Evolutionary determinants of reproductive seasonality: A theoretical approach by Burtschell, Lugdiwine, Dezeure, Jules, Huchard, Elise, Godelle, Bernard

“…Overall, this study contributes a powerful theoretical framework and modelling tool that may apply across the life-history space, as well as sheds new light on the emergence and maintenance of non-seasonal breeding in slow-living species, including humans. …”
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Insights into the Mode of Action of Novel Morpholinated Curcumin Derivatives Exhibiting Potent Antitumor Activity in Bladder Cancer Cells In Vitro by Paulina Kobylka, Pawel Bakun, Joanna Kuzminska, Tomasz Goslinski, Marek Murias, Malgorzata Kucinska

“…This study tested curcumin derivatives with modified feruloyl moieties (<b>2a</b> and <b>2a-B</b>) and the β-diketo moiety (<b>2a-B</b>) to better understand their anticancer mechanism against human bladder cancer cells. The anticancer activity of <b>2a</b> and <b>2a-B</b> was determined using MTT (hypoxic conditions) and LDH (normoxic conditions) assays. …”
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Collecting perspectives on project prioritisation process in the EU co-funded multinational partnership for the assessment of risks from chemicals (PARC) through focus group discus... by Katya Manuella Permana, Maria Tannous, Hanna Mouaziz, Pascal Sanders, Nathalie Bonvallot, Christophe Rousselle

“…Abstract Introduction The European Partnership for the Assessment of Risks from Chemicals (PARC) is a 7-year multinational partnership aimed at consolidating and strengthening European Union’s (EU) research and innovation capacity for chemical risk assessment (RA) to protect human health and the environment. It consists of nine work packages (WP) involving more than 200 participating organisations from 29 countries. …”
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The regulatory role of cystatin C in autophagy and neurodegeneration by T. A. Korolenko, A. B. Shintyapina, A. B. Pupyshev, A. A. Akopyan, G. S. Russkikh, M. A. Dikovskaya, V. A. Vavilin, E. L Zavjalov, M. A. Tikhonova, T. G. Amstislavskaya

“…The aim: to study the role of cystatin C in neurodegeneration and evaluate the results in relation to the mechanism of autophagy. In our study on humans, a higher concentration of cystatin C was noted in cerebrospinal fluid than in serum; much lower concentrations were observed in other biological fluids (intraocular fluid, bile, and sweat). …”
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Evaluation of the impact of PEPFAR transition on retention in care in South Africa’s Western Cape Province by J Chiliza, R Laing, F G Feeley, A T Brennan

“…We observed no RIC difference by facility size and a slight increase when two or more human resources transitioned from PEPFAR to the government. …”
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Psychoeducation of higher education seekers with using of the resource-oriented model of stress resiliency in war conditions by V.V. Ogorenko, A.E. Nikolenko, T.Y. Shusterman, V.O. Kokashynskyi, A.B. Khotimska, M.H. Koren

“…The «BASIC Ph» model of stress resiliency was utilized as a framework for determining optimal human resource utilization during crises, with six modalities forming individual style of resiliency. …”
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Collaborative Governance in the Digital Transformation Age: A Systematic Literature Review with Bibliometric Mapping by Rio Yusri Maulana, Mitja Dečman

“…As societies increasingly rely on digital platforms and online communication, the prime urge and necessity of the human race – i.e., to communicate and collaborate in tackling these challenges – puts collaborative governance in digital transformation high on the agenda of governments, the private sector, and citizens. …”
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Association between metabolic score for visceral fat index and BMI-adjusted skeletal muscle mass index in American adults by Yifan Zhou, Xiangjie Su, Haitao Tan, Jun Xiao

“…Both obesity and the reduction of muscle mass can significantly affect human health. However, research exploring the relationship between METS-VF and SMI remains limited. …”
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miR-576-5p Promotes the Proliferation of Papillary Thyroid Carcinoma through the MAPK4-AKT Pathway by Rui Hai, Yang Zhou, Fan Li, Qingxi Guo, Yang Long, Fang Wang, Lian Cheng, Fei Wu, Shi Chen, Xiangyu Zhou

“…MicroRNA-576-5p (miR-576-5p) plays an important role in different human cancers. However, the biological function of miR-576-5p in papillary thyroid carcinoma (PTC) is still unclear. …”
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Relationship between meteorological factors and the incidence of severe fever with thrombocytopenia syndrome: a systematic review and meta-analysis by Guangju Mo, Hongmei Zhu, Jing Li, Huaiping Zhu, Qiyong Liu

“…Future studies on the relationship between meteorological factors and the incidence of SFTS should fully consider human activities and environmental factors, and explore the pathogenesis and transmission mechanisms in greater depth, so as to provide targeted preventive measures. …”
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Exploring salivary gene expression clusters: A bioinformatics approach for advanced diagnosis and prognosis in head and neck squamous cell carcinoma by Rajesh Parsanathan, Rishaba Byju, D.S. Prabakaran

