Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis by Liming Liu, Cuiqing Zhao, Ying Yang, Xiaoxia Kong, Tuo Shao, Li Ren, Xinyu Zhuang, Baishuang Yin, Gerald Dryden, Craig McClain, Weimin Luan, Wenke Feng

“…In addition, 3T3-L1 cells were pretreated with IL-6, followed by recombinant human FGF21 (rhFGF21) treatment; lipolysis was assessed. …”
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Emerging Risk to Dengue in Asian Metropolitan Areas Under Global Warming by Cheng Jing, Guojie Wang, Kristie L. Ebi, Buda Su, Xiaoming Wang, Dong Chen, Tong Jiang, Zbigniew W. Kundzewicz

“…Changing weather patterns can also increase the numbers of Aedes mosquitoes, leading to greater human exposure and enhancing population health risks. …”
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Huntington’s disease modeling on HEK293 cell line by D. V. Sharipova, T. B. Malankhanova, A. A. Malakhova

“…Therefore, one of the important tasks is generation of an in vitro model system of Huntington’s disease based on human cell cultures. The new genome editing approaches, such as CRISPR/Cas9, allow us to generate isogenic cell lines that can be useful for drug screening and studying mechanisms of molecular and cellular events triggered by certain mutation on an equal genetic background. …”
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RIPK1 expression and inhibition in tauopathies: implications for neuroinflammation and neuroprotection by Ignacio Silva-Llanes, Ignacio Silva-Llanes, Ignacio Silva-Llanes, Enrique Madruga, Enrique Madruga, Ana Martínez, Ana Martínez, Isabel Lastres-Becker, Isabel Lastres-Becker, Isabel Lastres-Becker, Isabel Lastres-Becker

“…Our findings show elevated levels of RIPK1 mRNA levels across various forms of tauopathies, in both mouse models and human tissue samples associated with primary and secondary TAU-related disorders. …”
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Improving Sleep Disorder Diagnosis Through Optimized Machine Learning Approaches by Md. Atiqur Rahman, Israt Jahan, Maheen Islam, Taskeed Jabid, Md Sawkat Ali, Mohammad Rifat Ahmmad Rashid, Mohammad Manzurul Islam, Md. Hasanul Ferdaus, Md Mostofa Kamal Rasel, Mahmuda Rawnak Jahan, Shayla Sharmin, Tanzina Afroz Rimi, Atia Sanjida Talukder, Md. Mafiul Hasan Matin, M. Ameer Ali

“…Classifying sleep disorders, such as obstructive sleep apnea and insomnia, is crucial for improving human quality of life due to their significant impact on health. …”
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RUBY® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties by Barnabas Nyesiga, Mattias Levin, Anna Säll, Anna Rosén, Kim Jansson, Sara Fritzell, Karin Hägerbrand, Dietmar Weilguny, Laura von Schantz

“…Also, retained interaction with FcRn is demonstrated to translate into a pharmacokinetic profile in mice and non-human primates that is comparable to mAb controls. …”
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Impact of Climate Change on the Growth of Typical Crops in Karst Areas: A Case Study of Guizhou Province by Jun Ma, Baisha Weng, Wuxia Bi, Dan Xu, Ting Xu, Dengming Yan

“…The global rising temperature is supposed to alter climatic patterns like floods and droughts, thereby affecting human life supporting system and global food production. …”
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Larval Cytotoxic and Subacute Toxicity of Gardenia ternifolia, Rourea coccinea, and Cassytha filiformis Used in Traditional Medicine of Benin (West Africa) by E. Agbodjento, J. R. Klotoé, T. I. Sacramento, T. V. Dougnon, E. Déguenon, J. Agbankpé, K. Fabiyi, P. Assogba, M.-P. Hounkanrin, R. Akotegnon, T. J. Dougnon, J.-M. Atègbo

“…However, this unregulated or irrational use may pose a risk of toxicity to humans in the short and/or long term. Recent studies reported interesting ethnopharmacological, antioxidant, and phytochemical data on some medicinal plants used in the traditional treatment of male infertility in Benin. …”
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Effectiveness of three biomimetic remineralization procedures in artificial caries-affected dentin – an in-vitro pilot study by Rosário Costa, Sofia Arantes-Oliveira, Lisete Fernandes, Fábio G. Figueiras, João Cardoso Ferreira, Paulo Ribeiro de Melo

“…Methods: Seventy-two specimens of healthy human dentin were divided into twelve groups. Half of each group’s samples were analyzed using field-emission gun environmental scanning electron microscope/energy dispersive X-ray, while the other half were analyzed by X-ray diffraction and micro-Raman spectroscopy. …”
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Isolation and Characterisation of Mesenchymal Stem Cells from Rat Bone Marrow and the Endosteal Niche: A Comparative Study by Norhayati Yusop, Paul Battersby, Amr Alraies, Alastair J. Sloan, Ryan Moseley, Rachel J. Waddington

“…Such findings support further comparisons of human CB-MSCs and BM-MSCs, facilitating selection of optimal MSC populations for regenerative medicine purposes.…”
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Differentially Expressed MicroRNAs in the Development of Early Diabetic Retinopathy by Qiaoyun Gong, Jia’nan Xie, Yang Liu, Ying Li, Guanfang Su

