<i>shp-2</i> gene knockout upregulates CAR-driven cytotoxicity of YT NK cells by V. G. Subrakova, S. V. Kulemzin, T. N. Belovezhets, A. N. Chikaev, N. A. Chikaev, O. A. Koval, A. A. Gorchakov, A. V. Taranin

“…We demonstrate that the combination of shp-2 gene knockout and CAR expression increases the cytotoxicity of effector NK-like YT cells against human prostate cancer cell line Du-145 with ectopic expression of PSMA protein, which is specifically targeted by the CAR.…”
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Preassembled complexes of hAgo2 and ssRNA delivered by nanoparticles: a novel silencing gene expression approach overcoming the absence of the canonical pathway of siRNA processing... by Shimaa A. E-S. El-Sayed, Mohamed A. Rizk, Hang Li, Uday Kumar Mohanta, Iqra Zafar, Shengwei Ji, Zhuowei Ma, Thom Do, Yongchang Li, Daisuke Kondoh, Jerzy Jaroszewski, Xuenan Xuan

“…In this study, we preassembled complexes with the human enzyme argonaute 2 (hAgo2) and a small interfering RNA (siRNA)/single-stranded RNA (ssRNA) against B. gibsoni and B. microti metabolite transporters. …”
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Factors affecting hematological abnormality in HIV-infected patients at Dr. Wahidin Sudirohusodo Hospital Makassar, Indonesia by I. Nyoman Yogi Wiraguna, Andi Fachruddin Benyamin, Risna Halim, Syakib Bakri, Sahyuddin Saleh, Hasyim Kasim, Andi Alfian Zainuddin

“…Introduction Human immunodeficiency virus (HIV) is characterized by a progressive damage of immune system, resulting in a number of opportunistic infections and hematological abnormalities, and become more severe in late stages. …”
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Air quality protection behaviour and stock returns of public companies: Sectoral aspects by Maksim S. Maramygin, Natalya B. Boldyreva, Lyudmila G. Reshetnikova

“…In the new economic reality, air quality protection behaviour of companies remains a burning issue shifting the em phasis towards saving human life and health. The article explores the relationship between the air quality protection behav iour of public companies and stock returns in different economic sectors. …”
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A generic self-learning emotional framework for machines by Alberto Hernández-Marcos, Eduardo Ros

“…Validation through an emotional attribution survey, where human observers rated their pleasure-arousal-dominance dimensions, showed high statistical agreement, distinguishability, and strong alignment with experimental psychology accounts. …”
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Development of an Enzyme-Linked Immunosorbent Assay Based on a Monoclonal Antibody for the Rapid Detection of Citrinin in Wine by Xingdong Yang, Yang Qu, Chenchen Wang, Lihua Wu, Xiaofei Hu

“…The ingestion of food contaminated with citrinin (CIT) poses a variety of health risks to humans and animals. The immunogens (CIT-COOH-BSA, CIT-H-BSA) and detection antigen (CIT-COOH-OVA, CIT-H-OVA) were synthesised using the active ester method (-COOH) and formaldehyde addition method (-H). …”
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Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells by Seyung S. Chung, Yong Wu, Quincy Okobi, Debbie Adekoya, Mohammad Atefi, Orette Clarke, Pranabananda Dutta, Jaydutt V. Vadgama

“…STAT3 was bound to the promoter region of human telomerase reverse transcriptase (hTERT). IL-6 and TNF-α stimulation further enhanced STAT3 binding affinity. …”
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Social behavior and spatial orientation in rat strains with genetic predisposition to catatonia (GC) and stereotypes (PM) by V. S. Plekanchuk, O. I. Prokudina, M. A. Ryazanova

“…Rats with genetic catatonia (GC) and pendulum-like movements (PM) of the anterior half of the body have physiological and behavioral changes similar to those observed in schizophrenia and depression in humans and can be considered as incomplete experimental models of these pathologies. …”
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Multidimensional Analysis of PANoptosis-Related Molecule CASP8: Prognostic Significance, Immune Microenvironment Effect, and Therapeutic Implications in Hepatocellular Carcinoma by Fei Peng, Fang Zhu, Baodi Cao, Liang Peng

“…We conducted a comprehensive analysis using public data from the Cancer Genome Atlas, Human Protein Atlas, Tumor Immune Single Cell Hub, and STRING databases. …”
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Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells by Bum-Ho Bin, Juyeon Seo, Sung Tae Kim

