Impact of the Clinical Trials Act 2018 on clinical trial activity in Japan from 2018 to 2020: a retrospective database study using new and conventional Japanese registries by Hiroyuki Taruno, Mari S Oba, Osamu Takizawa, Kayoko Kikuchi, Kazuaki Matsui, Mayumi Shikano

“…The temporal trends in clinical trial activity after CTA enactment were examined.Results A total of 577 CTA-compliant specified clinical trials (ie, studies funded by pharmaceutical companies or studies evaluating the efficacy and safety of off-label drugs or devices in humans) were registered in the jRCT. During the same period, 5068 clinical trials were registered in the UMIN-CTR. …”
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Review of drug recalls and quality of pharmaceutical products in Nepal by Astha Neupane, Maheshwor Bastakoti, Sabita Tamang, Basant Giri

“…Objectives To evaluate the pattern of substandard and falsified pharmaceutical products recall in Nepal.Setting We analysed drug recall notices issued by the Department of Drug Administration (DDA), Nepal, and systematically reviewed peer-reviewed research articles during January 2010 to December 2020.Participants This study did not include human participants. However, data were collected from 72 drug recall notices issued by DDA and four research papers.Results A total of 346 pharmaceutical products were recalled during the reported period. …”
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Academic Philosophy as a Way of Life by Eli Kramer, Marta Faustino, Hélder Telo

“…As he comments in the same text: “Such is the lesson of ancient philosophy: an invitation to each human being to transform himself. Philosophy is a conversion, a transformation of one’s way of being and living, and a quest for wisdom.” …”
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H3K4 methylation regulates development, DNA repair, and virulence in Mucorales by Macario Osorio-Concepción, Carlos Lax, Damaris Lorenzo-Gutiérrez, José Tomás Cánovas-Márquez, Ghizlane Tahiri, Eusebio Navarro, Ulrike Binder, Francisco Esteban Nicolás, Victoriano Garre

“…Abstract Mucorales are basal fungi that opportunistically cause a potentially fatal infection known as mucormycosis (black fungus disease), which poses a significant threat to human health due to its high mortality rate and its recent association with SARS-CoV-2 infections. …”
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Runs of homozygosity in spontaneous abortions from families with recurrent pregnancy loss by N. A. Skryabin, S. A. Vasilyev, T. V. Nikitina, D. I. Zhigalina, R. R. Savchenko, N. P. Babushkina, M. E. Lopatkina, A. A. Kashevarova, I. N. Lebedev

“…All embryos had normal karyotypes according to metaphase karyotyping and conventional comparative genomic hybridization. SurePrint G3 Human CGH + SNP 4 × 180K microarrays (Agilent Technologies) were used to search for homozygous regions. …”
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All-Trans Retinoic Acid Inhibits Bone Marrow Mesenchymal Stem Cell Commitment to Adipocytes via Upregulating FRA1 Signaling by Linjun Xie, Liying Zou, Jie Chen, Youxue Liu

“…Obesity, caused by an increased number and volume of adipocytes, is a global epidemic that seriously threatens human health. Bone marrow mesenchymal stem cells (BMSCs) can differentiate into adipocytes. …”
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Therapy of genomic unstable solid tumours (WHO grade 3/4）in clinical stage III/IV using individualised neoantigen tumour peptides-INP trial (individualised neoantigen tumour peptid... by Ling Wang, Xia Chen, Juan Zhao, Jiaxi Tang, Wanyan Tang, Bin Liao, Weiqi Nian

“…Patients will be treated with their own individualised neoantigen polypeptide combined with a polypeptide adjuvant (human granulocyte-macrophage colony-stimulating factor). …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Bcl-2 (B-cell lymphoma 2), encoded by the human Bcl-2 gene, is a critical anti-apoptotic protein that regulates cell death pathways, primarily by inhibiting apoptosis. …”
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Machine vision-based detection of key traits in shiitake mushroom caps by Jiuxiao Zhao, Jiuxiao Zhao, Wengang Zheng, Wengang Zheng, Yibo Wei, Yibo Wei, Qian Zhao, Qian Zhao, Jing Dong, Jing Dong, Xin Zhang, Xin Zhang, Mingfei Wang, Mingfei Wang

“…In practical applications, this method improves the breeding process by rapidly and non-invasively assessing key traits such as the size and color of shiitake mushroom caps, which helps in efficiently screening strains and reducing human errors. Firstly, an edge detection model was established. …”
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Actinomycete-Derived Pigments: A Path Toward Sustainable Industrial Colorants by Blanca Hey Díez, Cristiana A. V. Torres, Susana P. Gaudêncio

“…The successful commercialization of actinomycete pigments can drive an industry-wide transition to environmentally responsible alternatives, offering substantial benefits for human health, safety, and environmental sustainability.…”
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The Role of Sulfur Emission from the Petroleum Industry on Ultrafine Particle Number Concentration in Singapore by Suyi Hou, Weihan Li, Liudongqing Yang, Guorong Chen, Yilin Zhang, Mikinori Kuwata

