Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment by Tatsuya Usui, Masashi Sakurai, Shuhei Enjoji, Hideyoshi Kawasaki, Koji Umata, Takashi Ohama, Nobuyuki Fujiwara, Ryotaro Yabe, Shunya Tsuji, Hideyuki Yamawaki, Shoichi Hazama, Hiroko Takenouchi, Masao Nakajima, Ryouichi Tsunedomi, Nobuaki Suzuki, Hiroaki Nagano, Koichi Sato

“…Here, we developed an ALI organoid model from normal and tumor colorectal tissues of human patients. Both organoids were successfully generated and showed cystic structures containing an epithelial layer and surrounding mesenchymal stromal cells. …”
Get full text

Effectiveness of Clinical Training in Influencing the Outcome of Visual Inspection with Acetic Acid in Selected Facilities at a County in Kenya by Evah Maina, Abednego Ongeso, Nancy Maingi

“…Background: Cervical cancer remains a major health concern in developing countries, primarily due to the presence of human papillomavirus (HPV) types 16 and 18. Visual Inspection with Acetic Acid (VIA) is a common and affordable screening method, yet its effectiveness is closely tied to the skills and competency of healthcare providers. …”
Get full text

Adopting Sustainability: The Role of Motivation and Intention to Forming Green Behavior by Khrisna Vembri Yudanto, Fanny Martdianty

“…Conclusion: This research has deep implications in enriching the perspective of implementing environmentally friendly behavior in the business environment and strengthening managerial management by providing comprehensive considerations for management in realizing environmentally friendly business processes as a whole, especially in the field of human resource management. Originality/value (State of the art): This research fills the empirical gap by providing research in the energy sector and increasing the number of samples used from previous research. …”
Get full text

Adaptation of the sulfophosphovanillin method of analysis of total lipids for various biological objects as exemplified by <i>Drosophila melanogaster</i> by M. A. Eremina, N. E. Gruntenko

“…In recent decades the model object Drosophila melanogaster has been actively used in the study of the fundamental issues of lipid metabolism and its disorders, including obesity, as well as in the search for therapeutic goals for the treatment of metabolic disorders in humans. Quick and accurate quantification of lipid content is an important step in solving these problems. …”
Get full text

Peripheral T-Cell Lymphoma with Aberrant Expression of CD19, CD20, and CD79a: Case Report and Literature Review by Rahul G. Matnani, Rachel L. Stewart, Joseph Pulliam, Chester D. Jennings, Melissa Kesler

“…The neoplastic cells were negative for Epstein-Barr virus (EBV) or Human Herpes Virus 8 (HHV-8). At the time of diagnosis, the PET scan demonstrated hypermetabolic neoplastic cells involving the left axilla, bilateral internal jugular areas, mediastinum, right hilum, bilateral lungs, and spleen. …”
Get full text

Challenges in safe environmental applications of biochar: identifying risks and unintended consequence by Mingying Dong, Mengyuan Jiang, Lizhi He, Zirun Zhang, Williamson Gustave, Meththika Vithanage, Nabeel Khan Niazi, Bo Chen, Xiaokai Zhang, Hailong Wang, Feng He

“…Furthermore, it provides a thorough overview of the adverse effects on animals, plants, microorganisms, and human health, elucidating the mechanisms of pollutant release, aging, and nano-effects from environmental geochemical processes involving biochar. …”
Get full text

Unraveling the degradation mechanism of multiple pyrethroid insecticides by Pseudomonas aeruginosa and its environmental bioremediation potential by Hui Liu, Wen-Juan Chen, Zeling Xu, Shao-Fang Chen, Haoran Song, Yaohua Huang, Kalpana Bhatt, Sandhya Mishra, Mohamed A. Ghorab, Lian-Hui Zhang, Shaohua Chen

“…Extensive use of pyrethroid insecticides poses significant risks to both ecological ecosystems and human beings. Herein, Pseudomonas aeruginosa PAO1 exhibited exceptional degradation capabilities towards a range of pyrethroid family insecticides including etofenprox, bifenthrin, tetramethrin, D-cypermethrin, allethrin, and permethrin, with a degradation efficiency reaching over 84 % within 36 h (50 mg·L-1). …”
Get full text

Efficacy and Interindividual Variability in Motor-Cortex Plasticity following Anodal tDCS and Paired-Associative Stimulation by Wolfgang Strube, Tilmann Bunse, Berend Malchow, Alkomiet Hasan

“…We aimed to compare the efficacy and response variability of two LTP-inducing stimulation protocols in the human motor cortex: anodal transcranial direct current stimulation (a-tDCS) and paired-associative stimulation (PAS25). …”
Get full text

