The Olive Oil Monophenolic Secoiridoid Ligstroside Aglycone Suppresses Melanoma Progression by Targeting the BRAF Signaling Pathway by Md Ashiq Mahmud, Abu Bakar Siddique, Afsana Tajmim, Judy Ann King, Khalid A. El Sayed

“…Daily oral 10 mg/kg LA exhibited potent in vivo antitumor effects against Malme-3M cells xenograft in a nude mouse model by targeting the BRAF signaling pathway. A human Clariom S microarray analysis of the collected Malme- 3M tumors identified 571 dysregulated genes, with the downregulation of pathways critical for melanoma cells growth and survival. …”
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REWORK COST ON BUILDING PROJECTS IN THE SOUTH WESTERN PART OF NIGERIA by Olatunji Ayodeji Aiyetan

“…Rework is doing something at least one extra time due to nonconformance to requirements, could suggest the abovementioned parameter negatively either on organisation or individual. Human beings are not perfect, based on this, errors occur that may lead to rework on site and should be accommodated adequately for an uninterrupted flow of construction activities and non-delay of delivery of projects. …”
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Decreased Regulatory T Cells in Vulnerable Atherosclerotic Lesions: Imbalance between Pro- and Anti-Inflammatory Cells in Atherosclerosis by Ilonka Rohm, Yevgeniya Atiskova, Stefanie Drobnik, Michael Fritzenwanger, Daniel Kretzschmar, Rudin Pistulli, Jürgen Zanow, Thomas Krönert, Gita Mall, Hans Reiner Figulla, Atilla Yilmaz

“…Anti-inflammatory cells like Tregs counterbalance inflammation in atherogenesis. In our study, human carotid plaque specimens were classified as stable (14) and unstable (15) according to established morphological criteria. …”
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Risk Factors Associated with Dengue Transmission and Spatial Distribution of High Seroprevalence in Schoolchildren from the Urban Area of Medellin, Colombia by Leidy Diana Piedrahita, Ivony Y. Agudelo Salas, Katherine Marin, Andrea I. Trujillo, Jorge E. Osorio, Sair Orieta Arboleda-Sanchez, Berta Nelly Restrepo

“…High DENV risk was found in districts with combined poorly socioeconomic conditions and densest human and mosquito populations. These findings may allow to target population for effective prevention and vaccination campaigns.…”
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Professional competencies' profile for the Internal Medicine specialist based on integrative medicine by Luis Aníbal Alonso Betancourt, Edilio Silva Velasco, Juan Carlos Baster Moro, Mayelín Cruz Batista

“…<p><strong>Foundation:</strong> the postgraduate academic training of human resources in health aims at consolidating professional competencies in their care, teaching, educational and administrative performances, innovation and creation, which is recognized with an academic title or a scientific degree.…”
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Neurotropic Tick-Borne Flavivirus in Alpine Chamois (<i>Rupicapra rupicapra rupicapra</i>), Austria, 2017, Italy, 2023 by Norbert Nowotny, Maria Lucia Mandola, Isabella Monne, Zoltán Bagó, Chiara Nogarol, Alice Fusaro, Katharina Dimmel, Barbara Moroni, Lisa Guardone, Jolanta Kolodziejek, Elisa Palumbo, Gabriela Stanclova, Adi Steinrigl, Gabriele Fidler, Cristina Bertasio, Irene Bertoletti, Alessandro Bianchi, Mattia Calzolari, Paola Prati, Nadia Vicari, Angela Salomoni, Maria Francesca Priore, Federica Gobbo, Aitor Garcia-Vozmediano, Tom Loney, Ahmad Abou Tayoun, Alawi Alsheikh-Ali, Paola De Benedictis, Jeremy V. Camp, Zdenek Hubalek, Ivo Rudolf, Davide Lelli, Ana Moreno

“…The European subtype of tick-borne encephalitis virus (TBEV-Eur; species <i>Orthoflavivirus encephalitidis</i>, family <i>Flaviviridae</i>) was the only tick-borne flavivirus present in central Europe known to cause neurologic disease in humans and several animal species. Here, we report a tick-borne flavivirus isolated from Alpine chamois (<i>Rupicapra rupicapra rupicapra</i>) with encephalitis and attached ticks, present over a wide area in the Alps. …”
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Sex ratio at birth in Kogi state, North-Central Nigeria by Adekunle Bakare, Deborah Peter, Motunrayo Mojoyin Coker, Silas Fagbenro, Okunola A. Alabi

“… The human secondary sex ratio is the male-to-female ratio at birth. …”
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Updated Mini-Review on Polychlorinated Diphenyl Ethers (PCDEs) in Food: Levels and Dietary Intake by Jose L. Domingo

“…As with other persistent organic pollutants (POPs), diet represents the primary route of human exposure to PCDEs. This mini-review focuses on recent studies evaluating the concentrations of PCDEs in foodstuffs. …”
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Global research trends in music therapy for surgery: a bibliometric analysis (2009–2023) by Xiaoping Xu, Zhenglan Zhong, Yong Yi

