Activating PKC-ε induces HIV expression with improved tolerability. by Alivelu M Irrinki, Jasmine Kaur, Bally Randhawa, Ryan McFadden, Chelsea Snyder, Hoa Truong, Daniel Soohoo, Eric Hu, Helen Yu, Bernard P Murray, Bing Lu, Dmytro Kornyeyev, Ishak Darryl Irwan, Lan Nguyen, Yu-San Yang, Jean-Philippe Belzile, Uli Schmitz, Todd C Appleby, Brian Schultz, Jay Lalezari, Steven Deeks, Tomas Cihlar, Jeffrey P Murry

“…Differential expression analysis indicated that PKC-ε and PKC-η isoforms are expressed at high levels in human CD4+ T cells but not in platelets. Using structure-based drug design, we developed a novel PKC agonist, C-233, with increased selectivity for PKC-ε. …”
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Characterizations of Size-segregated Ultrafine Particles in Diesel Exhaust by Jaehyun Lim, Cheolsoo Lim, Sungwoon Jung

“…Overall toxicity was high as UFPs can be deposited with high efficiency throughout the human respiratory tract.…”
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Clastogenic Effects of Glyphosate in Bone Marrow Cells of Swiss Albino Mice by Sahdeo Prasad, Smita Srivastava, Madhulika Singh, Yogeshwer Shukla

“…Nevertheless, occupational and environmental exposure to pesticides can pose a threat to nontarget species including human beings. Therefore, in the present study, genotoxic effects of the herbicide glyphosate were analyzed by measuring chromosomal aberrations (CAs) and micronuclei (MN) in bone marrow cells of Swiss albino mice. …”
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Thiopurines Induce Oxidative Stress in T-Lymphocytes: A Proteomic Approach by Misbah Misdaq, Sonia Ziegler, Nicolas von Ahsen, Michael Oellerich, Abdul R. Asif

“…We used a TPMT knockdown (kd) model of human Jurkat T-lymphocytes cells to study the effects of treatment with 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) on proteome and phosphoproteome. …”
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Hospital solid waste management strategies to prevent healthcare-associated infections from occupational exposure to bloodborne pathogens and improve occupational safety by Augusto Jorge Antonio Ibáñez-Cruz, Alejandra Micaela Elena Vergara-Florián, William C. Algoner

“…Bio-contaminated waste included patient care, bags with human blood and blood products, surgical and anatomicalpathological waste, sharps and biological objects, pharmaceuticals, and hazardous and radioactive chemicals. …”
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Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes by Jue Lin, Joshua Cheon, Rashida Brown, Michael Coccia, Eli Puterman, Kirstin Aschbacher, Elizabeth Sinclair, Elissa Epel, Elizabeth H. Blackburn

“…Leukocyte or peripheral blood mononuclear cell (PBMC) telomere length is a potential biomarker for human aging that integrates genetic, environmental, and lifestyle factors and is associated with mortality and risks for major diseases. …”
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NATO’s partnership policy: From the military alliance to the security community, and back again by I. L. Prokhorenko

“…The author concludes that in the wake of the Cold War, NATO faced a profound identity crisis and set a course for a radical functional expansion, in particular within the framework of partnership policy, by including the issues of post-conflict reconstruction, human and gender security, public diplomacy, climate change, etc. into its agenda. …”
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Cytotoxicity and Antiproliferative Activity Assay of Clove Mistletoe (Dendrophthoe pentandra (L.) Miq.) Leaves Extracts by Vida Elsyana, Maria Bintang, Bambang Pontjo Priosoeryanto

“…In the present study, we examined cytotoxicity of clove mistletoe leaves extracts against brine shrimps and conducted their antiproliferative activity on K562 (human chronic myelogenous leukemia) and MCM-B2 (canine benign mixed mammary) cancer cell lines in vitro. …”
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Associative Portrait of a Russian Student in the Context of the Emergency Transition to Distance Learning by L. I. Baturina, A. Yu. Simakov

“…With mass digitalization in all spheres of human activity, it is necessary to take a comprehensive and interdisciplinary approach to understanding and assessing the level of its acceptance and impact. …”
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Association of HLA Genotype and Fulminant Type 1 Diabetes in Koreans by Soo Heon Kwak, Yoon Ji Kim, Jeesoo Chae, Cue Hyunkyu Lee, Buhm Han, Jong-Il Kim, Hye Seung Jung, Young Min Cho, Kyong Soo Park

