Herpesvirus Infections After Chimeric Antigen Receptor T-Cell Therapy and Bispecific Antibodies: A Review by Joseph Sassine, Emily A. Siegrist, Roy F. Chemaly

“…Surveillance and prophylactic strategies for CMV need to be developed, whereas the risk factors for and the burden of CMV infections after BsAb are not yet well-defined. Human herpes virus 6 reactivation and end organ disease such as encephalitis are rarely reported after CAR-T and have not yet been reported after BsAb; additional research is needed.…”
Get full text

Metformin in the treatment of colorectal cancer and neuroendocrine tumours by Karolina Daniłowska, Natalia Picheta, Barbara I. Krupska, Anna Rudzińska, Oliwia Burdan, Katarzyna Szklener

“…In studies conducted on human cells and xenografts, the drug has shown its positive effects in combating these tumors by reducing proliferation, slowing the growth of cancer cells, and inhibiting metastasis. …”
Get full text

Oncolytic Viruses: The Power of Directed Evolution by Maxine Bauzon, Terry W. Hermiston

“…In this method, diverse viruses are grown under conditions that maximize diversity and then passaged under conditions meant to mimic those encountered in the human cancer microenvironment. Viruses which evolve to thrive under this selective pressure are isolated and tested to identify those with increased potency (i.e., ability to replicate and spread) and/or an increased therapeutic window (i.e., differentiated replication and spread on tumor versus normal cells), both of which have potential value but the latter of which defines an oncolytic virus. …”
Get full text

Are Polish Kindergartens Ready for The Outdoors? The State of (Im)maturity of the Polish Educational System and its Selected Members for Outdoor Education by Hanna Łoboda

“… As human beings, we are moving dramatically away from nature, which results in negative consequences for both mental and physical health. …”
Get full text

Ecological and Coevolutionary Dynamics in Modern Markets Yield Nonstationarity in Market Efficiencies by Colin M. Van Oort, John Henry Ring IV, David Rushing Dewhurst, Christopher M. Danforth, Brian F. Tivnan

“…These developments have supported the growth of a rich machine-trading ecology that leads to qualitative differences in trading behavior at human and machine time scales. We conduct a longitudinal analysis of comprehensive market data to quantify nonstationary dynamics throughout this system. …”
Get full text

Persistence of Brucella abortus in the Bone Marrow of Infected Mice by Cristina Gutiérrez-Jiménez, Lisiena Hysenaj, Alejandro Alfaro-Alarcón, Ricardo Mora-Cartín, Vilma Arce-Gorvel, Edgardo Moreno, Jean Pierre Gorvel, Elías Barquero-Calvo

“…Persistence of Brucella in the BM has been associated with hematological complications such as neutropenia, thrombocytopenia, anemia, and pancytopenia in human patients. In the mouse model, we observed that the number of Brucella abortus in the BM remained constant for up to 168 days of postinfection. …”
Get full text

Evaluating the implementation of a digital coordination centre in an Australian hospital setting: a mixed method study protocol by Timothy N Fazio, Daniel Capurro, Colin Malone, Sam Freeman, Wynona Black, Wendy W Chapman, Jana Gazarek, Meredith J Layton, Kayley Lyons, Laura Pumo, Samantha Plumb, Brad Astbury

“…Data sources will include interviews, project documentation and observations, with qualitative and quantitative analyses targeting metrics like emergency department boarding and length of stay.Ethics and dissemination This study has been approved by the RMH Human Research Ethics Committee (QA2023089). Findings will be shared through peer-reviewed publications and conference presentations.…”
Get full text

Facteurs socioéconomiques et décrochage des études au premier cycle universitaire by Alex Romeo SUEBANG, Daouda MAINGARI

“…The results obtained were interpreted on the basis of the social theory of Baudelot and Establet (1971) and Mballa Owono (1986) and the economic theory of human capital of Becker (1964). These results show the existence of a relationship between three factors (father's level of education, socio-professional level of the father, time spent by the student in a paid job during studies per week) and dropping out of undergraduate studies of FALSH at the University of Yaounde I.…”
Get full text

MicroRNA Profiling in Cartilage Ageing by Panagiotis Balaskas, Katarzyna Goljanek-Whysall, Peter Clegg, Yongxiang Fang, Andy Cremers, Pieter Emans, Tim Welting, Mandy Peffers

“…We undertook a microarray study on young and old human cartilages. Findings were validated in an independent cohort. …”
Get full text

