Bullatine A suppresses glioma cell growth by targeting SIRT6 by Zhi Wang, Yushuai Zhu, Can Luo, Fan Zhang, Jiannong Zhao, Chuanyi Fu

“…In this study, we investigated the effects of BLA on human brain malignant glioblastoma cells. Our results showed that BLA inhibited the proliferation of U87MG and U251 cells in a dose-dependent manner and decreased their survival rate. …”
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Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells by Katja Spiess, Mads G. Jeppesen, Mikkel Malmgaard-Clausen, Karen Krzywkowski, Thomas N. Kledal, Mette M. Rosenkilde

“…One recent example targeted the virus-encoded G protein-coupled receptor US28 as a strategy for specific and efficient treatment of human cytomegalovirus (HCMV) infections. US28 is expressed on virus-infected cells and scavenge chemokines by rapid internalization. …”
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Protocol for development, calibration and validation of the Patient-Reported Inventory of Self-Management of Chronic Conditions (PRISM-CC) by Tara Sampalli, Kylie Peacock, Tanya Packer, George Kephart, Åsa Audulv, America Keddy, Grace Warner

“…The expected completion date is early 2021.Ethics and dissemination This study will adhere to the Canadian Tri-Council Policy Statement on Ethical Conduct for Research Involving Humans. Ethics approval for all phases has been obtained from the Nova Scotia Health Authority Research Ethics Board. …”
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Classification, Processing Procedures, and Market Demand of Chinese Biscuits and the Breeding of Special Wheat for Biscuit Making by Xin Hu, Lejia Hu, Jing Zheng, Junkang Rong

“…Biscuits are composed of four main ingredients, which are flour, fat/oil, sugar, and water, whereas several secondary ingredients also are important sources of high molecular carbohydrates, plant proteins, vitamins, and minerals for human beings. In this study, we systematically summarized the related research of biscuits, including the main types of China’s biscuits, the market demands, and statistics of wheat planting, production, and import in recent ten years, as well as the research of soft wheat breeding for biscuit. …”
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Clinicopathological characteristics and long-term prognosis of triple-negative breast cancer patients with HER2-Low expression: a retrospective propensity score-matched cohort stud... by Xin Liu, Kaihua Zhao, Ziyan Zhang, Meiyan Liu, Hongwu Chu, Xiao Zou

“…Abstract Purpose The objective of the current research was to assess the clinicopathological characteristics and long-term prognosis of triple-negative breast cancer (TNBC) patients with human epidermal growth factor receptor 2 (HER2)-low status following breast surgery. …”
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Evaluating the impact of sustainable technology, resource utilization, and climate change on soil emissions: A CS-ARDL analysis of leading agricultural economies by Nazeer Ahmed, Guo Xinagyu, Mohamad Alnafissa, Mukut Sikder, Bonoua Faye

“…Climate change has become a significant environmental issue humanity has faced in the last few decades. The primary cause of this is the greenhouse effect and carbon dioxide (CO2) emissions. …”
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Clinical Characteristics and Short-Term Outcomes of HIV Patients Admitted to an African Intensive Care Unit by Arthur Kwizera, Mary Nabukenya, Agaba Peter, Lameck Semogerere, Emmanuel Ayebale, Catherine Katabira, Samuel Kizito, Cecilia Nantume, Ian Clarke, Jane Nakibuuka

“…In high-income countries, improved survival has been documented among intensive care unit (ICU) patients infected with human immune deficiency virus (HIV). There are no data from low-income country ICUs. …”
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Applicability of Retrospective and Prospective Gender Scores for Clinical and Health Data: Protocol for a Scoping Review by Lea Schindler, Hilke Beelich, Selina Röll, Elpiniki Katsari, Sylvia Stracke, Dagmar Waltemath

“… BackgroundGender is known to have a strong influence on human health and disease. Despite its relevance to treatment and outcome, gender is insufficiently considered in current health research. …”
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Interleukin-6 related signaling pathways as the intersection between chronic diseases and sepsis by Jie Yang, Lin Yang, Yanjiao Wang, Lu Huai, Bohan Shi, Di Zhang, Wei Xu, Di Cui

“…This article summarized the inflammatory mechanisms of IL-6 cross-talked with other mediators of some chronic diseases in vitro, animal models, and human experiments, leading to the activation of pathways and accelerating the progression of sepsis. …”
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Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer by Marisa Shiina, Lilly Y. W. Bourguignon

“…We determined that human head and neck cancer cells (HSC-3 cell line) contain a subpopulation displaying cancer stem cell (CSC) properties and are very tumorigenic. …”
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Projecting Surface Water Area Under Different Climate and Development Scenarios by Mollie D. Gaines, Mirela G. Tulbure, Vinicius Perin, Rebecca Composto, Varun Tiwari

