Pre-CCRT 18-fluorodeoxyglucose PET-CT improves survival in patients with advanced stages p16-negative oropharyngeal squamous cell carcinoma via accurate radiation treatment plannin... by Tsung-Ming Chen, Wan-Ming Chen, Mingchih Chen, Ben-Chang Shia, Szu-Yuan Wu

“…Abstract Purpose No large-scale prospective randomized study with a long-term follow-up period has evaluated the survival outcomes of preconcurrent chemoradiotherapy (CCRT) 18-fluorodeoxyglucose positron emission tomography–computed tomography (18FDG PET–CT) in patients with non–human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). …”
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Sex, Knowledge, and Attitude of Stroke Survivors Attending Bebe Herbal Center on Risk Factors before and after Stroke by Polycarp U. Nwoha, Florence O. Okoro, Emmanuel C. Nwoha, Fidelia N. Chukwu, Chidinma O. Nwoha, Nkeiru C. Ogoko, Peace N. Nwoha, Chika A. Idaguko, Augustine U. Obi, Ezenna M. Agwu, Iyanu O. Ayoola, Sunday O. Osonwa, Ifeoma H. Okpara

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Life cycle assessment of paper products based on recycled and virgin fiber by J. Simamora, E.I. Wiloso, M. Yani

“…The results of the impact assessment of global warming potential fossil, acidification, particulates, fossil abiotic depletion, and human toxicity-cancer for duplex board were 1,848.26 kilogram carbon dioxide equivalent, 8.12 kilogram-sulfur-dioxide-equivalent, 2.12 kilogram particulate matter 2.5-equivalent, 14,668.06 megajoule, and 0.0000017 comparative toxic unit, while for folding boxboard 2,651.25 kilogram carbon- dioxide-equivalent, 13.95 kilogram sulfur-dioxide-equivalent, 3.27 kilogram particulate matter 2.5-equivalent, 22,395.81 mega-joule, and 0.0000021 comparative toxic unit, respectively. …”
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Novel Thiosemicarbazone Derivatives from Furan-2-Carbaldehyde: Synthesis, Characterization, Crystal Structures, and Antibacterial, Antifungal, Antioxidant, and Antitumor Activities by Wilfredo Hernández, Fernando Carrasco, Abraham Vaisberg, Evgenia Spodine, Maik Icker, Harald Krautscheid, Lothar Beyer, Carmen Tamariz-Angeles, Percy Olivera-Gonzales

“…All prepared thiosemicarbazone derivatives were evaluated for their in vitro antibacterial, antifungal, and antitumor activities against Staphylococcus aureus strains, Candida albicans/Candida tropicalis fungi, and seven human tumor cell lines (HuTu80, H460, DU145, M-14, HT-29, MCF-7, and LNCaP), respectively. …”
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Source-specific acute cardio-respiratory effects of ambient coarse particulate matter exposure in California’s Salton Sea region by Yaning Miao, William C Porter, Tarik Benmarhnia, Catherine Lowe, Timothy W Lyons, Caroline Hung, Charles Diamond

“…Dropping water levels and unique biogeochemistry at the Salton Sea have raised concerns regarding the human health impacts of drying sediments exposed on shrinking shorelines, as well as potential lake spray emissions from the water surface itself. …”
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Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy by Siyu He, Chunyu Li, Mingxin Lu, Fang Lin, Sangyu Hu, Junfang Zhang, Luying Peng, Li Li

“…Infiltration and alterations in non-cardiomyocytes of the human heart involve crucially in the occurrence of DCM and associated immunotherapeutic approaches. …”
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In Situ Phytoremediation of Mine Tailings with High Concentrations of Cadmium and Lead Using <i>Dodonaea viscosa</i> (Sapindaceae) by Luis Fernando Acosta-Núñez, Patricia Mussali-Galante, María Luisa Castrejón-Godínez, Alexis Rodríguez-Solís, Joel Daniel Castañeda-Espinoza, Efraín Tovar-Sánchez

