Host Susceptibility to Brucella abortus Infection Is More Pronounced in IFN-γ knockout than IL-12/β2-Microglobulin Double-Deficient Mice by Ana Paula M. S. Brandão, Fernanda S. Oliveira, Natalia B. Carvalho, Leda Q. Vieira, Vasco Azevedo, Gilson C. Macedo, Sergio C. Oliveira

“…Brucella abortus is a facultative intracellular bacterial pathogen that causes abortion in domestic animals and undulant fever in humans. IFN-γ, IL-12, and CD8+ T lymphocytes are important components of host immune responses against B. abortus. …”
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Association between C-reactive protein to albumin ratio and chronic obstructive pulmonary disease: a cross-sectional study by Ting Ao, Yingxiu Huang, Peng Zhen, Ming Hu

“…Abstract Background Chronic obstructive pulmonary disease (COPD) is a widespread condition that significantly endangers human health. The C-reactive protein to albumin ratio (CAR) has been utilized as an important marker for the occurrence and development of various diseases. …”
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TRα1 mutant suppresses KLF9 to cause endometrial metaplasia with ectopic IL-33 expression leading to uterine fibrosis and infertility by Elijah Edmondson, Takahito Kimura, Eunmi Hwang, Minjun Kim, Andrew Warner, Yuelin Zhu, Li Zhao, Yanlin Yu, Xuguang Zhu, Maria Hernandez, Noemi Kedei, Sheue-yann Cheng

“…Mutations of THRA gene cause a human disease known as resistance to thyroid hormone (RTHα). …”
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Quarantine and anti-epidemic measures as an element of Emergency Law in Ukraine by O. O. Levytskyi

“…The article also analyses the impact of emergency law on human rights, democracy and the rule of law in Ukraine. …”
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Medical Cannabis for Chronic Noncancer Pain: A Systematic Review of Health Care Recommendations by Yaping Chang, Meng Zhu, Christopher Vannabouathong, Raman Mundi, Roland S. Chou, Mohit Bhandari

“…All the included publications provided a recommendation supporting medical cannabis for CNCP in general and for the specific conditions of neuropathic pain, chronic pain in people living with Human Immunodeficiency Virus (HIV), and chronic abdominal pain, with detailed information sharing and comprehensive consideration of a patient’s own values and preferences. …”
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Estimation of water storage changes in a tropical lake-floodplain system through remote sensing by Thijs de Klein, Victor Bense, Syed Mustafa

“…Study region: Lake Urema and its floodplain in Gorongosa National Park, Mozambique Study focus: Tropical lowland lake-floodplain systems are increasingly threatened by climate change effects and other human-induced pressures. Determining the effect of these pressures on the water balance is challenging because of a lack of hydrological monitoring data, which impedes water management decisions. …”
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Identification of mitochondrial carrier homolog 2 as an important therapeutic target of castration-resistant prostate cancer by Yankui Liu, Anjie Chen, Yufan Wu, Jiang Ni, Rong Wang, Yong Mao, Ning Sun, Yuanyuan Mi

“…MTCH2 is also upregulated in locally treated CRPC tissue and various primary human CRPC cells. Using genetic silencing via shRNA and knockout (KO) through the CRISPR-sgRNA approach, we showed that the depletion of MTCH2 impaired mitochondrial function, resulting in a reduced oxygen consumption rate, diminished complex I activity, and decreased ATP levels, mitochondrial depolarization, and increased reactive oxygen species production in primary CRPC cells. …”
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Umbilical Cord Tissue-Derived Mesenchymal Stem Cells Induce T Lymphocyte Apoptosis and Cell Cycle Arrest by Expression of Indoleamine 2, 3-Dioxygenase by Xiuying Li, Zhuo Xu, Jinping Bai, Shuyuan Yang, Shuli Zhao, Yingjie Zhang, Xiaodong Chen, Yimin Wang

“…It has been reported that human mesenchymal stem cells are able to inhibit T lymphocyte activation; however, the discrepancy among different sources of MSCs is not well documented. …”
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Biocompatibility of variable thicknesses of a novel directly printed aligner in orthodontics by Maximilian Bleilöb, Claudia Welte-Jzyk, Vanessa Knode, Björn Ludwig, Christina Erbe

“…Cytotoxicity was evaluated using the AlamarBlue assay on human gingival fibroblasts. Cell viability decreased with increasing specimen thickness (significant for 2 mm [p < 0.001], 4 mm [p < 0.0001], and 6 mm [p < 0.01]) under the manufacturer-recommended 20-min UV curing. …”
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Development of Prevascularized Synthetic Block Graft for Maxillofacial Reconstruction by Borvornwut Buranawat, Abeer Shaalan, Devy F. Garna, Lucy Di Silvio

