Identification and optimization of urban wetland ecological networks in highly urbanized areas: A case study of Haidian District, Beijing by Wang Zecheng, Zhao Xinsheng, Cui Lijuan, Lei Yinru, Guo Ziliang, Wang Jinzhi, Li Jing, Zhai Xiajie, Wang Rumiao, Li Wei

“…With the rapid development of urbanization, urban wetlands have been severely damaged by human activities and natural factors, leading to problems such as reduced area and decreased connectivity between wetlands. …”
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Protocol for a qualitative study exploring haemodialysis dependent patients’ arteriovenous fistula experience, values and concerns in Sydney, Australia by Vasi Naganathan, Sarah Joy Aitken, Bethany Miriam Stavert, Susan Monaro, Lisa Tienstra

“…Findings from this study will give a nuanced insight into the experiences of patients on haemodialysis with respect to their AVF.Ethics and dissemination Ethical approval for this study was provided by the Sydney Local Health District Human Research Ethics Committee (REGIS identifier: 2021/ETH00362, CH reference number: CH62/6/2021-033). …”
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Paraoxonase 2 Induces a Phenotypic Switch in Macrophage Polarization Favoring an M2 Anti-Inflammatory State by Marie Koren-Gluzer, Mira Rosenblat, Tony Hayek

“…The direct effect of PON2 was shown by transfecting human PON2 (hPON2) into PON2KO MPM. PON2 transfection attenuated the macrophages’ response to M1 activation and enhanced M2 response. …”
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Suppressive Activity of a Macrolide Antibiotic, Roxithromycin, on Pro-Inflammatory Cytokine Production in Vitro and in Vivo by H. Suzaki, K. Asano, S. Ohki, K. Kanai, T. Mizutani, T. Hisamitsu

“…In the first experiments, we examined the effect of RXM on in vitro cytokine production from lipopolysaccharide (LPS)-stimulated human peripheral blood monocytes. The monocytes were cultured in the presence of various doses of the agent. …”
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Abortion Laws in Indonesia and Islam: A Clash of Morality, Religion, and Rights by Salsabila Triandani, Windiahsari Windiahsari, Ali Masyhar, Aprila Niravita

“…The paper also addresses ongoing debates over potential legal reforms, considering global human rights perspectives and the influence of Islamic jurisprudence in shaping reproductive health policies. …”
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Uncertainties of the rainfall regime in a tropical semi-arid region: the case of the State of Ceará by Eunice Maia de Andrade, Maria Gina Torres Sena, Antonio Givanilson Rodrigues da Silva, Francisco Jairo Soares Pereira, Fernando Bezerra Lopes

“…The rural population of a tropical semi-arid region such as the northeast of Brazil is directly dependent on rainfall for agricultural production, pasture for livestock, and the storage of drinking water for human consumption. The region is characterised by the frequent occurrence of dry years and consecutive dry days (CDD) during the rainy season, demonstrating the vulnerability of rainfed agriculture. …”
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A multistage drug delivery approach for colorectal primary tumors and lymph node metastases by Yihang Yuan, Quanjun Lin, Hai-Yi Feng, Yunpeng Zhang, Xing Lai, Mao-Hua Zhu, Jue Wang, Jiangpei Shi, Yanhu Huang, Lele Zhang, Qin Lu, Zeli Yuan, Jonathan F. Lovell, Hong-Zhuan Chen, Peng Sun, Chao Fang

“…The liposomal membrane contains 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DPPG) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), two phospholipids sensitive to secreted phospholipase A2 in human colorectal tumors. In an orthotopic colorectal murine tumor model, phospholipase-induced membrane permeabilization triggers the liberation of DMSN from liposomes for enhanced tumor penetration, conferring an enhanced suppression for the primary tumor. …”
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Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy by Marisa Ojala, Chandra Prajapati, Risto-Pekka Pölönen, Kristiina Rajala, Mari Pekkanen-Mattila, Jyrki Rasku, Kim Larsson, Katriina Aalto-Setälä

“…We studied the properties of HCM cardiomyocytes (CMs) derived from patient-specific human induced pluripotent stem cells (hiPSCs) carrying either MYBPC3-Gln1061X or TPM1-Asp175Asn mutation. …”
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Discovery of Novel Nav1.7-Selective Inhibitors with the 1H-Indole-3-Propionamide Scaffold for Effective Pain Relief by Gaoang Wang, Hang Wu, Yingying Wang, Xiangying Liu, Shuijiao Peng, Wenxing Wang, Meijing Wu, Yifei Liu, Ercheng Wang, Zhe Wang, Lei Xu, Xiaojian Wang, Wei Yang, Haiyi Chen, Xi Zhou, Tingjun Hou

“…Nav1.7 is considered a promising target for developing next-generation analgesic drugs, given its critical role in human pain pathologies. Although most reported inhibitors with strong in vitro activity and high selectivity share the aryl sulfonamide scaffold, they failed to demonstrate marked clinical efficacy. …”
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Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+ Macrophages by R. Clive Landis, Pandelis Philippidis, Jan Domin, Joseph J. Boyle, Dorian O. Haskard

