Nanobody screening and machine learning guided identification of cross-variant anti-SARS-CoV-2 neutralizing heavy-chain only antibodies. by Peter R McIlroy, Le Thanh Mai Pham, Thomas Sheffield, Maxwell A Stefan, Christine E Thatcher, James Jaryenneh, Jennifer L Schwedler, Anupama Sinha, Christopher A Sumner, Iris K A Jones, Stephen Won, Ryan C Bruneau, Dina R Weilhammer, Zhuoming Liu, Sean Whelan, Oscar A Negrete, Kenneth L Sale, Brooke Harmon

“…Previously, we designed a next-generation synthetic humanized nanobody (Nb) phage display library and demonstrated that this library could be used to rapidly identify highly specific and potent neutralizing heavy chain-only antibodies (HCAbs) with prophylactic and therapeutic efficacy in vivo against the original SARS-CoV-2. …”
Get full text

Impact of COVID-19 on Utilization of Healthcare Services Among People Living with HIV (PLHIV): A Systematic Review by Enyinnaya Ukaegbu, Maulenkul Tilektes, Antonio Sarria-Santamera

“…., “COVID-19 pandemic”, “SARS-CoV-2”, “Health services utilization”, “People living with Human immunodeficiency virus”, was included. <i>Results:</i> There was an overall decline in the utilization of health services such as medical consultations, ART uptake, and viral load monitoring by PLHIV at primary health centers at the forefront of care delivery. …”
Get full text

A Novel Liposome Formulation Carrying Both an Insulin Peptide and a Ligand for Invariant Natural Killer T Cells Induces Accumulation of Regulatory T Cells to Islets in Nonobese Dia... by Hidetoshi Akimoto, Emi Fukuda-Kawaguchi, Omar Duramad, Yasuyuki Ishii, Kazunari Tanabe

“…Antigen-specific therapies using islet autoantigens for restoring immune tolerance have emerged as promising approaches for the treatment of T1D but have been unsuccessful in humans. Herein, we report that RGI-3100-iB, a novel liposomal formulation carrying both α-galactosylceramide (α-GalCer), which is a representative ligand for invariant natural killer T (iNKT) cells, and insulin B chain 9–23 peptide, which is an epitope for CD4+ T cells, could induce the accumulation of regulatory T cells (Tregs) in islets in a peptide-dependent manner, followed by the remarkable prevention of diabetes onset in nonobese diabetic (NOD) mice. …”
Get full text

Host-symbiont-gene phylogenetic reconciliation by Menet, Hugo, Trung, Alexia Nguyen, Daubin, Vincent, Tannier, Eric

“…We finally evaluate different hypotheses on human population histories in the light of their coevolving Helicobacter pylori symbionts, reconciled together with their genes. …”
Get full text

Effect of electrical stimulation with a cochlear implant on tinnitus impact: protocol of an individual patient data meta-analysis by Inge Stegeman, Adriana L Smit, Kelly Assouly

“…Second, linear regression analyses will be used to model the effect of electrical stimulation on tinnitus impact based on relevant predictors.Ethics and dissemination The Medical Research Involving Human Subject Act does not apply, and ethical approval is not required. …”
Get full text

In situ natural radioactivity and radiological hazard assessments of granite gneiss outcrops in parts of the Southwestern Basement Complex of Nigeria by Adedibu Sunny Akingboye, Omowumi Ademila

“…Radioactive emission (gamma ray) emanating from rock materials constitutes threats to humans and their environment. Hence, the natural radioactivity and radiological hazard indices of some granite gneiss outcrops with their residual soils from two different localities within the Southwestern Basement Complex of Nigeria were assessed using Gamma-ray spectrometry. …”
Get full text

TiO2 Nanocoatings with Controllable Crystal Type and Nanoscale Topography on Zirconia Implants to Accelerate Bone Formation by Nan Li, Zhichao Liu, Guanqi Liu, Zhi Wang, Xianwei Guo, Chuanbin Guo, Jianmin Han

“…In addition, in vitro cytocompatibility and osteogenic potential performance of the coatings were evaluated by human bone marrow mesenchymal stem cells (hBMSCs), and in vivo osseointegration performance was assessed in a rat femoral condyle model. …”
Get full text

Sodium dichloroisocyanurate: a promising candidate for the disinfection of resilient drain biofilm by Abbie Martin, Natasha Doyle, Tom F. O'Mahony

“…Biofilms can cause a range of human diseases and are responsible for 1.7 million hospital-acquired infections in the US annually, providing an economic burden of $11.5 billion in treatment costs. …”
Get full text

Development of a neural network for diagnosing the risk of depression according to the experimental data of the stop signal paradigm by M. O. Zelenskih, A. E. Saprygin, S. S. Tamozhnikov, P. D. Rudych, D. A. Lebedkin, A.  N. Savostyanov

“…An architecture was developed and a system was implemented for testing motor control indicators in humans, then it was tested in real experiments. A comparison of neural network technologies and methods of mathematical statistics was carried out. …”
Get full text

NeuroEPO influence on the fetal heart in a placental insufficiency model of rats by Nìnive Nùñez Lòpez, Julito Dos Santos Dos Santos, Aida María Suàrez Aguiar, María Antonia Cruz García, Claudia Joffre Frías, Carmen Inés Morales Paneque, Laura López Marín

“…<br /><strong>Objective:</strong> To evaluate the influence of human recombinant erythropoietin with low sialic acid content (NeuroEPO) on the fetal heart in a rat model of placental insufficiency.…”
Get full text

