Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food. by Laura Dearden, Isadora C Furigo, Lucas C Pantaleão, L W P Wong, Denise S Fernandez-Twinn, Juliana de Almeida-Faria, Katherine A Kentistou, Maria V Carreira, Guillaume Bidault, Antonio Vidal-Puig, Ken K Ong, John R B Perry, Jose Donato, Susan E Ozanne

“…We demonstrate that targets of miR-505-5p are enriched in fatty acid metabolism pathways and overexpression of miR-505-5p decreased neuronal fatty acid metabolism in vitro. miR-505-5p targets are associated with increased BMI in human genetic studies. Intra-cerebroventricular injection of miR-505-5p in wild-type mice increased HFD intake, mimicking the phenotype observed in offspring exposed to maternal obesity. …”
Get full text

B-doped nano-hydroxyapatite facilitates proliferation and differentiation of osteoblasts by Qiao Kang, Wenhao Wang, Shengtao Wu, Ganggang Hu

“…Methods B-nHAp characterization was accomplished by means of X-ray diffraction, scanning electron microscopy, inductively coupled plasma mass spectrometry, and transmission electron microscopy. Human bone marrow mesenchymal stem cells (hBMSCs) were subjected to flow cytometry, alizarin red S staining, and cell counting kit-8 assay for proliferation and differentiation determination. …”
Get full text

The Role of Silymarin in Mitigating Inflammation and Cognitive Impairment Induced by Ovariectomy in Wistar Rats by Razieh Moalefshahri, Hossein Javid, Fatemeh Gheybi, Somaye Fallahnezhad, Seyed Isaac Hashemy

“…Silymarin, a polyphenolic flavonoid found in milk thistle, has been used to treat liver and brain injuries in humans and animals. The study aims to investigate the protective effects of silymarin on spatial and passive avoidance memory, oxidative stress, and inflammatory factors in the brain and liver tissues of ovariectomized (OVX) Wistar rats. …”
Get full text

Physician wellbeing in a national rehabilitation hospital, a qualitative study utilizing Maslow’s hierarchy of needs as a framework for analysis by Áine Carroll, Claire Collins, Jane McKenzie

“…Maslow’s hierarchy of needs, an integrated hierarchy of human needs, has been utilised as a framework to assess wellbeing in doctors but not heretofore in Rehabilitation Medicine. …”
Get full text

Span-of-control’s role at the intersection of transactional leadership and employee commitment by Tabea R. Mabasa, Chukuakadibia E. Eresia-eke

“…Orientation: South African state-owned enterprises (SOEs) are overburdened by excessive top-level management, straining human capital budgets. Reducing this may increase the span of control, affecting the relationship between leadership style and employee commitment. …”
Get full text

Protective effects of Euphorbia heterophylla against testicular degeneration in streptozotocin-induced diabetic rats in relation to phytochemical profile. by Ahmed M Nagy, Heba A Fahmy, Mohamed F Abdel-Hameed, Rehab F Taher, Alaa M Ali, Mohamed M Amin, Sherif M Afifi, Tuba Esatbeyoglu, Mohamed A Farag, Abdelsamed I Elshamy

“…<h4>Background</h4>Diabetes mellitus (DM) poses a major risk to human health due to an array of implications, one of which is a detrimental effect on the testicular and reproductive functions. …”
Get full text

Resilience in virtual education: Designing and validating a scale in higher education by Ghanizadeh Afsaneh, Yazdi Maryam Majidi

“…The emergence of COVID-19 influenced different aspects of human life including education. Thanks to technology, especially ICT, Virtual Education (VE) provides the opportunity to continue education in such crises. …”
Get full text

MAN AND LOGOS: HERACLITUS’ SECRET by A. V. Halapsis

“…Despite all the differences between these approaches, each of them postulated the cosmic (divine) significance of human existence, which means that it brought anthropology to the ontological level.…”
Get full text

A Current Overview of Next-Generation Probiotics and Their Prospects in Health and Disease Management by Ke-Yan Loo, Joanne Yuen Heng Thong, Loh Teng-Hern Tan, Vengadesh Letchumanan, Kok-Gan Chan, Learn-Han Lee, Jodi Woan-Fei Law

“…This study aims to provide a comprehensive review on the recent evidence on NGPs by exploring their potential roles and applications in human health and agricultural settings. The literature search was conducted systematically across four databases with the keywords “next generation probiotics” and “gut health” or treatment” or “therapy”. …”
Get full text

Inotodiol induces hepatocellular carcinoma apoptosis by activation of MAPK/ERK pathway. by Yushuang Xing, Di Jia, Xinping Zhu, Jialu Yang, Zhipeng Gao, Nana Meng, Haohao Xu, Mengxiao Wang, Shijun Chang, Mingqian Zhao, Shanbo Zhang, Zichen Mu, Qiang Tang, Weiming Zhao

