A Case Report of Monkeypox in a 4-Year-Old Boy from the DR Congo: Challenges of Diagnosis and Management by Anna Korsgaard Eltvedt, Michael Christiansen, Anja Poulsen

“…Furthermore, closer contact between humans and bush animals could play a role along with the ongoing difficulties of controlling HIV in the same geographical area. …”
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Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography by Hannah Glover, Torben Saßmannshausen, Quentin Bertrand, Matilde Trabuco, Chavdar Slavov, Arianna Bacchin, Fabio Andres, Yasushi Kondo, Robin Stipp, Maximilian Wranik, Georgii Khusainov, Melissa Carrillo, Demet Kekilli, Jie Nan, Ana Gonzalez, Robert Cheng, Werner Neidhart, Tobias Weinert, Filip Leonarski, Florian Dworkowski, Michal Kepa, Josef Wachtveitl, Michael Hennig, Joerg Standfuss

“…Abstract G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors in humans. The binding and dissociation of ligands tunes the inherent conformational flexibility of these important drug targets towards distinct functional states. …”
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The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH3COO)Cl2(NH3)2(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier... by Elisabetta Gabano, Ilaria Zanellato, Giulia Pinton, Laura Moro, Mauro Ravera, Domenico Osella

“…The complexes were tested on a panel of human tumor cell lines. Complex 2 showed an anomalous higher cytotoxicity (similar to that of cisplatin) with respect to their analogues 1 and 3. …”
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The World as God’s Property in Psalm 24:1-2 as the Source of Man’s Right Attitude Towards Creation by Janusz Nawrot

“… The ongoing discussion on various forums regarding human responsibility for the ecological state of the surrounding world, should include the voice of the word spoken in the Bible by God, the Creator of heaven and earth. …”
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G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis by Morgan G. Stykel, Shehani V. Siripala, Eric Soubeyrand, Carla L. Coackley, Ping Lu, Suelen Camargo, Sharanya Thevasenan, Gerardo Balderas Figueroa, Raphaella W.L. So, Erica Stuart, Rachi Panchal, Elissavet-Kalliopi Akrioti, Jeffery T. Joseph, Omid Haji-Ghassemi, Era Taoufik, Tariq A. Akhtar, Joel C. Watts, Scott D. Ryan

“…Linking these deficits is critical to restoring DA signaling in PD. Using murine and human pluripotent stem cell (hPSC) models of PD coupled with human postmortem tissue, we show that accumulation of α-syn micro-aggregates impairs metabolic flux through the pentose phosphate pathway (PPP). …”
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The Pathophysiological Impact of HLA Class Ia and HLA-G Expression and Regulatory T Cells in Malignant Melanoma: A Review by Lasse Lindholm Johansen, Jørgen Lock-Andersen, Thomas Vauvert F. Hviid

“…Although there is still no standardized immunological treatment worldwide, the interaction between the human leucocyte antigen (HLA) system and tumor progression seems to be a promising focus in the way of optimizing the treatment of malignant melanoma.…”
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De la bibliothèque au « Tesseract » : une représentation borgésienne de la littérature dans le film de Christopher Nolan Interstellar (2014)  by Emmanuel Buzay

“…Because it is decisive for understanding the way in which the library, as a memory of the world, rethinks humanity, its mutations, and its limits in a journey through time, the constant represented by the figure of the “book in the film” reveals a double identity which, although based on scientific knowledge, nonetheless reactivates an immemorial imaginary with its mythologies. …”
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Insulin resistance compromises midbrain organoid neuronal activity and metabolic efficiency predisposing to Parkinson’s disease pathology by Alise Zagare, Janis Kurlovics, Catarina Almeida, Daniele Ferrante, Daniela Frangenberg, Armelle Vitali, Gemma Gomez-Giro, Christian Jäger, Paul Antony, Rashi Halder, Rejko Krüger, Enrico Glaab, Egils Stalidzans, Giuseppe Arena, Jens C Schwamborn

“…To investigate insulin resistance caused pathological changes in the human midbrain, which could predispose a healthy midbrain to PD development, we exposed iPSC-derived human midbrain organoids from healthy individuals to either high insulin concentration, promoting insulin resistance, or to more physiological insulin concentration restoring insulin signalling function. …”
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From Abnormal Hippocampal Synaptic Plasticity in Down Syndrome Mouse Models to Cognitive Disability in Down Syndrome by Nathan Cramer, Zygmunt Galdzicki

“…Down syndrome (DS) is caused by the overexpression of genes on triplicated regions of human chromosome 21 (Hsa21). While the resulting physiological and behavioral phenotypes vary in their penetrance and severity, all individuals with DS have variable but significant levels of cognitive disability. …”
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Managing the economic development of the country on the principles of ESG and digitalisation by M. S. Mokiy

“…The application of the system-transdisciplinary concept allows us to interpret economic relations as a fragment of humanity’s relations with nature. Economic relations arose as a systemic necessity for the existence and development of mankind. …”
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Interaction Design of Educational App Based on Collaborative Filtering Recommendation by Ying Xu, Tse-Kian Neo, Hin Hew Soon