Designing and testing novel artificial shelter traps to mass-trap overwintering brown marmorated stink bugs: a proof-of-concept study in Northwestern China by Jin-Ping Zhang, Gonzalo Avila, Gang Ma, Qian-Qian Mi, Adriana Najar-Rodriguez, Ju-Hong Chen, Chun-Sen Ma, Feng Zhang

“…It is also known to be a nuisance pest as it enters artificial structures, including human habitats, to overwinter and releases very unpleasant odours when disturbed. …”
Get full text

Genetic diversity of Rhododendron dauricum based on morphological traits and SSR markers by Dan Wang, Ying Ma, Xueli Zhao, Ling Wang

“…The diversity of R. dauricum germplasm resources in these areas has not been determined and it can be dynamic due to increasing climate change and human activities, which poses a challenge to effective conservation efforts. …”
Get full text

Isolation, Characterization and Genetic Diversity of Aspergillus flavus in Animal Feed by Dina Al-Shinawy, Reda E.M. Moghaieb, Sara B. Awaly, Gihan El-Moghazy, Dalia S. Ahmed

“…Aspergillus flavus is known for producing aflatoxins (AFs), which are harmful mycotoxins that can spoil food crops and represent significant health risks to animals and humans. The aim of this study was to analyze fifty samples of livestock and poultry feed to identify mycotoxigenic fungi at both morphological and molecular levels, focusing on their toxigenic potential and genetic diversity. …”
Get full text

The Effect of Excavation Disturbance on the Stability of Bedding Cataclastic Rock Mass High Slope Containing Multimuddy Interlayers by Fei Liu, Jiaming Zhang, Pengzheng Guo, Wenlian Liu, Zhiqiang Wang, Jipu Chen

“…These incidents lead to considerable human casualties and substantial economic losses. …”
Get full text

Development, in vitro and ex vivo characterization of lamotrigine-loaded bovine serum albumin nanoparticles using QbD approach by Maryana Salamah, Bence Sipos, Zsuzsanna Schelz, István Zupkó, Ágnes Kiricsi, Ágnes Szalenkó-Tőkés, László Rovó, Gábor Katona, György Tibor Balogh, Ildikó Csóka

“…The ex vivo study showed that LAM diffusion from the selected formulations through the human nasal mucosa was higher than in case of initial LAM. …”
Get full text

Analysis of serum levels and DNA methylation of fibroblast growth factor 21 using peripheral blood-derived genomes in patients with obesity by Hiroyuki Shinozaki, Shiori Kawai, Mami Gamo-Kawasaki, Ayano Takei, Kyoko Tsujikado, Kazunori Fukuda, Mototaka Yamauchi, Kenji Hara, Takafumi Tsuchiya, Kohzo Takebayashi, Koshi Hashimoto

“…In the present study, we analyzed the DNA methylation state of the FGF21 gene (FGF21) in obese patients using genomic DNA extracted from human monocytes and macrophages and investigated the pathophysiological significance of the FGF21 expression response to pemafibrate (PM), a PPARα ligand. …”
Get full text

Differential bone and vessel type formation at superior and dura periosteum during cranial bone defect repair by Yuankun Zhai, Zhuang Zhou, Xiaojie Xing, Mark Nuzzle, Xinping Zhang

“…Utilizing transgenic mouse models in conjunction with high-resolution multiphoton laser scanning microscopy (MPLSM), we have separately evaluated bone and vessel formation in the superior and dura periosteum before and after injury, as well as following intermittent treatment of recombinant peptide of human parathyroid hormone (rhPTH), Teriparatide. …”
Get full text

Metatranscriptomic time series insight into antibiotic resistance genes and mobile genetic elements in wastewater systems under antibiotic selective pressure by An-Dong Li, Yuanfang Chen, Lei Han, Ye Li, Ming Xu, Baoli Zhu

“…Abstract Background Wastewater systems are usually considered antibiotic resistance hubs connecting human society and the natural environment. Antibiotic usage can increase the abundance of both ARGs (antibiotic resistance genes) and MGEs (mobile gene elements). …”
Get full text

Enterococcus and Eggerthella species are enriched in the gut microbiomes of COVID-19 cases in Uganda by Carolina Agudelo, David Patrick Kateete, Emmanuel Nasinghe, Rogers Kamulegeya, Christopher Lubega, Monica Mbabazi, Noah Baker, Kathryn Y. Lin, Chang C. Liu, Arthur Shem Kasambula, Edgar Kigozi, Kevin Komakech, John Mukisa, Kassim Mulumba, Patricia Mwachan, Brenda Sharon Nakalanda, Gloria Patricia Nalubega, Julius Nsubuga, Diana Sitenda, Henry Ssenfuka, Giana T. Cirolia, Jeshua T. Gustafson, Ruohong Wang, Moses Luutu Nsubuga, Fahim Yiga, Sarah A. Stanley, Bernard Ssentalo Bagaya, Alison Elliott, Moses Joloba, Ashley R. Wolf

“…Abstract Background Infection with the COVID-19-causing pathogen SARS-CoV-2 is associated with disruption in the human gut microbiome. The gut microbiome enables protection against diverse pathogens and exhibits dysbiosis during infectious and autoimmune disease. …”
Get full text

Temporal and Spatial eDNA Analysis of Fish Assemblages in Postindustrial, Urban Coastal Habitats by Alice Cunnington, Erika Neave, Peter Shum, Rupert Collins, Stefano Mariani

“…ABSTRACT Urban coastal habitats experience substantial disturbances due to their proximity to human settlements and activities. Yet, despite the negative impact of urbanization on coastal environments, industrial structures can also provide artificial habitats. …”
Get full text