The association between PM2.5 and frailty: evidence from 122 cities in China and 7 countries in Europe by Yanchao Wen, Guiming Zhu, Kexin Cao, Jie Liang, Xiangfeng Lu, Tong Wang

“…PM2.5 particulate matter exposure is a significant factor affecting human health and is crucial in the aging process. …”
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A comparative bio-mechanical performance assessment of additively manufactured bone scaffolds using different beta Ti alloys and Gyroid based cellular structure by Mudassar Rehman, Yanen Wang, Kashif Ishfaq, Ray Tahir Mushtaq, Aqib Mashood Khan, Mohammed Alkahtani, Aamer Nazir, Maimoona Afzal

“…An exponential rise in demand for artificial implants has emphasized the need for novel biomaterials with good biocompatibility and mechanical properties comparable to human cortical and cancellous bone, to mitigate stress shielding and other post implantation challenges. …”
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An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors by Russell J. Schilder, Drew Rasco, Manish R. Sharma

“…Tyrosine kinase inhibitors (TKIs) targeting ALK have improved disease outcomes, but resistance mechanisms are common. This first-in-human trial evaluates ESK-440, a dual inhibitor of ALK and focal adhesion kinase, as a novel strategy for cancers with resistance to ALK-targeting TKIs. …”
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Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation by Qian-Lu Wang, Lei Yang, Yue Peng, Min Gao, Ming-Shi Yang, Wei Xing, Xian-Zhong Xiao

“…To investigate the protective effect of ginsenoside Rg1 on relieving sepsis-induced lung inflammation and injury in vivo and in vitro. Methods. Cultured human pulmonary epithelial cell line A549 was challenged with LPS to induce cell injury, and CLP mouse model was generated to mimic clinical condition of systemic sepsis. …”
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[18F]PARPi Imaging Is Not Affected by HPV Status In Vitro by Navjot Guru, Paula Demétrio De Souza França, Giacomo Pirovano, Cien Huang, Snehal G. Patel, Thomas Reiner

“…Background. Human papillomavirus- (HPV-) associated oropharyngeal squamous cell carcinomas (OPSCCs) are clinically and pathologically distinct from HPV-negative tumors. …”
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Impact of Notch3 Activation on Aortic Aneurysm Development in Marfan Syndrome by Kathryn Jespersen, Chenxin Li, Rishi Batra, Christopher A. Stephenson, Paul Harding, Kylie Sestak, Ryan T. Foley, Harrison Greene, Trevor Meisinger, Jason R. Cook, B. Timothy Baxter, Wanfen Xiong

“…The murine RNA-sequencing data were validated with mouse and human MFS aortic tissue, demonstrating elevated Notch3 activation in MFS. …”
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Spray-Induced Gene Silencing (SIGS): Nanocarrier-Mediated dsRNA Delivery Improves RNAi Efficiency in the Management of Lettuce Gray Mold Caused by <i>Botrytis cinerea</i> by Maria Spada, Claudio Pugliesi, Marco Fambrini, Diego Palpacelli, Andrea Caneo, Susanna Pecchia

“…The management of gray mold disease is still mainly based on the use of chemicals, which could have harmful effects not only due to impacts on the environment and human health, but also because they favor the development of fungicide-resistant strains. …”
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Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance by Santiago Rodríguez de Córdoba, Andrea Reparaz, Daniel Sanchez, Sheila Pinto, Lucia Juana Lopez, Héctor Martin Merinero, Iria Calvete, Julian Perez-Perez, Sydney S. Jellison, Yuzhou Zhang, Richard J. H. Smith, Inmaculada Moreno, Mercedes Dominguez

“…The visually-based immunochromatographic test (ICT) described herein allows for quick detection and quantification of IgG and IgM FH-FHAA complexes in human EDTA-plasma or serum. This ICT offers improved detection of FHAAs compared to ELISA as demonstrated by cases where the ICT identifies FH-FHAA complexes in samples that tested negative with the free FHAA ELISA. …”
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Fatal intoxication after oral ingestion of amphetamine: Two case reports by Evelyn Pawlik, Felix Mayer, Oliver Temme

“…The toxicity of the amphetamine by-products on the human body remains unclear and is subject of further studies.…”
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Genetic Analysis of Cytokine Promoters in Nonhuman Primates: Implications for Th1/Th2 Profile Characteristics and SIV Disease Pathogenesis by Pavel Bostik, Melanie Watkins, Francois Villinger, Aftab A. Ansari

“…The shift from a predominant synthesis of prototype Th1 cytokines to Th2 or Th0 type of cytokines by antigen activated PBMC's from HIV infected humans and SIV infected disease susceptible rhesus macaques (RM) has been shown to be associated with disease progression. …”
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HPV vaccination and Native Americans: protocol for a systematic review of factors associated with HPV vaccine uptake among American Indians and Alaska Natives in the USA by Sameer Vali Gopalani, Ami E Sedani, Amanda E Janitz, Shari C Clifton, Julie Stoner, Jennifer Peck, Ashley Comiford, Alicia L Salvatore, Janis Campbell

