Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β by Rebecca Faresjö, Elisabet O. Sjöström, Tiffany Dallas, Magnus M. Berglund, Jonas Eriksson, Dag Sehlin, Stina Syvänen

“…We developed and evaluated fusion proteins (FPs) combining VHHs with human IgG Fc domains or single-chain variable fragments (scFvs) of the anti-amyloid-beta (Aβ) antibody 3D6. …”
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Senescence-Associated Molecular and Epigenetic Alterations in Mesenchymal Stem Cell Cultures from Amniotic Fluid of Normal and Fetus-Affected Pregnancy by Jūratė Savickienė, Sandra Baronaitė, Aistė Zentelytė, Gražina Treigytė, Rūta Navakauskienė

“…Human amniotic-fluid-derived mesenchymal stem cells (AF-MSCs) are interesting for their multilineage differentiation potential and wide range of therapeutic applications due to the ease of culture expansion. …”
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Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs by Do-Hun Kim, Sang-Hwi Choi, Jin Jea Sung, Sieun Kim, Hanui Yi, Sanghyun Park, Chan Wook Park, Young Woo Oh, Jungil Lee, Dae-Sung Kim, Jong-Hoon Kim, Chul-Yong Park, Dong-Wook Kim

“…We inserted FE-FVIII with a human elongation factor-1 alpha (EF1α) promoter into the AAVS1 locus of HA patient-derived iPSCs via CRISPR/Cas9 (D10A) nickase to ensure expression in any cell type. …”
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Hypoxia-Inducible Factor-1α in Macrophages, but Not in Neutrophils, Is Important for Host Defense during Klebsiella pneumoniae-Induced Pneumosepsis by Natasja A. Otto, Liza Pereverzeva, Valentine Leopold, Ivan Ramirez-Moral, Joris J. T. H. Roelofs, Jeroen W. J. van Heijst, Alex F. de Vos, Tom van der Poll

“…We here determined the role of myeloid cell HIF1α in the host response during pneumonia and sepsis caused by the common human pathogen Klebsiella pneumoniae. To this end, we generated mice deficient for HIF1α in myeloid cells (LysM-cre × Hif1αfl/fl) or neutrophils (Mrp8-cre × Hif1αfl/fl) and infected these with Klebsiella pneumoniae via the airways. …”
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Research on “Identification–Cognition–Perception” of the Pedestrian Spaces Around Subway Stations near Popular Tourist Attractions from the Tourists’ Perspective: A Case Study of T... by Weiwei Liu, Jianwei Yan, Xiang Sun, Ruiqi Song

“…Future urban spatial optimization research should consider both cognitive and perceptual dimensions, enhancing the comprehensiveness of the human-centered perspective. The research results provide empirical references and guidance for the management and practice of urban space renewal around subway stations near major cities’ tourist attractions.…”
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The Cytokine and Bone Protein Expression by Ellagic Acid-Hydroxyapatite in Bone Remodelling Model by Dyah Noviana Primasari, Intan Nirwana, Hendrik Setia Budi, Agung Satria Wardhana, Annisa Fitria Sari, Novita Novita, Andika Putri Setyawan, Meircurius Dwi Condro Surboyo, Khairul Anuar Shariff

“…Ellagic acid, a phenolic compound with anti-inflammatory potential, can be used to accelerate the bone healing process and affect human health, while hydroxyapatite is the most commonly used bone graft material. …”
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Are Artificial Sweeteners a Healthier Alternative to Sugar? by Julia Buszek, Piotr Czerniak, Adrianna Antoszewska, Weronika Bargiel, Dominika Bąk, Halszka Wajdowicz, Mateusz Warzocha, Michał Medygrał, Sylwia Buszek, Aldona Sokołowska, Maciej Rumian, Alicja Kosel

“…Aim of the Study This study examines the effects of sweeteners on human health and evaluates their suitability as sugar substitutes for modern consumers, highlighting their benefits and potential risks. …”
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Teenage Pregnancy: Impact of the Integral Attention Given to the Pregnant Teenager and Adolescent Mother as a Protective Factor for Repeat Pregnancy by Maria José Carvalho Sant'Anna, Kepler Alencar Mendes Carvalho, Amanda Melhado, Verônica Coates, Hatim A. Omar

“…This study was approved by the Human Research Ethics Committee. The Epi-Info v6.0b software was used for data and result evaluation using the means and the chi-squared test. …”
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Targeting SLC4A4: A Novel Approach in Colorectal Cancer Drug Repurposing by Krunal Pawar, Pramodkumar P. Gupta, Pooran Singh Solanki, Ravi Ranjan Kumar Niraj, Shanker L. Kothari

“…Methods: The study utilized computational approaches, including receptor-based virtual screening and high-throughput docking, to identify potential SLC4A4 inhibitors. A model of the human SLC4A4 structure was generated based on CryoEM data (PDB ID 6CAA), and drug candidates from the DrugBank database were evaluated using two computational tools (DrugRep and CB-DOCK2). …”
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A girl with intragenic variants in MARS2 and a chondrodysplasia phenotype by Hiroyuki Iijima, Yuko Tsujioka, Yoshiyuki Tsutsumi, Gen Nishimura, Yasushi Okazaki, Kei Murayama, Mitsuru Kubota, Akira Ohtake