“…Because microRNAs (miRNAs) represent effective DR therapeutic targets, we identified aberrantly expressed miRNAs associated with cellular dysfunction in early DR and detected their potential targets. We exposed human retinal endothelial cells (HRECs) and a cell line of retinal pigment epithelial (RPE) cells to high glucose (25 mmol/L, 1–7 days) to mimic DR progression and used streptozotocin-injected rats (4–8 weeks) for an in vivo diabetes model. …”
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Multimodal heterogeneous graph fusion for automated obstructive sleep apnea-hypopnea syndrome diagnosis by Haoyu Wang, Xihe Qiu, Bin Li, Xiaoyu Tan, Jingjing Huang

“…This framework constructs two types of graph representations: physical space graphs, which map the spatial layout of sensors on the human body, and process knowledge graphs which detail the physiological relationships among breathing patterns, oxygen saturation, and vital signals. …”
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Development of Collagen-Based 3D Matrix for Gastrointestinal Tract-Derived Organoid Culture by Joo Hyun Jee, Dong Hyeon Lee, Jisu Ko, Soojung Hahn, Sang Yun Jeong, Han Kyung Kim, Enoch Park, Seon Young Choi, Sukin Jeong, Joong Woon Lee, Han-Jun Cho, Min-Soo Kwon, Jongman Yoo

“…Mouse small intestine–derived organoids, stomach-derived organoids, and human colon–derived organoids were also cultured, all of which were successfully grown in the collagen-based matrix and had similar properties compared to those cultured in Matrigel. …”
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IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome by Min Guo, Rui Yan, Hongmei Yao, Liqin Duan, Meng Sun, Zheng Xue, Yongping Jia

“…The expression of IRF-1 in human PBMC-derived macrophages was analyzed. Then, overexpression and inhibition of IRF-1 was performed in macrophages from patients with ACS to explore the possible role and mechanism of IRF-1 involvement in macrophage pyroptosis. …”
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Mesenchymal stem cell-derived extracellular vesicles enriched with miR-124 exhibit anti-inflammatory effects in collagen-induced arthritis by Guo Zhonghua, He Mengyuan, Shi Dongliang, Zhang Zhongbo, Wang Lisha, Ren Bowen, Wang Yunfei, Wang Junjie, Yang Shaoxiang, Yu Hongchao

“…This study investigated the anti-inflammatory effects of human umbilical cord-derived MSC (hUCSC)-EVs overexpressing miR-124 in collagen-induced arthritis (CIA). hUCSCs were transfected with miR-124, and hUCSC-EVs were isolated and characterized. …”
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AutoMEX: Streamlining material extrusion with AI agents powered by large language models and knowledge graphs by Haolin Fan, Junlin Huang, Jilong Xu, Yifei Zhou, Jerry Ying Hsi Fuh, Wen Feng Lu, Bingbing Li

“…AutoMEX utilizes a knowledge graph (KG) derived from the scientific literature to enable LLMs to provide expert recommendations on material selection, process parameters, and design considerations, thereby improving accessibility and efficiency. With minimal human intervention, the framework encompasses a complete workflow, including CAD model generation, printing parameter recommendation, slicing, and machine operation. …”
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Ameliorative effect of liprotide-encapsulated vitamin D3 on blood glucose, calcium homeostasis, and vitamin D level in a vitamin D and calcium deficient rat model by Gemala Anjani, Reza Achmad Maulana, Sylvia Rahmi Putri, Faizah Fulyani, Ahmad Syauqy, Diana Nur Afifah, Fitriyono Ayustaningwarno, Refani Alycia Kusuma, Zulfatul Masruroh

“…Vitamin D3, recognized for its higher bioavailability and direct cell utilization, plays a vital role in the human body. Applying β-lactoglobulin with oleic acid (β-Lg-AO) as an encapsulating agent is anticipated to protect and enhance the transport of vitamin D3 to the gastrointestinal system. …”
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Widely Targeted Metabolomics Analysis Reveals Key Quality-Related Metabolites in Kernels of Sweet Corn by Ruichun Yang, Yunfeng Li, Yuanyuan Zhang, Jun Huang, Junjie Liu, Zimei Lin, Qinqin Yu, Aimin Wu, Bo Wang

“…And the essential amino acids for the human body, methionine and threonine, were highly accumulated in the high-quality cultivar. …”
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Magnolol induces cell death through PI3K/Akt‐mediated epigenetic modifications boosting treatment of BRAF‐ and NRAS‐mutant melanoma by Abdullah Al Emran, Brinda Reddy Chinna Chowdary, Farzana Ahmed, Heinz Hammerlindl, Antje Huefner, Nikolas K. Haass, Wolfgang Schuehly, Helmut Schaider

“…Here, we show that magnolol, a constituent of Magnolia officinalis, induced G1 arrest, apoptosis and cell death in BRAF‐ and NRAS‐mutant melanoma cells at low concentration, with no effect in BRAF‐ and NRAS wild‐type melanoma cells and human keratinocytes. This was confirmed in a 3D spheroid model. …”
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Development and Implementation of an IoT-Based Early Flood Detection and Monitoring System Utilizing Time Series Forecasting for Real-Time Alerts in Resource-Constrained Environmen... by Nik Nor Muhammad Saifudin Nik Mohd Kamal, Ahmad Anwar Zainuddin, Abu Ubaidah Shamsudin, Muhamad Syariff Sapuan, Muhammad Hazim Amin Samsudin, Mohammad Adam Haikal Zulkfli

“…Traditional flood monitoring systems have severe limitations, including reliance on human data gathering, a lack of real-time capabilities, expensive prices, and slow response times, particularly in developing countries. …”
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