Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system by Sarah Hollingshead, Gareth McVicker, Maria R. Nielsen, YuGeng Zhang, Giulia Pilla, Rebekah A. Jones, Jonathan C. Thomas, Sarah E. H. Johansen, Rachel M. Exley, Ditlev E. Brodersen, Christoph M. Tang

“…Our findings highlight the links between plasmid maintenance and antibiotic tolerance, both of which can promote the development of antimicrobial resistance.IMPORTANCEOur work addresses two processes, the maintenance of plasmids and antibiotic tolerance; both contribute to the development of antimicrobial resistance in bacteria that cause human disease. Here, we found a single nucleotide change in the vapBC toxin:antitoxin system that stabilizes the large virulence plasmid of Shigella sonnei. …”
Get full text

Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils by Yixiang Jiang, Ning Wang, Jingyi Liu, Haoran Ren, Wenkang Jiang, Yanting Lei, Xidan Fu, Miao Hao, Xiujuan Lang, Yumei Liu, Xijun Liu, Rui Li, Hulun Li

“…Methods Secretory supernatants (hMSC-L) and cell lysate products (hMSC-M) from primary human umbilical cord mesenchymal stem cells-cultured medium were administered intranasally to mice with cerebral ischemia. …”
Get full text

Pre-exposure Prophylaxis Awareness and Endorsement among Adolescents and Young Adults in Tanzania: Insights from the 2022 Demographic and Health Survey by Alpha Johnson Kapola, Rahma Musoke, Glenda Marie Manayon, Hassan Fredrick Fussi, Hafidha Mhando Bakari, Haji Mbwana Ally, Swalehe Mustafa Salim, Zuhura Mbwana Ally, Lynn Moshi, Mariam Salim Mbwana, Habib Omari Ramadhani

“…Background: Pre-exposure prophylaxis (PrEP) is an effective measure for preventing human immunodeficiency virus (HIV) infection among people at risk, including adolescents and young adults (AYA). …”
Get full text

Seasonal Trends, Profiles, and Exposure Risk of PM2.5-bound Bisphenol Analogs in Ambient Outdoor Air: A Study in Shanghai, China by Janvier Munyaneza, Fahim A. Qaraah, Qilong Jia, Hanting Cheng, Huajun Zhen, Guangli Xiu

“…The particle can lodge deep in the lungs and bronchi of humans, causing diverse cardiovascular and respiratory diseases. …”
Get full text

Characteristics and real-world medication persistence of people living with HIV treated with DTG/3TC or BIC/FTC/TAF: a hospital claims database study in Japan by Rie Kanamori, Nozomi Aoki, Akio Kanazawa, Mayumi Yuda, Nao Makino, Emi Ohata, Nobuyuki Fukui, Hirotake Mori, Hirohide Yokokawa, Toshio Naito

“…BackgroundAs the life expectancy of people living with human immunodeficiency virus (HIV) (PLWH) has improved, chronic disease burden and polypharmacy have increased in PLWH. …”
Get full text

Identifikasi Gagal Ginjal Kronis dengan Mengimplementasikan Metode Support Vector Machine beserta K-Nearest Neighbour (SVM-KNN) by Alvin Tarisa Akbar, Novanto Yudistira, Achmad Ridok

“…Abstract Kidneys are a vital part for humans because they function to filter or clean the fluids we ingest so that they can be consumed safely. …”
Get full text

Ten simple rules for working with high resolution remote sensing data by Mahood, Adam L., Joseph, Maxwell B., Spiers, Anna I., Koontz, Michael J., Ilangakoon, Nayani, Solvik, Kylen K., Quarderer, Nathan, McGlinchy, Joe, Scholl, Victoria M., St. Denis, Lise A., Nagy, Chelsea, Braswell, Anna, Rossi, Matthew W., Herwehe, Lauren, Wasser, Leah, Cattau, Megan E., Iglesias, Virginia, Yao, Fangfang, Leyk, Stefan, Balch, Jennifer K.

Get full text

Rancang Bangun Purwarupa Pemilah Sampah Pintar Berbasis Deep Learning by Kahlil Muchtar, Nyak Twoman Anshari, Chairuman Chairuman, Khalid Alhabibie, Khairul Munadi

“…The algorithm is like human nerves and is one of supervised learning. In addition, this research use the Raspberry Pi as a microcontroller, the Raspberry Pi camera module which is used to take pictures, and the Intel Movidius Neural Compute Stick (NCS) to speed up the computing process so that the identification process is easier. …”
Get full text

The mutational landscape of ARMC5 in Primary Bilateral Macronodular Adrenal Hyperplasia: an update by Lucas Bouys, Anna Vaczlavik, Isadora P. Cavalcante, Florian Violon, Anne Jouinot, Annabel Berthon, Patricia Vaduva, Stéphanie Espiard, Karine Perlemoine, Peter Kamenicky, Marie-Christine Vantyghem, Antoine Tabarin, Gérald Raverot, Cristina L. Ronchi, Ulrich Dischinger, Martin Reincke, Maria C. Fragoso, Constantine A. Stratakis, Albain Chansavang, Eric Pasmant, Bruno Ragazzon, Jérôme Bertherat, for the COMETE and ENSAT Networks

Get full text

Analisis Faktor dan Metode untuk Menentukan Tipe Kulit Wajah: Tinjauan Literatur by Shinta Dewi Kusumaningrum, Izzati Muhimmah

“…Abstract Skin is the outer protective part that covers most of the human body. Facial skin is the most sensitive part of the skin hence it is more prone to problems than other parts. …”
Get full text

Knowledge Sharing antara Tenaga Pendidik Perguruan Tinggi Keagamaan Islam (PTKI) by Khairan AR, Nazaruddin Ahmad

