Status of seawater intrusion in Mexico: A review by Xiaoxiao Zha, Jesús Horacio Hernández Anguiano, Francisco Padilla Benítez, Arturo Cruz-Falcón, Raul Miranda-Avilés, Manuel E. Mendoza Cantú, Jorge Adrian Perera-Burgos, Xu Liao, Juan Manuel Navarro-Céspedes, Miguel Angel Acosta-Reyes, Yanmei Li

“…This synthesis of seawater intrusion highlights the role of climate change, which directly links to human-induced pressures. The findings offer insights into coastal regions worldwide grappling with similar challenges from climate change and increasing water demand.…”
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G Protein-Coupled Receptor 17 Inhibits Glucagon-like Peptide-1 Secretion via a Gi/o-Dependent Mechanism in Enteroendocrine Cells by Jason M. Conley, Alexander Jochim, Carmella Evans-Molina, Val J. Watts, Hongxia Ren

“…Here, we expressed the human GPR17 long isoform (hGPR17L) in GLUTag cells, a murine EEC line, and we used the GPR17 synthetic agonist MDL29,951 together with pharmacological probes and genetic approaches to quantitatively assess the contribution of GPR17 signaling to GLP-1 secretion. …”
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Preparation and in vitro biological evaluation of strontium doped β-tricalcium phosphate scaffolds for alveolar bone tissue regeneration by Congrui Liu, Guiyong Xiao, Zichen Wang, Mengchen Xu, Yinchuan Wang, Nan Wang, Zhenlong Sun, Xiaoyan Li, Yixin Yin

“…A range of strategies have been devised to boost the osteogenic differentiation capacity of various biomaterials. As a human trace element, strontium (Sr) plays a vital role in bone remodeling. …”
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Metabolomics and Lipidomics Reveal the Metabolic Disorders Induced by Single and Combined Exposure of Fusarium Mycotoxins in IEC-6 Cells by Xinlu Wang, Yanyang Xu, Haiqi Yu, Yushun Lu, Yongzhong Qian, Meng Wang

“…Deoxynivalenol (DON), fumonisin B₁ (FB₁), and zearalenone (ZEN) are typical fusarium mycotoxins that occur worldwide in foodstuffs, posing significant health hazards to humans and animals. Single and combined exposure of DON, FB₁, and ZEN leads to intestinal toxicity but the toxicology mechanism research is still limited. …”
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The Role of ChatGPT and AI Chatbots in Optimizing Antibiotic Therapy: A Comprehensive Narrative Review by Ninel Iacobus Antonie, Gina Gheorghe, Vlad Alexandru Ionescu, Loredana-Crista Tiucă, Camelia Cristina Diaconu

“…However, challenges such as inconsistent handling of clinical nuances, susceptibility to unsafe advice, algorithmic biases, data privacy concerns, and limited clinical validation underscore the importance of human oversight and refinement. <b>Conclusions:</b> AI chatbots have the potential to complement antibiotic stewardship efforts by promoting appropriate antibiotic use and improving patient outcomes. …”
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Prognostic significance of mast cell and microvascular densities in malignant peripheral nerve sheath tumor with and without neurofibromatosis type 1 by Roberto André Torres de Vasconcelos, Pedro Guimarães Coscarelli, Thyago Marsicano Vieira, Washington Silva Noguera, Davy Carlos Mendes Rapozo, Marcus André Acioly

“…Recently, the essential role of mast cells in the tumor onset of neurofibromatosis type 1 (NF1)‐associated neurofibromas and MPNSTs was confirmed in both experimental and human studies. In this study, we investigate mast cell density (MCD), microvascular density (MVD), and proliferation index (Ki‐67) in MPNST. …”
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AIM2 Mediates Inflammation-Associated Renal Damage in Hepatitis B Virus-Associated Glomerulonephritis by Regulating Caspase-1, IL-1β, and IL-18 by Junhui Zhen, Le Zhang, Jiachao Pan, Shumin Ma, Xiaojian Yu, Xiaobo Li, Shijun Chen, Wenjun Du

“…Following siRNA-mediated knockdown of AIM2 in HBV-infected and HBV-uninfected human glomerular mesangial (HGM) cells, expression of caspase-1, IL-1β, and IL-18 was detected by qRT-PCR and Western blot. …”
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Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis by Alexandra Noble, Rodrigo Motta, Silvia Cabras, Belen Moron Flores, Jan Nowak, Aleksandra Glapa-Nowak, Alessandra Geremia, Jack Satsangi, Emma Culver

“…Epigenetic age acceleration was observed in patients with IgG4-SC, but not in those with PSC or UC. meQTL analyses to identify genetic determinants of methylation revealed a strong human leucocyte antigen (HLA) signal in both PSC and IgG4-SC (HLA-DQB2, HLA-DPA1, HLA-F and HLA-DRA). …”
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Intensification of Natural Disasters in the State of Pará and the Triggering Mechanisms Across the Eastern Amazon by Everaldo B. de Souza, Douglas B. S. Ferreira, Luciano J. S. Anjos, Alan C. Cunha, João Athaydes Silva, Eliane C. Coutinho, Adriano M. L. Sousa, Paulo J. O. P. Souza, Waleria P. Monteiro Correa, Thaiane S. Silva Dias, Alexandre M. C. do Carmo, Carlos B. B. Gutierrez, Giordani R. C. Sodré, Aline M. M. Lima, Edson J. P. Rocha, Bergson C. Moraes, Luciano P. Pezzi, Tercio Ambrizzi

