Identification and Validation of Pivotal Genes in Osteoarthritis Combined with WGCNA Analysis by Yang C, Chen X, Liu J, Wang W, Sun L, Xie Y, Chang Q

“…Chengzhuo Yang,1,* Xinhua Chen,1,* Jin Liu,1 Wenhao Wang,1 Lihua Sun,2 Youhong Xie,1 Qing Chang1,* 1Department of The Affiliated Rehabilitation Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Rehabilitation Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Youhong Xie; Qing Chang, Email 172763320@qq.com; 651733149@qq.comIntroduction: The prevalence of osteoarthritis (OA), the most common chronic joint condition, is increasing due to the aging population and escalating obesity rates, leading to a significant impact on human health and well-being. Thus, analyzing the key targets of OA through bioinformatics can help discover new biomarkers to improve its diagnosis.Methods: The microarray and RNA-seq results were screened from the Gene Expression Omnibus (GEO) database. …”
Get full text

GENDER EQUALITY AS A MODERN PHENOMENON by S. V. Storozhuk, I. M. Hoyan

“…Originality lies in putting forward the new theoretical statements aimed to show that in the ancient and pre-modern society, gender inequality and discrimination did not exist, because at that time gender relations were considered either as a result of the biological characteristics of a human body, or were explained by worldview ideas about the origin and structural features of the world, prevailing in a specific historical dimension. …”
Get full text

Arsenic, manganese, and iron concentration in groundwater of northwestern part of Bangladesh using self-organizing maps: Implication for health risk assessment by Obaida Urme, AHM Selim Reza, Md Ibrahim Adham, Golam Sabbir Sattar

“…The SOM analysis elucidated the non-linear relationship of As with other elements in two-dimensional planes of having 49 nodes (7 × 7), which incorporated with Spearman's correlation coefficient quantified the positive correlation among As, Mn and Ca, and negative correlation among As, Fe, EC and pH. In accordance with human health risk was also explained in terms of non-carcinogenic and carcinogenic risk. …”
Get full text

Deconstruction of “The Pilgrim’s Progress” by John Bunyan in Kurt Vonnegut’s “Slaughterhouse-Five, or The Children’s Crusade” by Nataliya Krynytska

“…The article shows that Kurt Vonnegut in his anti-war postmodernist novel Slaughterhouse-Five manages to create a double code that allows to deconstruct John Bunyan’s important allegorical work The Pilgrim’s Progress, which at one time was an effective means of Protestant religious propaganda, and at the same time to urge readers to return to Christian humanism. The purpose of the article is to study the deconstruction of Bunyan’s work in Vonnegut’s novel through the lens of jeremiad as the Puritan rhetorical form. …”
Get full text

Current capabilities of prototyping technologies for multilayer printed circuit boards on a 3D printer by D. S. Vorunichev, K. Yu. Vorunicheva

“…The method allows the system to work roundthe-clock with minimal human intervention, significantly increasing the productivity of 3D printing and expanding the possibilities of prototyping. …”
Get full text

Detecting anomalies in graph networks on digital markets. by Agata Skorupka

“…In the former, an anomaly is defined as a bot, as opposed to a human user, whereas in the latter, an anomaly is a user who conducted a fraudulent transaction, which may (but does not have to) imply being a bot. …”
Get full text

Interferon‐β–Induced Injury During Pediatric Muscle Differentiation: Insight Into Juvenile Dermatomyositis Pathogenesis by Lauren T. Covert, Alaa Osman, George A. Truskey

“…We aimed to characterize the functional and structural effects of IFNβ on in vitro human pediatric myoblast growth and differentiation in a three‐dimensional skeletal muscle model (myobundles). …”
Get full text

Genetic analysis of ocular tumour-associated genes using large genomic datasets: insights into selection constraints and variant representation in the population by Jose S Pulido, Mandeep S Sagoo, Omar A Mahroo, Alexander Tanner

“…We explored these parameters in ocular tumour-associated genes.Methods A curated list of ocular tumour-associated genes was assessed using the genomic databases Genome Aggregation Database (gnomAD) and DatabasE of genomiC varIation and Phenotype in Humans using Ensembl Resources (DECIPHER) and compared with breast and lung cancer-associated gene lists. …”
Get full text

PSYCHO-SOCIAL CONGRUENCES BETWEEN RESILIENCE AND SOLITUDE by HARAZ Svetlana, SIMION Simion Dănuț

“…It is essential to find a balance and ensure that individuals have access to social support networks, as human connection that also plays a significant role in building resilience.…”
Get full text

Epidemiology of Pediatric Bite/Sting Injuries. One-Year Study of a Pediatric Emergency Department in Israel by Michal Hemmo-Lotem, Yoav Barnea, Claudia Jinich-Aronowitz, Liri Endy-Findling, David Leshem, Arik Zaretski, Joav Merrick

