Wilms tumor primary cultures capture phenotypic heterogeneity and facilitate preclinical screening by Lisa Götz, Jenny Wegert, Alireza Paikari, Silke Appenzeller, Sabrina Bausenwein, Christian Vokuhl, Taryn D. Treger, Jarno Drost, Christin Linderkamp, Dominik T. Schneider, Karen Ernestus, Steven W. Warman, Jörg Fuchs, Nils Welter, Norbert Graf, Sam Behjati, Rhoikos Furtwängler, Manfred Gessler

“…Sensitivity was related to MYCN status, a marker associated with adverse outcome across human cancers including WT. The combination of the three culture techniques represents a promising tool to both explore tumor heterogeneity in vitro and to facilitate characterization of candidate driver genes, in order to improve treatment regimens in the future.…”
Get full text

Happiness Issue – Moral Aspects of its Biochemical Enhancement by Zlatica Plašienková, Martin Farbák

“…The search for happiness is something that constitutes human existence from its beginning, and even though people have achieved unimaginable progress in science and technologies, they still have not found the secret of being happy. …”
Get full text

Localization Algorithms in Large-Scale Underwater Acoustic Sensor Networks: A Quantitative Comparison by Guangjie Han, Aihua Qian, Chenyu Zhang, Yan Wang, Joel J. P. C. Rodrigues

“…Recently underwater acoustic sensor networks (UASNs) have drawn much attention because of their great value in many underwater applications where human operation is hard to carry out. In this paper, we introduce and compare the performance of four localization algorithms in UASNs, namely, distance vector-hop (DV-hop), a new localization algorithm for underwater acoustic sensor networks (NLA), large-scale hierarchical localization (LSHL), and localization scheme for large scale underwater networks (LSLS). …”
Get full text

Simultaneous Determination of Uric Acid and Xanthine Using a Poly(Methylene Blue) and Electrochemically Reduced Graphene Oxide Composite Film Modified Electrode by Gen Liu, Wei Ma, Yan Luo, Deng-ming Sun, Shuang Shao

“…Finally, the proposed method was applied to simultaneously determine UA and Xa in human urine with good selectivity and high sensitivity.…”
Get full text

Analyzing the relationship between gene expression and phenotype in space-flown mice using a causal inference machine learning ensemble by James A. Casaletto, Ryan T. Scott, Makenna Myrick, Graham Mackintosh, Hamed Chok, Amanda Saravia-Butler, Adrienne Hoarfrost, Jonathan M. Galazka, Lauren M. Sanders, Sylvain V. Costes

“…Abstract Spaceflight has several detrimental effects on human and rodent health. For example, liver dysfunction is a common phenotype observed in space-flown rodents, and this dysfunction is partially reflected in transcriptomic changes. …”
Get full text

Schizophrenia recognition based on three-dimensional adaptive graph convolutional neural network by Guimei Yin, Jie Yuan, Yanjun Chen, Guangxing Guo, Dongli Shi, Lin Wang, Zilong Zhao, Yanli Zhao, Manjie Zhang, Yuan Dong, Bin Wang, Shuping Tan

“…This adaptive approach eliminates the human-specified criteria for feature selection and brain network construction. …”
Get full text

Interactions between key genes and pathways in prostate cancer progression and therapy resistance by Fan Wu, Hengsen Zhang, Miaomiao Hao

“…Prostate cancer is one of the most prevalent malignant tumors in men, particularly in regions with a high Human Development Index. While the long-term survival rate for localized prostate cancer is relatively high, the mortality rate remains significantly elevated once the disease progresses to advanced stages, even with various intensive treatment modalities. …”
Get full text

Spatial Analysis and Socio-Environmental Determinants of Canine Visceral Leishmaniasis in an Urban Area in Northeastern Brazil by Natan Diego Alves de Freitas, Lucas José Macedo Freire, Suely Ruth Silva, Nilton Guedes do Nascimento, Pedro Cordeiro-Estrela

“…Dogs are considered the main urban reservoir of VL, whose infections precede cases in humans. In order to understand the socio-environmental determinants associated with canine visceral leishmaniasis (CVL), we conducted a spatial analysis of CVL cases in northeastern Brazil from 2013 to 2015, georeferencing 3288 domiciled dogs. …”
Get full text

Does motivation theory really play any significant role on explaining university teachers’ performance: Understanding Bangladeshi context by Rebaka Sultana, Mohammad Faruk, Md. Saiful Islam, Md. Asif Khaled

“… The development of human capital is significantly impacted by the way teachers nurture and expand their students' intellectual capacity. …”
Get full text

