Establishment of a Rapid and Convenient Fluoroimmunoassay Platform Using Antibodies Against PDL1 and HER2 by Ji Eun Choi, Hanool Yun, Hee-Jin Jeong

“…In this study, we developed a simple and rapid fluorescence-linked immunosorbent assay (FLISA) using fluorescent dye-conjugated antibody fragments against programmed cell death ligand 1 (PDL1) and human epithelial growth factor receptor 2 (HER2). …”
Get full text

GÖRKEM AKGÖZ, “IN THE SHADOW OF WAR AND EMPIRE: INDUSTRIALISATION, NATION BUILDING, AND WORKING-CLASS POLITICS IN TURKEY” by Ivana Hadjievska

“…I believe that it is an important review subject, as it is a representative of the new currents in the field of labor history, where through a discursive approach to the sources testifying the human condition of the working class, new knowledge is gained about the processes of nation-building and capitalist modernization. …”
Get full text

Immunotherapeutic Approaches in Triple-Negative Breast Cancer: State of the Art and Future Perspectives by Karima Oualla, Loay Kassem, Lamiae Nouiakh, Lamiae Amaadour, Zineb Benbrahim, Samia Arifi, Nawfel Mellas

“…Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). …”
Get full text

Food as a lifestyle by M. V. Mayevskaya, R. M. Mayevsky

“…Obesity has multifactorial adverse effect on human body i.e.: predisposition to diabetes mellitus, cardiovascular diseases, excessive musculoskeletal load, cosmetic defect, etc. …”
Get full text

Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions by Michael Mullin, James McClory, Winston Haynes, Justin Grace, Nathan Robertson, Gino van Heeke

“…Specifically, the utilization of machine learning for structural prediction, lead identification, lead optimization, and humanization of VHH antibodies.…”
Get full text

Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II: Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment by Michael D. Taylor, Harvey J. Clewell, Melvin E. Andersen, Jeffry D. Schroeter, Miyoung Yoon, Athena M. Keene, David C. Dorman

“…., adult, pregnant, lactating, and neonatal rats, nonhuman primates, and adult, pregnant, lactating, and neonatal humans) and relevant risk assessment applications. …”
Get full text

Influence of Self-Compassion, Social Support, and Living Arrangements on Subjective Well-being of the Elderly by Yufi Adriani, Siska Handika

“…The dimensions of self-compassion, namely self-kindness, common humanity, and mindfulness, as well as perceived emotional support, and living with a partner, exhibited a positive association with the variable. …”
Get full text

Efficient One-Pot Synthesis of Novel Caffeic Acid Derivatives as Potential Antimalarials by Katarzyna Sidoryk, Silvia Parapini, Nicoletta Basilico, Magdalena Zaremba-Czogalla, Marek Kubiszewski, Marcin Cybulski, Jerzy Gubernator, Agnieszka Zagórska, Anna Jaromin

“…Their cytotoxicity to normal human dermal fibroblasts and their propensity to induce hemolysis have been also determined. …”
Get full text

The Costs of Managing an Urban Forest by Francisco Escobedo, Jennifer Seitz

“…Urban forests provide benefits to society often referred to as ecosystem services: they improve human health, environmental quality, and local economies by increasing property values and aesthetics in communities. …”
Get full text

The Cultural Science of Consumption: Brains, Networks, and Identities by Herrmann-Pillath Carsten

“…The paper proposes a general theory of consumer behaviour in ‘social network markets’ – where individual choices are determined by the choices of others – by conceptualising such markets as examples of distributed cognition; itself part of an ‘externalist’ perspective on human identity. The paper goes on to consider the issues raised by this move, by working through the implications of a distinction between the ‘object self’ (or evaluating agency) and the ‘acting self’ (or implementing agency), a distinction that is required to account for apparent failures of choice within an individual. …”
Get full text

Serological Survey of Hantavirus in Inhabitants from Tropical and Subtropical Areas of Brazil by Felipe Alves Morais, Alexandre Pereira, Aparecida Santo Pietro Pereira, Marcos Lazaro Moreli, Luís Marcelo Aranha Camargo, Marcello Schiavo Nardi, Cristina Farah Tófoli, Jansen Araujo, Lilia Mara Dutra, Tatiana Lopes Ometto, Renata Hurtado, Fábio Carmona de Jesus Maués, Tiene Zingano Hinke, Sati Jaber Mahmud, Monica Correia Lima, Luiz Tadeu Moraes Figueiredo, Edison Luiz Durigon

