Therapeutic effects of cyclophosphamide, dsDNA preparations and combinations thereof against Krebs-2 ascites cancer cells and various cancer transplants by E. A. Potter, E. V. Dolgova, A. M. Minkevich, Ya. R. Efremov, O. S. Taranov, V. V. Omigov, V. P. Nikolin, N. A. Popova, A. S. Proskurina, E. I. Vereschagin, A. V. Kozel, V. A. Rogachev, D. B. Petrov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…When Krebs-2 ascites are treated with human DNA 1-12 hours post CP injection, this results in either elimination of cells that internalize TAMRA-labeled DNA (TISCs) or alters their phenotype, which is accompanied with the loss of surface expression of CD34. …”
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Quinoid to benzenoid transition-driven glutathione sensing: Dual-emission carbon dots and smartphone-based ratiometric fluorescence analysis by Al-Montaser Bellah H. Ali, Ashraf M. Mahmoud, Yousef A. Bin Jardan, Aya M. Mostafa, James Barker, Mohamed M. El-Wekil

“…Practical validation using human serum samples demonstrated the method's robustness in complex biological matrices, achieving high recovery rates between 98.5 % and 101.0 %, confirming its suitability for real-world clinical applications. …”
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The Immunohistochemical Prognostic Value of Nuclear and Cytoplasmic Silent Information Regulator 1 Protein Expression in Saudi Patients with Breast Cancer by Bayan Alharbi, Alia Aldahlawi, Mourad Assidi, Fatemah Basingab, Kawther Zaher, Jehan Alrahimi, Sara Mokhtar, Jaudah Al-Maghrabi, Abdelbaset Buhmeida, Kaltoom Al-Sakkaf

“…Background: The mammalian NAD-dependent deacetylase sirtuin-1 family (named also silent information regulator or SIRT family, where NAD stands for “nicotinamide adenine dinucleotide” (NAD)) appears to have a dual role in several human cancers by modulating cell proliferation and death. …”
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Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study by Yunyi Yan, Nozomi Kondo, Kentaro Oniki, Hiroshi Watanabe, Tadashi Imafuku, Yuki Sakamoto, Takuro Shigaki, Akari Maruyama, Hitomi Nakazawa, Tetsuya Kaneko, Ayami Morita, Akira Yoshida, Hitoshi Maeda, Toru Maruyama, Hideaki Jinnouchi, Junji Saruwatari

“…Moreover, the HbA1c-SD and HbA1c-AUC were also associated with oxidized human serum albumin (HSA), an oxidative stress marker. …”
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hnRNPA2/B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherin/β-Catenin Signaling Modulation In Vitro by Yi Chen, Dan Tang, Linjie Zhu, Tianjie Yuan, Yingfu Jiao, Hexin Yan, Weifeng Yu

“…We investigated the effect of hnRNPA2/B1 on lipopolysaccharide- (LPS-) induced vascular endothelial injury in human umbilical vein endothelial cells (HUVECs) and the underlying mechanisms. …”
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Theory-based mobile phone text messaging intervention for blood pressure control (TEXT4BP) among hypertensive patients in Nepal: study protocol for a feasibility randomised control... by Buna Bhandari, Padmanesan Narasimhan, Abhinav Vaidya, Rohan Jayasuriya

“…This pilot study is not funded.Ethics and dissemination This study has received ethics approval from the University of New South Wales Human Research Ethics Committee B (HC190357), Nepal Health Research Council (302/2019) and Institutional Review Committee of Kathmandu Medical College and Teaching Hospital Kathmandu, Nepal (030520192). …”
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Can serum orexin levels be used as a marker in childhood epilepsy? by Mutluay Arslan, Canan Üstün, Ayşe Nur Coşkun, Hasan Çelik, Hacı Nadir Yalçın, Eda Karaismailoğlu, Erdim Sertoğlu, Bülent Ünay

“…Material and methods: The study was conducted between December 2021 and December 2022 in the Department of Pediatric Neurology of a tertiary hospital. 30 epilepsy patients who had a seizure in the last 24 h, 30 epilepsy patients in remission, and 17 healthy controls were included in the study. The Human Orexin‐A Enzyme‐Linked Immunosorbent Assay Kit was used to measure serum orexin‐A level. …”
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Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2 by Shaun Martin, Sarah van Veen, Tine Holemans, Seyma Demirsoy, Chris van den Haute, Veerle Baekelandt, Patrizia Agostinis, Jan Eggermont, Peter Vangheluwe