“…Hepatocellular carcinoma(HCC) has a high mortality and morbidity rate and seriously jeopardizes human life. Chemicals and chemotherapeutic agents have been experiencing problems such as side effects and drug resistance in the treatment of HCC, which cannot meet the needs of clinical treatment. …”
Get full text

Genetic Analysis Reveals A Missense Mutation In Reactivation Gene-2 Causing Severe Combined Immunodeficiency Disease In A Pakistani Family by Shahida Awais, Lubna Siddique, Nida Shafi, Sobia Humerah, Summyah Niazi, Wafa Omer

“…Exons specific polymerase chain reaction (PCR) was performed using oligonucleotide primers and subsequently DNA Sanger sequenced which resulted into an missense variant in the gene RAG2. Conclusion: In human reactivation gene 1 and 2 encode proteins with endonuclease activity which are involved in V(D)J rearrangement to generate variety of different types of T- and B- cell receptors. …”
Get full text

Yeasts with Fermentative Potential Associated with Fruits of Camu-Camu (Myrciaria dubia, Kunth) from North of Brazilian Amazon by Ítalo Thiago Silveira Rocha Matos, Vanderly Andrade de Souza, Giovana do Rosário D’Angelo, Spartaco Astolfi Filho, Edson Júnior do Carmo, Marcos José Salgado Vital

“…This paper is a rare report of C. orthopsilosis with endophytic habit because most of the references indicate it as a human pathogen. Besides this, M. caribbica is a promising fermenter for alcoholic beverages due to its osmotolerance and high ethanol yield. …”
Get full text

Localization of multiple jamming attackers in vehicular ad hoc network by Liang Pang, Xiao Chen, Yong Shi, Zhi Xue, Rida Khatoun

“…In order to address the issue of wireless jamming attacks, a new technique which localizes the jamming attackers and prevents vehicles from jamming through human intervention is proposed. In this article, we propose a range-free approach to localize the source of the attacker and determine the number of jamming attackers. …”
Get full text

Molecular identification and genetic diversity analysis of Cryptosporidium spp. infecting dogs from central and northern Jordan: Detection of zoonotic genotype IId. by Rami M Mukbel, Eman M Etoom, Haifa B Hammad, Heidi L Enemark, Marwan M Abu Halaweh

“…Cryptosporidium spp. are common causes of gastrointestinal disease in both humans and animals. This was a cross-sectional study conducted to determine the infection rate and genetic characteristics of Cryptosporidium infecting dogs in Jordan. …”
Get full text

Cytokine and eicosanoid regulation by Schistosoma mansoniduring LSE penetration by A. C. Fusco, B. Salafsky, T. Shibuya

“…Cercarial penetration, in low to moderate numbers, does not cause a normal skin inflammatory response; therefore, the authors sought to determine whether cercariae can down-regulate keratinocyte activation and thus the secretion of pro-inflammatory cytokines and eicosanoids. Human living skin equivalent (LSE, Organogenesis) consisting of dermal, epidermal and stratum corneum-like layers was used as the skin substrate. …”
Get full text

Serum-soluble ST2 as a novel biomarker for COVID-19 severity and mortality: A systematic review and meta-analysis by Kacper DZIEDZIC, Lukasz SZARPAK, Michal PRUC, Damian SWIECZKOWSKI, Gabriella NUCERA, Kavita BATRA, Hicham KHABBACHE, Mahmood BAHRAMIZADEH, Murat YILDRIM, Aldo SITIBONDO, Sagar GALWANKAR, Eryka KARBOWSKA, Krzysztof KUREK, Monika TOMASZEWSKA

Get full text

Consumer Behavior on the Organic Fruit and Vegetable Market: The Evidence from Poland by Joanna Pawlak, Wioletta Wróblewska

“…The conducted research showed that for the respondents, promotional campaigns aimed at popularizing organic food, its values and impact on human health are not without significance.…”
Get full text

Concerning the system of principles of scientific knowledge for the State power digitization by Emin Najafli

“…As a result, digitalization appears as a fragment of human activity to implement certain concepts that involve a conscious and appropriate transformation of state power and it is "the effectiveness of the influence of law on public relations that depends on the subject of law. …”
Get full text

HIV Drug Resistance-Associated Mutations in Antiretroviral Naïve HIV-1-Infected Latin American Children by Luis E. Soto-Ramirez, Roberto Rodriguez-Diaz, D. Robert Harris, Rohan Hazra

Get full text

Antibacterial and antioxidant potentials, detection of host origin compounds, and metabolic profiling of endophytic Bacillus spp. isolated from Rauvolfia serpentina (L.) Benth. ex... by Rusi Lata, Surendra Kumar Gond

“…Endophytic isolates RSLB3 and RSLB18 exhibited most potential antibacterial activity against tested human pathogenic bacteria and were identified as Bacillus sp. …”
Get full text