“…Materials and methods: A comprehensive keyword search was conducted to extract 74 salivary gland secretion genes from the Human Protein Atlas. GeneMANIA and STRING databases were employed to analyse protein-protein interactions and predict functional partners. …”
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Role of Subsurface Geo-Energy Pilot and Demonstration Sites in Delivering Net Zero by M. H. Stephenson, D. A. C. Manning, M. J. Spence, L. Stalker, Z. K. Shipton, A. A. Monaghan

“…Gaps were identified in two areas: 1) test facilities to aid the design of low cost, high resolution, unobtrusive seismic and other monitoring for a seismically noisy urban environment with a sensitive human population, for example for ATES in urban areas; and 2) a dedicated through-fault zone test site to understand fault transmissivity and reactivation. …”
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Climate change as a wildlife health threat: a scoping review by Sabrina S. Greening, Lucie R. Pascarosa, Avery L. Munster, Roderick B. Gagne, Julie C. Ellis

“…Amongst the subset of papers focused on vector distribution, top themes included concepts related to pathogen transmission dynamics, human/public health, and pathogen prevalence, while health papers focused on concepts related to increasing temperatures, species home ranges and distribution, and changing environmental variables. …”
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Estimation of median LC50 and toxicity of environmentally relevant concentrations of thiram in Labeo rohita by Sana Alam, Gulnaz Afzal, Riaz Hussain, Hafiz Muhammad Ali, Amtul Sami, Rabbiah Manzoor Malik, Raheela Jabeen, Farid Shokry Ataya, Kun Li

“…The findings demonstrate that thiram severely pollute the marine eco-system and is quite hazardous for aquatic species by causing severe health effects even at sub-lethal concentrations and thus, render the apparently clean water to be unfit for animal and human consumption.…”
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Chronic and infectious respiratory mortality and short-term exposures to four types of pollen taxa in older adults in Michigan, 2006-2017 by Peter S. Larson, Allison L. Steiner, Marie S. O’Neill, Alan P. Baptist, Carina J. Gronlund

“…Methods We obtained records for all Michigan deaths from 2006-2017 from the Michigan Department of Health and Human Services (MDHHS). Deaths from infectious and chronic respiratory-related causes were selected using International Classification of Diseases (ICD-10) codes. …”
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Synthetic inhibition of SREBP2 and the mevalonate pathway blocks rhabdomyosarcoma tumor growth in vitro and in vivo and promotes chemosensitization by Silvia Codenotti, Michela Asperti, Maura Poli, Luisa Lorenzi, Alberto Pietrantoni, Matteo Cassandri, Francesco Marampon, Alessandro Fanzani

“…Results: In silico analysis showed upregulation of sterol regulatory element-binding protein 2 (SREBP2) and MVP genes, including 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR), farnesyl-diphosphate synthase (FDPS), squalene epoxidase (SQLE), which correlated with worse overall patient survival. Targeting of MVP in human RD and RH30 lines by inhibitors of SREBP2 (fatostatin), HMGCR (lovastatin and simvastatin), and FDPS (zoledronic acid) resulted in impaired cell growth, migration, and viability, and increased oxidative cell death in combination with actinomycin D. …”
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Hydrothermal synthesis of a nickel-oxide-infused orange peel nanobiocomposite for enhanced heavy metal removal from mining wastewater by Jacques Romain Njimou, Velma Fai, Mary Tamwa Sieugaing, Djimongbaye Nguenamadje, John Godwin, Oben Bessem Genola, Guy Bertrand Noumi, Bankim Chandra Tripathy

“…Heavy metals in various geochemical forms, such as exchangeable ions, carbonates, and oxides, pose significant risks to human health and the environment due to their persistence and bioaccumulation. …”
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Development and progression association of various ophthalmic pathologies with the gut microbiome state (literature review) by G.N. Rezbaeva, A.E. Babushkin, O.I. Orenburkina, I.A. Gimranova

“…Modern researches focus on studying the effect of changes in the gut microbiome on human health, including his eyes. This suggests the potential use of this indicator as a non-invasive biomarker during differential diagnosis, as well as its introduction for ophthalmic therapy purposes. …”
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The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases by Aleksandra Pogoda-Wesołowska, Nina Sługocka, Agnieszka Synowiec, Klaudia Brodaczewska, Marcin Mejer-Zahorowski, Maciej Ziękiewicz, Wojciech Szypowski, Piotr Szymański, Adam Stępień

“…The activating receptor belonging to the NKG2D is stimulated by specific ligands: in humans these are major histocompatibility complex (MHC) class I polypeptide–related sequence A (MICA) and MHC class I polypeptide-related sequence B (MICB) proteins and UL16 binding 1–6 proteins (ULBP1-6). …”
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First genome-scale insights into the virulence of the snow mold causal fungus Microdochium nivale by Ivan Tsers, Ekaterina Marenina, Azat Meshcherov, Olga Petrova, Olga Gogoleva, Alexander Tkachenko, Natalia Gogoleva, Yuri Gogolev, Evgenii Potapenko, Olga Muraeva, Mira Ponomareva, Viktor Korzun, Vladimir Gorshkov

“…The genetic potential to synthesize human-dangerous mycotoxins (fumonisin, ochratoxin B, aflatoxin, and gliotoxin) has been revealed for M. nivale. …”
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