“…Using a recombinant nucleocapsid protein of Araraquara virus, we performed ELISA to detect IgG antibodies against hantavirus in human sera. The aim of this study was to analyze hantavirus antibody levels in inhabitants from a tropical area (Amazon region) in Rondônia state and a subtropical (Atlantic Rain Forest) region in São Paulo state, Brazil. …”
Get full text

Deep learning to decode sites of RNA translation in normal and cancerous tissues by Jim Clauwaert, Zahra McVey, Ramneek Gupta, Ian Yannuzzi, Venkatesha Basrur, Alexey I. Nesvizhskii, Gerben Menschaert, John R. Prensner

“…Abstract The biological process of RNA translation is fundamental to cellular life and has wide-ranging implications for human disease. Accurate delineation of RNA translation variation represents a significant challenge due to the complexity of the process and technical limitations. …”
Get full text

National antibiotic consumption is strongly related to the prevalence of antibiotic resistance across bacterial clades by Stilianos Louca

“…Here, I examine the prevalence of 155 antibiotic resistance genes (ARGs) in 300,209 bacterial genomes, from non-clinical non-human-associated terrestrial environments at over 9,600 locations in 44 countries. …”
Get full text

Archéologie participative avec les Wayana dans les Tumuc-Humac (Mont Mitaraka, crique Alama, Guyane Française) by Marie Fleury, Aimawale Opoya, Aitalewa Palanaiwa, Anaima Putpu, Daniel Sabatier, Martijn van den Bel

“…Many archaeological objects were discovered during both missions, suggesting an important ancient human occupation of this particular region. Moreover, the oral history of the Wayana pin-points the genesis of their people in this particular part of the Tumuc Humac Plateau. …”
Get full text

Discovery of novel PRMT1 inhibitors: a combined approach using AI classification model and traditional virtual screening by Jungan Zhang, Yixin Ren, Yixin Ren, Yun Teng, Han Wu, Jingsu Xue, Lulu Chen, Xiaoyue Song, Yan Li, Ying Zhou, Zongran Pang, Zongran Pang, Hao Wang, Hao Wang, Hao Wang

“…Among the PRMT family, PRMT1 is the most abundant and ubiquitously expressed in the human body. Although extensive research has been conducted on PRMT1, the reported inhibitors have not successfully passed clinical trials. …”
Get full text

Complete and Partial Lesions of the Pyramidal Tract in the Rat Affect Qualitative Measures of Skilled Movements: Impairment in Fixations as a Model for Clumsy Behavior by Ian Q. Whishaw, Dionne M. Piecharka, Felicia R. Drever

“…The finding that complete and partial pyramidal tract lesions produce chronic impairment in fixations provides insight for understanding clumsy behavior in humans and its potential remediation via specific training in making fixations.…”
Get full text

Helminth Parasites and the Modulation of Joint Inflammation by Chelsea E. Matisz, Jason J. McDougall, Keith A. Sharkey, Derek M. McKay

“…Helminth parasites are accomplished masters at modifying their hosts' immune activity, and so attention has focused on rodent-helminth model systems to uncover the workings of the mammalian immune response to metazoan parasites, with the hope of revealing molecules and/or mechanisms that can be translated into better treatments for human autoimmune and idiopathic disorders. Substantial proof-of-principal data supporting the concept that infection with helminth parasites can reduce the severity of concomitant disease has been amassed from models of mucosal inflammation. …”
Get full text

VBioindex: A Visual Tool to Estimate Biodiversity by Dong Su Yu, Seung Hwa Yoo

“…As biodiversity is closely related to human welfare and quality of life, many efforts to restore and maintain the biodiversity of species have been made by government agencies and non-governmental organizations, thereby drawing a substantial amount of international attention. …”
Get full text

Basic concepts and curriculum theory in education by Indah Rizki Ramadani, Firman Firman, Riska Ahmad

“…The curriculum functions in shaping and developing cognitive, affective and psychomotor aspects of humans by achieving the vision, mission and goals of national education. …”
Get full text

Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans by Saif Hameed, Zeeshan Fatima

“…Considering the worrying evolution of MDR and significance of C. albicans being the most prevalent human fungal pathogen, this review summarizes these new regulatory mechanisms which could be exploited to prevent MDR development in C. albicans as established from recent studies.…”
Get full text