Differential Effects of Angelicin Analogues on NF-κB Activity and IL-8 Gene Expression in Cystic Fibrosis IB3-1 Cells by Ilaria Lampronti, Maria Giulia Manzione, Gianni Sacchetti, Davide Ferrari, Susanna Spisani, Valentino Bezzerri, Alessia Finotti, Monica Borgatti, Maria Cristina Dechecchi, Giorgia Miolo, Giovanni Marzaro, Giulio Cabrini, Roberto Gambari, Adriana Chilin

“…These findings encouraged us to analyze new synthetic analogues of TMA in order to evaluate their biological activities on human bronchial epithelial CF IB3-1 cells and to find more potent anti-NF-κB agents exhibiting only minor antiproliferative effects. …”
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Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads? by Periyasamy Sivalingam, Kui Hong, John Pote, Kandasamy Prabakar

“…Conversely, cancer is a growing complex human disease that demands new drugs with no or fewer side effects. …”
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The Studies of Chlorogenic Acid Antitumor Mechanism by Gene Chip Detection: The Immune Pathway Gene Expression by Tian Yi Kang, Hua Rong Yang, Jie Zhang, Dan Li, Jie Lin, Li Wang, XiaoPing Xu

“…Persistently increasing incident of cancer in human beings has served to emphasize the importance of studies on mechanism of antitumor substances. …”
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Natural antifibrosis potential of anthocyanin in Ipomoea batatas against Transforming Growth Factor beta Type II receptor by in silico ADMET and molecular docking study by Evi Lusiana, Ernawati Sinaga, Zen Hafy, Debby Handayati Harahap, Ramzi Amin, Irsan Saleh

“…Purple sweet potato (Ipomoea batatas) are known to have bioactive anthocyanin compounds with numerous human therapeutic benefits. Anthocyanins derived from I. batatas can suppress the action of Transforming Growth Factor beta Type II Receptor (TGFβRII) to prevent fibrosis progression. …”
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Navigating a Climate in Crisis through a Biomimetic Epistemology by Elizabeth McCormick, David Thaddeus

“… We have entered a geological epoch where environmental change is driven primarily by human activity. The technology-centric approach to sustainable development as the dominant model of innovation in industrialized countries has led to expansive ecological degradation. …”
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Single-Cell RNA Sequencing Reveals Macrophage Dynamics During MASH in <i>Leptin</i>-Deficient Rats by Xiaoming Xin, Yaohua Ni, Jing Wang, Fenglin Wu, Meichen Liu, Lingjuan Wu, Jiaxing Dai, Chenglin Wu, Xiaolei Song, Wang Zhang, Guangrui Yang, Ruling Shen, Xianmin Zhu

“…Macrophages play important roles in metabolic dysfunction-associated steatohepatitis (MASH), an advanced and inflammatory stage of metabolic dysfunction-associated steatotic liver disease (MASLD). In humans and mice, the cellular heterogeneity and diverse function of hepatic macrophages in MASH have been investigated by single cell RNA sequencing (scRNA-seq). …”
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Temporal drivers of abundance and community structure of scyphozoan jellyfish in tropical coastal waters by Wan Mohd Syazwan, Amy Yee-Hui Then, Ving Ching Chong, Mohammed Rizman-Idid

“…Population blooms of scyphozoan jellyfish in tropical shallow water regions can fuel localized fisheries but also negatively impact human welfare. However, there is a lack of baseline ecological data regarding the scyphozoans in the region, which could be used to manage a fast-growing fishery and mitigate potential impacts. …”
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Probiotic Characterization of Lactic Acid Bacteria from Donkey Feces in China by Yanqiu Wu, Shousong Yue, Jinhui Yu, Fei Bian, Gao Chen, Yan Zhang

“…Probiotics are beneficial to humans and animals and often used for regulating immunity, intestinal microbiota balance, and animal growth performance. …”
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Inhibition of Horseradish Peroxidase Activity by Boroxine Derivative, Dipotassium-trioxohydroxytetrafluorotriborate K2[B3O3F4OH] by Jelena Ostojic, Safija Herenda, Semira Galijasevic, Borivoj Galic, Mladen Milos

“…Recently research shows that horseradish peroxidase, HRP, when combined with other compounds, is highly reactive toward different human tumour cells and that better understanding of catalytic mechanism and inhibition HPR could lead to a new targeted cancer therapy. …”
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The Effect of a Training Program (Retention) on the Clinical Competence, Self-Efficacy, and Occupational Stress of Undergraduate Students of Anesthesia: The Transition from Student... by Ali Khalafi, Shahla Assadi Hovyzian, Nooshin Sarvi-Sarmeydani

