Programmable Multiplexed Nucleic Acid Detection by Harnessing Specificity Defect of CRISPR‐Cas12a by Xin Guan, Rui Yang, Jiongyu Zhang, Jeong Moon, Chengyu Hou, Chong Guo, Lori Avery, Danielle Scarola, Daniel S. Roberts, Rocco LaSala, Changchun Liu

“…With the assay, 14 high‐risk human papillomavirus (HPV) subtypes are simultaneously detected, collectively responsible for 99% of cervical cancer cases, with attomolar sensitivity. …”
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Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment by Alberto N. Peón, Yadira Ledesma-Soto, Jonadab E. Olguín, Marcel Bautista-Donis, Edda Sciutto, Luis I. Terrazas

“…However, few helminth-derived immunomodulators have been tested in experimental autoimmune encephalomyelitis (EAE), an animal model of the human disease multiple sclerosis (MS). The immunomodulatory activities of Taenia crassiceps excreted/secreted products (TcES) that may suppress EAE development were sought for. …”
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Comparative study of some species of the genus Acer L. in the Hirkan flora using dendrochronological methods by Agamalieva Aydan Gahraman, Mehrelieva Hokume Ilham, Mammadova Shalala Abuzer, Alieva Khadija Hezi, Esli Ilaida Aga Aleskerova

“…Recently, due to global climate change and unregulated human economic activities, biodiversity has significantly degraded, which has led to changes and reductions in the ranges of species. …”
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Aronia melanocarpa Leaves as a Source of Chlorogenic Acids, Anthocyanins, and Sorbitol, and Their Anti-Inflammatory Activity by Agnieszka Zielińska, Dorota Bryk, Katarzyna Paradowska, Iwona Wawer

“…Chokeberry leaf extracts from green and red leaves were subjected to the in vitro study on human umbilical vein endothelial cells (HUVCs). Both extracts suppressed TNF-α-induced surface expression of ICAM-1 and VCAM-1 molecules, and exhibited anti-adhesive and anti-inflammatory properties. …”
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Estimation level of public welfare on the basis of methods of intellectual analysis by S. Kozlovskyi, L. Nikolenko, O. Peresada, O. Pokhyliuk, O. Yatchuk, N. Bolgarova, O. Kulhanik

“…Input factors of the model are international indices and indicators, such as Index of Economic Freedom, Global Peace Index, Democracy Index, Corruption Perceptions Index, Human Development Index, Prosperity Index, Global Competitiveness Index as well as an indicator that reflects the characteristic property of the Ukrainian economy, namely the minimum living wage. …”
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Understanding mediation as an out-of-judicial procedure for the settlement of civil-legal and labor disputes by Mahnovskyi I.

“…Results.In the research process, it was recognized that among the practice of dissemination, which is demanded by time, effective tools based on safe reconciliation and mutually beneficial agreement, which are distinguished by their flexibility, extrajudicial, independent, alternative ways of settling civil and labor disputes and conflicts, in the domestic legal mechanism of ensuring human rights, mediation is becoming more and more widespread. …”
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Distribution and environmental dissemination of antibiotic resistance genes in poultry farms and surrounding ecosystems by ShangMin Li, Kai Wang, DanPing Wang, HongZhi Wang, HuaXuan Zhao, JunHua Pu, KeHua Wang, ChunMei Li

“…Antibiotic resistance poses a significant threat to human and animal health worldwide, with farms serving as crucial reservoirs of Antibiotic Resistance Genes (ARGs) and Antibiotic-resistant bacteria. …”
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Classification and Monitoring of Salt Marsh Vegetation in the Yellow River Delta Based on Multi-Source Remote Sensing Data Fusion by Ran Xu, Yanguo Fan, Bowen Fan, Guangyue Feng, Ruotong Li

“…In recent years, salt marsh vegetation has experienced severe degradation, which is primarily due to invasive species and human activities. Therefore, the accurate monitoring of the spatial distribution of these vegetation types is critical for the ecological protection and restoration of the Yellow River Delta. …”
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Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders by Hanyang Ruan, Geya Tong, Minghui Jin, Kathrin Koch, Zhen Wang

“…In this review, we provide an overview across studies investigating the effects of NAc DBS in humans and animals and discuss potential mechanisms underlying its clinical efficacy. …”
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Sequence Analysis of How Disability Influenced Life Trajectories in a Past Population from the Nineteenth-Century Sundsvall Region, Sweden by Lotta Vikström, Helena Haage, Erling Häggström Lundevaller

“…To our knowledge this is the first study to employ sequence analysis on a substantially large number of cases to provide demographic evidence of how disability shaped human trajectories in the past during an extended period of life. …”
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Phytochemical Screening and Biological Activity of Mentha × piperita L. and Lavandula angustifolia Mill. Extracts by Ersilia Alexa, Corina Danciu, Isidora Radulov, Diana Obistioiu, Renata Maria Sumalan, Adriana Morar, Cristina Adriana Dehelean

