Residual nitrite and nitrate in processed meats and meat analogues in the United States by Siyuan Sheng, Erin M. Silva, Rodrigo Tarté, James R. Claus

“…Abstract Residual nitrite (NO2 −) and nitrate (NO3 −) have been widely studied in the past few decades for their function to improve processed meat quality and their impact on human health1–4. In this study we examined how the residual nitrite and nitrate (NOx −) content of major classes of processed meats products (n = 1132) produced locally from three regions (East Coast, Midwest and West Coast) and plant protein-based meat analogues (n = 53) available at retail in the United States was influenced by their composition, processing, and geographical attributes. …”
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Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment by Moiz Mumtaz, Jeffrey Fisher, Benjamin Blount, Patricia Ruiz

“…Such collaborative efforts have led to the development and use of transparent and user-friendly models. The “human PBPK model toolkit” is one such project. While not necessarily state of the art, this toolkit is sufficiently accurate for screening purposes. …”
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Future Trends in Worldwide River Nitrogen Transport and Related Nitrous Oxide Emissions: A Scenario Analysis by Carolien Kroeze, Sybil P. Seitzinger, Rita Domingues

“…The results indicate that moderate changes in the human diet in North America and Europe, reducing worldwide fertilizer use by only 16%, relative to Business-as-Usual (BAU) levels, may reduce DIN export rates to the North Atlantic and European Seas by about one third and associated N2O emissions by 36 to 77%. …”
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Conformational Dynamics of Mitochondrial Inorganic Pyrophosphatase hPPA2 and Its Changes Caused by Pathogenic Mutations by Ekaterina Bezpalaya, Svetlana Kurilova, Nataliya Vorobyeva, Elena Rodina

“…The current work describes the conformational dynamics of a structural model of human mitochondrial pyrophosphatase hPPA2 using molecular dynamics simulation, all-atom principal component analysis, and coarse-grained normal mode analysis. …”
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Effect of UV-degraded microplastics on Dissolved Air Flotation (DAF) removal by Pit Sovannary, Sangpreedeekorn Jirawat, Phengsaart Theerayut, Janjaroen Dao

“…Microplastics (MPs) are ubiquitous environmental pollutants that cause significant effects on the aquatic ecosystem and human health, including challenging water treatment systems due to their small particle size and high environmental persistence. …”
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Third-Generation Anti-CD47-Specific CAR-T Cells Effectively Kill Cancer Cells and Reduce the Genes Expression in Lung Cancer Cell Metastasis by Huyen Thi La, Dao Bich Thi Tran, Hai Manh Tran, Linh Trong Nguyen

“…We used the complementarity-determining regions (CDRs) of the B6H12 mouse antibody grafted onto the IgG1 framework to create the humanized single-chain variable fragment (scFv) with linker (G4S)x3. scFv was used to design the chimeric antigen receptor with the structure CD8signal-CD47scFv-CD8a hinge-CD4TM-CD28-41BB-CD3ζ, which was then transformed into T lymphocytes by the lentivirus to create third generation of CAR-T. …”
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IMPLEMENTING ETHNIC TOURISM AS A TOOL CONTRIBUTING TO THE DESTINATION COMMUNITY WELL-BEING IN THE CENTRAL HIGHLANDS, VIETNAM by Thi Thanh Kieu Nguyen

“…By conducting a community workshop with 34 local tourism stakeholders in the Central Highlands, the study found that the top priority was placed on human capital and political capital. First, local wisdom and genuine characteristics of naivete, honesty, friendliness, and hospitality need to be promoted to attract visitors, while local residents need to be educated and trained to build capacity for improving tourism services and to actively engage in the tourism decision-making process. …”
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Benchmarking cell type annotation methods for 10x Xenium spatial transcriptomics data by Jinming Cheng, Xinyi Jin, Gordon K. Smyth, Yunshun Chen

“…Results We compared performance of five reference-based methods (SingleR, Azimuth, RCTD, scPred and scmapCell) with the marker-gene-based manual annotation method on an imaging-based Xenium data of human breast cancer. A practical workflow has been demonstrated for preparing a high-quality single-cell RNA reference, evaluating the accuracy, and estimating the running time for reference-based cell type annotation tools. …”
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PREVENTION OF INFERIORITY COMPLEX ATTITUDES ACCORDING TO THE QUR'AN by A Asnawiyah, Abd Wahid, Nurullah Amri, Muhammad Hadi Husni

“…The results of this study show that the mufassir emphasize that true strength lies in faith, solid faith is the initial key in overcoming the sense of inferiority complex, inferiority complex is the spiritual part of human beings and spiritual studies sourced from the Qur'an are the initial stages in fighting the inferiority complex. …”
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Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers by Shiyi Yu, Chengyang Jiang, Yawen Yang, Fei Cheng, Fangchen Liu, Chang Liu, Xue Gong

“…Therefore, dysregulation of DNA/RNA binding proteins such as purine-rich element binding protein alpha (PURα) disrupts signaling transduction and often leads to human diseases including cancer. PURα was initially recognized as a tumor suppressor in acute myeloid leukemia (AML) and prostate cancer (PC). …”
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Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder by Syouichi Katayama, Noriyuki Sueyoshi, Tetsuya Inazu, Isamu Kameshita

