Human neural rosettes secrete bioactive extracellular vesicles enriched in neuronal and glial cellular components by Malena Herrera Lopez, Matías Bertone Arolfo, Mónica Remedi, Laura Gastaldi, Carlos Wilson, Gonzalo G. Guendulain, Danilo Ceschin, Andrés Cardozo Gizzi, Alfredo Cáceres, Ana Lis Moyano

“…Remarkably, hNR-EVs carry neuronal and glial cellular components involved in human CNS development. Importantly, hNR-EVs stimulate stem cells to change their cellular morphology and promote neurite growth in human and murine neurons with a significant dysregulation of SOX2 levels. …”
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Production of Adult Human Synovial Fluid-Derived Mesenchymal Stem Cells in Stirred-Suspension Culture by Kristen D. Jorgenson, David A. Hart, Roman Krawetz, Arindom Sen

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Comparative analysis of microelectromechanical inertial measurement units of various manufacturers for human motor activity monitoring by G. A. Fofanov

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Trace elements in fish species from the Punjnad headworks: Bioaccumulation and human health risk assessment. by Saima Naz, Qudrat Ullah, Dalia Fouad, Abdul Qadeer, Maria Lateef, Muhammad Waqar Hassan, Ahmad Manan Mustafa Chatha

“…The right bank showed higher accumulation (p < 0.00) of all TTEs in all fish species compared to the left bank. The human health risk assessment showed that Cd and Pb had higher exposure levels than Cu and Ni. …”
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Cortical arealization of interneurons defines shared and distinct molecular programs in developing human and macaque brains by Xiangling Feng, Yingjie Gao, Fan Chu, Yuwen Shan, Meicheng Liu, Yaoyi Wang, Ying Zhu, Qing Lu, Mingfeng Li

“…Here, we recruit 685,692 interneurons from cerebral cortex and subcortex including ganglionic eminence within the developing human and macaque species. Our integrative and comparative analyses reveal that less transcriptomic alteration is accompanied by interneuron migration within the ganglionic eminence subdivisions, in contrast to the dramatic changes observed in cortical tangential migration, which mostly characterize the transcriptomic specification for different destinations and for species divergence. …”
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Perikymata number and spacing on early modern human teeth: evidence from Qafzeh cave, Israel by Janet M. Monge, Anne-Marie Tillier, Alan Mann

“…The literature on perikymata numbers and packing as reported over the last 20 years, shows a huge range of variation within modern humans. The variation is so large in fact that virtually every fossil hominin species can be encompassed within the range except for some but not most of the robust australopithecines. …”
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The challenges of consent in a decentralised metaverse: exploring ethically informed protections and standards to safeguard humans by Carl Hayden Smith, Judith Molka-Danielsen, Jean-Brunel Webb-Benjamin, Jazz Rasool

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Sensory Neuropeptides and Endogenous Opioids Expression in Human Dental Pulp with Asymptomatic Inflammation: In Vivo Study by Daniel Chavarria-Bolaños, Hector Flores-Reyes, Nelson Lombana-Sanchez, Bernardino Cerda-Cristerna, Amaury Pozos-Guillen

“…This study quantified the expression of substance P (SP), calcitonin gene-related peptide (CGRP), β-endorphins (β-End), and methionine-enkephalin (Met-Enk) in human dental pulp following orthodontic intrusion. …”
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A multi-strain human skin microbiome model provides a testbed for disease modeling by Angela L. Maloney, Tyler Crawford, Jordan Hurlbut, Monica Martinez, Thomas J. Mulhern, Elizabeth L. Wiellette, Else M. Vedula, Vidhya Vijayakumar

“…Current evaluation of human host and microbiome interactions relies on post hoc studies after disease onset. …”
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Through-wall Human Pose Reconstruction and Action Recognition Using Four-dimensional Imaging Radar by Rui ZHANG, Hanqin GONG, Ruiyuan SONG, Yadong LI, Zhi LU, Dongheng ZHANG, Yang HU, Yan CHEN

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Transcriptomic-Based Identification of miR-125a Novel Targets in Human Hepatocarcinoma Cells by Ilenia De Leo, Nicola Mosca, Mariaceleste Pezzullo, Danila Valletta, Francesco Manfrevola, Vincenza Grazia Mele, Rosanna Chianese, Aniello Russo, Nicoletta Potenza

“…Hepatocellular carcinoma (HCC) is among the most aggressive and lethal human tumors. Many functional studies have demonstrated the role of non-coding RNAs (ncRNA), particularly microRNAs (miRNA), in the regulation of hepatocarcinogenesis driving pathways. …”
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Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples by Oya Cingöz, John M. Coffin

