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621
A Comparative Study between outcome of 25% glucose in glycerin and submucosal human placental extract injection in the management of Primary Atrophic Rhinitis
Published 2025-02-01Subjects: “…Keywords: Atrophic rhinitis, submucosal human placental extract, glucose in glycerin nasal drop.…”
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622
Anticancer effects of PEP06 (TB01) in combination with Trifluridine/Tipiracil (TAS-102) in a xenograft model of human colorectal cancer
Published 2024-12-01“…Methods This study utilized the human CRC HCT-116 xenograft nude mouse model to evaluate the antitumor effects of TAS-102 and TB01, both as mono-therapies and in combination therapies. …”
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Safety and efficacy of edoxaban monotherapy after bioabsorbable polymer everolimus-eluting stent implantation in a human-like coronary atherosclerotic porcine model
Published 2025-03-01“…Methods: We evaluated the safety and efficacy of edoxaban monotherapy in the LDL-R−/− pig model with human-like unstable coronary plaques induced by a high-cholesterol, high-fat diet. …”
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Coronil effectively inhibits the interaction of clinically relevant Omicron mutants of SARS-CoV-2 spike proteins with human ACE2 receptor
Published 2025-02-01“…Background: Accumulating evidence suggests that the receptor binding domain (RBD) of the SARS-CoV-2 Omicron variant has several times more binding affinity to the human angiotensin-converting enzyme 2 (ACE2) receptor compared to the RBD of the original Covid-19 strain. …”
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631
Growth factors IGF-1 and KGF and adipose-derived stem cells promote migration and viability of primary human keratinocytes in an in vitro wound model
Published 2025-02-01“…For optimum translation into the clinical setting, primary human keratinocytes and patient-matched ADSCs were isolated and used in an in vitro wound model.ResultsThe keratinocyte migration and viability increased after treatment with the growth factors insulin-like growth factor 1 (IGF-1) and keratinocyte growth factor (KGF). …”
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The human‐specific noncoding RNA RP11‐424G14.1 functions at the intersection of sexually dimorphic pathways in inflammation, senescence, and metabolism
Published 2025-02-01“…Abstract Sexual dimorphism is a fundamental characteristic of various physiological and pathological processes in humans, including immune responses, senescence, and metabolism. …”
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635
Validated HPLC method for simultaneous determination of azelastine hydrochloride fluticasone propionate and oxymetazoline in nasal mucosa and nasopharyngeal swabs from real human samples
Published 2025-02-01“…We established an efficient methodology for the determination of those analytes in spiked nasal mucosa and nasopharyngeal swabs from real human samples. A simple and quick protein precipitation method was used for sample extraction, using acetonitrile. …”
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Addressing the limitations of the regulatory landscape in South Africa regarding advanced cell and gene therapies and related sectors involving human cells, tissues and organs
Published 2025-02-01“…However, South Africa (SA)’s regulatory frameworks for medicines, human biological materials and genetically modified organisms have not kept pace with scientific and technological developments, leaving regulatory gaps. …”
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Weight loss-independent changes in human growth hormone during water-only fasting: a secondary evaluation of a randomized controlled trial
Published 2025-02-01“…IntroductionWater-only fasting for one day or more may provide health benefits independent of weight loss. Human growth hormone (HGH) may play a key role in multiple fasting-triggered mechanisms. …”
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Antioxidant activity of Micractinium sp. (Chlorophyta) extracts against H2O2 induced oxidative stress in human breast adenocarcinoma cells
Published 2024-11-01“…Moreover, extracts from Micractinium sp. exhibited remarkable cytoprotective activity by effectively inhibiting hydrogen peroxide-induced oxidative stress and cell death in human breast adenocarcinoma (MCF-7) cells. In conclusion, with its diverse biochemical composition and adaptability to different growth regimens, Micractinium sp. emerges as a robust candidate for mass cultivation in nutraceutical and food applications.…”
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Evaluating the toxicity of sea-dumped conventional and chemical munition degradation products to fish and human cells using a combination of cell viability assays
Published 2025-02-01“…The research examines three CWA&RC (1,4-oxathiane, 1,4-dithiane, thiodiglycol) and four E&RC (2,4,6-trinitrotoluene, tetryl, 1,3-dinitrobenzene, picric acid) using the RTgill-W1 cell line (rainbow trout gill cells) as a proxy for fish toxicity and human cell lines (Caco2 and HepG2) to model potential human exposure via contaminated seafood. …”
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