Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal by Seyed Mohammad Doodmani, Payman Rahimzadeh, Najma Farahani, Seyedalireza Mirilavasani, Mina Alimohammadi, Noushin Nabavi, Elmira Alaei, Afshin Taheriazam, Maryam Abedi, Nadia Shafiee, Salman Daneshi, Mehrdad Hashemi

“…When combined with chemotherapy drugs, SFN enhances tumor suppression and mitigates drug resistance in human cancers. This is achieved primarily by promoting apoptosis, reducing proliferation, and inhibiting metastasis. …”
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Climate change and migration dynamics in Somalia: a time series analysis of environmental displacement by Abdikadir Ahmed Mohamed, Ibtisam Mohamed Omar, Abdi Majid Yusuf Ibey, Mahdi Mohamed Omar

“…Climate change is a significant driver of human migration, especially in vulnerable regions like Somalia. …”
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Functional connectome gradient of prefrontal cortex as biomarkers of high risk for internet gaming disorder by Xinwen Wen, Lirong Yue, Zhe Du, Jiahao Zhao, Mengjiao Ge, Cunfeng Yuan, Hongmei Wang, Qinghua He, Kai Yuan

“…We used functional connectome gradient (FCG) to capture the macroscopic hierarchical organization of human brain. Canonical correlation analysis was employed to identify components mapping relationships between FCG and behavioral scores. …”
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Statistical Distribution of Urban Area Reveals a Converging Trend of Global Urban Land Expansion by Shengjie Hu, Zhenlei Yang, Sergio Andres Galindo Torres, Zipeng Wang, Haoying Han, Yoshihide Wada, Thomas Cherico Wanger, Ling Li

“…Abstract Urban land expansion is a major driver of many environmental and societal changes that challenge human well‐being and sustainable development, but its evolutionary process and dynamics are neither clear nor well‐integrated into urban science quantitatively. …”
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From Bench to Brain: A Metadata-driven Approach to Research Data Management in a Collaborative Neuroscientific Research Center by Marlene Pacharra, Tobias Otto, Nina Olivia Caroline Winter

“…Using this metadata schema, neuroscientific data from more than 3,200 human subjects and lab animals are currently shared within the CRC. …”
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Urinary Microvesicle-Bound Uromodulin: A Potential Molecular Biomarker in Diabetic Kidney Disease by Neng-jun Lou, Yi-hong Ni, Hong-ying Jia, Jing-ti Deng, Lu Jiang, Feng-jie Zheng, Ai-li Sun

“…This study was designed to investigate the changes of urinary microvesicle-bound uromodulin and total urinary uromodulin levels in human urine and the correlations with the severity of diabetic kidney disease (DKD). 31 healthy subjects without diabetes and 100 patients with type 2 diabetes mellitus (T2DM) were included in this study. …”
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Point of Care Perioperative Coagulation Management in Liver Transplantation and Complete Portal Vein Thrombosis by Cristiano Piangatelli, Lucia Faloia, Claudia Cristiani, Ilaria Valentini, Marco Vivarelli

“…Based on ROTEM findings, the patient received 16 g of human fibrinogen concentrate, half preoperatively (with prothrombin complex concentrate 2000 IU, tranexamic acid 1 g, and platelets 2 IU), and two doses of 4 g before and after graft reperfusion; we achieved normalization of all monitored parameters. …”
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Peroxisome Proliferator-Activated Receptor α Reduces Endothelin-1-Caused Cardiomyocyte Hypertrophy by Inhibiting Nuclear Factor-κB and Adiponectin by Hsu-Lung Jen, Po-Len Liu, Yung-Hsiang Chen, Wei-Hsian Yin, Jaw-Wen Chen, Shing-Jong Lin

“…The purpose of this study was to evaluate the effect of PPARα activation on endothelin-1- (ET-1-) caused cardiomyocyte hypertrophy and explore its underlying mechanisms. Human cardiomyocytes (HCMs) were cultured with or without ET-1, whereafter the inhibitory effects of fenofibrate, a PPARα activator, on cell size and adiponectin protein were tested. …”
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The Effect of Organizational Intelligence on Improving the Performance of Bushehr Public Library Staff by Abbas Doulani, mahnaz saadat, Roya Baradar

“…Identifying and strengthening the various components of organizational intelligence can enhance library staff performance.Value: This research emphasizes the importance of human resources and highlights the role of organizational intelligence in improving performance, which is particularly relevant in the context of public libraries.…”
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Preliminary Evaluation of a Nuclear Scenario Involving Innovative Gas Cooled Reactors by Barbara Vezzoni, Nicola Cerullo, Giuseppe Forasassi, Emil Fridman, Guglielmo Lomonaco, Vincenzo Romanello, Eugene Shwageraus