“…Here, we analyzed stable human SHSY5Y cell lines overexpressing wild-type (WT) or ATP13A2 mutants in which three N-terminal lipid binding sites (LBS1–3) were mutated. …”
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Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in Cameroon by Kagoué Simeni Luc-Aimé, Yindom Louis-Marie, Loni Ekali Gabriel, Clauvis Kunkeng Yengo, F. Esemu Livo, Nguedia Jules Clement Assob

“…This may be partly due to differences in host immunogenetic factors in highly polymorphic regions of the human genome such as those encoding the killer-cell immunoglobulin-like receptor (KIR) molecules which modulate the activities of natural killer cells. …”
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A novel non-invasive murine model for rapidly testing drug activity via inhalation administration against Mycobacterium tuberculosis by Xirong Tian, Xirong Tian, Xirong Tian, Xirong Tian, Yamin Gao, Yamin Gao, Yamin Gao, Yamin Gao, Chunyu Li, Chunyu Li, Chunyu Li, Chunyu Li, Wanli Ma, Wanli Ma, Wanli Ma, Wanli Ma, Jingran Zhang, Jingran Zhang, Jingran Zhang, Jingran Zhang, Yanan Ju, Yanan Ju, Yanan Ju, Yanan Ju, Jie Ding, Jie Ding, Jie Ding, Jie Ding, Sanshan Zeng, Sanshan Zeng, Sanshan Zeng, Sanshan Zeng, H. M. Adnan Hameed, H. M. Adnan Hameed, H. M. Adnan Hameed, H. M. Adnan Hameed, Htin Lin Aung, Htin Lin Aung, Htin Lin Aung, Nanshan Zhong, Gregory M. Cook, Gregory M. Cook, Gregory M. Cook, Gregory M. Cook, Jinxing Hu, Jinxing Hu, Tianyu Zhang, Tianyu Zhang, Tianyu Zhang, Tianyu Zhang, Tianyu Zhang

“…This novel approach offers several advantages: (1) it eliminates the need for anesthesia in mice during administration and simplifies the instrument manipulation; (2) it is cost-effective by utilizing mice instead of larger animals; (3) it shortens the time from several months to 16 or 17 days for obtaining result; (4) it is non-invasive by directly measuring the live RLUs of mice as a surrogate marker for colony-forming units for in vivo drug activity testing; (5) up to six mice can be administrated daily and simultaneously, even 2–3 times/day; (6) results are relatively objective and reproducible results minimizing human factors. Proof-of-concept experiments demonstrated that inhalable rifampicin, isoniazid, and ethambutol showed anti-M. tuberculosis activity at concentrations as low as 0.5, 0.5, and 0.625 mg/mL, respectively, as evidenced by comparing the live RLUs of mice. …”
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Tailoring traditional Chinese medicine in cancer therapy by Shuiquan Li, Xi Chen, Hui Shi, Ming Yi, Bing Xiong, Tianye Li

“…The traditional Chinese medicine (TCM), as an embodiment of ancient wisdom, has been validated to regulate the holistic human capacity against both internal and external “evils” in accordance with TCM principles. …”
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Community-based culturally tailored education programmes for black adults with cardiovascular disease, diabetes, hypertension and stroke: a systematic review protocol of primary em... by Hardeep Singh, Michelle LA Nelson, Joseph IV Fulton, Oya Pakkal, Elizabeth M Uleryk

“…The aggregated data will be presented through textual descriptions of programme characteristics and outcomes.Ethics and dissemination This systematic review protocol does not require ethics approval without the inclusion of human participants and will use studies that have previously obtained informed consent. …”
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Identification and functional analysis of hub genes involved in deoxynivalenol-induced enterotoxicity in porcine (Sus scrofa) by Jinhua He, Geng Zhao, Mingxia Chen, Ximing Ren, Peizhi Zhu, Zhizhong Liu, Jiayi Zhou, Hanwei Chen, Chuqiao Xiao, Xiang-Guang Li