Recombinant production platform for Group A Streptococcus glycoconjugate vaccines by Sowmya Ajay Castro, Ian J. Passmore, Didier Ndeh, Helen Alexandra Shaw, Alessandro Ruda, Keira Burns, Sarah Thomson, Rupa Nagar, Kathirvel Alagesan, Mark Reglinski, Kieron Lucas, Sherif Abouelhadid, Ulrich Schwarz-Linek, Fatme Mawas, Göran Widmalm, Brendan W. Wren, Helge C. Dorfmueller

“…Abstract Group A Streptococcus (Strep A) is a human-exclusive bacterial pathogen killing annually more than 500,000 patients, and no current licensed vaccine exists. …”
Get full text

Monitoring and quantification of rural urbanisation: Case of Arris and Theniet Elabed, Algeria by Soto Sabrina, Hamouda Abida, Rebah Halim

“…In recent decades, rural agglomerations in the Aurès (Algeria) have undergone an to increasing human pressure and major transformations within an uncontrolled urbanization leading not only to a loss of natural and agricultural areas but an intensive artificialization of ecosystems as well. …”
Get full text

Research Advances in the Role of Cereal Dietary Fiber in Modulating Glucose and lipid Metabolism via the Gut Microbiota-Bile Acid by DONG Hong-wang, QI Wen-tao, PENG Wen-ting, SONG Ge, FANG Wei

“…It provides new insights into how grain dietary fiber improves metabolic health and supports human well-being.…”
Get full text

Automated Generation of Traffic Incident Response Plan Based on Case-Based Reasoning and Bayesian Theory by Yongfeng Ma, Wenbo Zhang, Jian Lu, Li Yuan

“…With a reasonable and feasible traffic incident response plan, related agencies will save many losses, such as humans and wealth. In this paper, how to generate traffic incident response plan automatically and specially was solved. …”
Get full text

LC-MS/MS Quantification of Tramadol and Gabapentin Utilizing Solid Phase Extraction by Pappula Nagaraju, Balaji Kodali, Peda Varma Datla, Surya Prakasarao Kovvasu

“…An accurate, highly sensitive, and precise method for quantitative analysis of tramadol (TMD) and gabapentin (GBP) by high performance liquid chromatography and tandem mass spectrometry in human plasma was proposed and validated successfully using venlafaxine and pregabalin as internal standards (ISTDs), respectively. …”
Get full text

Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity by Mingjiong Zhang, Jiahua Cui, Haoyan Chen, Yifan Cheng, Qiaoyu Chen, Feng Zong, Xiao Lu, Lang Qin, Yu Han, Xingwang Kuai, Yuxing Zhang, Minjie Chu, Shuangshuang Wu, Jianqing Wu

“…Mechanically, ex vivo human and mouse Treg cell data and in vivo mouse tumor models suggest that SOAT2 overexpression in Treg cells promotes cholesterol metabolism by activating the SREBP2-HMGCR-GGPP pathway, leading to enhanced Treg suppresser functions but reduced CD8+ T cell proliferation, migration, homeostasis and anti-tumor immunity. …”
Get full text

Formation of a mechanism for regulating the long-term care system for senior citizens in Stavropol Krai of the Russian Federation by I. I. Deren, K. A. Samofatova

“…Based on the results of the article, the authors concluded that the formed mechanism is able to ensure coordinated and interdepartmental interaction between all participants in the long-term care system at the regional and municipal levels, as well as attracting additional financial, human, organizational resources to provide social care services of proper quality, which will fully satisfy the need for them among the recipients of services.…”
Get full text

The effect of growth, intellectual capital, financial performance on firm value by Indah Ayu Johanda Putri

“…One important non-financial factor is intellectual capital, which includes human resources, customer relationships, and innovation capabilities. …”
Get full text

Examining the impact of artificial intelligence (AI) tools on Saudi Arabian ESL students’ writing skills by Samah Abduljawad

“…There were also disparities in AI tool use, which included the possibility of coming up with content not being referred to as human-like, failure to recognize creativity, and capacity to cheat. …”
Get full text

The Ranking of municipal responsibilities importance and satisfaction in the citizens perspectives (Case study: Tehran Municipality-region 6) by leyla ghasemi, farveh rahmani, tahereh bayat

“…Humans in the course of urban development in order to conduct the affairs of the citizens have attempted to establish a municipal entity and the duties and responsibilities to municipalities are considered. municipal performance analysis can be the best way to ensure proper duties as mayor. this study aimed to evaluate the satisfaction level of citizens the function and importance of the services that municipalities offer is made. the research method is descriptive-analytical and data collection method based on the Library, and field documents (questionnaires, respectively). …”
Get full text

Evaluation of the DWT-PCA/SVD Recognition Algorithm on Reconstructed Frontal Face Images by Louis Asiedu, Bernard O. Essah, Samuel Iddi, K. Doku-Amponsah, Felix O. Mettle

“…The face is the second most important biometric part of the human body, next to the finger print. Recognition of face image with partial occlusion (half image) is an intractable exercise as occlusions affect the performance of the recognition module. …”
Get full text