Get full text

Impact evaluation of hilsa fishery restoration in Bangladesh: money well spent? by Essam Yassin Mohammed, A. B. M. Mahfuzul Haque, Md. Nahiduzzaman

“…The hilsa fishery, Bangladesh’s largest single-species fishery, generates over USD 3 billion annually, contributing 12% to annual fish production and supporting 2.5 million people. However, the growing human population and the associated demand for fish protein have led to overfishing of both adult and juvenile hilsa in the gill net fishery. …”
Get full text

Investigation of alpha-glucosidase inhibition activity of Artabotrys sumatranus leaf extract using metabolomics, machine learning and molecular docking analysis. by Dela Rosa, Berna Elya, Muhammad Hanafi, Alfi Khatib, Eka Budiarto, Syamsu Nur, Muhammad Imam Surya

“…Molecular docking simulation, both to 3A4A (α-glucosidase enzyme from Saccharomyces cerevisiae, usually used in bioassay test) and 3TOP (a part of α-glucosidase enzyme in human gut) showed strong to very strong binding of the identified predicted active compounds to both receptors, with exception of neomangiferin which only showed strong binding to 3TOP receptor. …”
Get full text

Corallocarpus glomeruliflorus: Pharmacological potential revealed by phytochemical and in silico investigations by Fatima Saleh Naji Bin-Asal, Adel A.M. Saeed, Abdul-Rahman Alawi Bin Yahia

“…Most significantly, the CGP extract exhibited more potent selective anticancer effects on human breast (MCF-7) and colon (HCT-116) cancer cell lines than previously reported for related Cucurbitaceae species, with IC50 values of 49.18 ± 2.81 μg/mL and 244.2 ± 9.86 μg/mL, respectively. …”
Get full text

Detection of Viable but Nonculturable E. coli Induced by Low-Level Antimicrobials Using AI-Enabled Hyperspectral Microscopy by MeiLi Papa, Aarham Wasit, Justin Pecora, Teresa M. Bergholz, Jiyoon Yi

Get full text

Comparison of methods for selecting a promising walnut gene pool according to fruit quality by S. G. Biganova, Yu. I. Sukhorukikh, E. K. Pchikhachev

“…Walnut (Juglans regia L.) is considered a particularly valuable plant for humans. A number of methods have been developed to select the species’ gene pool that produces high-quality fruits. …”
Get full text

Absence of Tuberculosis-Causing Mycobacteria from Slaughtered Livestock Tissues and Environmental Samples, Gauteng Province, South Africa by Vuyokazi Mareledwane, Abiodun A. Adesiyun, Tiny M. Hlokwe

“…Mycobacterium tuberculosis complex (MTBC) is a group of bacteria responsible for causing tuberculosis in animals and humans. In South Africa (S.A), slaughterhouses are registered by the government and closely inspected and audited for hygienic slaughter practices. …”
Get full text

Influence of chlorhexidine dentin disinfection on universal adhesive performance: Interfacial adaptation and bond strength assessments. by Alaa Turkistani, Helal M Sonbul, Mai Almarzouki

“…<h4>Methods</h4>Class I cavities were prepared in the coronal dentin of extracted human teeth and assigned to two etching modes (SE or ER), then subdivided by disinfection with or without CHX (n = 5). …”
Get full text

ANTITUMOR EFFECT OF ELECTROMAGNETIC FIELDS AND THEIR EFFECT ON PAIN IN EXPERIMENTAL AND CLINICAL ONCOLOGY by E. M. Frantsiyants, E. A. Sheiko

“…The review examined and analyzed scientific publications on the effect of electromagnetic fields (EMF) on various sys­tems of the human body and animals with tumors, as well as on pain in the experiment and the clinic. …”
Get full text

Educational Policy of Kazakhstan in the Context of Youth Migration by V. Yu. Ledeneva, O. V. Lomakina, A. M. Dzhunusov, B. T. Begasilov

“…Educational migration largely determines the dynamics and nature of the country’s economic development and is viewed as a factor in increasing the country’s competitiveness and building up human capital. In this context, an increasing problem for Kazakhstan is the regulation of educational migration in the context of fierce competition in the international market of educational services.A review of publications showed that the issues of regulating educational migration from Kazakhstan are not widely covered in scientific discourse. …”
Get full text

3D Chaotic Nonlinear Dynamic Population-Growing Mathematical System Modeling with Multiple Controllers by Shaymaa Hussain, Suzan Obaıys, Nadia Al-saidi, Yeliz Karaca

“…Accordingly, a 3D-discrete and dynamic human population growth system with many controllers is proposed by examining the stability and symmetry of controller system clarifications. …”
Get full text