New derivatives of sulfonylhydrazone as potential antitumor agents: Design, synthesis and cheminformatics evaluation by Sabbah Dima A., Al-Azaideh Bara’a A., Talib Wamidh H., Hajjo Rima, Sweidan Kamal, Al-Zuheiri Aya M., Sheikha Ghassan Abu, Shraim Sawsan

“…Target compounds exhibited an antiproliferative effect against the human colon carcinoma (HCT-116) cell line. Our cheminformatics analysis indicated that the para-tailored derivatives [p-NO2 (3) and p-CF3 (7)] have better ionization potentials based on calculated Moran autocorrelations and ionization potentials. …”
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Limits and Risks of Digital Transformation by T. S. Akhromeeva, G. G. Malinetskiy, S. A. Posashkov

“…It happens when artificial intelligence systems are assigned strategically important tasks that they must solve at a speed inaccessible to humans.The analysis shows that managing the risks of digital transformation and its limitations requires the attention of the scientific and expert community, as well as active participants in this process.…”
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Analysis of Roadside Land Use Changes and Landscape Ecological Risk Assessment Based on GF-1: A Case Study of the Linghua Expressway by Mengdi Wen, Liangliang Zhang, Huawei Wan, Peirong Shi, Longhui Lu, Zixin Zhao, Zhiru Zhang, Jinhui Wu

“…Landscape ecological risk assessment, as an important means to predict and measure the adverse effects of human activities on the ecological environment, is being paid more and more attention. …”
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Buildings, Causalities, and Injuries Innovative Fuzzy Damage Model during Earthquakes by Mohammad Reza Amiri Shahmirani, Abbas Akbarpour Nikghalb Rashti, Mohammad Reza Adib Ramezani, Emadaldin Mohammadi Golafshani

“…One of the human concerns has always been to estimate the damage caused before the earthquake and predict the extent of injuries and causalities. …”
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Clinical Application of Development of Nonantibiotic Macrolides That Correct Inflammation-Driven Immune Dysfunction in Inflammatory Skin Diseases by Carmen Rodriguez-Cerdeira, Elena Sanchez-Blanco, Alberto Molares-Vila

“…Inflammation-driven immune dysfunction supports the development of several chronic human disorders including skin diseases. Nonantibiotic macrolides have anti-inflammatory and/or immunomodulatory activity that suggests the exploitation of these in the treatment of skin diseases characterized by inflammatory disorders. …”
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Intratympanic administration of dexamethasone attenuates radiation induced damage to middle ear mucosa by Hyuk Chan Kwon, Sup Kim, Sheng Jin, Sun-Ae Shin, Jeong Han Lee, Min Jung Park, Soo Jeong Kim, Yong-Ho Park

“…The present study investigated the effects and underlying mechanisms of DEX delivered via intratympanic administration on RTx-induced damage to the middle ear and human middle ear epithelial (HMEE) cells. Sprague–Dawley (SD) rats were exposed to fractionated RTx (6.6 Gy/day for 5 days), and middle ear samples were collected at 1 and 4 months. …”
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Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration by Paul Tamburini, Dennis Vestergaard Pedersen, Denise Devore, Josh Cone, Rekha Patel, Todd Hunter, Fang Sun, Gregers Rom Andersen, Jeffrey Hunter

“…Tarperprumig incorporates a C-terminal variable domain of a heavy chain only antibody (VHH) that binds properdin (FP) connected via a flexible linker to an N-terminal VHH that binds human serum albumin (HSA). The purified bispecific VHH antibody exhibits an experimental molecular weight average of 27.4 kDa and can be formulated at > 100 mg/mL. …”
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Protocol for a qualitative study to explore acceptability, barriers and facilitators of the implementation of new teleophthalmology technologies between community optometry practic... by Ann Blandford, Konstantinos Balaskas, Rima Hussain, Sarah Abdi, Angela Aristidou, Josie Carmichael, Giulia Cappellaro

“…Findings will be reported through academic journals and conferences in ophthalmology, health services research, management studies and human-computer interaction.…”
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Congenital cytomegalovirus - current state of knowledge on the treatment and prevention of fetuses and newborns by Katarzyna Miedzińska, Mateusz Grego, Łukasz Stojak, Dariusz Popiela, Karina Urbańska, Filip Kwiatkowski, Mateusz Baczewski, Witold Czyż

“… Cytomegalovirus (CMV)  is common  pathogen in the human population and one of the most  causes of intrauterine infections of the fetus. …”
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Characterization of the Sodium Multi-Vitamin Transporter in the Mosquito <i>Anopheles stephensi</i> and Its Capacity to Mobilize Pantothenate and Biotin by Jun Isoe, Brendan F. Riske, Megan E. Dobson, Hannah L. Kaylor, Jessica C. Brady, Yared Debebe, Laura M. Saavedra, Shirley Luckhart, Michael A. Riehle