“…Cyclin-dependent kinase-like 5 (CDKL5, also known as STK9) is a serine/threonine protein kinase originally identified in 1998 during a transcriptional mapping project of the human X chromosome. Thereafter, a mutation in CDKL5 was reported in individuals with the atypical Rett syndrome, a neurodevelopmental disorder, suggesting that CDKL5 plays an important regulatory role in neuronal function. …”
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Extraction of Psychological Effects of COVID-19 Pandemic through Topic-Level Sentiment Dynamics by Abdul Razzaq, Touqeer Abbas, Sarfraz Hashim, Salman Qadri, Imran Mumtaz, Najia Saher, Muzammil Ul-Rehman, Faisal Shahzad, Syed Ali Nawaz

“…The proposed framework illustrates the insight impact of COVID-19 on human physiological and mainly focuses on the evaluation of sentiment dynamics at the topical level.…”
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Kidney Stone Disease: An Update on Current Concepts by Tilahun Alelign, Beyene Petros

“…It is an increasing urological disorder of human health, affecting about 12% of the world population. …”
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Data augmentation with occluded facial features for age and gender estimation by Lu En Lin, Chang Hong Lin

“…Abstract Here, the feature occlusion, a data augmentation method that simulates real‐life challenges on the main features of the human face for age and gender recognition is proposed. …”
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NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts by Selim Terhzaz, David Kerrigan, Floriane Almire, Agnieszka M. Szemiel, Joseph Hughes, Jean-Philippe Parvy, Massimo Palmarini, Alain Kohl, Xiaohong Shi, Emilie Pondeville

“…Some bunyaviruses are transmitted between vertebrate hosts by blood-sucking arthropods and cause major diseases in humans and animals. It is not understood why only some bunyaviruses have evolved the capacity to be transmitted by arthropod vectors. …”
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Modulation of Th1/Th2 Immune Responses by Killed Propionibacterium acnes and Its Soluble Polysaccharide Fraction in a Type I Hypersensitivity Murine Model: Induction of Different A... by Carla Cristina Squaiella-Baptistão, Daniela Teixeira, Juliana Sekeres Mussalem, Mayari Eika Ishimura, Ieda Maria Longo-Maugéri

“…Propionibacterium acnes (P. acnes) is a gram-positive anaerobic bacillus present in normal human skin microbiota, which exerts important immunomodulatory effects, when used as heat- or phenol-killed suspensions. …”
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Effect of Anatomical Customization of the Fiber Post on the Bond Strength of a Self-Adhesive Resin Cement by Adricyla Teixeira Rocha, Leticia Machado Gonçalves, Ana Júlia de Carvalho Vasconcelos, Etevaldo Matos Maia Filho, Ceci Nunes Carvalho, Rudys Rodolfo De Jesus Tavarez

“…Twelve endodontically treated, human, upper central incisors were randomly divided into two groups (n=6): control (glass fiber posts cemented with Relyx® U200) and customized (glass fiber posts anatomically customized with translucent composite resin cemented with Relyx U200). …”
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Molecular dynamics-guided reaction discovery reveals endoperoxide-to-alkoxy radical isomerization as key branching point in α-pinene ozonolysis by Huan Yang, Umberto Raucci, Siddharth Iyer, Galib Hasan, Thomas Golin Almeida, Shawon Barua, Anni Savolainen, Juha Kangasluoma, Matti Rissanen, Hanna Vehkamäki, Theo Kurtén

“…Abstract Secondary organic aerosols (SOAs) significantly impact Earth’s climate and human health. Although the oxidation of volatile organic compounds (VOCs) has been recognized as the major contributor to the atmospheric SOA budget, the mechanisms by which this process produces SOA-forming highly oxygenated organic molecules (HOMs) remain unclear. …”
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CHEMOTYPE VERBOCCIDENTAFURAN IN Baccharis punctulata (Asteraceae): FURANIC SESQUITERPENES CORRELATION AND MOLECULAR DOCKING INTO THE BENZODIAZEPINE RECEPTOR by Jociani Ascari, Murilo S. de Oliveira, André L. Rüdiger, Elaine Elisabetsky, Domingos S. Nunes, Jorge Iulek, Dilamara R. Scharf, Gustavo Heiden

“…Considering the occurrence and availability of 1 in the species B. punctulata and its structural similarity to compound 2, docking calculations were performed for the interaction of both compounds with the human a1-ß2-y2 GABAA receptor. The results suggest that both compounds 1 and 2 must have affinity for the cavity at a1-y2 interface and support the development of pharmacological research on the compound verboccidentafuran 1 as a drug candidate for modulating the GABA/benzodiazepine complex in the central nervous system.…”
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A Corticobasal Syndrome Variant of Familial Creutzfeldt-Jakob Disease with Stroke-Like Onset by Ján Necpál, Martin Stelzer, Silvia Koščová, Michal Patarák

“…Creutzfeldt-Jakob disease (CJD) is an untreatable rare human prion disease characterized by rapidly progressive dementia along with various neurological features, including myoclonus and sometimes other movement disorders. …”
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