RIPK1 expression and inhibition in tauopathies: implications for neuroinflammation and neuroprotection by Ignacio Silva-Llanes, Ignacio Silva-Llanes, Ignacio Silva-Llanes, Enrique Madruga, Enrique Madruga, Ana Martínez, Ana Martínez, Isabel Lastres-Becker, Isabel Lastres-Becker, Isabel Lastres-Becker, Isabel Lastres-Becker

“…Our findings show elevated levels of RIPK1 mRNA levels across various forms of tauopathies, in both mouse models and human tissue samples associated with primary and secondary TAU-related disorders. …”
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Improving Sleep Disorder Diagnosis Through Optimized Machine Learning Approaches by Md. Atiqur Rahman, Israt Jahan, Maheen Islam, Taskeed Jabid, Md Sawkat Ali, Mohammad Rifat Ahmmad Rashid, Mohammad Manzurul Islam, Md. Hasanul Ferdaus, Md Mostofa Kamal Rasel, Mahmuda Rawnak Jahan, Shayla Sharmin, Tanzina Afroz Rimi, Atia Sanjida Talukder, Md. Mafiul Hasan Matin, M. Ameer Ali

“…Classifying sleep disorders, such as obstructive sleep apnea and insomnia, is crucial for improving human quality of life due to their significant impact on health. …”
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Challenges of environmental and climate change: response of Global South (BRICS) countries by Z.T. Rahman, R. Lal, R. Rena

“…It has become a threat to human civilization and the existing vegetations and animals. …”
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Serum Lipid and Glycemic Profile in HARRT-Naïve and HARRT-Exposed HIV Patients in Enugu State, Nigeria: A Case–Control Study by Esther A. Ekwe, Birinus A. Ezeala-Adikaibe, Basden Onwubere, Julius Okoye, Collins Ugwu, Chidinma B. Nwatu, Ijoma Chinweuba, Chidimma Orah-Okpala, Raphael Anakwue, Oladipupo O. Fasa, Celestine C. Okwara, Uchechi Q. Arinze, Paschal Njoku

“…Background: Although highly active antiretroviral therapy (HAART) has improved immunologic and virologic outcomes, as well as the quality of life of human immunodeficiency virus (HIV)-positive patients, it has worsened a wide range of metabolic derangements associated with HIV/AIDS. …”
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The role of Artificial Intelligence in detecting breast lesions using ultrasound by Daria Ziemińska, Karina Motolko, Rafał Burczyk, Konrad Duszyński, Elżbieta Tokarczyk, Martyna Michalska, Adam Łabuda

“…Brief knowledge status: AI develops systems that simulate human intelligence, excelling in breast imaging by detecting patterns and providing accurate results. …”
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RUBY® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties by Barnabas Nyesiga, Mattias Levin, Anna Säll, Anna Rosén, Kim Jansson, Sara Fritzell, Karin Hägerbrand, Dietmar Weilguny, Laura von Schantz

“…Also, retained interaction with FcRn is demonstrated to translate into a pharmacokinetic profile in mice and non-human primates that is comparable to mAb controls. …”
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Impact of Climate Change on the Growth of Typical Crops in Karst Areas: A Case Study of Guizhou Province by Jun Ma, Baisha Weng, Wuxia Bi, Dan Xu, Ting Xu, Dengming Yan

“…The global rising temperature is supposed to alter climatic patterns like floods and droughts, thereby affecting human life supporting system and global food production. …”
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Larval Cytotoxic and Subacute Toxicity of Gardenia ternifolia, Rourea coccinea, and Cassytha filiformis Used in Traditional Medicine of Benin (West Africa) by E. Agbodjento, J. R. Klotoé, T. I. Sacramento, T. V. Dougnon, E. Déguenon, J. Agbankpé, K. Fabiyi, P. Assogba, M.-P. Hounkanrin, R. Akotegnon, T. J. Dougnon, J.-M. Atègbo

“…However, this unregulated or irrational use may pose a risk of toxicity to humans in the short and/or long term. Recent studies reported interesting ethnopharmacological, antioxidant, and phytochemical data on some medicinal plants used in the traditional treatment of male infertility in Benin. …”
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Effectiveness of three biomimetic remineralization procedures in artificial caries-affected dentin – an in-vitro pilot study by Rosário Costa, Sofia Arantes-Oliveira, Lisete Fernandes, Fábio G. Figueiras, João Cardoso Ferreira, Paulo Ribeiro de Melo

“…Methods: Seventy-two specimens of healthy human dentin were divided into twelve groups. Half of each group’s samples were analyzed using field-emission gun environmental scanning electron microscope/energy dispersive X-ray, while the other half were analyzed by X-ray diffraction and micro-Raman spectroscopy. …”
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Isolation and Characterisation of Mesenchymal Stem Cells from Rat Bone Marrow and the Endosteal Niche: A Comparative Study by Norhayati Yusop, Paul Battersby, Amr Alraies, Alastair J. Sloan, Ryan Moseley, Rachel J. Waddington