“…In this work, we examined Pan levels in the important human malaria vector <i>Anopheles stephensi</i>, including the abundance of Pan during immature development and adulthood. …”
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Employment Chances Are “Satisfactory”: What Prevents Young People from Finding a Job in Conditions of Personnel Shortage? by O. B. Solodovnikova, E. E. Malkova, P. I. Tynkova

“…Among the macro-level factors are a lack of a well-thought- out system for converting university graduate competencies into qualifications required in the labor market (both in the humanities and natural sciences), as well as a lack of interregional forecasting of demand for certain specialties; as a result, labor force mobility is reduced. …”
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Synthesis, antiproliferative and antiplasmodial evaluation of new chloroquine and mefloquine-based harmiquins by Pavić Kristina, Poje Goran, Carvalho Lais Pessanha De, Held Jana, Rajić Zrinka

“…Testing of the antiproliferative activity of the new UT harmiquins, and previously prepared triazole-(TT) and amide-type (AT) CQ-based harmiquins, against a panel of human cell lines, revealed TT harmiquine 16 as the most promising compound, as it showed pronounced and selective activity against the tumor cell line HepG2 (IC50 = 5.48 ± 3.35 μmol L−1). …”
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Photobiomodulation: An Effective Approach to Enhance Proliferation and Differentiation of Adipose-Derived Stem Cells into Osteoblasts by Daniella Da Silva, Anine Crous, Heidi Abrahamse

“…Osteoporosis is regarded as the most common chronic metabolic bone condition in humans. In osteoporosis, bone mesenchymal stem cells (MSCs) have reduced cellular function. …”
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Challenges and possible improvements for healthcare teams at outreach clinics in Nepal – a qualitative study by Ingrid Eriksen, Eirin Helene Rasmussen, Biraj Karmacharya, Seema Das, Elisabeth Darj, Maria Lisa Odland

“…Potential ways of overcoming the perceived challenges of underutilising available healthcare services include financial and human resources. The rural population´s health awareness needs to be increased, and the work environment for rural healthcare workers needs to be improved. …”
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ORGANIZATION OF STUDENTS’ SELF-GUIDED WORK IN BIOMEDICAL DEPARTMENTS OF MEDICAL UNIVERSITY USING DISTANT LEARNING TECHNOLOGY by Eduard F. Barinov, Raisa V. Basiy, Olga P. Shatova

“…The aim of the investigation to substantiate and analyze the practical implementation of using distance learning technologies (DLT) for managing the formation of basic knowledge during students’ individual work in the Department of Histology, Cytology and Embryology, Human Anatomy and Biological Chemistry.Methods. The methods involve analysis of an individual students’ work.Results. …”
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A Novel Pattern Recognition Method for Self-Powered TENG Sensor Embedded to the Robotic Hand by Azat Balapan, Rauan Yeralkhan, Alikhan Aryslanov, Gulnur Kalimuldina, Azamat Yeshmukhametov

“…This paper presents the development and implementation of a human-like robotic hand integrated with advanced triboelectric nanogenerator (TENG) based tactile sensors for shape and material recognition. …”
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Assessing Educators’ Readiness for Innovative Professional and Pedagogical Activities by G. R. Khusainova, S. G. Karstina, M. F. Galikhanov

“…The ongoing transformations in the modern world have a significant impact on the sustainable development of national economies, unify the requirements for human capital, and its educational level. Taking into account current trends, governments are taking significant measures to ensure and maintain the link between education, the economy and socio-economic development. …”
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A Comprehensive Review of the Usefulness of Prebiotics, Probiotics, and Postbiotics in the Diagnosis and Treatment of Small Intestine Bacterial Overgrowth by Adrian Martyniak, Magdalena Wójcicka, Iwona Rogatko, Tomasz Piskorz, Przemysław J. Tomasik

“…This review is based on research studies no older than 10 years old and those using only human models. In summary, clinical studies have shown that the efficacy of SIBO therapy can be increased by combining antibiotics with probiotics, especially in vulnerable patients such as children and pregnant women. …”
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Challenges and Current Trends in Preventing Antimicrobial Resistance in EU Water Law Context by Justyna Rogowska, Grażyna Gałęzowska, Agnieszka Zimmermann

“…The increasing consumption of pharmaceuticals, including antibiotics, and their improper disposal have resulted in both pharmaceuticals and their metabolites being released into the environment, where they pose a risk to both ecosystems and human health. One of the most serious threats to public health associated with the presence of antibiotics in the environment is antimicrobial resistance (AMR). …”
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Bone Marrow-Derived Mesenchymal Stem Cells Repair Necrotic Pancreatic Tissue and Promote Angiogenesis by Secreting Cellular Growth Factors Involved in the SDF-1α/CXCR4 Axis in Rats... by Daohai Qian, Jian Gong, Zhigang He, Jie Hua, Shengping Lin, Chenglei Xu, Hongbo Meng, Zhenshun Song

“…The capacities of proliferation, migration, and repair of human umbilical vein endothelial cells were enhanced by BMSCs supernatant. …”
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