Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases by Shih-Wen Huang, Yein-Gei Lai, Hao-Ting Liao, Chin-Ling Chang, Ruo-Yu Ma, Yung-Hsiang Chen, Yae-Huei Liou, Zhen-Qi Wu, Yu-Chen Wu, Ko-Jiunn Liu, Yen-Tsung Huang, Jen-Lung Yang, Ming-Shen Dai, Nan-Shih Liao

“…The inverse correlation between NK activity and metastasis incidence supports a critical role for NK cells in human metastatic surveillance. However, autologous NK cell therapy has shown limited benefit in treating patients with metastatic solid tumors. …”
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Upregulation of HSP90α in the lungs and circulation in sarcoidosis by Takuma Isshiki, Takuma Isshiki, Takuma Isshiki, Motoko Sunakawa, Megan Vierhout, Megan Vierhout, Anmar Ayoub, Anmar Ayoub, Pareesa Ali, Pareesa Ali, Safaa Naiel, Safaa Naiel, Shion Miyoshi, Asghar Naqvi, Nathan Hambly, Kazuma Kishi, Kjetil Ask, Kjetil Ask, Martin R. J. Kolb

“…Extracellular HSP90α released from macrophages was examined in human primary cells and an immortalized cell line.ResultsMacrophages and granulomas in sarcoidosis-affected lungs showed high HSP90α expression. …”
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Proteome-Wide Identification and Comparison of Drug Pockets for Discovering New Drug Indications and Side Effects by Renxin Zhang, Zhiyuan Chen, Shuhan Li, Haohao Lv, Jinjun Li, Naixue Yang, Shaoxing Dai

“…This study evaluated the druggability of the entire human proteome using Fpocket. We identified 15,043 druggable pockets in 20,255 predicted protein structures, significantly expanding the estimated druggable proteome from 3000 to over 11,000 proteins. …”
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How do improved lentil varieties affect farmers’ livelihood status in central Bangladesh? by Monira Sultana, Jannatul Ferdous Shetu, Fatema Sarker, Sharif Ahammad, Md. Hayder Khan Sujan

“…Major changes were observed in the human, natural, and physical capital of the lentil growers. …”
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Prevalence and Knowledge about Genital and other Warts among Students in Sulaimani Polytechnic University: A cross-sectional study by Burhan Karadaghy, Niaz Mustafa Kamal, Nasih Othman

“…Genital warts and other warts are an epidermal manifestation attributed to the epidermotropic human papillomavirus (HPV) some of which have been linked directly to an increased neoplastic risk in men and women. …”
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The Efficacy of Chimeric Antigen Therapy in Viral Infectious Diseases: A Systematic Review of Randomized Controlled Trials by Hossein Hatami, Elnaz Ataei, Mohammadjavad Nasiri, Hamed Ghorani

“…Three studies investigated the efficacy of CAR T-cell therapy against human immunodeficiency virus (HIV), hepatitis B virus (HBV), and cytomegalovirus (CMV). …”
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Oxidized LDL Induces Alternative Macrophage Phenotype through Activation of CD36 and PAFR by Francisco J. Rios, Marianna M. Koga, Mateus Pecenin, Matheus Ferracini, Magnus Gidlund, S. Jancar

“…It was found that the presence of oxLDL during macrophage differentiation induced high mRNA levels to IL-10, mannose receptor, PPARγ and arginase-1 and low levels of IL-12 and iNOS. When human THP-1 macrophages were pre-treated with oxLDL then stimulated with LPS, the production of IL-10 and TGF-β significantly increased, whereas that of IL-6 and IL-8 decreased. …”
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Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy by Shunqiao Jin, Shunqiao Jin, Xiaojiao Liu, Xiaojiao Liu, Lingqin Cai, Lingqin Cai, Jiayu Yan, Ling Li, Hongjun Dong, Yuxue Gao, Xicong Zhu, Cong Zhang, Xuezhu Xu

“…Furthermore, itraconazole suppressed Hedgehog signaling and counteracted the activation of the Hedgehog agonist recombinant human Sonic Hedgehog (rhShh). In vivo, itraconazole significantly reduced tumor growth in A375 and A2058 xenograft models.ConclusionItraconazole induces autophagy-mediated apoptosis in melanoma cells by inhibiting Hedgehog signaling, underscoring its potential as a therapeutic option for melanoma treatment.…”
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A Multispectral Automated Transfer Technique (MATT) for Machine-Driven Image Labeling Utilizing the Segment Anything Model (SAM) by James E. Gallagher, Aryav Gogia, Edward J. Oughton

“…This research greatly contributes to the study of multispectral object detection by providing a novel and open-source method to rapidly segment, label, and train multispectral object detection models with minimal human interaction. Future research needs to focus on applying these methods to 1) space-based multispectral; and 2) drone-based hyperspectral imagery.…”
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Studies on banana for propagation, conservation and genome analysis by Susmita Shukla, Ritambhara Bhutani, Nibha Gupta, Shiv Kant Shukla, Taramla Raman, Mohamed A. El-Sheikh, Hosam O. Elansary, Ihab Mohamed Moussa

“…Decline in plant diversity can be ascribed to a multitude of variables encompassing human activities, climate change and exploitation of natural resources. …”
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Deep gradient reinforcement learning for music improvisation in cloud computing framework by Fadwa Alrowais, Munya A. Arasi, Saud S. Alotaibi, Mohammed Alonazi, Radwa Marzouk, Ahmed S. Salama

