Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders by Hanyang Ruan, Geya Tong, Minghui Jin, Kathrin Koch, Zhen Wang

“…In this review, we provide an overview across studies investigating the effects of NAc DBS in humans and animals and discuss potential mechanisms underlying its clinical efficacy. …”
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Sequence Analysis of How Disability Influenced Life Trajectories in a Past Population from the Nineteenth-Century Sundsvall Region, Sweden by Lotta Vikström, Helena Haage, Erling Häggström Lundevaller

“…To our knowledge this is the first study to employ sequence analysis on a substantially large number of cases to provide demographic evidence of how disability shaped human trajectories in the past during an extended period of life. …”
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Phytochemical Screening and Biological Activity of Mentha × piperita L. and Lavandula angustifolia Mill. Extracts by Ersilia Alexa, Corina Danciu, Isidora Radulov, Diana Obistioiu, Renata Maria Sumalan, Adriana Morar, Cristina Adriana Dehelean

“…In terms of biological activity against MDA-MB-231 breast carcinoma cell line, and A375 human melanoma cell line, at the highest employed concentration, 150 μg·mL–1, the tested extracts present a weak antiproliferative effect.…”
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Extraction of Spatial Distribution Characteristics of Jiangnan Urban Landscape under the Influence of Geomorphology by Shuhua Wang, Anhua Qin

“…From the perspective of spatial variability, the main features of traditional landscape construction in Jiangnan are analyzed through three levels: the characteristics of the process of humanized landscapes evolving into natural landscapes, the comparative analysis of similarities and differences in the construction of cities and towns, and the characteristics of the system of regional landscape construction. …”
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Why are women still leaving academic medicine? A qualitative study within a London Medical School by Christopher J Peters, Lesley Regan, Victoria Salem, Clare Lloyd, Dhruti Hirani

“…Thematic analysis was performed on the transcribed conversations.Participants and setting Nine women physicians who completed a postgraduate degree (MD or PhD) at a large London Medical School and Academic Health Sciences Centre, Imperial College London, but did not go on to pursue a career in academic medicine.Results Influences to leave clinical academia were summarised under eight themes—career intentions, supervisor support, institutional human resources support, inclusivity, work–life balance, expectations, mentors and role models, and pregnancy and maternity leave.Conclusion The women in our focus group reported several factors contributing to their decision to leave clinical academia, which included lack of mentoring tailored to specific needs, low levels of acceptance for flexible working to help meet parental responsibilities and perceived explicit gender biases. …”
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The percentage of Body Fat and its Relationship with Blood Pressure in Adults from Rural and Urban Areas by Carlos Enrique García Yerena, Omar Oliveros Rangel, Brian Johan Bustos Viviescas, Amalia Villamizar Navarro, John Alexander García Galviz

“…<strong>Foundation:</strong> excess body fat is marked by a permanent imbalance between food consumption and energy expenditure of human beings that generate various health risks, including increased blood pressure. …”
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Neuroplasticity of Acupuncture for Stroke: An Evidence-Based Review of MRI by Jinhuan Zhang, Chunjian Lu, Xiaoxiong Wu, Dehui Nie, Haibo Yu

“…After searching PubMed, Web of Science, and Embase databases, 24 human and five animal studies were identified. This review focuses on the evidence on the possible mechanisms underlying mechanisms of acupuncture therapy in treating stroke by regulating brain plasticity. …”
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Assessment of groundwater intrinsic vulnerability using GIS-based DRASTIC method in district Karak, Khyber Pakhtunkhwa, Pakistan by Muhammad Muneer, Mumtaz Ali Khan, Fayaz Ullah Shinwari, Ijaz Ahmed, Syed Mamoon Siyar, Fahad Alshehri, Muhammad Shahab

“…The concentration of Nitrate &gt;10 ppm represent that some human action has contributed toward the highest concentration.…”
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Stellettin B Isolated from Stelletta Sp. Reduces Migration and Invasion of Hepatocellular Carcinoma Cells through Reducing Activation of the MAPKs and FAK/PI3K/AKT/mTOR Signaling P... by Tsung-Chang Tsai, Wen-Tung Wu, Jen-Jie Lin, Jui-Hsin Su, Yu-Jen Wu

“…In this study, we used Stellettin B, an active compound isolated from Stelletta sponges, as the experimental drug and evaluated its inhibition effects on cell migration and invasion in human hepatoma cells (HA22T and HepG2). MTT assay, gelatin zymography, and western blotting were employed. …”
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Semantic Modeling for SNPs Associated with Ethnic Disparities in HapMap Samples by HyoYoung Kim, Won Gi Yoo, Junhyung Park, Heebal Kim, Byeong-Chul Kang

“…Single-nucleotide polymorphisms (SNPs) have been emerging out of the efforts to research human diseases and ethnic disparities. A semantic network is needed for in-depth understanding of the impacts of SNPs, because phenotypes are modulated by complex networks, including biochemical and physiological pathways. …”
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Quantification of Malondialdehyde in Atmospheric Aerosols: Application of the Thiobarbituric Acid Method by David H. Gonzalez, Suzanne E. Paulson