“…Abstract Music therapy, known for its profound impact on human emotions and physiology, has gained increasing attention for its applications in medical settings, particularly in surgery. …”
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Analysis of Signals Leading to Differentiation of Immature HL-60 after Administration of IL-4 by Simon Vassiliadis

“…For instance, induction of HLA-DR antigens on human promyelocytic leukaemia HL-60 cells by interleukin-4 (IL-4) is of pivotal importance in immunology not only because class II expression is prerequisite to antigen recognition and response but also because IL-4 participates in a plethora of inflammatory or non-inflammatory reactions. …”
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Pharmacological Evaluation of the SCID T Cell Transfer Model of Colitis: As a Model of Crohn's Disease by Thomas Lindebo Holm, Steen Seier Poulsen, Helle Markholst, Stine Reedtz-Runge

“…The finding that some well-established IBD therapeutics do not have any effect in the model highlights important differences between the experimental model and the human disease.…”
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Multimodal learning–based reconstruction of high-resolution spatial wind speed fields by Matteo Zambra, Nicolas Farrugia, Dorian Cazau, Alexandre Gensse, Ronan Fablet

“…Wind speed at the sea surface is a key quantity for a variety of scientific applications and human activities. For its importance, many observation techniques exist, ranging from in situ to satellite observations. …”
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Assurer la maitrise du ruissellement grâce aux zones humides au voisinage des infrastructures de transport dans une perspective de conservation de la biodiversité by Camille Fressignac, Pascal Breil, Yannick Matillon, Andréa Nullans, Blandine Chazelle, Benoît Sarrazin, Dominique Vallod

“…The conservation of biodiversity is currently a major problem which is gradually inserted into the development of public policy of administrative territory, with the aim of controlling the impact of human activity on the natural environment. Land transport infrastructure creates disruptions to ecosystems and landscapes. …”
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Basketball technical action recognition based on a combination of capsule neural network and augmented red panda optimizer by Nu Sha

“…The study conducts the tasks presented by changing lighting settings and complicated human movements in basketball. By means of the suggested CapsNets/ARPO model, the network’s capability can be improved in distinguishing the dynamic targets. …”
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Survival Analysis of Risk Factors for Mortality in a Cohort of Patients with Tuberculosis by Yi Xie, Jing Han, Weili Yu, Junping Wu, Xue Li, Huaiyong Chen

“…Cox regression analysis showed that advanced age, male sex, human immunodeficiency virus (HIV) positivity, first sputum positivity, retreated tuberculosis, and a delayed visit (≥14 days) were risk factors for mortality in patients with pulmonary tuberculosis receiving antituberculosis treatment under DOTS. …”
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Timing of dietary effects on the epigenome and their potential protective effects against toxins by Lynnea A. Nicholls, Kendall A. Zeile, London D. Scotto, Rebecca J. Ryznar

“…Exposure to toxins causes lasting damaging effects on the body. Numerous studies in humans and animals suggest that diet has the potential to modify the epigenome and these modifications can be inherited transgenerationally, but few studies investigate how diet can protect against negative effects of toxins. …”
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Green banana flour does not alter lipid and inflammatory profile of women overweight by Sandra Tavares da Silva, Carolina Araújo dos Santos, Júlia Cristina Cardoso Carraro, José Luiz Marques Rocha, Josefina Bressan

“…However, there are no controlled studies on their real effects in human studies. The objective of this study was to analyze the effects of consumption of GBF in body weight, lipid pro- file, inflammatory parameters and food consumption in adult overweight women. …”
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Étude ethnotaxonomique des espèces fruitières spontanées comestibles chez l’ethnie Diola d’Oussouye (Sénégal) by Yves Djihounouck, Doudou Diop, César Bassène, Mame Samba Mbaye, Richard Demba Diop, Babacar Faye, Kandioura Noba

“…However, climate change and human action have led to a degradation of the natural ecosystems and extinction for certain plant. …”
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Inflammatory Profile of Awake Function-Controlled Craniotomy and Craniotomy under General Anesthesia by Markus Klimek, Jaap W. Hol, Stephan Wens, Claudia Heijmans-Antonissen, Sjoerd Niehof, Arnaud J. Vincent, Jan Klein, Freek J. Zijlstra

“…Surgical stress triggers an inflammatory response and releases mediators into human plasma such as interleukins (ILs). Awake craniotomy and craniotomy performed under general anesthesia may be associated with different levels of stress. …”
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Effects of trehalose on bone healing, physical function, and pain in patients with pertrochanteric fractures: a randomized controlled trial protocol by Reza Zandi, Hosna Omidi Razani, Amir Mehrvar, Mohammad-Reza Jowshan, Amirhossein Sahebkar, Bahar Nikooyeh, Hoda Zahedi, Shahin Talebi

“…We hope that trehalose can accelerate bone fracture healing in humans, alleviate pain, and ultimately enhance the individual’s quality of life. …”
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