-Induced RANKL, OPG, TNFα, and IL-6 Expression in Human Rheumatoid Synoviocyte MH7A by Xiaoke Feng, Chengyin Lv, Fang Wang, Ke Gan, Miaojia Zhang, Wenfeng Tan

“…Here, we investigated modulatory effect of 1,25(OH)2D3 on the expression of RANKL and its decoy receptor osteoprotegerin (OPG) in an inflammatory condition of human rheumatoid synoviocyte MH7A. MH7A cells were stimulated with IL1β and then treated with different concentrations of 1,25(OH)2D3 for 48 h. …”
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Distribution of Candida Species Isolated from People Living with Human Immunodeficiency Virus With Oropharyngeal and Oral Candidiasis in Africa in the Era Of Universal Test and Treat Policy: A Systematic Review and Meta-Analysis. by Musinguzi, Benson, Obuku, Ekwaro A., Mwesigwa, Alex, Migisha, Richard, Kinengyere, Alison Annet, Ndagire, Regina, Baguma, Andrew, Okek, Erick Jacob, Olum, Ronald, Itabangi, Herbert, Mboowa, Gerald, Sande, Obondo James, Achan, Beatrice

“…Background The introduction of antiretroviral therapy (ART) and the implementation of the human immunodeficiency virus (HIV) universal test and treat (UTT) policy have led to a decline in the incidence of opportunistic infections. …”
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İNSAN HAKLARI DÜŞÜNCESİNİN TEMELİ OLAN “İNSANIN ONURU” SORUNU by Haluk Aşar

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The regional historiography in the system of russian university science by Petr A. Kuzminov, A. M. Kumykov, K. Ph. Dzamikhov

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Mapping evidence on barriers to and facilitators of diagnosing noncommunicable diseases (NCDs) among people living with human immunodeficiency virus (PLWH) in low- and middle-income countries (LMICs) in Africa: A scoping review protocol. by Abebe Sorsa Badacho, Ozayr Harron Mahomed

“…<h4>Background</h4>Noncommunicable diseases (NCDs) represent a global public health challenge in all population groups, but the prevalence of major NCDs, such as depression, hypercholesterolemia, hypertension, obesity and diabetes, is increasing at a rapid rate among people living with human immunodeficiency virus (PLWH). Studies show that integrated NCDs and human immunodeficiency virus (HIV) services have improved the patient outcome of PLWH with comorbidities with NCDs. …”
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Human Bot Fly, torsalo (Central America), moyocuil (Mexico), berne (Brasil), mucha (Colombia, mirunta (Peru), and ura (Argentina, Paraguay, and Uruguay), Dermatobia hominis (Linnaeus, Jr.)... by Stephanie K. Larrick, C. Roxanne Rutledge-Connelly

“…Published by the UF Department of Entomology and Nematology, September 2008. EENY 440/IN775: Human Bot Fly, Torsalo (Central America), Moyocuil (Mexico), Berne (Brasil), Mucha (Colombia, Mirunta (Peru), and Ura (Argentina, Paraguay, and Uruguay), Dermatobia hominis (Linnaeus, Jr.) …”
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