“…Artificial intelligence (AI) in music improvisation offers promising new avenues for developing human creativity. The difficulty of writing dynamic, flexible musical compositions in real time is discussed in this article. …”
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Dual-Modality Monitoring of Tumor Response to Cyclophosphamide Therapy in Mice with Bioluminescence Imaging and Small-Animal Positron Emission Tomography by Xibo Ma, Zhaofei Liu, Xin Yang, Qiujuan Gao, Shouping Zhu, Chenghu Qin, Kai Liu, Bo Zhang, Dong Han, Fan Wang, Jie Tian

“…Firefly luciferase (fLuc) transfected HCC-LM3-fLuc human hepatocellular carcinoma cells were injected subcutaneously into BALB/c nude mice to establish the experimental tumor model. …”
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Compound events in Germany in 2018: drivers and case studies by E. Xoplaki, E. Xoplaki, F. Ellsäßer, F. Ellsäßer, J. Grieger, K. M. Nissen, J. G. Pinto, M. Augenstein, T.-C. Chen, T.-C. Chen, H. Feldmann, P. Friederichs, D. Gliksman, D. Gliksman, L. Goulier, K. Haustein, K. Haustein, J. Heinke, L. Jach, F. Knutzen, S. Kollet, J. Luterbacher, J. Luterbacher, N. Luther, S. Mohr, S. Mohr, C. Mudersbach, C. Müller, E. Rousi, F. Simon, L. Suarez-Gutierrez, L. Suarez-Gutierrez, L. Suarez-Gutierrez, S. Szemkus, S. M. Vallejo-Bernal, S. M. Vallejo-Bernal, S. M. Vallejo-Bernal, O. Vlachopoulos, F. Wolf

“…This contribution highlights several case studies with special focus on 2018, a year marked by an exceptional sequence of compound events across large parts of Europe, resulting in severe impacts on human lives, ecosystems, and infrastructure. We provide new insights into the drivers of spatially and temporally compound events, such as heat and drought, and heavy precipitation combined with extreme winds, and their adverse effects on ecosystems and society, using large-scale atmospheric patterns. …”
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Alcohol consumption and allergic diseases: Mendelian randomization evidence from China by Chen Zhu, Timothy Beatty, Yingxiang Li, Gang Chen, Qiran Zhao, Qihui Chen

“…A Mendelian Randomization (MR) design was employed in data analysis, leveraging the random allocation of genes at meiosis in humans to create instrumental variables for alcohol intake. …”
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GIS-based frequency ratio and Shannon entropy modeling for landslide susceptibility mapping: A case study in Kundah Taluk, Nilgiris District, India by Senthilkumar Harithaa, Selvaraj Evany Nithya

“…Kundah taluk in the Nilgiris has witnessed an increasing number of landslide events in recent years, primarily attributed to heavy monsoon rainfall, steep terrain and human-induced factors. This highlights the necessity for mapping landslide susceptibility and effective planning. …”
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Deep learning-based prediction of autoimmune diseases by Donghong Yang, Xin Peng, Senlin Zheng, Shenglan Peng

“…T cells, as a core component of the immune system, play a critical role in the human immune system and have a significant impact on the pathogenesis of autoimmune diseases. …”
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The concept of sustanaible development in the globalization of the world economy by Оksana Urban, Мykola Dziamulych, Natalia Chyzh

“…There are many global problems that have an impact on the development of humanity and the biosphere. That is why the work is focused on finding opportunities to minimize the negative impact of global problems on socio-economic network processes. …”
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Thyroid disorders and the incidence of type 2 diabetes: insights from a 10-year cohort study in Germany by Theresia Sarabhai, Karel Kostev

“…Background: Thyroid dysfunctions, such as hypothyroidism and hyperthyroidism, are known to influence metabolism, but their long-term impact on the development of type 2 diabetes (T2D) mellitus in humans remains elusive. Thus, this study aimed to assess the cumulative incidence and association between thyroid disorders and T2D development. …”
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Epidemiological trends and predictions of urinary tract infections in the global burden of disease study 2021 by Yining He, Jing Zhao, Lanhui Wang, Chao Han, Ruxue Yan, Peiqi Zhu, Tianyang Qian, Siyao Yu, Xiaolin Zhu, Weiming He

“…The estimated annual percentage change was used to depict temporal trends, whereas Pearson correlation analysis explore its correlation with the human development index (HDI), the SDI, and age-standardised rates (ASRs). …”
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Macrophages facilitate tumor cell PD‐L1 expression via an IL‐1β‐centered loop to attenuate immune checkpoint blockade by Cheng Xu, Yu Xia, Bai‐Wei Zhang, Emmanuel Kwateng Drokow, Hua‐Yi Li, Sen Xu, Zhen Wang, Si‐Yuan Wang, Ping Jin, Tian Fang, Xiao‐Ming Xiong, Pu Huang, Ning Jin, Jia‐Hong Tan, Qing Zhong, Yu‐Xin Chen, Qi Zhang, Yong Fang, Fei Ye, Qing‐Lei Gao

“…Here, we revealed that interleukin (IL)‐1β was among the most abundant cytokines within the in vitro tumor‐macrophage coculture system, and enhanced IL‐1β expression was associated with impaired cytotoxicity of CD8+ T cells in human ovarian cancer, indicating the possibility that IL‐1β mediated immunosuppression during tumor‐TAMs crosstalk. …”
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