“…Here, we review the relationship of the human and mouse virus isolates and discuss the potential complications associated with the detection of MLV-like sequences from clinical samples.…”
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Fine Needle Ethanol Injection Therapy for Human Pancreatic Adenocarcinoma Subcutaneously Xenografted in Nude Mice by Pierre C Gagnon, Marguerite Daumas, Norbert Allieres, Paul D Vincensini, Thierry Ponchon, Etienne Hollande

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Comprehensive toxicity assessment of silver nanoparticles on Bacteria, human vein endothelial cells, and Caenorhabditis Elegans by Bircan Dinç

“…In this study, it was investigated the effects of AgNPs on bacteria (Escherichia coli and Bacillus subtilis), a model organism (Caenorhabditis elegans), and human vein endothelial cells (HUVECs) at low concentrations (10, 30, and 50 μg/mL).The AgNPs were synthesized using a chemical reduction method and thoroughly characterized, showing a hydrodynamic size of 55 nm, a zeta potential of −57 mV, and thermal decomposition temperatures ranging from 182 to 318 °C. …”
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Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening by Anand Ramani, Giovanni Pasquini, Niklas J. Gerkau, Vaibhav Jadhav, Omkar Suhas Vinchure, Nazlican Altinisik, Hannes Windoffer, Sarah Muller, Ina Rothenaigner, Sean Lin, Aruljothi Mariappan, Dhanasekaran Rathinam, Ali Mirsaidi, Olivier Goureau, Lucia Ricci-Vitiani, Quintino Giorgio D’Alessandris, Bernd Wollnik, Alysson Muotri, Limor Freifeld, Nathalie Jurisch-Yaksi, Roberto Pallini, Christine R. Rose, Volker Busskamp, Elke Gabriel, Kamyar Hadian, Jay Gopalakrishnan

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Perancangan User Experience Aplikasi Info COVID-19 Menggunakan Metode Human Centered Design by Pradya Mutiarahma, Hanifah Muslimah Az-Zahra, Yusi Tyroni Mursityo

“…Perancangan dilakukan dengan menggunakan metode Human Centered Design (HCD). Hasil akhir dari rancangan sistem adalah berupa high-fidelity prototype yang kemudian dievaluasi menggunakan teknik usability testing. …”
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New approach to generating of human monoclonal antibodies specific to the proteolytic domain of botulinum neurotoxin A by Marina Vladimirovna Silkina, Alena Sergeevna Kartseva, Alena Konstantinovna Riabko, Mariia Aleksandrovna Makarova, Metkhun Madibronovich Rogozin, Yana Olegovna Romanenko, Igor Georgievich Shemyakin, Ivan Alekseevich Dyatlov, Victoria Valerievna Firstova

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Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia by Huiling Guo, Yao Xiao, Shuai Dong, Jingyu Yang, Pengfei Zhao, Tongtong Zhao, Aoling Cai, Lili Tang, Juan Liu, Hui Wang, Ruifang Hua, Rongxun Liu, Yange Wei, Dandan Sun, Zhongchun Liu, Mingrui Xia, Yong He, Yankun Wu, Tianmei Si, Fay Y. Womer, Fuqiang Xu, Yanqing Tang, Jie Wang, Weixiong Zhang, Xizhe Zhang, Fei Wang

“…Methods We analyzed datasets from both rodents and humans. The rodent studies included a genetic model (P11 knockout) and an environmental stress model (chronic unpredictable mild stress), while the human data comprised 748 participants from three cohorts. …”
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Aberrant Phenotype in Human Endothelial Cells of Diabetic Origin: Implications for Saphenous Vein Graft Failure? by Anna C. Roberts, Jai Gohil, Laura Hudson, Kyle Connolly, Philip Warburton, Rakesh Suman, Peter O’Toole, David J. O’Regan, Neil A. Turner, Kirsten Riches, Karen E. Porter

“…This study explored the concept that endothelial cells (EC) cultured from T2DM and nondiabetic (ND) patients are phenotypically and functionally distinct. Cultured human saphenous vein- (SV-) EC were compared between T2DM and ND patients in parallel. …”
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Potential Pathways Involved in Elaidic Acid Induced Atherosclerosis in Human Umbilical Vein Endothelial Cells by Huahong Yu, Xiangmei Li, Zhongshang Liang, Bin Qiu, Siguang Li, Ting Luo, Jing Li, Hongyan Li, Zeyuan Deng

“…In the presented study, two-dimensional electrophoresis based proteomics was used to discover the role of elaidic acid in atherosclerosis. In human umbilical vein endothelial cells (HUVEC), twenty-two and twenty-three differentially expressed proteins were identified in low (50 μmol/L) and high (400 μmol/L) concentration elaidic acid simulated groups, respectively, comparing with the control group. …”
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