“…Although it has been reported that class II human leukocyte antigen (HLA) genotype is associated with fulminant T1DM, the genetic predisposition is not fully understood. …”
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Immunohistological Localization of BMP-2, BMP-7, and Their Receptors in Knee Joints with Focal Cartilage Lesions by Hagen Schmal, Alexander T. Mehlhorn, Ingo H. Pilz, David Dovi-Akue, Christina Kirchhoff, Norbert P. Südkamp, Ulrike Gerlach, Christian Lohrmann, Philipp Niemeyer

“…Although it is well known that BMP-2 and BMP-7 play significant roles in cartilage metabolism, data about intra-articular expression and localization of these proteins and their receptors in humans are rare. Methods. Biopsies of synovia and debrided cartilage were taken in patients undergoing autologous chondrocyte implantation. …”
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A DBN-Based Deep Neural Network Model with Multitask Learning for Online Air Quality Prediction by Jiangeng Li, Xingyang Shao, Rihui Sun

“…To avoid the adverse effects of severe air pollution on human health, we need accurate real-time air quality prediction. …”
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Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis by Yan Lin, Yu Dong, Yanfeng Gao, Ranran Shi, Yubing Li, Xiuman Zhou, Wenwen Liu, Guodong Li, Yuanming Qi, Yahong Wu

“…With the increasing number of drug-resistant Mycobacterium tuberculosis (MTB) strains and prevalence of coinfection of MTB with human immunodeficiency virus, many challenges remain in the prevention and treatment of tuberculosis. …”
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Worst-Case Response Time of Mixed Vehicles at Complex Intersections by Radha Reddy, Luis Almeida, Harrison Kurunathan, Miguel Gutierrez Gaitan, Pedro M. Santos, Eduardo Tovar

“…Operating autonomous vehicles (AVs) and human-driven vehicles (HVs) at urban intersections while observing requirements of safety and service level is complex due not only to the existence of multiple inflow and outflow lanes, conflicting crossing zones, and low-speed conditions but also due to differences between control mechanisms of HVs and AVs. …”
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Monitoring of specific activities of long-lived radioactive elements along the Mini- Okoro/Oginigba Creek, Port Harcourt by Gregory O Avwiri, Olanrewaju Lawal, Edith I Nwokeoji

“…Presence and concentrations of radionuclides could be as a result of natural and human activities. This  study examined the associations and differences  among soil, sediment and water specific activities of long-lived radioactive element (LLRE). …”
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Differences according to Sex in Sociosexuality and Infidelity after Traumatic Brain Injury by Jhon Alexander Moreno, Michelle McKerral

“…Theoretical implications are discussed in terms of evolutionary theories of human sexuality and neuropsychology.…”
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The anomalously thundery month of June 1925 in southwest Spain: description and synoptic analysis by F. J. Acero, M. Antón, A. J. P. Aparicio, A. J. P. Aparicio, N. Bravo-Paredes, V. M. S. Carrasco, M. C. Gallego, J. A. García, M. Núñez, I. Tovar, J. Vaquero-Martínez, J. M. Vaquero

“…<p>In a routine search for meteorological events with a great impact on society in the Extremadura region (southwest interior of the Iberian Peninsula) using newspapers, the month of June 1925 was detected as exceptional due to the large number of thunderstorms associated with significant losses of human lives and material resources. This extraordinary month underwent a detailed examination from various complementary perspectives. …”
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Assessment of changes in vitamin content and morphological characteristics in strawberries modified with a pulsed electric field using chromatography and optical coherence tomograp... by Ewa Korzeniewska, Ilona Gałązka-Czarnecka, Joanna Sekulska-Nalewajko, Jarosław Gocławski, Tomasz Dróźdż, Paweł Kiełbasa

“…Vitamins B and C are crucial for maintaining human health, so it is important to develop effective methods to support their extraction from products of plant origin. …”
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Impact of Vitamin D on Skin Aging, and Age-Related Dermatological Conditions by Sankalya S. Ambagaspitiya, Gayan A. Appuhamillage, Sunil J. Wimalawansa

“…Human skin is a physical and biochemical barrier that protects the internal body from the external environment. …”
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Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes by Ying-zhong Lin, Shan-he Lu, Zheng-de Lu, Ying Huang, Ying Shi, Ling Liu, Xiao-yan Wang, Qing-wei Ji

“…CD4+LAP+ Treg cells are a novel subset of Tregs that have been found to ameliorate atherosclerosis in ApoE-/- mice, and these cells also exist in humans. The present study was designed to investigate whether CD4+LAP+ Treg cells are involved in the onset of ACS. …”
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