“…The porcine digestive system is physiologically similar to that of humans, making pigs a suitable model for studying DON-induced enterotoxicity. …”
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Characterization of Amino Acid Composition, Nutritional Value, and Taste of Fruits from Different Actinidia arguta Resources by Yanli He, Hongyan Qin, Jinli Wen, Lin Wang, Weiyu Cao, Shutian Fan, Wenpeng Lu, Jiaqi Li, Changyu Li

“…The results of the nutritional value evaluation showed that the Leu of the fruits of the A. arguta resources all conformed to the ideal model proposed by FAO/WHO, and the Leu content of all the resources exceeded the human body’s needs, and it was also found that the first limiting amino acid of the Actinidia argute resources was Ile and the second limiting amino acid was Lys. …”
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Detection and Classification of Teacher-Rated Children’s Activity Levels Using Millimeter-Wave Radar and Machine Learning: A Pilot Study in a Real Primary School Environment by Tianyi Wang, Takuya Sakamoto, Yu Oshima, Itsuki Iwata, Masaya Kato, Haruto Kobayashi, Manabu Wakuta, Masako Myowa, Tokomo Nishimura, Atsushi Senju

“…Traditional assessments of children’s health and behavioral issues primarily rely on subjective evaluation by adult raters, which imposes major costs in time and human resource to the school system. This pilot study investigates the utilization of millimeter-wave radar coupled with machine learning for the objective and semi-automatic detection and classification of children’s activity levels, defined as restlessness, within a real classroom environment. …”
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Renewable energy consumption, institutional quality and life expectancy in EU countries: a cointegration analysis by Anca-Florentina Vatamanu, Mihaela Onofrei, Elena Cigu, Florin Oprea

“…Using panel data from 27 European countries over the period 2000–2020, this study examines the effects of renewable energy consumption on human life expectancy as well as how institutional quality and investment in renewable energy projects might promote better health outcomes. …”
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What motivates West African cocoa farmers to value trees? Taking the 4 W approach to the heart of the field by Marie Ruth Dago, Irié Casimir Zo‐Bi, Isaac Kouamé Konan, Aimé Kouadio Kouassi, Stéphane Guei, Patrick Jagoret, Anny Estelle N'Guessan, Elsa Sanial, Chloé Tankam, Soulemane Traoré, Bruno Hérault

“…The distribution of use values by category shows that the highest values are associated with (i) agronomic uses (such as shade for cocoa trees and soil fertilization), (ii) food for human consumption, (iii) social purposes, and (iv) medicinal uses. …”
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Impact of alternative diagnostic labels for melanoma in situ on management choices and psychological outcomes: protocol for an online randomised study by Brooke Nickel, Lisa Parker, Jon Emery, Richard A Scolyer, Raymond Barnhill, David Elder, Katy JL Bell, Elspeth Davies, Blake O'Brien, Adewole S Adamson, Alexander C J van Akkooi, Farzaneh Boroumand, Zhuohan Wu, Peter M Ferguson, Donald Low, Cynthia Low, Sherrie Liu, Stacey Lewis, Bella Spongberg-Ross

“…Ethics approval has been received from The University of Sydney Human Research Ethics Committee (2024/HE000019). …”
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Whole Genome Sequencing Reveals Substantial Genetic Structure and Evidence of Local Adaptation in Alaskan Red King Crab by Carl A. St. John, Laura E. Timm, Kristen M. Gruenthal, Wesley A. Larson

“…A long tradition of responsible fisheries management has sustained these species for generations, but modern threats from climate change, habitat loss, and new fishing technologies threaten their ecosystems and the human communities that depend on them. Among these species, Alaska's most charismatic megafaunal invertebrate, the red king crab, faces all three of these threats and has declined substantially in many parts of its distribution. …”
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Building knowledge to improve access to inclusive and equitable care for trans and gender-diverse survivors of sexual assault and intimate partner violence: a qualitative research... by Alexa R Yakubovich, Janice Du Mont, Sarah Daisy Kosa, Sheila Macdonald, Danielle Toccalino, C Emma Kelly, Sav Jonsa, Adam Davies

“…Introduction Intimate partner violence (IPV) and sexual assault are pervasive public health and human rights concerns that disproportionately impact trans and gender-diverse (TGD) individuals. …”
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