PTOV1 exerts pro-oncogenic role in colorectal cancer by modulating SQSTM1-mediated autophagic degradation of p53 by Yongli Fan, Yuqin Li, Xia Luo, Shiqi Xiang, Jia Hu, Jingchun Zhan, Weilong Chang, Rui Deng, Xianwen Ran, Yize Zhang, Yudie Cai, Weiwei Zhu, Huifen Wang, Zhibo Liu, Di Wang

“…Results Here, we revealed that PTOV1 was highly expressed in human CRC tissues, especially at advanced stages, and associated with reduced survival time among CRC patients. …”
Get full text

Subseasonal Prediction of Heat‐Related Mortality in Switzerland by Maria Pyrina, Ana M. Vicedo‐Cabrera, Dominik Büeler, Sidharth Sivaraj, Christoph Spirig, Daniela I. V. Domeisen

“…Abstract Heatwaves pose a range of severe impacts on human health, including an increase in premature mortality. …”
Get full text

Seroprevalence and Risk Factors of Toxoplasma gondii Infection among Domestic Ruminants in East Hararghe Zone of Oromia Region, Ethiopia by Berhanu Tilahun, Yacob Hailu Tolossa, Getachew Tilahun, Hagos Ashenafi, Shihun Shimelis

“…In conclusion, T. gondii infection is common and widespread among the domestic ruminants of the study area, indicating the potential transmission to humans from these animals when they are used as a source of food. …”
Get full text

GWAS of a soybean breeding collection from South East and South Kazakhstan for resistance to fungal diseases by A. Zatybekov, S. Abugalieva, S. Didorenko, A. Rsaliyev, Y. Turuspekov

“…In Kazakhstan the area under soybean is increasing every year, helping to solve the problem of protein deficiency in human nutrition and animal feeding. One of the main problems of soybean production is fungal diseases causing yields losses of up to 30 %. …”
Get full text

VisGraphVar: A benchmark generator for Assessing Variability in Graph Analysis Using Large Vision-Language Models by Camilo Chacon Sartori, Christian Blum, Filippo Bistaffa

“…Geometric structures, particularly graphs with their inherent flexibility and complexity, serve as an excellent benchmark for evaluating these models’ predictive capabilities. While human observers can readily identify subtle visual details and perform accurate analyses, our investigation reveals that state-of-the-art LVLMs exhibit consistent limitations in specific visual graph scenarios, especially when confronted with stylistic variations. …”
Get full text

Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups by Helen Ruth Yusuf a , Sunday Abraham Musa a , Abel Nosereme Agbon , Ejike Daniel Eze , Akeem Ayodeji Okesina , Ismail Onanuga , Theophilus Pius , Victor Archibong , Mario Edgar Fernandez Diaz , Juma John Ochieng , Nicholas Kusiima , Bot Yakubu Sunday , Ibe Michael Usman

“…Over time, the use of plant-derived agents in the management of various human health conditions has gained a lot of attention. …”
Get full text

Normative Database of Spatiotemporal Gait Metrics Across Age Groups: An Observational Case–Control Study by Lianne Mobbs, Vinuja Fernando, R. Dineth Fonseka, Pragadesh Natarajan, Monish Maharaj, Ralph J. Mobbs

“…Introduction: Gait analysis is a vital tool in the assessment of human movement and has been widely used in clinical settings to identify potential abnormalities in individuals. …”
Get full text

Editorial by Jörg Tremmel, Edward Page, Konrad Ott

“…Combined with other inertias integral to the climate system, the bulk of the expected harm to humans from climate change will be felt by future generations…”
Get full text

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition by Antonino Glaviano, Hannah Si-Hui Lau, Lukas M. Carter, E. Hui Clarissa Lee, Hiu Yan Lam, Elena Okina, Donavan Jia Jie Tan, Wency Tan, Hui Li Ang, Daniela Carbone, Michelle Yi-Hui Yee, Muthu K. Shanmugam, Xiao Zi Huang, Gautam Sethi, Tuan Zea Tan, Lina H. K. Lim, Ruby Yun-Ju Huang, Hendrik Ungefroren, Elisa Giovannetti, Dean G. Tang, Tullia C. Bruno, Peng Luo, Mads Hald Andersen, Bin-Zhi Qian, Jun Ishihara, Derek C. Radisky, Salem Elias, Saurabh Yadav, Minah Kim, Caroline Robert, Patrizia Diana, Kurt A. Schalper, Tao Shi, Taha Merghoub, Simone Krebs, Anjali P. Kusumbe, Matthew S. Davids, Jennifer R. Brown, Alan Prem Kumar

Get full text

Evaluation of Urban Composite Carbon Sink Value: A Case Study of Shenyang by Tiemao SHI, Di WANG, Yu TANG, Peiying LI

“…This is because human activities such as urban construction, transportation, and industrial production can have both positive and negative impacts on carbon sink. …”
Get full text