“…Background: The human mitochondrial methionyl-tRNA is crucial for mitochondrial translation, serving as both initiator and elongator in polypeptide chains. …”
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“Sichuanvirus”, a novel bacteriophage viral genus, able to lyse carbapenem-resistant Klebsiella pneumoniae by Juan Li, Qingqing Fang, Huan Luo, Yan Feng, Yu Feng, Zhiyong Zong

“…Abstract Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a severe threat for human health and urgently needs new therapeutic approaches. …”
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Dengue Virus NS1 Protein as a Diagnostic Marker: Commercially Available ELISA and Comparison to qRT-PCR and Serological Diagnostic Assays Currently Used by the State of Florida by Jason H. Ambrose, Shamala Devi Sekaran, Azliyati Azizan

“…These comparisons were made among a group of 21 human sera. Results. Nine of 14 (64.3%) DENV qRT-PCR+ samples were also DENV NS1+. …”
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Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanate by Huagui Huang, Kaizhong Wang, Xiangyan Liu, Xin Liu, Jinzuo Wang, Moran Suo, Hui Wang, Shuang Chen, Xin Chen, Zhonghai Li

“…Piezoelectric materials have the same piezoelectric effect as human bone, and they are able to deform in response to physiological movement, thus providing electrical stimulation to cells or damaged tissue without the need for an external power source. …”
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The Mitochondria-Targeted Antioxidant SkQ1 Downregulates Aryl Hydrocarbon Receptor-Dependent Genes in the Retina of OXYS Rats with AMD-Like Retinopathy by M. L. Perepechaeva, A. Yu. Grishanova, E. A. Rudnitskaya, N. G. Kolosova

“…It has been shown that SkQ1 reduces clinical signs of retinopathy in senescence-accelerated OXYS rats, which are a known animal model of human age-related macular degeneration (AMD). The aim of this work was to test whether SkQ1 affects transcriptional activity of AhR (aryl hydrocarbon receptor) and Nrf2 (nuclear factor erythroid 2-related factor 2), which are considered as AMD-associated genes in the retina of OXYS and Wistar rats. …”
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Comparison of the mechanical properties of different skin sites for auricular and nasal reconstruction by M. F. Griffin, B. C. Leung, Y. Premakumar, M. Szarko, P. E. Butler

“…Methods Using ten fresh human cadavers, the tensile Young’s Modulus of the skin from the forehead, forearm, temporoparietal, post-auricular and submandibular neck was assessed. …”
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Microneedle technology for enhanced topical treatment of skin infections by Tingting Peng, Yangyan Chen, Xuanyu Luan, Wanshan Hu, Wentao Wu, Bing Guo, Chao Lu, Chuanbin Wu, Xin Pan

“…Skin infections caused by microbes such as bacteria, fungi, and viruses often lead to aberrant skin functions and appearance, eventually evolving into a significant risk to human health. Among different drug administration paradigms for skin infections, microneedles (MNs) have demonstrated superiority mainly because of their merits in enhancing drug delivery efficiency and reducing microbial resistance. …”
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Artificial Taste: Advances and Innovative Applications in Healthcare by Letao Wang, Yuzhang Li, Yao Zhang, Bin Zheng

“…Targeted original research papers were analyzed, with data extracted to address five key aspects: interface design, stimulation parameters, sensation verification results, applications to health problems, and potential side effects in human subjects. Results: A total of 19 relevant papers were identified. …”
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Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb by Sabrina Burattini, Federico Gianfanti, Francesco Onesimo, Sabrina Donati Zeppa, Barbara Canonico, Mariele Montanari, Giovanna Panza, Daniele Lopez, Giosuè Annibalini, Fabiana Fanelli, Roberta Saltarelli, Michele Mari, Michele Retini, Riham Osman, Aghna Mariam, Matteo Micucci, Giovanni Caprioli, Agnese Santanatoglia, Deborah Agostini, Michela Battistelli

“…Through HPLC-ESI-MS/MS, the chemical analysis identified key phenolic compounds, including (−)-epicatechin, procyanidin B2, and p-coumaric acid. Human immortalized keratinocyte cell lines (HaCaT) were treated with CCRE in healthy and UVB-induced conditions to assess their impact on oxidative stress and aging. …”
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Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen by Michael L. McCaleb, Steven G. Hughes, Tamar R. Grossman, Ashley Frazer-Abel, Bill Jung, Lixuan Yin, Scott P. Henry, Brett P. Monia, Eugene Schneider, Richard Geary, Gary T. Brice

“…An over-active alternative complement pathway has been implicated in the pathophysiology of multiple diseases, including IgA nephropathy and geographic atrophy secondary to age related macular degeneration. In first-in-human double-blind, placebo-controlled phase 1 studies, the safety and pharmacodynamic effects of sefaxersen (RO7434656), a GalNAc-conjugated 2’-MOE antisense oligonucleotide targeting the complement factor B mRNA, was investigated. …”
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Spatial genetic characterization of the red fox (Vulpes vulpes) in the area between the Alps and the Central Dinaric Mountains by A. Devedžić, F. F. Urzi, B. Pokorny, G. Vengušt, D. Ž. Vengušt, F. Janžekovič, L. Velić, T. Eterović, B. K. Stroil, E. Bužan

“…Studying genetic diversity is crucial for the resilience and adaptability of populations, ensuring their survival amid environmental changes and human-induced pressures.…”
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