“…The waste generated during metal mining activities contains mixtures of heavy metals (HM) that are not biodegradable and can accumulate in the surrounding biota, increasing risk to human and environmental health. Plant species with the capacity to grow and develop on mine tailings can be used as a model system in phytoremediation studies. …”
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hBMSC-EVs alleviate weightlessness-induced skeletal muscle atrophy by suppressing oxidative stress and inflammation by Mengyuan Chang, Ruiqi Liu, Bingqian Chen, Jin Xu, Wei Wang, Yanan Ji, Zihui Gao, Boya Liu, Xinlei Yao, Hualin Sun, Feng Xu, Yuntian Shen

“…Methods In this study, human BMSCs-EVs (hBMSC-EVs) were isolated using super-centrifugation and characterized. …”
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Common pathogenic aspects of diabetic retinopathy and nephropathy. Kidney transplantation and the course of diabetic retinopathy by I.V. Vorobyeva, L.K. Moshetova, A.V. Pinchuk, Е.V. Bulava, E.P. Delver, A.A. Belogurov

“…Evdokimov Moscow University of Medicine &amp; Dentistry, Moscow, Russian Federation</b> </p> <p> <b>⁴Research Institute of Public Health Organization and Medical Management, Moscow, <br> &nbsp;Russian Federation</b> </p> <p> <b>⁵National Medical Research Center of Cardiology, Moscow, Russian Federation</b> </p> <p> <i>Epidemics of diabetes and its complications is a global threat to the health of human population. In 2040, the number of patients with diabetes is predicted to rise to 642 million. …”
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Efficacy of tranilast in preventing exacerbating cardiac function and death from heart failure in muscular dystrophy patients with advanced-stage heart failure: a single-arm, open-... by Tsuyoshi Matsumura, Takayasu Fukudome, Yasufumi Motoyoshi, Akinori Nakamura, Satoshi Kuru, Kazuhiko Segawa, Ruriko Kitao, Chigusa Watanabe, Takuhisa Tamura, Toshiaki Takahashi, Hiroya Hashimoto, Masahiro Sekimizu, Akiko M. Saito, Masanori Asakura, Koichi Kimura, Yuko Iwata

“…Despite the presence of progressive disease, cardiac indices such as brain natriuretic peptide level, human atrial natriuretic peptide level, and fractional shortening, remained stable, and only brain natriuretic peptide levels at 144 weeks showed significant changes. …”
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Intrinsic subtype and immunity score in identification of triple-negative breast cancer at low risk by Xinyu Ren, Tong Zhou, Yu Song, Huanwen Wu, Jeff Chou, Lance D. Miller, Zhiyong Liang, Songjie Shen

“…Intrinsic subtypes (basal-like, immune-enhanced, human epidermal growth factor receptor-2 [HER2]-enriched and luminal A/B) and tumor environmental immunity were evaluated using expression profiles of a 72-gene panel. …”
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Pathogenic potential of ornithogenic <i>Escherichia coli</i> strains detected in the Earth's polar regions by Batyrbek I. Aslanov, Daniil V. Azarov, Maria A. Makarova, Elizaveta G. Marysheva, Lyudmila A. Kraeva, Aleksey S. Mokhov, Ekaterina A. Lebedeva, Nikita E. Goncharov, Natalya V. Lebedeva, Dmitry A. Starikov, Victoria V. Kolodzhieva, Dmitry E. Polev, Artemy E. Goncharov

“…Pathogenic strains of Escherichia coli are an important object of surveillance within the One Health concept in the wild, agriculture and human society. Migratory bird colonies and high latitude avian colonies may be points of active intraspecies and interspecies contact between different animal species, accompanied by the spread of pathogens. …”
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Factors associated with caffeine intake among undergraduates: a cross-sectional study from Palestine by May Hamdan, Souzan Zidan, Fatima Al-Amouri, Hiba Niroukh, Manar Abu Dawod, Sajeda Ashour, Shahd Sameer Dweik, Manal Badrasawi

“…Moderate caffeine intake has beneficial health effects, while increased caffeine intake may have harmful effects in the human body. Existing literature indicated that undergraduates consume caffeine excessively. …”
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Poly (ADP-ribose) (PAR) levels in Peripheral Blood Mononuclear Cells (PBMC) during peri-implantation and early pregnancy in buffalo cows by Giovanna De Matteis, Anna Reale, Michele Zampieri, Emanuela Rossi, Federica Signorelli, Olimpia Barbato, Vittoria Lucia Barile