“… Background: Transferring students from university to the workplace due to facing many challenging and stressful factors is one of the important stages that, if the educational authorities do not pay attention, it leads to low efficiency and an increase in the number of resignations from the workplace, which leads to financial and human losses for the system. Purpose: Investigating the effect of a training program on the clinical competence, self-efficacy, and occupational stress of Anesthesiology undergraduate students, in their transition from the studenthood to the clinical workforce. …”
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From fitness trackers to medical devices: wearable technologies by Zhi Zhou

“…The multiple possibilities they offer have spread towards previously hard-to-imagine fields, like e-health or human physiological monitoring. An application has been developed for its usage in scenarios where data collection is applied to smart spaces, aiming at its usage in firefighting and sports. …”
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Multiband Planar Inverted-F Antenna with Independent Operating Bands Control for Mobile Handset Applications by Mustapha El Halaoui, Abdelmoumen Kaabal, Hassan Asselman, Saida Ahyoud, Adel Asselman

“…The distribution of specific absorption rate for both European and American standards for each operating band and at various distances between the antenna and the human head is also studied.…”
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The Efficiency of Direct Maturation: the Comparison of Two hiPSC Differentiation Approaches into Motor Neurons by Catherine Schaefers, Simone Rothmiller, Horst Thiermann, Theo Rein, Annette Schmidt

“…Motor neurons (MNs) derived from human-induced pluripotent stem cells (hiPSC) hold great potential for the treatment of various motor neurodegenerative diseases as transplantations with a low-risk of rejection are made possible. …”
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3D Face Modeling Algorithm for Film and Television Animation Based on Lightweight Convolutional Neural Network by Cheng Di, Jing Peng, Yihua Di, Siwei Wu

“…The LW-CNN model adopts a separable convolution structure, which can propose more accurate features with fewer parameters and can extract 3D feature points of a human face. In order to enhance the accuracy of feature extraction, a face detection method based on the inverted triangle structure is used to detect the face frame of the images in the training set before the model extracts the features. …”
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Morphometric Factors Controlling the Old and New Debris-Laden Floods in the South-Southwest Catchment Area of the Esence Mountains with the Example of Günebakan (Erzincan) Flood by Pınar Polat, İbrahim Kopar, Fatih Yalçın

“…In this study, the formation and development processes of two flood-overflow events that occurred in Günebakan Stream Basin, the first on 17/07/2011 and the second on 03/07/2020, in the size of a natural disaster and resulted in significant property losses, and their effects on the natural and human environment were examined. In addition, the morphometric characteristics of the Günebakan, Çadırtepe, and Allahmedet stream basins, which are adjacent to each other in the south-southwest catchment area of the Esence Mountains, which surround the Erzincan Plain from the north, were revealed and their flood-overflow potentials were investigated. …”
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A comprehensive environmental index for monitoring ecological quality of typical alpine wetlands in Central Asia by Jiudan Zhang, Junli Li, Changming Zhu, Anming Bao, Amaury Frankl, Philippe De Maeyer, Tim Van de Voorde

“…Furthermore, the driving factors behind these changes were analyzed by combining meteorological precipitation data with human activities. Long-term monitoring results indicate that the Bayanbulak Wetland has experienced significant expansion, with its ecological quality improving remarkably over the past 45 years, particularly in the Big Urdus basin. …”
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Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy by Amaury Herbet, Marie Hautière, Frédéric Jean-Alphonse, Delphine Vivier, Christophe Leboeuf, Narciso Costa, Aloïse Mabondzo, Guilhem Bousquet, Franck Denat, Eric Reiter, Didier Boquet

“…Methods We previously reported the rendomab B49 antibody (RB49) exhibiting a preferential affinity for the activated conformation of human endothelin B receptor (ETB), not displaced by high endothelin levels, and without any pharmacological properties that could inhibit the division of melanoma cells. …”
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Pre-trained artificial intelligence-aided analysis of nanoparticles using the segment anything model by Gabriel A. A. Monteiro, Bruno A. A. Monteiro, Jefersson A. dos Santos, Alexander Wittemann

“…The presented method, which employs a pre-trained deep learning model, outperforms traditional techniques by circumventing systemic errors and human bias. It can effectively automate the analysis of particles, thereby providing more accurate and efficient results.…”
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Vascular Endothelial Growth Factor in Tear Samples of Patients with Systemic Sclerosis by Anikó Rentka, Jolán Hársfalvi, András Berta, Krisztina Köröskényi, Zoltán Szekanecz, Gabriella Szücs, Peter Szodoray, Ádám Kemény-Beke

“…Our aim was to assess the levels of VEGF in human tears of patients with SSC. Patients and methods. …”
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Plasma C1q/TNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction by Mariko Asada, Tomoaki Morioka, Yuko Yamazaki, Yoshinori Kakutani, Reina Kawarabayashi, Koka Motoyama, Katsuhito Mori, Shinya Fukumoto, Atsushi Shioi, Tetsuo Shoji, Masanori Emoto, Masaaki Inaba

“…This study indicates a potential role of CTRP9 in atherosclerosis progression in human type 2 diabetes.…”
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