“…Introduction The nine-valent human papillomavirus (HPV) vaccine could prevent an estimated 92% of the cancers attributable to HPV types targeted by the vaccine. …”
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The Role of Antioxidant Activity of Chitosan-Pinus merkusii Extract Nanoparticle in against Lead Acetate-Induced Toxicity in Rat Pancreas by G. Wardani, Ernawati, K. Eraiko, S. A. Sudjarwo

“…Lead is one of the heavy metals with oxidative stress that causes toxicity in human and animals. The aim of this study was to evaluate the antioxidant activity of Chitosan-Pinus merkusii extract nanoparticle on lead acetate-induced toxicity in rat pancreas. …”
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Comprehensive analysis of H3K27me3 LOCKs under different DNA methylation contexts reveal epigenetic redistribution in tumorigenesis by Yuan Liang, Mengni Liu, Bingyuan Liu, Benjamin Ziman, Guanjie Peng, Qiong Mao, Xingzhe Wang, Lizhen Jiang, De-Chen Lin, Yueyuan Zheng

“…Result In this study, we identify and categorize H3K27me3 LOCKs in 109 normal human samples, distinguishing between long and short LOCKs. …”
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Distribution and Conservation of Ephedra rhytidosperma by Chao Tan, David Kay Ferguson, Yong Yang

“…ABSTRACT With global warming and increasingly intensified human activities, numerous species are on the verge of extinction, ca. 28% of living species are threatened globally, although conservation of endangered species has received worldwide attention. …”
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Nanobody screening and machine learning guided identification of cross-variant anti-SARS-CoV-2 neutralizing heavy-chain only antibodies. by Peter R McIlroy, Le Thanh Mai Pham, Thomas Sheffield, Maxwell A Stefan, Christine E Thatcher, James Jaryenneh, Jennifer L Schwedler, Anupama Sinha, Christopher A Sumner, Iris K A Jones, Stephen Won, Ryan C Bruneau, Dina R Weilhammer, Zhuoming Liu, Sean Whelan, Oscar A Negrete, Kenneth L Sale, Brooke Harmon

“…Previously, we designed a next-generation synthetic humanized nanobody (Nb) phage display library and demonstrated that this library could be used to rapidly identify highly specific and potent neutralizing heavy chain-only antibodies (HCAbs) with prophylactic and therapeutic efficacy in vivo against the original SARS-CoV-2. …”
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Impact of COVID-19 on Utilization of Healthcare Services Among People Living with HIV (PLHIV): A Systematic Review by Enyinnaya Ukaegbu, Maulenkul Tilektes, Antonio Sarria-Santamera

“…., “COVID-19 pandemic”, “SARS-CoV-2”, “Health services utilization”, “People living with Human immunodeficiency virus”, was included. <i>Results:</i> There was an overall decline in the utilization of health services such as medical consultations, ART uptake, and viral load monitoring by PLHIV at primary health centers at the forefront of care delivery. …”
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A Novel Liposome Formulation Carrying Both an Insulin Peptide and a Ligand for Invariant Natural Killer T Cells Induces Accumulation of Regulatory T Cells to Islets in Nonobese Dia... by Hidetoshi Akimoto, Emi Fukuda-Kawaguchi, Omar Duramad, Yasuyuki Ishii, Kazunari Tanabe

“…Antigen-specific therapies using islet autoantigens for restoring immune tolerance have emerged as promising approaches for the treatment of T1D but have been unsuccessful in humans. Herein, we report that RGI-3100-iB, a novel liposomal formulation carrying both α-galactosylceramide (α-GalCer), which is a representative ligand for invariant natural killer T (iNKT) cells, and insulin B chain 9–23 peptide, which is an epitope for CD4+ T cells, could induce the accumulation of regulatory T cells (Tregs) in islets in a peptide-dependent manner, followed by the remarkable prevention of diabetes onset in nonobese diabetic (NOD) mice. …”
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Move to improve - Prescribing physical activity and deprescribing paracetamol for low back pain: Protocol for a hybrid type III feasibility study by David Roberts, Paulo H Ferreira, Josielli Comachio, Paula R Beckenkamp, Thomas Patterson, Mark Halliday, Emma Kwan-Yee Ho

“…Qualitative (open-ended questions) will be integrated with the feasibility trial outcomes to inform the design of a full-scale randomised controlled trial.Ethics and dissemination This study has ethical approval from the Sydney Local Health District Human Research Ethics Committee (2023/ETH02683). …”
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Host-symbiont-gene phylogenetic reconciliation by Menet, Hugo, Trung, Alexia Nguyen, Daubin, Vincent, Tannier, Eric

“…We finally evaluate different hypotheses on human population histories in the light of their coevolving Helicobacter pylori symbionts, reconciled together with their genes. …”
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Evaluation of relationships between dogs and owners: the turkish translation, reliability and validity study of cat/dog owner relationship scale (c/dors) by Ufuk Kaya, Dogukan Ozen, Murat Onur Yazlik, Selim Kosem, İsmayil Safa Gurcan

“…In addition, this study will encourage the examination of pet-human relationships in Turkey through with scale development and adaptation studies.…”
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