TCR Gene Transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 Epitopes as Melanoma-Specific Immune Targets by Trudy Straetemans, Mandy van Brakel, Sabine van Steenbergen, Marieke Broertjes, Joost Drexhage, Joost Hegmans, Bart N. Lambrecht, Cor Lamers, Pierre van Der Bruggen, Pierre G. Coulie, Reno Debets

“…We identified MC2/A2 and MA3/DP4-specific TCR-Vα3/Vβ28 and TCR-Vα38/Vβ2 chains and validated these TCRs in vitro upon gene transfer into primary human T cells. The MC2 and MA3 TCR were surface-expressed and mediated CD8 T-cell functions towards melanoma cell lines and CD4 T-cell functions towards dendritic cells, respectively. …”
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LPS from P. gingivalis and Hypoxia Increases Oxidative Stress in Periodontal Ligament Fibroblasts and Contributes to Periodontitis by L. Gölz, S. Memmert, B. Rath-Deschner, A. Jäger, T. Appel, G. Baumgarten, W. Götz, S. Frede

“…We hypothesize that hypoxic and inflammatory events induce oxidative stress in the periodontal ligament (PDL) by activating NOX4. Human primary PDL fibroblasts were stimulated with lipopolysaccharide from Porphyromonas gingivalis (LPS-PG), a periodontal pathogen bacterium under normoxic and hypoxic conditions. …”
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Composition and Biological Properties of Agaricus bisporus Fruiting Bodies – a Review by Muszyńska Bożena, Kała Katarzyna, Rojowski Jacek, Grzywacz Agata, Opoka Włodzimierz

“…Studies of tyrosinase isolated from this species show its very high similarity to human tyrosinase. This points directly to the fact that this species could be a rich source of tyrosinase used for medicinal and cosmetics purposes. …”
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Des bois dans les Maisons. Rôles du système social dans la forêt rurale des paysages des Coteaux de Gascogne (Sud-ouest de la France) by Marc Deconchat, Julien Blanco, Émilie Andrieu, Anne Sourdril

“…It focuses on the benefits of closely associating approaches of landscape ecology and human and social sciences to understand the current state and recent history of these woodlots and to help in designing landscape projects adapted to local contexts. …”
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MFGE8, ALB, APOB, APOE, SAA1, A2M, and C3 as Novel Biomarkers for Stress Cardiomyopathy by Xiao-Yu Pan, Zai-Wei Zhang

“…These DEGs were mainly enriched in ECM-receptor interaction, dilated cardiomyopathy (DCM), human papillomavirus infection, and focal adhesion, whereas in GO function classification, they were mainly enriched in the extracellular region, positive regulation of the multicellular organismal process, establishment of localization, and intracellular vesicle. …”
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Methodology for ensuring employee engagement in the context of enterprise digital transformation by I. V. Kablashova, I. V. Logunova, V. N. Rodionova

“…The results of the research can be useful to scientists and practitioners dealing with the problems of human resource management in innovations and digital standards of industrial enterprises implementation.…”
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Increased Kappa/Lambda Hybrid Antibody in Serum Is a Novel Biomarker Related to Disease Activity and Inflammation in Rheumatoid Arthritis by Lang Yi, Mingju Hao, Tian Lu, Guigao Lin, Lida Chen, Ming Gao, Gaowei Fan, Dong Zhang, Guojing Wang, Xin Yang, Yulong Li, Kuo Zhang, Rui Zhang, Yanxi Han, Lunan Wang, Jinming Li

“…The κ/λ hybrid antibodies in normal human serum were reported recently, but their clinical relevance has not yet been explored. …”
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Quantitative Proteomic Analysis of Hepatic Tissue of T2DM Rhesus Macaque by Tingfu Du, Shuaiyao Lu, Qinfang Jiang, Yun Li, Kaili Ma

“…Type 2 diabetes mellitus (T2DM) is a metabolic disorder that severely affects human health, but the pathogenesis of the disease remains unknown. …”
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Spatiotemporal Variation and Abrupt Change Analysis of Temperature from 1960 to 2012 in the Huang-Huai-Hai Plain, China by Yanyu Yin, Hui Liu, Xiangsheng Yi, Weidong Liu

“…The abrupt change time for winter temperature was in the late 1970s, while it was in the late 1980s and early 1990s for spring, autumn, and annual temperature. (4) Macroscopic effects of global and regional climate warming and human activities were probably responsible for the temperature changes. …”
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Successful Integration of Hepatitis C Virus Point-of-Care Tests into the Denver Metro Health Clinic by A. Jewett, A. A. Al-Tayyib, L. Ginnett, B. D. Smith

“…The Centers for Disease Control and Prevention (CDC) recommends testing and linkage to care for persons most likely infected with hepatitis C virus (HCV), including persons with human immunodeficiency virus. We explored facilitators and barriers to integrating HCV point-of-care (POC) testing into standard operations at an urban STD clinic. …”
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Immune and Inflammation in Acute Coronary Syndrome: Molecular Mechanisms and Therapeutic Implications by Haiming Wang, Zifan Liu, Junjie Shao, Lejian Lin, Min Jiang, Lin Wang, Xuechun Lu, Haomin Zhang, Yundai Chen, Ran Zhang

