A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease by Rossana Scutari, Giulia Linardos, Stefania Ranno, Mara Pisani, Anna Chiara Vittucci, Luana Coltella, Luna Colagrossi, Velia Chiara Di Maio, Annamaria Sisto, Livia Mancinelli, Simona Landi, Sebastian Cristaldi, Massimiliano Raponi, Paola Bernaschi, Alberto Villani, Cristina Russo, Carlo Federico Perno

“…Rhinovirus, Metapneumovirus and Parainfluenza-virus were the most prevalent in our pediatric population. Co-infections of human bocavirus with B.pertussis were observed exclusively in patients with respiratory failure. …”
Get full text

Lateralization study of the basal ganglia, thalamus and supplying arteries in healthy individuals based on structure and connectivity analysis using 7.0T MRI by Hongqin Liang, Yawei Gu, Xiaoqi Yi, Li Kong, Jian Wang, Fajin Lv

“…The human cerebral cortex is known for its hemispheric specialization, which underpins a variety of functions and activities. …”
Get full text

Exploring the anti-metastatic potential of sunitinib and novel analogs in colorectal cancer: insights into HIF-1α mediated metastasis by Fatemeh B. Rassouli, Maryam M. Matin, Maryam M. Matin, Farzin Hadizadeh, Farzin Hadizadeh, Masoud Nejabat, Hossein Allahverdizadeh, Hamidreza Jamali, Shahin Gharedaghi, Halimeh Hassanzadeh

“…Due to the urgent demand for potent anti-metastatic agents, we aimed to determine the effects of sunitinib and novel analogs on the metastatic behavior of human CRC cells in hypoxic condition for the first time.MethodsFor in silico analyses, pathogenic targets of metastatic CRC were identified, PPI network was constructed and KEGG pathway enrichment analysis was conducted. …”
Get full text

Fall detection method based on spatio-temporal coordinate attention for high-resolution networks by Xiaorui Zhang, Qijian Xie, Wei Sun, Ting Wang

“…Abstract Fall behavior is closely related to the high mortality rate of the elderly, so fall detection has become an important and urgent research area in human behavior recognition. However, the existing fall detection methods, suffer from the loss of detailed action information during feature extraction due to the downsampling operation, resulting in subpar performance when detecting falls with similar behaviors such as lying and sitting. …”
Get full text

HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO) by Aijaz Zeeshan Khan, Omer Sabir, Adnan Hussain Shahid, Muhammad Bilal Basit, Syeda Arzinda Fatima Shah, Qamar Sajad

“… Background: Dengue Fever, also known as break-bone fever, is a viral illness and transmitted to humans by bites of infected Aedes aegypti and Aedes albopictus mosquitoes. …”
Get full text

Association between sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis by Kasra Pirahesh, Ali Zarrinnia, Leila Nikniaz, Zeinab Nikniaz

“…Observational studies were included if they assess the association between sleep duration and NAFLD or compare the mean sleep duration between patients with NAFLD and healthy population. All studies done in humans without restriction on sex, age, and language were included. …”
Get full text

Lysine Reacts with Cholesterol Hydroperoxide to Form Secosterol Aldehydes and Lysine-Secosterol Aldehyde Adducts by George Wafula Wanjala, Arnold Nola Onyango, David Rasugu Abuga, John Kamathi Muchuna, Calvin Onyango, Moses Makayoto

“…Two cholesterol secosterol aldehydes, namely, 3β-hydroxy-5-oxo-5,6-secocholestan-6-al (secosterol A) and its aldolization product 3β-hydroxy-5β-hydroxy-B-norcholestane-6β-carboxyaldehyde (secosterol B), are highly bioactive compounds which have been detected in human tissues and potentially contribute to the development of physiological dysfunctions such as atherosclerosis, Alzheimer’s disease, diabetes, and cancer. …”
Get full text

Male involvement in prevention of mother-to-child transmission of HIV, and its association with knowledge and residence in Ethiopia: a systematic review and meta-analysis by Mastewal Arefaynie, Yitayish Damtie, Bereket Kefale, Melaku Yalew, Bezawit Adane, Habtamu Shiferaw, Yesuf Ahemed, Abel Shiferaw, Tenaw Yimer, Hasab Tibebu

“…Introduction Male involvement is crucial in preventing vertical transmission of human immunodeficiency virus (HIV) among pregnant and lactating women. …”
Get full text

Magnetoelectric Extracellular Vesicle Latency-Targeting (MELT) Nanotherapeutic for the Block-Lock-and-Kill HIV Eradication Strategy by Mickensone Andre, Nagesh Kolishetti, Adriana Yndart, Arti Vashist, Madhavan Nair, Andrea D. Raymond

“…Background: Human immunodeficiency virus (HIV) establishes latent infections in cellular reservoirs, including microglia. …”
Get full text

An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing by Jacob W. Fleming, Molly C. McCloskey, Kevin Gray, David R. Nash, Vincent Leung, Christos Michas, Shawn M. Luttrell, Christopher Cavanaugh, Julie Mathieu, Shawn Mcquire, Mark Bothwell, David L. Mack, Nicholas A. Geisse, Alec S.T. Smith