“…Such findings support further comparisons of human CB-MSCs and BM-MSCs, facilitating selection of optimal MSC populations for regenerative medicine purposes.…”
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Modern possibilities of sodium hyaluronate in tear substitutive therapy of patients with “dry eye” syndrome by V.V. Brzheskiy, V.Yu. Popov

“…In a number of experimental studies, the efficacy and safety of the Vismed line is proved: in vitro — on the culture of epithelial cells of the human conjunctiva, in vivo — on the model of traumatic corneal erosion in rabbits. …”
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Differentially Expressed MicroRNAs in the Development of Early Diabetic Retinopathy by Qiaoyun Gong, Jia’nan Xie, Yang Liu, Ying Li, Guanfang Su

“…Because microRNAs (miRNAs) represent effective DR therapeutic targets, we identified aberrantly expressed miRNAs associated with cellular dysfunction in early DR and detected their potential targets. We exposed human retinal endothelial cells (HRECs) and a cell line of retinal pigment epithelial (RPE) cells to high glucose (25 mmol/L, 1–7 days) to mimic DR progression and used streptozotocin-injected rats (4–8 weeks) for an in vivo diabetes model. …”
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Molecular Detection of <i>Rickettsia</i> spp. and Other Tick-Borne Pathogens in Ticks from a Nature Reserve: Implications for Zoonotic Transmission by Santina Di Bella, Valeria Blanda, Silvia Scibetta, Ilenia Giacchino, Antonino Gentile, Giuseppina Chiarenza, Vincenza Cannella, Giovanni Provinzano, Francesca Grippi, Annalisa Guercio

“…Ticks are a major concern for both animal and human health, as they are primary vectors of infectious pathogens. …”
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Multimodal heterogeneous graph fusion for automated obstructive sleep apnea-hypopnea syndrome diagnosis by Haoyu Wang, Xihe Qiu, Bin Li, Xiaoyu Tan, Jingjing Huang

“…This framework constructs two types of graph representations: physical space graphs, which map the spatial layout of sensors on the human body, and process knowledge graphs which detail the physiological relationships among breathing patterns, oxygen saturation, and vital signals. …”
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CFP-AL: Combining Model Features and Prediction for Active Learning in Sentence Classification by Keuntae Kim, Yong Suk Choi

“…Particularly, obtaining high-quality labeled datasets for supervised learning requires human annotation, and an effective active learning strategy can greatly reduce annotation costs. …”
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Development of Collagen-Based 3D Matrix for Gastrointestinal Tract-Derived Organoid Culture by Joo Hyun Jee, Dong Hyeon Lee, Jisu Ko, Soojung Hahn, Sang Yun Jeong, Han Kyung Kim, Enoch Park, Seon Young Choi, Sukin Jeong, Joong Woon Lee, Han-Jun Cho, Min-Soo Kwon, Jongman Yoo

“…Mouse small intestine–derived organoids, stomach-derived organoids, and human colon–derived organoids were also cultured, all of which were successfully grown in the collagen-based matrix and had similar properties compared to those cultured in Matrigel. …”
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Understanding Indigenous knowledge of conservation and stewardship before implementing co-production with Western methodologies in resource management by Stafford Maracle, Jennifer Maracle, Stephen Lougheed

“… In the face of an increasing global human popula­tion and multiple anthropogenic environmental stressors including climate change, the limitations of relying solely on Western science and ap­proaches to mitigating impacts, conserving bio­diversity, and managing resources sustainably is apparent. …”
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IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome by Min Guo, Rui Yan, Hongmei Yao, Liqin Duan, Meng Sun, Zheng Xue, Yongping Jia

“…The expression of IRF-1 in human PBMC-derived macrophages was analyzed. Then, overexpression and inhibition of IRF-1 was performed in macrophages from patients with ACS to explore the possible role and mechanism of IRF-1 involvement in macrophage pyroptosis. …”
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Mesenchymal stem cell-derived extracellular vesicles enriched with miR-124 exhibit anti-inflammatory effects in collagen-induced arthritis by Guo Zhonghua, He Mengyuan, Shi Dongliang, Zhang Zhongbo, Wang Lisha, Ren Bowen, Wang Yunfei, Wang Junjie, Yang Shaoxiang, Yu Hongchao

“…This study investigated the anti-inflammatory effects of human umbilical cord-derived MSC (hUCSC)-EVs overexpressing miR-124 in collagen-induced arthritis (CIA). hUCSCs were transfected with miR-124, and hUCSC-EVs were isolated and characterized. …”
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AutoMEX: Streamlining material extrusion with AI agents powered by large language models and knowledge graphs by Haolin Fan, Junlin Huang, Jilong Xu, Yifei Zhou, Jerry Ying Hsi Fuh, Wen Feng Lu, Bingbing Li

“…AutoMEX utilizes a knowledge graph (KG) derived from the scientific literature to enable LLMs to provide expert recommendations on material selection, process parameters, and design considerations, thereby improving accessibility and efficiency. With minimal human intervention, the framework encompasses a complete workflow, including CAD model generation, printing parameter recommendation, slicing, and machine operation. …”
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