“…Therefore, restoring the balance in autoimmune regulation is essential because proatherogenic and antiatherogenic immunomodulatory effects are equally important in the complex human immune network. In this review, we summarized the recent evidence of the roles of proatherogenic and antiatherogenic immune networks in the pathogenesis of ACS and discussed how immune and inflammation contribute to atherosclerosis progression, plaque instability, and adverse cardiovascular events. …”
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Chronic nitrogen legacy in the aquifers of China by Xin Liu, Fu-Jun Yue, Li Li, Feng Zhou, Hang Wen, Zhifeng Yan, Lichun Wang, Wei Wen Wong, Cong-Qiang Liu, Si-Liang Li

“…Here we used machine learning and decision tree-heatmap analysis by compiling nitrate concentrations and isotope data from 4047 groundwater sites across China to understand their dynamics and drivers across gradients of geographical, climate, and human factors. Results show that nitrate concentrations vary substantially over depth and are generally lower in deeper groundwater, indicating potentially higher nitrate removal rates according to nitrate isotopic pattern such as denitrification at depth. …”
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Effect of Hepatitis E Virus on the Male Reproductive System: A Review of Current Evidence by Ahmed A. Kotb, Mohamed A. El-Mokhtar, Ibrahim M. Sayed

“…However, the effect of HEV infection on male infertility is not confirmed. One study including human samples showed male infertility associated with HEV genotype 4 infection. …”
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An Incremental Self-Adaptive Wood Species Classification Prototype System by Peng Zhao, Zhen-Yu Li, Yue Li

“…Last, if one cluster of one unknown species has an adequate amount of wood samples, these wood samples are removed and identified by human experts or other schemes to ensure to get the correct wood species name. …”
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Sonic Hedgehog Signaling Drives Proliferation of Synoviocytes in Rheumatoid Arthritis: A Possible Novel Therapeutic Target by Mingxia Wang, Shangling Zhu, Weixiang Peng, Qiuxia Li, Zhaoxia Li, Minqi Luo, Xiaoxue Feng, Zhuofeng Lin, Jianlin Huang

“…Sonic hedgehog (Shh) signaling controls many aspects of human development, regulates cell growth and differentiation in adult tissues, and is activated in a number of malignancies. …”
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Evaluation of hesperidin as a potential larvicide against Culex pipiens with computational prediction of its mode of action via molecular docking by Abdullah Haikal, Mahmoud Kamal, Eslam M. Hosni, Yhiya Amen

“…Culex pipiens, commonly known as the northern house mosquito, is a major vector of several human pathogens, such as the West Nile virus and filariasis, making it a key target in the fight against vector-borne diseases. …”
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Synergistic Effects of Cabozantinib and EGFR-Specific CAR-NK-92 Cells in Renal Cell Carcinoma by Qing Zhang, Kang Tian, Jinjing Xu, Haixu Zhang, Liantao Li, Qiang Fu, Dafei Chai, Huizhong Li, Junnian Zheng

“…Furthermore, the CAR-NK-92 cells show synergistic therapeutic efficacy with cabozantinib against human RCC xenograft models. Our results provided the basis for combination with chemotherapy as a novel strategy for enhancing the therapeutic efficacy of CAR-modified immune effector cells for solid tumors.…”
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Inhibition of mutagenic activation of orthoaminoazotoluene increases its carcinogenicity for mouse liver by V. I. Kaledin, L. P. Ovchinnikova, S. I. Ilnitskaya, T. S. Morozkova, N. A. Popova

“…Various mutationally impaired genes are often found in malignant tumors of animals and humans. At the same time, a large number of carcinogens demonstrate positive activity in different in vitro tests for mutagenicity. …”
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ApoM maintains cellular homeostasis between mitophagy and apoptosis by affecting the stability of Nnt mRNA through the Zic3-ApoM-Elavl2-Nnt axis during neural tube closure by Qing Liu, Dan Liu, Yuejiao Wang, Xiaowei Wei, Wei Ma, Hui Gu, Shanshan Jia, Yiwen He, Wenting Luo, Songying Cao, Zhonghua Yang, Anhua Wu, Zhengwei Yuan

“…We demonstrated that ApoM expression was reduced in the spinal cord samples of rat models and human fetuses with NTDs respectively. Specifically, lack of ApoM resulted in reduced cytosolic localization of Elavl2 and caused Nnt mRNA degradation, which further led to impaired cell homeostasis by suppressing PINK1-PRKN-mediated mitophagy and promoting apoptosis and subsequent NTDs formation. …”
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Breaking the Frame: Arabesque and Metric Complexity in the Sunrise Scene from Ravel’s Daphnis et Chloé (1912) by Gurminder Kaur Bhogal

“…At this moment, the motif bursts into the foreground to suggest the symbolic fusion of nature, divinity, and human emotion. The structural role of the arabesque figure on metric and narrative levels unsettles prevailing viewpoints of ornament as meaningless and non-essential. …”
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