“…The detailed characterization of disasters on a municipal scale is relevant in terms of the scientific contribution applied to the strategic decision-making, planning, and implementation of public policies aimed at early risk management (rather than post-disaster response), which is critical for safeguarding human well-being and strengthening the resilience of Amazonian communities vulnerable to climate change.…”
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EEG-based functional and effective connectivity patterns during emotional episodes using graph theoretical analysis by Majid Roshanaei, Hamzeh Norouzi, Julie Onton, Scott Makeig, Alireza Mohammadi

“…These findings enhance our understanding of emotional processing and have practical applications in mental health, biomarker identification, and human-computer interaction.…”
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Lipidomics-based association study reveals genomic signatures of anti-cancer qualities of pigmented rice sprouts by Rhowell Navarro Tiozon, Rhowell Navarro Tiozon, Erstelle Pasion-Uy, Saleh Alseekh, Saleh Alseekh, Kristel June D. Sartagoda, Shem Gempesaw, Joel H. G. Tolentino, Alisdair R. Fernie, Alisdair R. Fernie, Nese Sreenivasulu

“…This study offers valuable insights into the health-promoting potential of germinated rice sprouts as a rich dietary source of antioxidants beneficial to human health.…”
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Use of digital data from open sources during the investigation of criminal offenses: certain aspects by Basysta I., Havrylyuk L., Hutnyk A., Khytra A.

“…An analysis of national legislation, national judicial practice, the Berkeley protocol for conducting an investigation using open digital data (hereinafter referred to as the Berkeley Protocol), the practice of the European Court of Human Rights, the International Criminal Court and scientific research, based on which, by means of a synthesis, the basis of the problem was identified. …”
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Science-based communication and education needed to improve forest carbon science, policy, and management outcomes by Chad C Papa, Kylie Clay, Lauren T Cooper, Scott C Stark

“…Climate change is one of the most pressing issues facing humanity and forests are increasingly seen as a key pathway to mitigating and adapting to the climate crisis. …”
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Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states— A Gout, Hyperuricaemia and Crystal-Associated Disease... by Georgios Filippou, Antonella Adinolfi, Emilio Filippucci, Nicola Dalbeth, Robert Terkeltaub, Tristan Pascart, Edoardo Cipolletta, Silvia Sirotti, Charlotte Jauffret, Sara Tedeschi, Daniele Cirillo, Luca Ingrao, Alessandro Lucia

“…This systematic literature review constituted its first step and aimed to provide a state-of-the-art analysis of the medical literature of the last 20 years.Methods A systematic literature search was undertaken in the PubMed, Cochrane and Embase databases between 2000 and 2022, restricted to studies on humans and in the English language. Eight reviewers independently and manually extracted labels related to CPPD concepts, according to an a priori list generated by the authors: pathogenic conditions and pathogenic crystal labels, elementary imaging condition elements and asymptomatic and symptomatic condition states. …”
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The N-acetyltransferase 10 inhibitor [11C]remodelin: synthesis and preliminary positron emission tomography study in mice by Rui Luo, Yiding Zhang, Katsushi Kumata, Lin Xie, Yusuke Kurihara, Masanao Ogawa, Tomomi Kokufuta, Nobuki Nengaki, Feng Wang, Ming-Rong R. Zhang

“…Moreover, remodelin has been found to enhance healthspan in an animal model of the human accelerated ageing syndrome. In this study, we synthesized C-11-labelled remodelin ([11C]remodelin) for the first time as a positron emission tomography (PET) probe and assessed its biodistribution in mice using PET. …”
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Nucleotide Sequencing and Identification of Some Wild Mushrooms by Sudip Kumar Das, Aninda Mandal, Animesh K. Datta, Sudha Gupta, Rita Paul, Aditi Saha, Sonali Sengupta, Priyanka Kumari Dubey

“…The determined nucleotide sequences of the mushrooms may provide additional information enriching GenBank database aiding to molecular taxonomy and facilitating its domestication and characterization for human benefits.…”
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Structural basis for the interaction between the Drosophila RTK Sevenless (dROS1) and the GPCR BOSS by Jianan Zhang, Yuko Tsutsui, Hengyi Li, Tongqing Li, Yueyue Wang, Salma Laraki, Sofia Alarcon-Frias, Steven E. Stayrook, Daryl E. Klein

“…Our findings provide a fundamental understanding of the regulatory function of dROS1 and further provide mechanistic insight into the human ortholog and oncogene ROS1.…”
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Epigenome-wide association study of perceived discrimination in the Multi-Ethnic Study of Atherosclerosis (MESA) by Wei Zhao, Lisha Lin, Kristen M. Kelly, Lauren A. Opsasnick, Belinda L. Needham, Yongmei Liu, Srijan Sen, Jennifer A. Smith

“…DNA methylation (DNAm) may be a potential mechanism by which stressors get embedded into the human body at the molecular level and subsequently affect health outcomes. …”
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The opposite association of HRAS and KRAS mutations with clinical variables of bladder cancer by M. P. Smal, A. I. Rolevich, T. N. Nabebina, S. A. Krasny, R. I. Goncharova

“…Although the role of RAS gene mutations in the pathogenesis of various human cancers has been established, the clinical significance of these molecular alterations in bladder cancer remains unclear. …”
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A multiresolution approach with method-informed statistical analysis for quantifying lymphatic pumping dynamics by Mohammad S. Razavi, Katarina J. Ruscic, Elizabeth G. Korn, Marla Marquez, Timothy T. Houle, Dhruv Singhal, Lance L. Munn, Timothy P. Padera

“…For example, the reliability of the peak-and-valley analysis of human lymphatic vessels was increased 3-fold using the described approach. …”
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