“…In this study, we examined whether scavenging of polymorphic Hp:Hb complexes differentially generated downstream anti-inflammatory signals in cultured human macrophages culminating in interleukin (IL)-10 secretion. …”
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IUPHAR Review: Alpha6-containing GABAA receptors – Novel targets for the treatment of schizophrenia by Lih-Chu Chiou, Werner Sieghart

“…So far, the beneficial actions of these modulators have been demonstrated in animal models of neuropsychiatric disorders, only. Future human studies have to investigate the safety and possible side effects of these modulators and to clarify, to which extent individual symptoms of schizophrenia can be reduced by these drugs in patients during acute and chronic dosing.…”
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On the Design and Development of Planar Monopole Antenna for Bone Crack/Void Detection by Ananda Venkatesan Boologam, Kalimuthu Krishnan, Sandeep Kumar Palaniswamy, Sachin Kumar, Shreya Bhowmik, Nivesh Sharma, Deepesh Vaish, Sourish Chatterjee

“…This method can detect bone fractures in a noninvasive manner. The human arm model is constructed, and the effect of bone cracks of different lengths on the resonating frequency is investigated. …”
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Stabilizing milk-derived extracellular vesicles (mEVs) through lyophilization: a novel trehalose and tryptophan formulation for maintaining structure and Bioactivity during long-te... by Alan B. Dogan, Spencer R. Marsh, Rachel J. Tschetter, Claire E. Beard, Md R. Amin, L. Jane Jourdan, Robert G. Gourdie

“…In addition to undertaking established mEV assays of structure and function on our preparations, we introduce a novel, efficient, high throughput assay of mEV bioactivity based on Electric Cell Substrate Impedance Sensing (ECIS) in Human dermal fibroblast monolayers. By adding appropriate excipients, such as trehalose and tryptophan, we describe a protective formulation that preserves mEV bioactivity during long-term, room temperature storage. …”
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Mechanism of Action of Lacticaseibacillus paracasei HNU502 and Fecal Microbiota Transplantation in Alleviating Antibiotic Side Effects by CHEN Lin, LI Ao, LI Jiahe, ZHANG Zeng, ZHANG Jiachao

“…This study contributes to a better understanding of the link between human health and gut microbiota, and provides new therapeutic options for mitigating antibiotic side effects, which is of great significance for improving patients’ health status and quality of life.…”
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Spatial-temporal differentiation and influencing factors of ecosystem health in Three-River-Source national Park by Yanqin Wang, Huaju Xue, Aiqing Li, Xiaofan Ma, Ailing Sun, Jinhe Zhang

“…It also showed significant “high-high” and “low-low” clustering effects in the eastern and northwestern regions. (3) Among all the indicators assessed, ecosystem vigor was the indicator that contributed the most to the growth of the ecosystem health index. (4) Variations in ecosystem health of TNP were mainly shaped by land use intensity and precipitation, and interactions between natural environmental factors and human activity factors enhanced the explanation of these changes. …”
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Feeding Patterns and Xenomonitoring of Trypanosomes among Tsetse Flies around the Gashaka-Gumti National Park in Nigeria by Solomon Ngutor Karshima, Idris A. Lawal, Oluseyi Oluyinka Okubanjo

“…Tsetse flies fed predominantly on cattle and less frequently on humans and also showed mixed feeding habits.…”
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Awifauna wodno-błotna środkowej Wisły w okresie lęgowym: wpływ działalności człowieka na rozmieszczenie, liczebność i bogactwo gatunkowe by Dariusz Bukaciński, Monika Bukacińska, Arkadiusz Buczyński

“…It will allow us to estimate soberly how very the intensity of human utilization of the river affects the distribution of avifauna of the Vistula, determining the richness and abundance of valuable and/or endangered species breeding in a given area.…”
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Urinary glucose detection with spiral shape hollow core photonic crystal fiber: Towards improved diabetes management by Md. Safiul Islam, A.H.M. Iftekharul Ferdous, Md. Jakir Hossen, Abdullah Al Mamun, Khalid Sifulla Noor, Diponkar Kundu, Md. Galib Hasan

“…Insufficient insulin leads to an inability to transform glucose into energy, resulting in increased amounts of glucose in human body. Acute diabetes treatment and follow-up rely on urine glucose detection since it provides a non-invasive, reasonably priced means to assess glucose levels and regulate the progression of the disease. …”
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Geospatial perspective for monitoring SDG 6.6.1 based on spatial and temporal analysis of lake water storage variations in Dongting Lake, China by Huanhua Peng, Zihan Tang, Zhiming Chen, Yating Wu, Yuan Yuan, Qian Shi, Lelin Li, Hao Chen

“…This study not only provide a geospatial perspective for monitoring water storage for SDG 6.6.1 under the climate oscillations and human impacts in a large floodplain lake but also provide an important scientific basis for improving the optimal allocation of water resources of the Dongting Lake area. …”
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RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining by Mansoor Hussain, Prabhat Khadka, Komal Pekhale, Tomasz Kulikowicz, Samuel Gray, Alfred May, Deborah L. Croteau, Vilhelm A. Bohr

“…Mutations in RECQL4 have been associated with various human diseases, including Rothmund–Thomson syndrome. …”
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