Investigating new drugs from marine seaweed metabolites for cervical cancer therapy by molecular dynamic modeling approach by Sk Injamamul Islam, Sheikh Sunzid Ahmed, Sarower Mahfuj, Gunjan Das, Md. Mohaimenul Islam Tareq, Mazen Almehmadi, Mamdouh Allahyani, Naif Alsiwiehri, Partha Biswas, Md. Nazmul Hasan, Foysal Ahammad

“…Abstract The etiology of cervical cancer in women is attributed to the continuous infection of the human papillomavirus (HPV). The high costs and side effects of standard treatments and the limited efficacy of HPV vaccination have led to a quest for novel, cost-effective cervical cancer treatments, particularly in middle- and low-income countries. …”
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A copy number variation detection method based on OCSVM algorithm using multi strategies integration by Mengjiao Zhou, Jinxin Dong, Hua Jiang, Zuyao Zhao, Tianting Yuan

“…Abstract Copy number variation (CNV) is an important part of human genetic variations, which is associated with various kinds of diseases. …”
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A Metabolic Study on Colon Cancer Using 1H Nuclear Magnetic Resonance Spectroscopy by Zahra Zamani, Mohammad Arjmand, Farideh Vahabi, Seyed Mahmood Eshaq Hosseini, Sadegh Mohammad Fazeli, Ayda Iravani, Parastoo Bayat, Akbar Oghalayee, Mahshid Mehrabanfar, Reza Haj Hosseini, Mohammad Tashakorpour, Mohsen Tafazzoli, Sedigheh Sadeghi

“…Metabolites were identified using Human Metabolic Data Base (HDMB) and the main metabolic cycles were identified using Metaboanalyst software. …”
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An Investigation of the Changes in the Iran Precipitation Extreme Indices in Two Normal Climate Periods, 1981-2010 and 2020-1991 by Zohreh Javanshiri, Ebrahim Asadi Oskouei, Fatemeh Abbasi

“…Excessive or insufficient precipitation can result in severe floods and droughts, causing significant consequences for both nature and humanity. For this reason, it is vital to understand the variability, behavioral changes, and extreme precipitation levels to successfully manage industries like agriculture, water resources, urban planning, and transportation. …”
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Molecular docking of phytosterols in Stenochlaena palustris as anti-breast cancer by Dona Marisa, Lisda Hayatie, Siti Juliati, Eko Suhartono, Noer Komari

“…Conclusion: By suppressing ERa, phytosterols from S. palustris may have potential anti-breast cancer activity and may be used to prevent estrogen-dependent human cancers like breast cancer. …”
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Optimized measurement methods and systems for the dielectric properties of active biological tissues in the 10Hz-100 MHz frequency range by Yueying Shi, Xiaoxiao Bai, Jingrong Yang, Xinyu Wu, Lei Wang

“…Accurately understanding the dielectric properties of active human tissues holds significant value for disease diagnosis and electromagnetic protection. …”
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Enigma of Retrotransposon Biology in Mammalian Early Embryos and Embryonic Stem Cells by Ying Yin, Liquan Zhou, Shuiqiao Yuan

“…Notably, abundant retrotransposon expression in mouse embryonic stem cells (ESCs) marks transient totipotency status, while retrotransposon enrichment in human ESCs indicates naive-like status. Some retrotransposon elements retained the capacity to retrotranspose, such as LINE1, producing genetic diversity or disease. …”
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Design and optimization of hollow microneedle spacing for three materials using finite element methods by Xiaodan Zhang, Qifei Gu, Xue Sui, Jie Zhang, Jingwei Liu, Rui Zhou

“…Abstract The main advantages of microneedles are precise drug delivery through human skin, minimal tissue damage and painlessness. …”
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Biallelic mutations in CDC20 cause female infertility due to oocyte maturation abnormality by Guangzhong Jiao, Jinhao Xing, Zhaoli Du, Hongchu Bao, Xiaoyan Liu

“…A total maturation arrest of human oocytes is rarely observed during in vitro fertilization (IVF). …”
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An Assessment of Heavy Metals Toxicity in Asian Clam, Corbicula fluminea, from Mekong River, Pa Sak River, and Lopburi River, Thailand by Ai Yin Sow, Koh Han Dee, Seong Wei Lee, Aweng A. L. Eh Rak

“…Bioaccumulation of heavy metals in Asian clam (Corbicula fluminea) may be likely to cause serious health effects on human beings. The clams sampled from three different rivers (Mekong, Pa Sak, and Lopburi) from Thailand were analyzed for the presence of heavy metals (Zn, Cu, Cd, Cr, Mn, and Pb) with an air-acetylene flame atomic absorption spectrophotometer (AAS). …”
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Prevalence and molecular characterization of Enterocytozoon bieneusi in endangered Eld’s deer (Rucervus eldii) in Hainan, China by Yun Zhang, Yun Zhang, Guangxu Ren, Guangxu Ren, Qingqing Lu, Jiaqi Li, Jiaqi Li, Yu Qiang, Youyou Li, Xiuyi Lai, Yuan Wang, Xingyue Yu, Sheng Lei, Yu Li, Yunxing Chang, Xianrong Liu, Xuning Qi, Zhi Xie, Tingting Li, Jiang Du, Rui Duan, Xinyu Chang, Hesheng Wang, Hesheng Wang, Gang Lu, Gang Lu