Systematization of scientific approaches in the contemporary motivation system and staff incentives by A. J. Bonyani

“…They can be solved only with professionally formed human capital. Therefore, the author presents in the article an analysis of the existing types and forms of personnel motivation and incentive systems, and also highlights the factors of the modern world that dictate the introduction of new tools and methods for motivating employees of enterprises. …”
Get full text

Social semiotic analysis and efforts to preserve the old mantra of Serdang Malay ethnomedicine in Serdang Bedagai regency, north Sumatra by Rahmat Kartolo, Sutikno Sutikno, Sutarini Sutarini, Nirmawan Nirmawan, Mimi Rosadi, Putri Juwita

“…The two words "Hu" have a social meaning as a place to express requests for desires, recognition of human helplessness, and special sentences in begging. …”
Get full text

Schadenfreude Scale: Construct Validity Test with Confirmatory Factor Analysis by Achmad Syahid, Muhamd Khalid Akbar, Moh. Irvan, Peter Paul Moormann

“…In conclusion, the research showed the cultural relevance of Schadenfreude in understanding human emotions and social behavior.…”
Get full text

Probiotics, metabolism and the functional condition of cardio-vascular system by Ye. A. Kashukh, V. T. Ivashkin

“…According to recent studies human gastrointestinal microbiome may increase cardiovascular risk due to bacterial production of proinflammatory proteins that both promote development of atherosclerosis and directly affect the heart and vessels. …”
Get full text

Le face à face hirak-pouvoir : La crise de la représentation by Louisa Dris Aït-Hamadouche, Chérif Dris

“…How could a mass movement of this magnitude, with all its spatial, human and even temporal variations, have been able to unfold in a peaceful and lasting way, in spite of the periods when the mobilization had ebb? …”
Get full text

Determination of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) in plant foods: exploring dietary sources by Gabriela Fabiana Soares Alegre, Glaucia Maria Pastore

“…Understanding the levels of its biosynthetic precursors, NMN and NR, in foods is essential for assessing their dietary contributions to human nutrition and health. We conducted a comprehensive analysis of NMN, NR, and NAD+ levels for the first time in various common plant foods and non-conventional food plants from the Amazon, using a validated HPLC-DAD/UV method, further confirmed by LC-MS/MS. …”
Get full text

The Potential Capacity of Hamlets: Comparative Research on Small European Municipalities by Michiel S. de Vries, Iwona Sobis

“…However, the institutional and human resource conditions in which small municipalities operate might work both ways, being profitable as well as disadvantageous. …”
Get full text

Energy-Optimized Consensus Formation Control for the Time-Delayed Bilateral Teleoperation System of UAVs by Hui-yu Sun, Guang-ming Song, Zhong Wei, Ying Zhang

“…Under the optimized topology with environmental constraints, communication complexity and energy dissipation can be minimized while the rigid formation can be maintained and transformed persistently in the obstructed environment. Finally, the human-in-the-loop simulations are performed to validate the effectiveness of the proposed scheme.…”
Get full text

Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration by Peisheng Liu, Hao Guo, Xiaoyao Huang, Anqi Liu, Ting Zhu, Chenxi Zheng, Fei Fu, Kaichao Zhang, Shijie Li, Xinyan Luo, Jiongyi Tian, Yan Jin, Kun Xuan, Bingdong Sui

“…Abstract Healthy aging is a common goal for humanity and society, and one key to achieving it is the rejuvenation of senescent resident stem cells and empowerment of aging organ regeneration. …”
Get full text

A New Hybrid Model Predictive Controller Design for Adaptive Cruise of Autonomous Electric Vehicles by Yuanhang Chen, Guodong Feng, Shaofang Wu, Xiaojun Tan

“…Autonomous driving is an appealing research topic for integrating advanced intelligent algorithms to transform automotive industries and human commuting. This paper focuses on a hybrid model predictive controller (MPC) design for an adaptive cruise. …”
Get full text

Presentation of Machine Learning Approaches for Predicting the Severity of Accidents to Propose the Safety Solutions on Rural Roads by Mohammad Habibzadeh, Mahmoud Ameri, Hassan Ziari, Neda Kamboozia, Seyede Mojde Sadat Haghighi

“…By comparing the results of artificial neural network (ANN) models and the Friedman test, it was indicated that the human factor had a remarkable effect on accident severity. …”
Get full text