<i>Ex Vivo</i> Regional Gene Therapy Compared to Recombinant BMP-2 for the Treatment of Critical-Size Bone Defects: An In Vivo Single-Cell RNA-Sequencing Study by Arijita Sarkar, Matthew C. Gallo, Jennifer A. Bell, Cory K. Mayfield, Jacob R. Ball, Mina Ayad, Elizabeth Lechtholz-Zey, Stephanie W. Chang, Osamu Sugiyama, Denis Evseenko, Jay R. Lieberman

“…Compared to recombinant human BMP-2 (rhBMP-2), which is approved for clinical use, regional gene therapy may have unique benefits related to the addition of MSCs and the sustained release of BMP-2. …”
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The Importance of Platelet-Derived Growth Factors as Markers of Survival and Severity of COVID-19 in Patients Undergoing Monthly Follow-Up by Elżbieta Cecerska-Heryć, Dominika Nieszpór, Natalia Serwin, Ewa Pius Sadowska, Marta Gliźniewicz, Bartłomiej Grygorcewicz, Karol Serwin, Anna Michalczyk, Marta Budkowska, Małgorzata Goszka, Aleksandra Polikowska, Radosław Birger, Bogusław Machaliński, Barbara Dołęgowska

“…Platelets are the first to reach the site of tissue damage and secrete substances like platelet growth factors (GFs), which perform many different functions in the human body. Many studies suggest that GFs such as transforming GF (TGF), platelet-derived GF (PDGF), or insulin-like GF-1 (IGF-1) may be markers of survival, disease severity, and post-coronavirus disease (COVID) complications. …”
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A Systematic Review and Meta-analysis of Single-group Studies Assessing the Role of Calcium Hydroxylapatite in Aesthetic Enhancements and Satisfaction by Mojgan Amiri, MSc, Renald Meçani, MD, Christa D. Niehot, MSc, Terri L. Phillips, MD, Katherine Goldie, MD, Janina Kolb, MD, Taulant Muka, PhD, Hua Daughtry, PhD

“…Single-group studies with at least 10 human adults were included. Summary measures of patients satisfaction and global aesthetic improvement scores were combined using the generalized linear mixed model. …”
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The Australian and New Zealand Fontan Registry Quality of Life Study: Protocol for a population-based assessment of quality of life among people with a Fontan circulation, their pa... by Daniel S J Costa, Kim Dalziel, Yves d’Udekem, David S Winlaw, David S Celermajer, Nadine A Kasparian, Diana Zannino, Rachel Bishop, Kate H Marshall, Susan R Woolfenden, Gary F Sholler

“…Descriptive analyses and multilevel models will be used to examine QOL across groups and to investigate potential explanatory variables.Ethics and Dissemination Approval has been obtained from all relevant Human Research Ethics Committees (HRECs), including the Sydney Children’s Hospitals Network and the Royal Children’s Hospital Melbourne HRECs. …”
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Genetic determinants of COVID-19 severity and mortality: ACE1 Alu 287 bp polymorphism and ACE1, ACE2, TMPRSS2 expression in hospitalized patients by João Locke Ferreira de Araújo, Átila Duque Rossi, Jessica Maciel de Almeida, Hugo José Alves, Isabela de Carvalho Leitão, Renata Eliane de Ávila, Anna Carla Pinto Castiñeiras, Jéssica da Silva Oliveira, Rafael Mello Galliez, Marlon Daniel Lima Tonini, Débora Souza Faffe, Shana Priscila Coutinho Barroso Barroso, Gustavo Gomes Resende, Cássia Cristina Alves Gonçalves, Terezinha Marta Pereira Pinto Castiñeiras, Amilcar Tanuri, Mauro Martins Teixeira, Renato Santana Aguiar, Cynthia Chester Cardoso, Renan Pedra de Souza

“…Background The angiotensin-converting enzyme 2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) are central human molecules in the SARS-CoV-2 virus-host interaction. …”
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Performance of HPV16/18 in Triage of Cytological Atypical Squamous Cells of Undetermined Significance by Xiaoqin Cao, Shuzheng Liu, Manman Jia, Hongmin Chen, Dongmei Zhao, Bing Dong, Zhen Guo, Lingyan Ren, Shaokai Zhang, Xibin Sun

“…Context. Human papillomavirus (HPV) testing is widely used in cervical cancer screening in women; however, its efficiency in triaging women with atypical squamous cells of undetermined significance (ASC-US) needs to be validated. …”
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The record-breaking precipitation event of December 2022 in Portugal by T. M. Ferreira, T. M. Ferreira, R. M. Trigo, T. H. Gaspar, J. G. Pinto, A. M. Ramos

“…<p>Extreme precipitation events (EPEs) potentially present an enormous societal risk and often lead to major human and economic impacts. In the mid-latitudes, such EPEs are often triggered by intense extratropical cyclones and their associated frontal systems. …”
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Modeling optimal combination of breast and cervical cancer screening strategies in China by Xuewei Liu, Yanbo Wang, Bei Gao, Xinlin Lu, Yuan Wang, Wenli Lu