“…IntroductionEnterocytozoon bieneusi is one of the most frequent microsporidia species causing digestive disorder mainly diarrhea in humans and animals. Eld’s deer (Rucervus eldii) is the class I national key protected wildlife and only distributed on Hainan Island in China. …”
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Empathy moments by Nathalie Barbosa De La Cadena

“…To recognize the other Ego is an involuntary act that happens in consciousness when I come face-to-face with another human being. To open myself up to the other Ego is a spiritual act derived from freedom. …”
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Gene Expression Differences Predict Treatment Outcome of Merkel Cell Carcinoma Patients by Loren Masterson, Bryan J. Thibodeau, Laura E. Fortier, Timothy J. Geddes, Barbara L. Pruetz, Rajwant Malhotra, Richard Keidan, George D. Wilson

“…Laser capture microdissection was used to isolate tumor cells for subsequent RNA isolation and gene expression analysis with Affymetrix GeneChip Human Exon 1.0 ST arrays. Among the 191 genes demonstrating significant differential expression between prognostic groups, keratin 20 and neurofilament protein have previously been identified in studies of MCC and were significantly upregulated in tumors from patients with a poor prognosis. …”
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A ‘torn bag mechanism’ of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes) by Tamás Visnovitz, Dorina Lenzinger, Anna Koncz, Péter M Vizi, Tünde Bárkai, Krisztina V Vukman, Alicia Galinsoga, Krisztina Németh, Kelsey Fletcher, Zsolt I Komlósi, Csaba Cserép, Ádám Dénes, Péter Lőrincz, Gábor Valcz, Edit I Buzas

“…We previously found evidence that human colorectal cancer cells in vivo release large multivesicular body-like structures en bloc. …”
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The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights by Zhuo Huang, Zhuo Huang, Qinyan Yao, Qinyan Yao, Shuang Ma, Shuang Ma, Jinjie Zhou, Jinjie Zhou, Xiaoxuan Wang, Xiaoxuan Wang, Qingguo Meng, Qingguo Meng, Yaxin Liu, Yaxin Liu, Zihan Yu, Zihan Yu, Xin Chen, Xin Chen

“…The gut microbiota plays a pivotal role in human metabolic health by influencing immune responses, digestion, and metabolic homeostasis. …”
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Numerical Simulation Analysis of Slope Instability and Failure of Limestone Mine in Weibei by Kuiming Liu, Hui Li, Shihui Pang, Meng Mi, Jianping Chen, Kui Sun

“…The joint and fissure are developed, the rock mass is broken, and the hidden danger of engineering geological disaster is high. (2) There is a sliding trend in both sides during excavation, and the maximum vertical displacement is 2.1 cm. (3) If the slope is reinforced according to the design scheme, the slope stability safety factor will be increased from 1.062 to 1.203 in a stable state, which greatly improves the stability of the slope and provides a guarantee for human and financial resources.…”
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Groundwater and Subsidence Modeling Combining Geological and Multi-Satellite SAR Data over the Alto Guadalentín Aquifer (SE Spain) by Pablo Ezquerro, Carolina Guardiola-Albert, Gerardo Herrera, José Antonio Fernández-Merodo, Marta Béjar-Pizarro, Roberta Bonì

“…In the current context of climate change, improving groundwater monitoring and management is an important issue for human communities in arid environments. The exploitation of groundwater resources can trigger land subsidence producing damage in urban structures and infrastructures. …”
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The occurrence and safety evaluation of phthalic acid esters in Oasis agricultural soils of Xinjiang, China by Hejiang Liu, Xiuting Liu, Kai Wang, Xingwang Ma, Haihe Gao, Xuejun Liu, Changrong Yan

“…Furthermore, the concentrations of all PAEs were below China's soil quality risk control standards, and the non-carcinogenic risks to both adults and children were below the current threshold, indicating relatively low risks to both the human health and the environment. These findings are crucial for understanding the presence and safety evaluation of PAEs in Xinjiang Oasis farmland, and they provide important reference data for managing and controlling PAE contamination in agricultural soils.…”
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Evaluating chia (Salvia hispanica L.) seed administration for cholesterol reduction in quail (Coturnix coturnix) by Rahimatul Uthia, Ira Oktaviani Rz, Sri Vina Hidayani, Kustiasih Lestari, Fathul Jannah

“…This research provides a foundation for further exploration into practical applications of S. hispanica L. seeds in cholesterol management, both in animals and potentially in humans. …”
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Navigating the landscape: Unveiling the reflection of AI in the sharing economy through bibliometric-based approach by Veljko Uskoković, Milica Maričić, Aleksandra Dacić-Pilčević, Veljko Jeremić

“…Additionally, AI plays a crucial role in promoting energy-efficient behaviour in smart accommodations, while algorithmic oversight is increasingly integrated into digital labour platforms to balance automation with human dignity. Furthermore, AI optimizes resource allocation and improves matching algorithms on online labour platforms, thereby boosting platform efficiency. …”
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