“…Animal models of the neuromuscular junction (NMJ) have been widely studied but exhibit critical differences from human biology limiting utility in drug and disease modelling. …”
Get full text

Probiotic Amelioration of Azotemia in 5/6th Nephrectomized Sprague-Dawley Rats by Natarajan Ranganathan, Beena Patel, Pari Ranganathan, Joseph Marczely, Rahul Dheer, Tushar Chordia, Stephen R. Dunn, Eli A. Friedman

“…Derivative trials of probiotic treatment of larger animals and humans will further assess the potential role of probiotic formulations in delaying the onset and clinical severity of clinical illness at different stages of renal failure.…”
Get full text

Patients with colorectal cancer combined with HIV had a worse overall survival after surgery: a meta-analysis by Wen-Wen Yang, Wen-Wen Yang, Xiong Zhou, Gan He

“…PurposeThe purpose of this current study was to find out whether human immunodeficiency virus (HIV) affected overall survival (OS) of colorectal cancer (CRC) patients after surgery.MethodsPubMed, Embase, the Cochrane Library, and CNKI were searched from inception to March 27, 2023 to find eligible studies. …”
Get full text

An Interdisciplinary Analysis of the Late Islamic Cemeteries Within the Cathedral (15th–18th Century CE) and the Ruins of Adulis (Mid-19th–Early 20th Century CE), Massawa, Eritrea:... by Omar Larentis, Nelly Cattaneo, Paolo Lampugnani, Susanna Bortolotto, Emanuele Zappa, Andrea Gregorini, Yotam Gezae, Tsegai Medin, Ilaria Gorini, Serena Massa

“…These discoveries have enabled, for the first time in Eritrea, a detailed scientific study of the biological characteristics of the human remains, the funerary architecture, and the burial rites of Muslim communities from the 15th to the early 20th century. …”
Get full text

Impact of sex on the adaptation of adult mice to long consumption of sweet-fat diet by N. M. Bazhan, T. V. Iakovleva, A. D. Dubinina, E. N. Makarova

“…In rodents, the most adequate model of human diet-induced obesity is obesity caused by the consumption of a sweet-fat diet (SFD), which causes more pronounced adiposity in females than in males. …”
Get full text

An evaluation of osseous regeneration capability of novel autogenous tooth graft along with orthobiologics for long bone segmental defects by N. Hussain, M.A. Khan, A.K. Mahmood, M.Y. Tipu, S. Aslam

“…Though usage of aforementioned regimens in-vivo needs further trials but overall, we may suggest that autogenous tooth is not only a novel and viable graft in solo but its healing capacity, osteointegration and firm callus formation can be augmented with appropriate orthobiologic materials and in future may be useful for bone defect treatments, not only in animals but humans as well.…”
Get full text

Health and Educational Inequalities among the Third Gender Community in Lahore, Pakistan by Ayesha Humayun, Muhammad Hassan, Hira Ashfaq, Zulqarnain Haider, Nauman Naeem, Mubashar Munir

“…Conclusion: The third gender community faces significant barriers in accessing education and healthcare, depriving them of basic human rights. Urgent policy reforms promoting equity, inclusivity, and community sensitization are needed to end their social neglect. …”
Get full text

Spirituality of HIV-infected female patients treated in a secondary care hospital in Thailand: a preliminary investigation by Natawan Khumsaen, Panarat Chenchob, Supannee Peawnalaw

“…Introduction Globally, acquired immune deficiency syndrome (AIDS) and human immunodeficiency virus (HIV) infection are major public health concerns. …”
Get full text

Clinical profile and outcomes analysis of HIV infection by Ashwant Kumar, Yoganathan Chidambaram, Clement J. Dhas, Nekkanti Abilash, Murali Alagesan

“…Background India has the third largest number of human immunodeficiency virus (HIV) patients, but the national prevalence is continuously receding owing to dedicated health centers as well as highly active antiretroviral therapy (HAART), which is associated with newer manifestations and outcomes. …”
Get full text

Meta-Analysis of Integrated Therapeutic Methods in Noninvasive Lower Back Pain Therapy (LBP): The Role of Interdisciplinary Functional Diagnostics by Aleksandra Bitenc-Jasiejko, Krzysztof Konior, Danuta Lietz-Kijak

“…Quite often, it is a consequence of many years of disturbed distribution of tension within the human body caused by local conditions (injuries, hernias, stenoses, spondylolisthesis, cancer, etc.), global factors (postural defects, structural integration disorders, lifestyle, type of activity, etc.), or systemic diseases (connective tissue, inflammation, tumours, abdominal aneurysm, and kidney diseases, including urolithiasis, endometriosis, and prostatitis). …”
Get full text

Spatial and temporal characteristics and driving mechanisms of recreational ecosystem services supply-demand mismatch in rapidly urbanizing areas: Evidence from the Yangtze River D... by Ruien Tang, Guolin Hou, Yueyi Chen, Xiao Liu, Shaoying Chu, Li Li

“…Understanding the spatial and temporal processes of Recreational Ecosystem Services (RES) supply–demand matching and their driving mechanisms is essential for the enhancement of human well-being and the sustainable management of socio-ecological systems in the region. …”
Get full text