“…The co-culture of endothelial cells (ECs) with human alveolar osteoblasts (aHOBs) on the scaffold led to the formation of tube-like structures and intrinsic VEGF release, reaching 10,455.6 pg/mL This level approached the optimal dose for vascular formation. …”
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Investigating the Relationship between Traffic Violations and Crashes at Signalized Intersections: An Empirical Study in China by Ze-Hao Jiang, Xiao-Guang Yang, Tuo Sun, Tao Wang, Zheng Yang

“…About 90% of traffic crashes are caused by human factors, within which traffic violations are one of the most typical and common causes. …”
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Formin protein DAAM1 positively regulates PD-L1 expression via mediating the JAK1/STAT1 axis in pancreatic cancer by Rui Xu, Mengyun Wan, Jiadong Pan, Jie Mei, Ji Zhou, Yan Shen, Jiayue Yang, Yichao Zhu, Jing Sun

“…Abstract Background Dishevelled-associated activator of morphogenesis1 (DAAM1) is a member of the evolutionarily conserved Formin family and plays a significant role in the malignant progression of various human cancers. This study aims to explore the clinical and biological significance of DAAM1 in pancreatic cancer. …”
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The negative impacts of bisphenols on thyroid function in adults with bisphenol A exposure level exceeding the tolerable daily intake by Ziwei Pei, Lei Zhang, Yan Bao, Jingguang Li, Qin Zhuo

“…In 2023, European Food Safety Authority (EFSA) published a re-evaluation of the safety of bisphenol A (BPA), establishing the new tolerable daily intake (TDI) as 0.2 ng/kg·bw/day with a 20,000-fold reduction compared to 2015, which regained public concern about the impact of bisphenols (BPs) on human health. In order to explore the health risk to thyroid function of BPs, in this study, we assessed the internal exposure levels of BPs and the relationships between urinary BPs and thyroid function in general adults. …”
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Structure- and Ligand-Based Virtual Screening for Identification of Novel TRPV4 Antagonists by Atefeh Saadabadi, Linda Wilkman, Marja Rantanen, Ari-Pekka Koivisto, Outi M. H. Salo-Ahen

“…Since a high-resolution experimental structure of the human TRPV4 (hTRPV4) was not available during this study, we used a comparative model of hTRPV4 for the structure-based screening by molecular docking. …”
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The Impact of Time-Restricted Eating and Intermittent Fasting on Glycemia, Body Weight, and Overall Well-Being in Patients with Type 2 Diabetes – A Review of Studies by Szymon Przemysław Stolarczyk, Kuba Borys Romańczuk, Zofia Martyna Wójcik, Bartosz Omasta, Daria Rybak, Magdalena Agata Czerska, Paulina Dorota Pietrukaniec, Olga Krupa, Katarzyna Kamińska-Omasta, Kinga Furtak

“…Aim Of The Study The objective of this article was to analyze studies conducted on both animal and human models. This analysis enabled a presentation of the benefits and potential risks associated with time-restricted eating in the context of type 2 diabetes. …”
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The Opportunistic Nature of Soviet Jewish Policy by Boris N. Mironov

“…The author concludes that anti-Semitism was not a principle of Soviet national policy which was not fundamentally anti-Jewish but was fundamentally opportunistic; this policy did not exclude Jews from public life, or from the elite and management of society, but, on the contrary, it had the goal of effectively using the fruits of their human capital in the interests of the state.…”
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Kinerja Kelompok Penyelenggara Pemungutan Suara Pemungutan Suara Ulang pada PEMILU 2019 di Kota Tebing Tinggi by Dian Husri Hurasan, Muryanto Amin, Hatta Ridho

“…The workload of the 2019 election that causes Human Error.…”
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CONDITIONS OF SKIN AND INTESTINE MICROBIOTES IN PATIENTS WITH PSORIASIS by Ya.O. Yemchenko, K.E. Ishcheikin, I.P. Kaidashev, G.Yu. Morokhovets

“…Disorders in the regulation of skin microbiota may become a new therapeutic target in patients with psoriasis, and the restoration of symbiosis may increase the effectiveness of existing treatments. Thus, the human microbiota plays a key role in various aspects of the disease, from its pathogenesis to response to treatment.…”
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The use of the model organism Caenorhabditis elegans in the investigation of the adverse effects of electronic cigarettes by Kamila Melnikov, Alžbeta Kaiglová, Soňa Kucharíková

“…Preliminary observations made in C. elegans can provide insight into the consequences of exposure to fundamental cellular physiology, which can then be used for future research in humans and mammalian models.…”
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A Smart Machine Learning Model for the Detection of Brain Hemorrhage Diagnosis Based Internet of Things in Smart Cities by Hang Chen, Sulaiman Khan, Bo Kou, Shah Nazir, Wei Liu, Anwar Hussain

“…To reduce the death rates and propose accurate treatment, this paper presents a smart IoT-based application using machine learning algorithms for the human brain hemorrhage diagnosis. Based on the computerized tomography scan images for intracranial dataset, the support vector machine and feedforward neural network have been applied for the classification purposes. …”
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