“…However, integration has many dimensions to study, especially those related to the readiness of human resources in tertiary institutions that have a process and are willing to share their knowledge, to support the achievement of the scientific integration process at PTKI. …”
Get full text

An optimized approach for predicting water quality features and a performance evaluation for mapping surface water potential zones based on Discriminant Analysis (DA), Geographical... by Abhijeet Das

“…Globally, ecosystems, and human health are in danger because river water quality is deteriorating. …”
Get full text

Risk Management in Sustainable Construction Projects: A Systematic Review and Bibliometric Analysis by Kasra Hosseini, Youness Javid

“…The content analysis of the articles, based on research themes, indicated that the articles were classified into five main themes: general risks of sustainability, sustainable procurement, supply chain, technology adoption, and human resources. A deeper exploration of the papers revealed that SCPs' risks were primarily categorized into eight dimensions: financial and economic; social; executive, managerial, and organizational; knowledge and skills; governmental and legal; stakeholders/employers; environmental; and technology, equipment, and resources. …”
Get full text

Iron triggers TvPI4P5K proteostasis and Arf-mediated cell membrane trafficking to regulate PIP2 signaling crucial for multiple pathogenic activities of the parasitic protozoan Tric... by Kuan-Yi Wu, Yen-Ju Chen, Shu-Fan Lin, Hong-Ming Hsu

“…Beyond cytoadherence, during host-parasite interactions, TvArf220 influenced both contact-dependent and -independent cytotoxicity, as well as phagocytotic capacity, contributing to the cytopathogenesis of human vaginal epithelial cells. Our findings underscore the key upstream regulation mechanisms of the PIP2 signaling, orchestrating the interplay between TvArf220-PIP2-calcium signaling and downstream actin cytoskeleton-driven pathogenicity in T. vaginalis.IMPORTANCETrichomonas vaginalis actin cytoskeleton-centric pathogenicity is regulated by the phosphatidylinositol 4,5-bisphosphates (PIP2)-triggered calcium signaling cascade in response to environmental iron, though the detailed mechanism by which iron modulates PIP2 signaling remains unclear. …”
Get full text

TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles by Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Konstantina Psatha, Dimitris Kletsas, Michalis Aivaliotis, Carl-Henrik Heldin, Aristidis Moustakas

“…Results We report that TGF-β, by activating its type I receptor and MEK-ERK1/2 signaling, increased the numbers of EVs released by human cancer cells. Upon examining cholesterol as a mediator of EV biogenesis, we delineated a pathway whereby ERK1/2 acted by phosphorylating sterol regulatory element-binding protein-2 that transcriptionally induced 7-dehydrocholesterol reductase expression, thus raising cholesterol abundance at both cellular and EV levels. …”
Get full text

Klasifikasi Kelas Kata (Part-Of-Speech Tagging) untuk Bahasa Madura Menggunakan Algoritme Viterbi by Ilham Firmansyah, Putra Pandu Adikara, Sigit Adinugroho

“…Abstract Natural language is a form of language used by human, either in writing or speaking form. There is a specific field in computer science that processes natural language, which is called Natural Language Processing. …”
Get full text

Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance by Irena Josephina Johanna Muffels, Hans R. Waterham, Giuseppina D’Alessandro, Guido Zagnoli-Vieira, Michael Sacher, Dirk J. Lefeber, Celine Van der Vinne, Chaim M. Roifman, Koen L. I. Gassen, Holger Rehmann, Desiree Y. Van Haaften-Visser, Edward S. S. Nieuwenhuis, Stephen P. Jackson, Sabine A. Fuchs, Femke Wijk, Peter van Hasselt

Get full text

AI prediction model for endovascular treatment of vertebrobasilar occlusion with atrial fibrillation by Zhi-Xin Huang, Andrea M. Alexandre, Alessandro Pedicelli, Xuying He, Quanlong Hong, Yongkun Li, Ping Chen, Qiankun Cai, Aldobrando Broccolini, Luca Scarcia, Serena Abruzzese, Carlo Cirelli, Mauro Bergui, Andrea Romi, Erwah Kalsoum, Giulia Frauenfelder, Grzegorz Meder, Simona Scalise, Maria Porzia Ganimede, Luigi Bellini, Bruno Del Sette, Francesco Arba, Susanna Sammali, Andrea Salcuni, Sergio Lucio Vinci, Giacomo Cester, Luisa Roveri, Xianjun Huang, Wen Sun

Get full text

Call for Papers - Advancing Astropharmacy and Sports Pharmacy by Ashley Anderson, Ahmer Raza, Shireen Aziz, Misbah Noreen

“…Her research interest are on pharmacokinetic and pharmacodynamic (PKPD) changes in space, drug stability under space conditions, and the effects of the space environment on human physiopharmacology. In addition to her clinical pharmacy research, Shireen is actively working on advancing the concept of Astropharmacy, exploring innovative pharmaceutical solutions for long-duration space missions and extraterrestrial environments. …”
Get full text

Menciptakan Layanan Pengawasan Ketenagakerjaan secara Profesional, Moderm dan Bermartabat Berbasis Teknologi Digital by Yeni Nuraeni, Nurlia Rahmatika, Firdausi Nuzula, Faizal Amir Nasution

“…Diperlukan regulasi yang kuat dalam pengaturan koordinasi antar instansi terkait dalam penyediaan data serta pengembangan TIK dibidang pengawasan ketenagakerjaan. Abstract The limited human resources of labor inspection and the geographical condition of Indonesia, which is an archipelago, are the main reasons for the importance of using digital technology in the implementation of labor inspection. …”
Get full text