“…There are 14 ZIP family members in humans. They form a homo- or heterodimer with 8 transmembrane domains and extra-/intracellular domains of various lengths. …”
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Predicting Interplanetary Shock Occurrence for Solar Cycle 25: Opportunities and Challenges in Space Weather Research by Denny M. Oliveira, Robert C. Allen, Livia R. Alves, Séan P. Blake, Brett A. Carter, Dibyendu Chakrabarty, Giulia D’Angelo, Kevin Delano, Ezequiel Echer, Cristian P. Ferradas, Matt G. Finley, Bea Gallardo‐Lacourt, Dan Gershman, Jesper W. Gjerloev, John Bosco Habarulema, Michael D. Hartinger, Rajkumar Hajra, Hisashi Hayakawa, Liisa Juusola, Karl M. Laundal, Robert J. Leamon, Michael Madelaire, Miguel Martínez‐Ledesma, Scott M. McIntosh, Yoshizumi Miyoshi, Mark B. Moldwin, Emmanuel Nahayo, Dibyendu Nandy, Bhosale Nilam, Katariina Nykyri, William R. Paterson, Mirko Piersanti, Ermanno Pietropaolo, Craig J. Rodger, Trunali Shah, Andy W. Smith, Nandita Srivastava, Bruce T. Tsurutani, S. Tulasi Ram, Lisa A. Upton, Bhaskara Veenadhari, Sergio Vidal‐Luengo, Ari Viljanen, Sarah K. Vines, Vipin K. Yadav, Jeng‐Hwa Yee, James W. Weygand, Eftyhia Zesta

“…Such effects can pose considerable threats to human assets in space and on the ground, including satellites in the upper atmosphere and power infrastructure. …”
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Activities of civic organizations in the field of protection of prisoners and rehabilitated persons in the soviet period legal assessment of russian crimes in Ukraine by Demyanchuk T.

“…Legally, public organizations could not fundamentally influence the work of the criminal-executive system, but they showed its totalitarian and anti-human character, contributed to the collapse of this system and the USSR itself. …”
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Linguocultorological reasons for the different levels of somatization of sadness in languages of the world by Eleonora Girina

“…Considering their important role in human life the study of emotions is of great interest for linguistic science. …”
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Combining Bayesian Networks and MCDA methods to maximise information gain during reconnaissance in emergency situations by Daniel Lichte

“…In an operation that precedes the intervention of human first responders, such devices can gather information about the situation, providing knowledge about the locations of stressors (e.g. fire), the inaccessibility of parts of the infrastructure or the presence of hazardous materials. …”
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Estimated baseline density of a spotted hyaena population in a post-war landscape by Willem D. Briers-Louw, Tamar A. Kendon, Matthew S. Rogan, Alison J. Leslie, Drew Bantlin, Emma Evers, David Gaynor, Peter Lindsey, João Almeida, Vincent N. Naude

“…These densities are well below the estimated carrying capacity for the landscape and are comparable to published densities in high human-impact, miombo woodland-dominated and arid environments. …”
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Model-agnostic neural mean field with a data-driven transfer function by Alex Spaeth, David Haussler, Mircea Teodorescu

“…Empirical data is increasingly available from ex vivo human brain organoids and surgical samples, as well as in vivo animal models, so the problem of modeling the behavior of large-scale neuronal systems is more relevant than ever. …”
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The change in the level of responsibility in the rehabilitation process of persons suffering from drug addiction by Tatiana A. Serezhko, Natalia M. Volobueva

“…This is especially true in such areas of life as: the scope of failures in activities, the sphere of family relations, the sphere of interpersonal relations, health, which is primarily due to a lack of understanding of the meaning of responsibility and its role in human life and their own. Drug addicts can not cope with the negative emotions that arise at a time when the activity or situation is quite complex.At the second stage, the author monitored the course of the rehabilitation process and participated in its psychological support. …”
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Establishing normal range of fetal renal artery RI and PI values in singleton pregnancies during 18-38 weeks of gestation by Beenish Nadeem, Naushaba Malik, Anam Zahoor

“… INTRODUCTION: Human kidney constitutes an integral organ during the period of embryogenesis. …”
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Unveiling early-life microbial colonization profile through characterizing low-biomass maternal-infant microbiomes by 2bRAD-M by Shuwen Hou, Yuesong Jiang, Feng Zhang, Tianfan Cheng, Dan Zhao, Jilong Yao, Ping Wen, Ping Wen, Lijian Jin, Shi Huang

“…IntroductionThe microbial composition of human breast milk and infant meconium offers critical insights into the early microbial colonization profile, and it greatly contributes to the infant’s immune system and long-term health outcomes. …”
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Unveiling emerging polycyclic aromatic compounds in the urban atmospheric particulate matter by Jia-Yong Lao, Tingyu Li, Le Jing, Xian Qin, Wenyuan Su, Huiju Lin, Yuefei Ruan, Ting Ruan, Eddy Y. Zeng, Kenneth M.Y. Leung, Paul K.S. Lam

“…However, PAHs and oxygenated PAHs exhibited stronger overall abilities to induce non-carcinogenic adverse outcomes in human body when compared to the other PACs. Among PACs, total PAHs exhibited the highest carcinogenic and non-carcinogenic risks, while emerging PAHs accounted for 47% and 27% of total carcinogenic and non-carcinogenic risks, respectively. …”
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