“…Results The optimal combination strategy was biennial breast ultrasonography (BUS) and mammography (MAM) in parallel screening and quinquennial human papillomavirus (HPV) for breast and cervical cancer screening under the threshold of the annual per capita social cost investment (PCSCI) (18.80 USD) in China. …”
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Operativity of the Taunsa Barrage, Pakistan: Experimental Investigation on the Subsidiary Weir by Muhammad Zahid Ullah, Habib-Ur-Rehman Mughal, Noor Yaseen, Noor Muhammad Khan, Giada Varra, Luca Cozzolino, Renata Della Morte

“…River barrages ensure water availability for enhanced irrigation and human consumption. Of course, effective and sustainable management of existing barrages requires controlling riverbed erosion through appropriately designed stilling basins with their appurtenances. …”
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CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration through the miR-217/SIRT... by Yongbo Zhang, Sheng Yang, Xuan You, Zhengguang Li, Liuyang chen, Rui Dai, Hua Sun, Liang Zhang

“…Results CircSPG21 expression was significantly decreased in both human and rat IVDD tissues, whereas miR-217 was upregulated and SIRT1 was downregulated. …”
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Basal Cell Carcinoma Diagnosed by Dermoscopy in Dermatology Clinic of the Miguel Enríquez University Hospital by Delia María Gálvez Medina, Yurelbis Loida Lobaina Mejías, Juliette Massip Nicot, Lisbeth Fernández González, Carmen Oraida Tenorio Morión, Dayné Leyva Duthil

“…<strong>Foundation:</strong> basal cell carcinoma is a very common malignant tumor in humans. It is considered locally invasive, also aggressive and destructive. …”
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Bioactive phytochemical compounds characterization, anti-oxidant and anti-microbial activity of the methanol and acetonitrile leaf extracts of Pithecellobium dulce by M. Kiranmayee, K. Riazunnisa

“…Therefore, P. dulce leaf extracts may play a significant role in inhibiting human infections.…”
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In Vitro Antibacterial, Antioxidant, Cytotoxicity Activity, and In Silico Molecular Modelling of Compounds Isolated from Roots of Hydnora johannis by Teshome Degfie, Milkyas Endale, Muhdin Aliye, Rajalakshmanan Eswaramoorthy, Tariku Nefo Duke, Aman Dekebo

“…The cytotoxicity of extracts from roots of H. johannis was conducted against MCF-7 cell lines (human breast cancer) by MTT assay. According to the cytotoxicity study, n-hexane extract exhibited a high level of toxicity with 28.9 ± 5.6% cell viability. …”
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Sub-regional efforts to achieve gender equality in land ownership by Marcel Loyd MINKA

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Elucidating the synergistic effects of aeration and non-thermal plasma on the degradation pathways of specific pollutants in wastewater by Mahdiyeh Bakhtiyari-Ramezani, Narges Ziveh, Navid Ghaemi

“…Organic pollutants originating from industrial discharges pose significant threats to human health and ecological balance. Conventional pretreatment methods face challenges due to high costs, limited efficiency, and the generation of residual sludge. …”
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Evaluation of willingness to pay and challenges to community empowerment in urban drinkable water by N.I.D. Arista, H.A. Negoro, D.E. Purba

“…BACKGROUND AND OBJECTIVES: Environmental degradation, especially that related to water, has the potential to result in an unhealthy life. Humans drinkable water for basic needs, but poor water quality can cause disease. …”
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CODE-ACCORD: A Corpus of building regulatory data for rule generation towards automatic compliance checking by Hansi Hettiarachchi, Amna Dridi, Mohamed Medhat Gaber, Pouyan Parsafard, Nicoleta Bocaneala, Katja Breitenfelder, Gonçal Costa, Maria Hedblom, Mihaela Juganaru-Mathieu, Thamer Mecharnia, Sumee Park, He Tan, Abdel-Rahman H. Tawil, Edlira Vakaj

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Effect of different ceramic materials and dentin sealing on occlusal veneers bond strength and fracture resistance by Dina Mohamed Nasr, Rewaa Gaber AboElHassan

“…Materials and methods Human mandibular molars (N = 64/test) were prepared for occlusal veneer restorations fabricated from Lithium disilicate ceramic (LS) (control group), Zirconia-reinforced lithium Silicate ceramic (ZLS), High translucent zirconia ceramic (HZ), and Resin nano ceramic (LU) (n = 16). …”
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The a criminal’s identity as an element of forensic characteristics of causing negligent serious or moderate bodily harm by K. M. Penzieva

“…The following criminologically significant features inherent in the person of the criminal have been analyzed, such as demographic data, moral qualities, psychological features; a set of psychophysical properties and qualities, motivational attitudes, emotional and rational spheres of human consciousness; social and legal data, natural and biological information about a person; socio-demographic properties, psychological qualities, biological features; social, biological, psychological and other characteristics. …”
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Association between the triglyceride glucose body mass index and asthma: evidence from NHANES 2011–2018 by Sijia Yu, Shiping Wu, Shouxin Wei

“…Abstract Background Asthma is a common chronic respiratory disease whose increasing prevalence poses a significant burden to human health and the economy. Several studies indicate that insulin resistance (IR) is associated with asthma development. …”
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