“…In terms of biological activity against MDA-MB-231 breast carcinoma cell line, and A375 human melanoma cell line, at the highest employed concentration, 150 μg·mL–1, the tested extracts present a weak antiproliferative effect.…”
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Why are women still leaving academic medicine? A qualitative study within a London Medical School by Christopher J Peters, Lesley Regan, Victoria Salem, Clare Lloyd, Dhruti Hirani

“…Thematic analysis was performed on the transcribed conversations.Participants and setting Nine women physicians who completed a postgraduate degree (MD or PhD) at a large London Medical School and Academic Health Sciences Centre, Imperial College London, but did not go on to pursue a career in academic medicine.Results Influences to leave clinical academia were summarised under eight themes—career intentions, supervisor support, institutional human resources support, inclusivity, work–life balance, expectations, mentors and role models, and pregnancy and maternity leave.Conclusion The women in our focus group reported several factors contributing to their decision to leave clinical academia, which included lack of mentoring tailored to specific needs, low levels of acceptance for flexible working to help meet parental responsibilities and perceived explicit gender biases. …”
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The percentage of Body Fat and its Relationship with Blood Pressure in Adults from Rural and Urban Areas by Carlos Enrique García Yerena, Omar Oliveros Rangel, Brian Johan Bustos Viviescas, Amalia Villamizar Navarro, John Alexander García Galviz

“…<strong>Foundation:</strong> excess body fat is marked by a permanent imbalance between food consumption and energy expenditure of human beings that generate various health risks, including increased blood pressure. …”
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Neuroplasticity of Acupuncture for Stroke: An Evidence-Based Review of MRI by Jinhuan Zhang, Chunjian Lu, Xiaoxiong Wu, Dehui Nie, Haibo Yu

“…After searching PubMed, Web of Science, and Embase databases, 24 human and five animal studies were identified. This review focuses on the evidence on the possible mechanisms underlying mechanisms of acupuncture therapy in treating stroke by regulating brain plasticity. …”
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Assessment of groundwater intrinsic vulnerability using GIS-based DRASTIC method in district Karak, Khyber Pakhtunkhwa, Pakistan by Muhammad Muneer, Mumtaz Ali Khan, Fayaz Ullah Shinwari, Ijaz Ahmed, Syed Mamoon Siyar, Fahad Alshehri, Muhammad Shahab

“…The concentration of Nitrate &gt;10 ppm represent that some human action has contributed toward the highest concentration.…”
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Stellettin B Isolated from Stelletta Sp. Reduces Migration and Invasion of Hepatocellular Carcinoma Cells through Reducing Activation of the MAPKs and FAK/PI3K/AKT/mTOR Signaling P... by Tsung-Chang Tsai, Wen-Tung Wu, Jen-Jie Lin, Jui-Hsin Su, Yu-Jen Wu

“…In this study, we used Stellettin B, an active compound isolated from Stelletta sponges, as the experimental drug and evaluated its inhibition effects on cell migration and invasion in human hepatoma cells (HA22T and HepG2). MTT assay, gelatin zymography, and western blotting were employed. …”
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Semantic Modeling for SNPs Associated with Ethnic Disparities in HapMap Samples by HyoYoung Kim, Won Gi Yoo, Junhyung Park, Heebal Kim, Byeong-Chul Kang

“…Single-nucleotide polymorphisms (SNPs) have been emerging out of the efforts to research human diseases and ethnic disparities. A semantic network is needed for in-depth understanding of the impacts of SNPs, because phenotypes are modulated by complex networks, including biochemical and physiological pathways. …”
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Quantification of Malondialdehyde in Atmospheric Aerosols: Application of the Thiobarbituric Acid Method by David H. Gonzalez, Suzanne E. Paulson

“…Abstract Based on available toxicity data, malondialdehyde (MDA; O=CHCH2CH=O) has been designated as a potential human carcinogen. A handful of studies suggest that MDA forms in the gas and aerosol phase in the troposphere, potentially contributing to inhalation toxicity, yet it has never been quantified in ambient air. …”
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Microscopic Photosensitization: A New Tool to Investigate the Role of Mitochondria in Cell Death by May-Ghee Lum, Tetsuhiro Minamikawa, Phillip Nagley

“…Using mitochondrially localized CMXRos as a photosensitizer coupled to laser irradiation by confocal laser scanning microscopy, we demonstrate that partial irradiation of about half the mitochondria in human 143B TK– cells induces rapid loss of mitochondrial membrane potential (ΔΨm) in nonirradiated mitochondria. …”
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Overcoming the Constraints of Anti-HIV/CD89 Bispecific Antibodies That Limit Viral Inhibition by Xiaocong Yu, Mark Duval, Melissa Gawron, Marshall R. Posner, Lisa A. Cavacini

“…To this end, bispecific constructs of human antibody F240, reactive with well-conserved gp41 epitope and antibody 14A8, reactive with the IgA receptor (CD89) on effector cells, were constructed. …”
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