Navigating healthcare pathways: Cascade of prevention and care for chronic viral hepatitis in asylum seekers and refugees. A multicenter analysis in Northern Italy by Beatrice Formenti, Roberto Benoni, Jacopo Testa, Giulia Bertoli, Giacomo Stroffolini, Maria Grazia Pizzi, Barbara Menzaghi, Niccolò Ronzoni, Paola Magro, Issa El Hamad, Carla Scolari, Angiola Spinetti, Serena Zaltron, Francesco Castelli, Valentina Marchese, Alberto Matteelli

Get full text

Visual Environment Factors Influencing Staying Behaviors During Cycling on Countryside Greenways by Ting WEN, Yun ZHANG, Ming DU

“…Since visual perception accounts for 80%-90% of the information humans receive from their environment, it exerts a profound influence on human behavior and environmental experiences. …”
Get full text

Azithromycin to prevent acute lower respiratory infections among Australian and New Zealand First Nations and Timorese children (PETAL trial): study protocol for a multicentre, int... by Anne B Chang, Keith Grimwood, Yuejen Zhao, Gabrielle B McCallum, Catherine A Byrnes, Heidi Smith-Vaughan, Peter S Morris, Christine Connors, Adrian Trenholme, Shirley Lawrence, Joshua Francis, Kobi L Schutz, Mark D Chatfield, Nevio Sarmento, Robyn L. Marsh, Emily R Bowden, Nicholas Fancourt, Adriano Vieira, Kim M Hare, Dennis Bonney, Felicity Marwick, Bronwyn Karvonen, Carolyn Maclennan, Milena Santos Lay, Endang Soares da Silva

“…The secondary outcomes are the rates and proportions of children with ALRI-related hospitalisation, chronic symptoms/signs suggestive of underlying chronic suppurative lung disease or bronchiectasis, serious adverse events, and antimicrobial resistance in the upper airways, and cost-effectiveness analyses.Ethics and dissemination The Human Research Ethics Committees of the Northern Territory Department of Health and Menzies School of Health Research (Australia), Health and Disability Ethics Committee (New Zealand) and the Institute National of Health-Research Technical Committee (Timor-Leste) approved this study. …”
Get full text

Comparison of autism domains across thirty rare variant genotypesResearch in context by Nabila M.H. Ali, Samuel J.R.A. Chawner, Leila Kushan-Wells, Carrie E. Bearden, Jennifer Gladys Mulle, Rebecca M. Pollak, Raquel E. Gur, Wendy K. Chung, Michael J. Owen, Marianne B.M. van den Bree, Harriet Housby, Irene Lee, David Skuse, Jeanne Wolstencroft, William Mandy, Spiros Denaxas, Kate Baker, Lucy Raymond, Marianne van den Bree, Samuel Chawner, Jeremy Hall, Peter Holmans, Josh Hope-Bell, Danielle Le Roux, Sally Morrin, Michael Owen, Shreeya Sivakumar

Get full text

Positron emission tomography molecular imaging for pathological visualization in multiple system atrophy by La Dong, Rui Zhou, Jinyun Zhou, Ke Liu, Chentao Jin, Jing Wang, Chenxi Xue, Mei Tian, Hong Zhang, Yan Zhong

Get full text

Presenting the professional thinking model of employees based on the dimensions of ambivalence and psychological empowermen by Abdolmajid Kord, Mansur Garkaz, Alireza Maetoofi, Ali khuzin, Alireza Hasan Maleki

“…Many thinkers have recognized the solution to this problem (preparation of human resources to face the changes and progress of the organization) by empowering the human force, and have tried to provide the necessary background for training capable employees (Kurdi, 2023). …”
Get full text

Designing a structural model to improve the productivity of higher education managers by Kiana Kaveh, Amineh ahmadi, mojtaba moazzami

“…There are also a series of individual and moral factors that can be common in all organizations, because all managers, apart from their job and system positions, have common human characteristics, hence the basic research question is: what is the structural model for improving the productivity of higher education managers?…”
Get full text

Investigating effective factors in the model of high organizational commitment in government organizations in charge of educational and cultural affairs by Seyed Alireza Mirjafari, Abdul Khaliq Gholami Anarestan, Karam Elah Daneshfard

“…According to the present research, it is suggested that government organizations in charge of educational and cultural affairs pay more attention to the criteria of the proposed model, especially human resource management, and remind their employees of their importance by providing appropriate training, and consider complying with them by Organizations and their employees necessary, and try to promote them to increase productivity in the organization. …”
Get full text

Designing a cyber insurance implementation model using foundational data theory by Behzad Esmaeilifar, manouchehr Ansari

“…These factors take into account the technical equipment and cyber infrastructural readiness level, and include hardware capability, software factors, tool power or strength, information content, information technology, human factors, and cyber policies. According to the research results, the consequences of cyber insurance can be divided into two positive and negative sections. …”
Get full text

Designing a model for re-employment of employees during retirement (Study case: Ministry of Education) by Fatemeh Fatemeh Bina Baji, Hamid Rezaei Far, Mohammad Mohammadi, Monireh Salehnia

“…According to existence-dependence-growth theory, human needs include existence needs, dependence needs, and growth needs (Naili, 2014). …”
Get full text