“…., EPR-SNF directly disposed) shows a reduction of the time needed to reach a fixed reference level from ∼170000 years to ∼1550 years (comparable with typical human times and for this reason more acceptable by the public opinion). …”
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Adaptive Recognition of Motion Posture in Sports Video Based on Evolution Equation by Rui Yuan, Zhendong Zhang, Yanyan Le, Enqing Chen

“…The application of artificial intelligence technology to the training of athletes to recognize athletes’ posture can help coaches assist in decision-making and greatly enhance athletes’ competitive ability. The human body movements embodied in sports are more complicated, and the accurate recognition of sports postures plays an active and important role in sports competitions and training. …”
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BIOLOGICAL CHARACTERISTICS OF STAPHYLOCOCCUS AUREUS ISOLATES RECOVERED FROM MILK AND DAIRY PRODUCTS MANUFACTURED IN THE REPUBLIC OF CRIMEA by I. V. Borodkina

“…Intoxication occurs due to staphylococcal exotoxins entering the human body. One of the main sources of staphylococcal toxins is milk and dairy products contaminated with pathogenic staphylococci. …”
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Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. by Markus Schrettl, Elaine Bignell, Claudia Kragl, Yasmin Sabiha, Omar Loss, Martin Eisendle, Anja Wallner, Herbert N Arst, Ken Haynes, Hubertus Haas

“…Siderophore biosynthesis by the highly lethal mould Aspergillus fumigatus is essential for virulence, but non-existent in humans, presenting a rare opportunity to strategize therapeutically against this pathogen. …”
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Use of Digital Twins-Based Intelligent Navigation Visual Sensing Technology in Environmental Art Design of Scenic Spots by Chuanbao Sun, Xudong Zhou

“…This technology is adopted in the preliminary design of environmental art in the scenic spot, and it can predict the design feasibility of environmental art in the scenic spot, avoid mistakes in decision-making to a great extent and save human and material resources. And also it can analyze and predict some possible dangerous situations, which can greatly improve the environmental safety factor of the scenic spot. …”
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MSC-EXs inhibits uranium nephrotoxicity by competitively binding key proteins and inhibiting ROS production by Xinrui Yang, Jing Liu, Yaru Yin, Luxun Yang, Mingquan Gao, Zifei Wu, Binghui Lu, Shenglin Luo, Weidong Wang, Rong Li

“…In this study, we investigate the therapeutic potential of human umbilical cord-derived mesenchymal stem cell exosomes (MSC-EXs) in mice exposed to DU. …”
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Dose and strain dependent lethality of Usutu virus in an Ifnar−/− mouse model by Johanna M. Duyvestyn, Eleanor M. Marshall, Peter J. Bredenbeek, Barry Rockx, Martijn J. van Hemert, Marjolein Kikkert

“…While usually mild or asymptomatic in humans, neurological disorders are increasingly observed, which has boosted interest and the need for better understanding of the pathogenesis of various USUV lineages. …”
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Multispanning membrane protein SIDT2 increases knockdown activity of gapmer antisense oligonucleotides by Kohshi Kusumoto, Kiyomi Sasaki, Yasunori Uchida, Ayaka Utsumi, Tokuyuki Yoshida, Satoshi Obika, Takao Inoue, Keiichiro Okuhira

“…By inducing SIDT1 or SIDT2 expression in human cell lines, we demonstrated that SIDT2 enhanced the knockdown activity of gapmer ASOs and potentially promoted their endosomal escape into the cytosol. …”
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Validating aggregates and bitumen characteristics in road maintenance and safety management for motorizing countries using multidimensional diagrammatic models by Khawaja Sheeraz, Naeem Aziz Memon, Aftab Hameed Memon, Nafees Ahmed Memon, Syed Faraz Jafri

“…The dependent factors include traffic accidents on blackspots, contributory causes like pavement and geometric features, and human or vehicle issues. As per the research, more than 75% of accidents are reported due to the deteriorated conditions of the roads in a metropolitan city, Karachi, Pakistan. …”
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Motivations of Retailers Accepting Cryptocurrency Payments and Their Implications on Retail Customer Experience by Muhammed Ali Yetgin, Kasım Yılmaz, Volkan Temizkan

“…The level of technology use of humanity has increased, while the interest in digital assets has increased with the effect of the pandemic period. …”
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Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression by Joseph M. Josephides, Chun-Long Chen

“…The copy number and scRT profiles obtained by analysing >119,000 high-quality human single cells from different cell lines, patient tumours and patient-derived xenograft samples leads to a multi-sample heterogeneity-resolved scRT atlas. …”
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