“…Due to the operational characteristics of gesture interaction in the interface of a smart terminal application (app), this mode of human-computer interaction has become the mainstream mode of human-computer interaction. …”
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The Analysis of Legislative Criminal Policy of Iran, Iraq, and United Arab Emirates in Soil Conservation (Comparative Study) by ruhollah akrami, ali nabi

“…First, damages to the soil and then Positive Law and the taken criminal policy in each field have been investigated to clarify government’s approaches to the environment in general and to the soil in particular, considering that the center of attention of criminal policy is environmental protection as a fundamental value or it is dependent on human and his interest. Recognizing these components substantively and the responsibility of the criminal policy of these three countries to the criminal phenomenon (including crime and deviation) in terms of form specify their criminal policy position in the categorization of big criminal policy systems; finally, this study showed that human-oriented approach to environment has overcome ecological protection balance and considering cognitive model, the criminal policy of all three countries is near to liberal government-society in the field of soil conservation.…”
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Politiets brug af peberspray by Diverse: Garly Andersen & Vedel Kessing

“…Pepper spray contains pepper extract and has been assessed as capable of causing serious health risks by the Danish Health Authority. International human rights bodies have also expressed concerns about the use of pepper spray. …”
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An antibody cocktail targeting two different CD73 epitopes enhances enzyme inhibition and tumor control by Jin-Gen Xu, Shi Chen, Yang He, Xi Zhu, Yanting Wang, Zhifeng Ye, Jin Chuan Zhou, Xuanhui Wu, Lei Zhang, Xiaochen Ren, Huifeng Jia, Haijia Yu, Xiaoyue Wei, Yujie Feng, Xiaofang Chen, Xiaopei Cui, Xianfei Pan, Shaojie Wang, Simin Xia, Hongjie Shang, Yueqing Pu, Wei Xu, Haidong Li, Qian Chen, Zeyu Chen, Manfu Wang, Xiaodong Yan, Hui Shi, Mingwei Li, Yisui Xia, Roberto Bellelli, Shunli Dong, Jun He, Jun Huang, Chen-Leng Cai, Xiangyang Zhu, Yifan Zhan, Li Wan

“…In this study, we have developed a therapeutic anti-human CD73 antibody cocktail, HB0045. HB0045 is a 1:1 mixture of two humanized monoclonal IgG1 antibodies (mAbs), HB0038 and HB0039. …”
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The transcriptional and translational landscape of HCoV-OC43 infection. by Stefan Bresson, Emanuela Sani, Alicja Armatowska, Charles Dixon, David Tollervey

“…The coronavirus HCoV-OC43 circulates continuously in the human population and is a frequent cause of the common cold. …”
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Scientific and Societal Considerations in Selecting Assessment Endpoints for Environmental Decision Making by Elizabeth M. Strange, Joshua Lipton, Douglas Beltman, Blaine D. Snyder

“…It is sometimes argued that, from an ecological point of view, population-, community-, and ecosystem-level endpoints are more relevant than individual-level endpoints for assessing the risks posed by human activities to the sustainability of natural resources. …”
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Transglutaminase 2 Induces Deficits in Social Behavior in Mice by Amanda Crider, Talisha Davis, Anthony O. Ahmed, Lin Mei, Anilkumar Pillai

“…These findings in mice and human postmortem brain samples identify changes in TG2 activity in the possible dysregulation of social behavior.…”
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MUHAMMADIYAH EDUCATION'S READINESS IN THE SOCIETY 5.0 ERA by Rahmad Sugianto, Rani Darmayanti, M. Nurul Humaidi

“…In this spirit, Muhammadiyah intellectuals challenge and construe society 5.0 based on human-centered. Muhammadiyah education in this era tries to improve educational facilities for digital-based learning in Muhammadiyah schools or madrasas; able to improve teacher human resources to innovate in digital-based learning both online and offline; able to apply humanist learning with the main characteristics of respecting the opinions of others, respecting, and communicating correctly.…”
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Ammonia and hydrogen sulfide - new insights into gut microbiota and male infertility through meta-analysis by Yanan Hao, Yanan Hao, Yanan Hao, Xin Du, Chang Cai, Yong Zhao, Yonglin Ren

“…BackgroundAmmonia (NH3) and hydrogen sulfide (H2S) are produced during digestion in the human gut, yet the impact of these internally generated gases on male reproduction have received limited attention in scientific research.MethodsWe systematically reviewed 935 scientific publications, spanning from 1947 to 2023, focusing on external or internal NH3 and/or H2S, male infertility, and gut microbiota. …”
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The transformative role of the media in the formation of virtuous citizens: A contribution to reconciliation in a post-apartheid South Africa by E. Baron

“…Abundant evidence suggests that, during those years, the print media served as instruments for propaganda, for the apartheid regime, while the Argus group, for instance, exposed the atrocities and human rights violations of the same regime. However, 24 years into democracy, what is the role of the media in a post-apartheid South Africa, where citizens still suffer from the ghosts of apartheid, the continued human rights violations, racial discrimination, and related issues that make it seem as if South Africa is “irreconcilable”? …”
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