Pancasila in the Context of Indonesian Legal Reform: A Critical Evaluation and International Debate by Elfrida Herawati Siregar, Cahyo Budi Utomo, Muh Sholeh

“…Through a doctrinal and socio-legal analysis, the study examines the compatibility of Pancasila with contemporary global legal norms, including human rights, environmental law, and economic governance. …”
Get full text

Navigating challenges, solutions and requirements in the provision of trauma care in conflict settings by humanitarian actors: a scoping literature review by Nikolaos Markou-Pappas, Luca Ragazzoni, Claudia Truppa, Flavio Salio, Francesco Barone-Adesi, Hamdi Lamine

“…Abstract Background The evolving nature of irregular warfare and the increasingly frequent violations of human rights law and international humanitarian law pose unique challenges for humanitarian actors delivering trauma care in conflict settings. …”
Get full text

Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency by Jungnam Lee, Naweed Mohammad, Kyudong Han, Kyudong Han, Tammy Flagg-Dowie, Maria Magallon, Mark L. Brantly, Karina A. Serban, Karina A. Serban

“…IgG-mediated phagocytosis and NTHi adherence, engulfment and phagocytosis were measured in human alveolar macrophages and monocyte-derived macrophages (MDM) isolated from patients with AATD and from healthy individuals. …”
Get full text

A New Diagnosing Method for Psoriasis From Exhaled Breath by Bilge Han Tozlu, Omer Faruk Akmese, Cemaleddin Simsek, Engin Senel

“…It has become a popular approach for physicians as a support system, as it classifies biological data collected without human intervention in various ways with machine learning methods. …”
Get full text

A reliable supply chain network design for perishable crops with disruption risk consideration (case study: tomato supply chain) by Fateme Letafat, Mohammad Reza Gholamian, Mahsa Arabi

“…The growing global demand to provide food for the human population has caused a significant increase in cultivation. …”
Get full text

Impact of Soil Erosion on Agricultural Production in Muramba Sub - County Kisoro District. by Ndagijimana ,Vallence

“…The findings reveal that the incidence of soil erosion in the Sub-County is rampant and both human-induced and natural factors are responsible for soil erosion in the sub-county. …”
Get full text

Effect of Small and Medium Enterprises on Growth of Business in Kabale Municipality: A Case Study of Kabale Central Market. by Atukunzire, Pross

“…Solutions proposed to address these challenges included enhancing the development of the financial sector, expanding and diversifying market opportunities, promoting good governance practices, and investing in human and cultural capital development. In conclusion, the study underscored the importance of government initiatives to support and enhance the growth of Small Scale Businesses (SSBs) for the overall economic development of the nation.…”
Get full text

Progressive Efforts in the Implementation of Integrated Water Resources Management (IWRM) in Uganda. by Turyasingura, Benson, Akatwijuka, Rogers, Tumwesigye, Wycliffe, Ayiga, Natal, Ruhiiga, Tabukeli Musigi, Banerjee, Abhishek, Benzougagh, Brahim, Frolov, Denis

“…Worldwide, water is essential in creating the environment and human life. Uganda’s Vision 2040 promises general use and safe access to drinking water for all Ugandans. …”
Get full text

Determining the Water Quality from Selected Underground Water Springs and Other Selected Sources of Water Around Kabale Municipality. by Kemigisha, Angella

“…This study aimed at helping residents within the sampled sites to identify which of the water is suitable for human consumption. This involved the determination of the physicochemical parameters (pH, chloride ion concentration, and total hardness) of water obtained from the selected domestic water sources by quantitative analysis which involved titration except for water pH which was determined using a pH meter at the location. …”
Get full text

Production of Sweet-Potato Based Indigenous Micro-Organisms (IMO) for Sustainable Agriculture. by Kobusinguzi, Anociata

“…However, these chemical inputs pose significant risks to the environment, human health, and the sustainability of agricultural systems, which are issues that cannot be overlooked. …”
Get full text

Role of Wildlife Conservation on Socio-Economic Development of Households: A Case Study of Muramba Sub-County Kisoro District. by Turinayo, John

“…However, challenges such as human-wildlife conflicts, inadequate community involvement, and limited access to conservation benefits were identified. …”
Get full text

Customer Service and Performance of Commercial Banks: A Case Study of Post Bank Kabale. by Dushime, Grace

“…The study recommended that the bank should develop the capacities of its human resources in the field of public relations and client management as this will generally improve the growth of banks by resolving any queries raised by clients.…”
Get full text