“…Abstract Ultrafine particles, defined as particles with a diameter (dp) smaller than 100 nm, serve as an important component of cloud condensation nuclei, in addition to impacting human health. The dominant sources of ultrafine particles include traffic emissions and nucleation. …”
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What makes health systems resilient? An analytical framework drawing on European learnings from the COVID-19 pandemic based on a multitiered approach by Thomas Czypionka, Markus Kraus, Miriam Reiss, Monika Riedel

“…Both sections are further divided into six building blocks that were adapted from the WHO health system framework: governance and leadership, information and research, financing, physical resources, human resources, and service delivery. An overarching component on contextual factors—subdivided into situational, structural, cultural and international factors—represents an important addition to the existing spectrum of resilience frameworks.Conclusions Foundations for a resilient health system must be laid in ‘normal’ times and in all areas of the health system. …”
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Willingness of end users to pay for e-waste recycling by H.T.T. Nguyen, C.-H. Lee, R.-J. Hung

“…<strong>BACKGROUND AND OBJECTIVES:</strong> The sheer volume of electrical and electronic waste (e-waste) has presently been generated in Vietnam, posing a growing concern regarding its impact can have on the environment and human health. Therefore, the need for developing policies and regulations towards the environmentally sound management of e-waste is becoming crucial. …”
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DIGITALISATION OF CRISIS MANAGEMENT AND RESOURCE BALANCING FOR EDUCATIONAL QUALITY ASSURANCE AT A DISPLACED UNIVERSITY by Oleksandr Spivakovsky, Daria Malchykova, Viktoria Yatsenko

“…The crisis management strategy at Kherson State University involved seeking a balance of resources (material, financial, human, communicational, managerial, and innovative) to ensure the proper quality of education. …”
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REDD1 expression in podocytes facilitates renal inflammation and pyroptosis in streptozotocin-induced diabetic nephropathy by Siddharth Sunilkumar, Sandeep M. Subrahmanian, Esma I. Yerlikaya, Allyson L. Toro, Edward W. Harhaj, Scot R. Kimball, Michael D. Dennis

“…In contrast with diabetic REDD1+/+ mice, diabetic REDD1−/− mice did not exhibit albuminuria, increased pro-inflammatory factors, or renal macrophage infiltration. In cultured human podocytes, exposure to hyperglycemic conditions promoted REDD1-dependent activation of NF-κB signaling. …”
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Multislice B1 Mapping Method Using Magnetic Resonance Composite Spin Echo Sequences and Simultaneous Echo Refocusing by Suchit Kumar, Kyu Chan Lee, Jong-Min Kim, Jeung-Hoon Seo, Chulhyun Lee, Chang-Hyun Oh

“…In addition, the proposed B1 mapping methods were compared to the multislice iterative signal intensity mapping method in both phantom and in vivo human experiments, and there was no remarkable difference between the two methods regarding the flip angle distribution in these experiments. …”
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Simulating the Tone River eastward diversion project in Japan carried out 4 centuries ago by J. Trošelj, J. Trošelj, N. Hanasaki

“…We show that it is possible to bridge two different disciplines, history, and numerical hydrological modeling to obtain a better understanding of human–water interactions. One limitation is that we only reconstructed historical land maps in the present study; the meteorological forcing inputs employed were identical to those of the 20th century. …”
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Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses by Valentina Stock, Rebecca Hofer, Franziska Lochmann, Vera Spanke, Klaus R. Liedl, Jakob Troppmair, Thierry Langer, Hubert Gstach, Christian Dank, Chris A. Mayhew, Sarah Kammerer, Veronika Ruzsanyi

“…For the first time, we identify an isotopically unlabelled CYP3A4 substrate, tolterodine that leads to the formation of a non-toxic volatile metabolite, acetone, which could potentially be applied to monitor CYP3A4 activity in humans. In vitro biotransformation of tolterodine by HepG2 cells overexpressing CYP3A4, CYP2D6 or CYP2C9 was investigated by LC-MS analysis of cell culture supernatant for the non-volatile metabolite, N-dealkylated tolterodine, and PTR-ToF-MS analysis of the headspace for acetone. …”
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Strategies for H-score Normalization of Preanalytical Technical Variables with Potential Utility to Immunohistochemical-Based Biomarker Quantitation in Therapeutic Reponse Diagnost... by William E. Pierceall, Michele Wolfe, Jessica Suschak, Hua Chang, Yan Chen, Kam M. Sprott, Jeffery L. Kutok, Stella Quan, David T. Weaver, Brian E. Ward

“…To examine the effects of preanalytical fixation variation on biomarker quantitation and potential utility of candidate calibrators to address such issues, 6 surgically-resected human breast cancer patient specimens were divided into 6 portions and fixed under distinct conditions (fixation following resection in formalin for 2 hr, 8 hr or 48 hr, or held overnight at 4°C in buffered saline prior to formalin fixation for 2 hr, 8 hr, or 48 hr). …”
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Evaluating cognitive bias in clinical ethics supports: a scoping review by Louise Giaume, Antoine Lamblin, Nathalie Pinol, Frédérique Gignoux-Froment, Marion Trousselard

“…Our main result first shows an overview of bias related to the working human environment and to information gathering that concerns different types of CES. …”
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