“…However, most projections of surface water dynamics focus on climate drivers using local‐scale hydrological models, with few studies accounting for climate and human drivers such as land‐use/land‐cover change. …”
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Unified Visual-Aware Representations for Data Analytics by Ladislav Peska, Ivana Sixtova, David Hoksza, David Bernhauer, Jakub Lokoc, Tomas Skopal

“…The visual representations serve for data analytics tasks performed by human users as well as serve for universal data representations used in machine learning models for automated tasks. …”
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Corrosion behavior of NiTi alloys fabricated by laser powder bed fusion in relation to the formed passive films in Hank's solution by Yi-Fan Zhang, Liang-Yu Chen, Yong Liu, Hong-Yu Yang, Jin-Hua Peng, Chuanbo Zheng, Lina Zhang, Lai-Chang Zhang

“…Varying the parameters of the L-PBF process may result in the NiTi alloys with different ratios of B2 and B19′ phases, thereby, the different corrosion performance in the human body. However, a dearth of research efforts remains dedicated to resolving this issue. …”
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A systematic review of neurological symptoms and brain abnormalities in SARS-CoV-2 infections by Daniel Montoya, Jacobo Albert, Sarah Lopez-Martin

“… The aim of this systematic review is to show some clear evidence of COVID-19 infections in the human brain and draw attention to the neurological symptoms that were described during the early stages of the pandemic. …”
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Dredging and sediment discharge in a river with floodplain. Physicochemical and microbiological effects in Paraná river by Maria Josefina Gonzalez, Stella Maris Gonzalez, Aldo Raul Paira, Pablo Agustín Collins

“…Alterations caused by human activities in the environment, such as dredging, modify the physicochemical conditions and affect the habitat. …”
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Topography and dimensions of the auditory tube at the end of the fetal period by O.D. Sapunkov, L.O. Bogdanova, A.L. Kosakovskyi, I.A. Kosakivska, V.V. Syniachenko

“…The study was performed on 35 human fetuses of 231.0-375.0 mm parietococcygeal length (PCL) and 11 neonatal cadavers. …”
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Thrombin-Induced Calpain Activation Promotes Protease-Activated Receptor 1 Internalization by Alejandro Alvarez-Arce, Irene Lee-Rivera, Edith López, Arturo Hernández-Cruz, Ana María López-Colomé

“…Due to the irreversible nature of PAR1 activation, its inactivation must be efficiently regulated in order to terminate signaling. Using ARPE-19 human RPE cell line, we characterized thrombin-induced [Ca+2]i increase and demonstrated the calcium-dependent activation of μ-calpain mediated by PAR1. …”
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Comparative immobilization of lead, cadmium, and copper in soil using dead bacterial biomass and graphitic carbon nitride nanomaterials by Asifa Farooqi, Ejaz ul Haq, Hooria Ikram Raja, Hafiz Abdul Malik, Yousaf Shad Muhammad, Syed Hamza Safeer, Sohail Yousaf, Maximilian Lackner

“…Heavy metals (HM) are known to pose severe harm to the soil, crops, and human beings. The usefulness and efficiency of metal immobilization of Pb, Cd, and Cu ions using different doses of dead bacterial biomass (BM) and graphitic carbon nitride (g-C3N4) was evaluated and compared in spiked soil. …”
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γ-H2AX: A Novel Prognostic Marker in a Prognosis Prediction Model of Patients with Early Operable Non-Small Cell Lung Cancer by E. Chatzimichail, D. Matthaios, D. Bouros, P. Karakitsos, K. Romanidis, S. Kakolyris, G. Papashinopoulos, A. Rigas

“…The use of artificial neural networks in prediction problems is well established in human medical literature. The aim of the current study was to assess the prognostic value of a series of clinical and molecular variables with the addition of γ-H2AX—a new DNA damage response marker—for the prediction of prognosis in patients with early operable non-small cell lung cancer by comparing the γ-H2AX-based artificial network prediction model with the corresponding LR one. …”
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The multidrug-resistant Candida auris, Candida haemulonii complex and phylogenetic related species: Insights into antifungal resistance mechanisms by Lívia S. Ramos, Pedro F. Barbosa, Carolline M.A. Lorentino, Joice C. Lima, Antonio L. Braga, Raquel V. Lima, Lucas Giovanini, Ana Lúcia Casemiro, Nahyara L.M. Siqueira, Stefanie C. Costa, Célia F. Rodrigues, Maryam Roudbary, Marta H. Branquinha, André L.S. Santos

“…The rise of multidrug-resistant (MDR) fungal pathogens poses a serious global threat to human health. Of particular concern are Candida auris, the Candida haemulonii complex (which includes C. haemulonii sensu stricto, C. duobushaemulonii and C. haemulonii var. vulnera), and phylogenetically related species, including C. pseudohaemulonii and C. vulturna. …”
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