“…Abstract Based on available toxicity data, malondialdehyde (MDA; O=CHCH2CH=O) has been designated as a potential human carcinogen. A handful of studies suggest that MDA forms in the gas and aerosol phase in the troposphere, potentially contributing to inhalation toxicity, yet it has never been quantified in ambient air. …”
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Microscopic Photosensitization: A New Tool to Investigate the Role of Mitochondria in Cell Death by May-Ghee Lum, Tetsuhiro Minamikawa, Phillip Nagley

“…Using mitochondrially localized CMXRos as a photosensitizer coupled to laser irradiation by confocal laser scanning microscopy, we demonstrate that partial irradiation of about half the mitochondria in human 143B TK– cells induces rapid loss of mitochondrial membrane potential (ΔΨm) in nonirradiated mitochondria. …”
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Nutraceutical COMP-4 confers protection against endothelial dysfunction through the eNOS/iNOS-NO-cGMP pathway. by Monica G Ferrini, Andrea Abraham, Revecca Millán, Leslie Graciano, Sriram V Eleswarapu, Jacob Rajfer

“…We hypothesized that COMP-4 may have a protective, stimulatory effect on the vascular endothelial cell. Human umbilical arterial endothelial cells were incubated for 24 hours with or without COMP-4 and, to replicate impairment of endothelial function, co-incubated with or without H2O2. …”
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Overcoming the Constraints of Anti-HIV/CD89 Bispecific Antibodies That Limit Viral Inhibition by Xiaocong Yu, Mark Duval, Melissa Gawron, Marshall R. Posner, Lisa A. Cavacini

“…To this end, bispecific constructs of human antibody F240, reactive with well-conserved gp41 epitope and antibody 14A8, reactive with the IgA receptor (CD89) on effector cells, were constructed. …”
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TCR Gene Transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 Epitopes as Melanoma-Specific Immune Targets by Trudy Straetemans, Mandy van Brakel, Sabine van Steenbergen, Marieke Broertjes, Joost Drexhage, Joost Hegmans, Bart N. Lambrecht, Cor Lamers, Pierre van Der Bruggen, Pierre G. Coulie, Reno Debets

“…We identified MC2/A2 and MA3/DP4-specific TCR-Vα3/Vβ28 and TCR-Vα38/Vβ2 chains and validated these TCRs in vitro upon gene transfer into primary human T cells. The MC2 and MA3 TCR were surface-expressed and mediated CD8 T-cell functions towards melanoma cell lines and CD4 T-cell functions towards dendritic cells, respectively. …”
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Profiling protease cleavage patterns in plasma for pancreatic cancer detection by Morgan R. Stewart, Arnaud Quentel, Elise Manalo, Jose Montoya Mira, Srivathsan Ranganathan, Bruce P. Branchaud, Jared M. Fischer, Eugene Tu, Fehmi Civitci, Yu-Jui Chiu, Adem Yildirim

“…However, the complexity of the human proteome makes it challenging to develop sensitive and selective tests against a specific protease biomarker. …”
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Novel Design on Knee Exoskeleton with Compliant Actuator for Post-Stroke Rehabilitation by Lin Wu, Chao Wang, Jiawei Liu, Benjian Zou, Samit Chakrabarty, Tianzhe Bao, Sheng Quan Xie

“…A variable impedance control method was also implemented to achieve accurate position tracking of the exoskeleton, and performance tests were conducted with and without human participants. A preliminary clinical study involving two stroke patients demonstrated the exoskeleton’s potential in reducing muscle spasticity, particularly at faster movement velocities. …”
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Harnessing the AI/ML in Drug and Biological Products Discovery and Development: The Regulatory Perspective by Fahimeh Mirakhori, Sarfaraz K. Niazi

“…The term AI itself has become commonplace to argue that greater “human oversight” for “machine intelligence” is needed to harness the power of this revolutionary technology for both potential and risk management, and hence to call for more practical regulatory guidelines, harmonized frameworks, and effective policies to ensure safety, scalability, data privacy, and governance, transparency, and equitable treatment. …”
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LPS from P. gingivalis and Hypoxia Increases Oxidative Stress in Periodontal Ligament Fibroblasts and Contributes to Periodontitis by L. Gölz, S. Memmert, B. Rath-Deschner, A. Jäger, T. Appel, G. Baumgarten, W. Götz, S. Frede

“…We hypothesize that hypoxic and inflammatory events induce oxidative stress in the periodontal ligament (PDL) by activating NOX4. Human primary PDL fibroblasts were stimulated with lipopolysaccharide from Porphyromonas gingivalis (LPS-PG), a periodontal pathogen bacterium under normoxic and hypoxic conditions. …”
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Implementing the Concept of Co-Parenting in Divorce Cases: An Analysis Using the Maslahah Approach by Ibnu Radwan Siddik Turnip, Sumper Mulia Harahap, Abdul Halim Talli, Arminsyah Arminsyah, Muhamad Hasan Sebyar

“…Such reforms would provide a robust legal foundation to safeguard children's human rights post-divorce, covering aspects such as education, health, and protection from parental conflict. …”
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