“…Despite many studies on humans, very little data on PAR in livestock are reported in the literature. …”
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Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system by Sarah Hollingshead, Gareth McVicker, Maria R. Nielsen, YuGeng Zhang, Giulia Pilla, Rebekah A. Jones, Jonathan C. Thomas, Sarah E. H. Johansen, Rachel M. Exley, Ditlev E. Brodersen, Christoph M. Tang

“…Our findings highlight the links between plasmid maintenance and antibiotic tolerance, both of which can promote the development of antimicrobial resistance.IMPORTANCEOur work addresses two processes, the maintenance of plasmids and antibiotic tolerance; both contribute to the development of antimicrobial resistance in bacteria that cause human disease. Here, we found a single nucleotide change in the vapBC toxin:antitoxin system that stabilizes the large virulence plasmid of Shigella sonnei. …”
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Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils by Yixiang Jiang, Ning Wang, Jingyi Liu, Haoran Ren, Wenkang Jiang, Yanting Lei, Xidan Fu, Miao Hao, Xiujuan Lang, Yumei Liu, Xijun Liu, Rui Li, Hulun Li

“…Methods Secretory supernatants (hMSC-L) and cell lysate products (hMSC-M) from primary human umbilical cord mesenchymal stem cells-cultured medium were administered intranasally to mice with cerebral ischemia. …”
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Transcriptome analysis reveals that PRV XJ delgE/gI/TK protects against intestinal damage in nose-dropping-infected mice by regulating ECM-ITGA/ITGB-P-FAK by Tong Xu, Yang Zhang, Qian Tao, Lei Xu, Si-Yuan Lai, Yan-Ru Ai, Jian-Bo Huang, Ben-Lu Yang, Ling Zhu, Zhi-Wen Xu

“…Therefore, we hypothesized that PRV promotes self-infection through activation of the ECM-ITGA/ITGB-p-FAK signaling pathway and that PRV XJ delgE/gI/TK immunization could attenuate the intestinal damage caused by PRV by inhibiting the activation of this pathway.IMPORTANCEPseudorabies virus (PRV) poses a significant threat to the swine industry and public health due to its ability to infect multiple species, including humans, leading to substantial economic losses and potential health risks. …”
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The compensatory enrichment of sphingosine-1-phosphate on HDL in FSGS enhances the protective function of glomerular endothelial cells compared to MCD by Yunfeng Xiong, Qiuping Ye, Lifang Liu, Wanjun Lin, Yonggen Liao, Ruiyu Gao, Jiaming Xu, Xinyu Zhang, Ruoyan Chen, Sihui Chen, Qiaoling Chen, Lixin Wei

“…Various HDL samples, comprising intact, apo-HDL, pho-HDL and rHDL, were co-cultivated with human renal glomerular endothelial cells (HRGECs). …”
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Protocol for a multisite randomised controlled trial assessing the effect of the Telehealth for Early Developmental Intervention in babies born very preterm (TEDI-Prem) programme o... by Alicia J Spittle, Peter J Anderson, Angela T Morgan, Rachel Schembri, Li Huang, Kim Dalziel, Rod W Hunt, Katherine Lee, Anne E Holland, Karli Treyvaud, Abbey L Eeles, Stacey Dusing, Shaaron Brown, Susan M Fehring, Gillian Henty, Elizabeth Kozaris

“…All models will be fitted via generalised estimating equations to account for multiple births and adjusted for the hospital sites.Ethics and dissemination This trial has Royal Children’s Hospital Human Research and Ethics Committee approval (HREC/67604/RCHM-2020) with specific site approval for all participating sites. …”
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Study of water pollution parameters in the dry and rainy seasons on the pollution index of the Mesuji River, Lampung, Indonesia by Abu Rosid Istomi, Suharso, Buhani, Tugiyono, Heri Satria, Emi Artika, Annisaa Siti Zulaicha

“…Background: The Mesuji River is a vital natural water resource, yet increasing human activities have resulted in significant pollution through chemical, physical, and biological contamination. …”
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