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An online emergency medical management information system using mobile computing
Published 2025-01-01“…Findings – It reduces the total time of the EMS procedures and it allows for an easier management of EMS, by providing a better allocation of human resources and a better geographical distribution of ambulances. …”
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Evaluation and Influencing Factors of Urban Blue-Green Space Publicness in Changsha
Published 2025-01-01“…Drawing on the theories of the human-land relationship and landscape ecology, we established an evaluation system for UBGS publicness based on the "element-function-structure" framework. …”
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Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors
Published 2022-01-01“…Here we assess and identify spatially restricted exposure to a novel strongly Treg-depleting, checkpoint-blocking, vectorized αCTLA-4, as a highly efficacious and potentially safe strategy to target CTLA-4.Methods A novel human IgG1 CTLA-4 antibody (4-E03) was identified using function-first screening for monoclonal antibodies (mAbs) and targets associated with superior Treg-depleting activity. …”
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16767
CD32B1, a versatile non-signaling antibody-binding scaffold for enhanced T cell adhesion to tumor stromal cognate antigens
Published 2025-02-01“…We thus generated a non-signaling CD32B1 mutant lacking the ITIM motif (termed ITIM-less CD32B1, or ILCD32B1) and successfully expressed it in human T cells which normally do not express this FcR. …”
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4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models
Published 2025-02-01“…Biodistribution studies of muFAP-4-1BBL indicated enriched tumor targeting to irradiated tumors. Human colorectal cancer samples pre and post irradiation showed enhanced FAP expression after radiotherapy.Conclusion Increased FAP expression in the TME as a result of radiotherapy can be exploited to target agonist 4-1BB immunotherapy to malignant tumor lesions using an FAP-4-1BBL antibody fusion protein.…”
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Sdd3 regulates the biofilm formation of Candida albicans via the Rho1-PKC-MAPK pathway
Published 2025-02-01“…ABSTRACT Candida albicans, the most frequently isolated fungal pathogen in humans, forms biofilms that enhance resistance to antifungal drugs and host immunity, leading to frequent treatment failure. …”
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NL-Augmenter: A Framework for Task-Sensitive Natural Language Augmentation
Published 2023-04-01“…The transformations incorporate noise, intentional and accidental human mistakes, socio-linguistic variation, semantically-valid style, syntax changes, as well as artificial constructs that are unambiguous to humans. …”
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Arginase-1-specific T cells target and modulate tumor-associated macrophages
Published 2025-01-01“…Next, we established that human Arg1+TAMs present Arg1-derived peptides and are directly recognized by proinflammatory CD4+Arg1-specific T cell clones. …”
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Fhl1, a new spatially specific protein, regulates vein graft neointimal hyperplasia
Published 2024-12-01“…Adenovirus‐mediated FHL1 overexpression in human saphenous vein have beneficial effects in preventing neointimal hyperplasia. …”
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Modeling the relationship between the moral charter derived from Islamic teachings and performance with the mediating variable of employees' perception
Published 2024-11-01“…He believed that the personal benefit of a human kind is the providence of God, not the will of the state. …”
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Evaluating the level of digitalization of the innovation process with artificial intelligence approach in the digital transformation of knowledge-based companies
Published 2025-02-01“…Artificial intelligence Artificial intelligence is sometimes called machine intelligence, refers to the intelligence shown by machines in various situations, which is in contrast to the natural intelligence in humans; in other words, artificial intelligence refers to systems that can react similar to human intelligent behavior, including understanding complex situations, simulating human thinking processes and reasoning methods and successfully responding to them, learning and having the ability to acquire knowledge and reason to solve problems (Teece et al., 1997). …”
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Situating complexity: information behaviour in the contact zone
Published 2024-06-01“…This paper argues that contact and zone are both key aspects of information behaviour, as information encounters take place in specific sites, between diverse human and nonhuman agents with different levels of power and influence. …”
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Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway
Published 2021-01-01“…Overexpressed survivin is associated with worse survival of several types of human tumors. In this study, the antitumor activity of shikonin in non-small-cell lung cancer (NSCLC) by regulating survivin pathway was investigated. …”
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Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection
Published 2013-01-01“…Fetal and neonatal infections caused by human cytomegalovirus (CMV) are important causes of morbidity and occasional mortality. …”
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