Trial protocol of an open-label pilot study of oral naltrexone–bupropion combination pharmacotherapy for the treatment of methamphetamine use disorder (the NABU trial) by Jonathan Brett, Paul S Haber, Nicholas Lintzeris, Didier Jutras-Aswad, Nadine Ezard, Brendan Clifford, Krista J Siefried, Adrian John Dunlop, Liam Acheson, Carl Moller, Michael Christmass, Kirsten Morley, Steven Shoptaw, Madhukar H Trivedi

“…Qualitative interviews will assess the acceptability of the intervention and outcome measures.Ethics and dissemination This study received ethics approval from the St Vincent’s Hospital Human Research Ethics Committee (2023/ETH00549). …”
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Electrochemical properties of hydroxyapatite immobilization material for potential cytosensor fabrication by Dennis Adusei, Bernard O. Asimeng, Francis D. Krampa, Elvis K. Tiburu

“…The SHAp/PEDOT: PSS blend was used to modify a screen-printed carbon electrode (SPCE) by drop-casting, followed by seeding of pheochromocytoma (PC 12) and human embryonic kidney (HEK)-293T cells on the modified SPCE to record the EP using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). …”
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Multi-dimensional evidence from the UK Biobank shows the impact of diet and macronutrient intake on aging by Chen Zhu, Youfa Wang, Xiaosong Yang, Qiran Zhao, Wenyan Xu, Xiaolu Wang, Yanjun Liang, Qihui Chen, Shenggen Fan

“…Abstract Background The role of diet in aging is crucial, yet research findings on how specific diets influence human aging remain inconsistent. Understanding the relationship between dietary factors and aging could inform interventions to promote healthier aging outcomes. …”
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Enhancing feature selection for multi-pose facial expression recognition using a hybrid of quantum inspired firefly algorithm and artificial bee colony algorithm by Mu Panliang, Sanjay Madaan, Siddiq Ahmed Babikir Ali, Gowrishankar J., Ali Khatibi, Anas Ratib Alsoud, Vikas Mittal, Lalit Kumar, A. Johnson Santhosh

“…Abstract Facial expression recognition (FER) has advanced applications in various disciplines, including computer vision, Internet of Things, and artificial intelligence, supporting diverse domains such as medical escort services, learning analysis, fatigue detection, and human-computer interaction. The accuracy of these systems is of utmost concern and depends on effective feature selection, which directly impacts their ability to accurately detect facial expressions across various poses. …”
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Tumor characteristics and survival rate of axillary metastatic breast cancer patients: a three decades retrospective cohort study by Seyed Mohamad Sadegh Mousavi-kiasary, Mahdis Bayat, Fereshteh Abbasvandi, Batoul Khoundabi, Fatemeh Mousavi, Atieh Akbari, Maryam Bagherian, Afsoon Zandi, Behnam Honarvar, Mohammad Esmaeil Akbari

“…Moreover, estrogen and progesterone receptors, human epidermal growth factor2, tumor pathology type and tumor grade were prognostic factors of axillary LN status. …”
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Phytomedicinal armamentarium: A review of inula racemosa-derived alantolactones and isoalantolactones in anticancer therapy by Joshi Gaurav Santoshrao, Smriti Jamwal, Rakesh Kumar, Ekta Bisht, Bisen Harsh Krishnakumar, Shreya Katoch, R.K. Asrani

“…Future studies should focus on clinical trials to establish their efficacy and safety in humans, paving the way for new cancer therapies.…”
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Design of an Improved Method for Visual Rendering in the Metaverse Using CIEM and MSRANet by Janapati Venkata Krishna, Priyanka Singh, Regonda Nagaraju, Setti Vidya Sagar Appaji, Attuluri Uday Kiran, K. Spandana

“…Finally, BEER, standing for Bioinspired Energy-Efficient Rendering, borrows from the energy-efficient way of visual processing in the human brain through a spiking neural network that reduces energy consumption by 35% without image quality degradation. …”
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Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology by Arthur D. Stem, Cole R. Michel, Peter S. Harris, Keegan L. Rogers, Matthew Gibb, Carlos A. Roncal-Jimenez, Richard Reisdorph, Richard J. Johnson, James R. Roede, Kristofer S. Fritz, Jared M. Brown

“…Methods In order to characterize the impact of sugarcane ash derived (SAD) SiNPs on human kidney proximal convoluted tubule (PCT) cells and identify potential mechanisms of toxicity, HK-2 cells were exposed to treatments of either pristine, manufactured, 200 nm SiNPs or SAD SiNPs and changes to cellular energy metabolism and redox state were determined. …”
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Unaccountable counting: the folly of incorporating open ocean carbon sinks in Nationally Determined Contributions by Berger, Manon, Comte, Adrien, Kwiatkowski, Lester, Bopp, Laurent

“…However, it should be noted that this anthropogenic carbon uptake results from the physical and biogeochemical properties of water masses, rather than from human management practices. Additionally, the EEZ oceanic carbon sink is already considered in estimates of remaining carbon budgets to meet the goals of the Paris Agreement. …”
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An optimized deep-forest algorithm using a modified differential evolution optimization algorithm: A case of host-pathogen protein-protein interaction prediction by Jerry Emmanuel, Itunuoluwa Isewon, Jelili Oyelade

“…The performance of the optimized deep forest model was evaluated on human-Plasmodium falciparum protein sequence datasets using 10-fold cross-validation. …”
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Exploring the role of spiritual leadership among nurse colleagues: an associative analysis of its impact on passion and altruism by Huda Gaber Hamzaa, Mohamed Hussein Ramadan Atta, Heba Mostafa Ali Taha, Mervat Amin Sayed, Asmaa Kamal Ahmed, Ahmed Abdellah Othman, Nadia Mohamed Ibrahim Wahba

“…Abstract Background Spiritual leadership emphasizes that nurses encounter situations that require compassion, empathy, and a deep understanding of the human experience. Passion can drive nurses' motivation, engagement, and commitment to patient care. …”
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Letter and Person Recognition in Freeform Air-Writing Using Machine Learning Algorithms by Huseyin Kunt, Zeki Yetgin, Furkan Gozukara, Turgay Celik

“…Air-writing is an emerging form of human-computer interaction that enables text entry through hand movements in the air. …”
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Quantitative evaluation of essential amino acids and omega-3 long-chain polyunsaturated fatty acids from global marine bivalve aquaculture by Karsoon Tan, Peng Xu, Leiheng Huang, Cong Luo, KhaiHang Choong, Zexin Li, Yu Guo, Kit-Leong Cheong

“…The rapid growth of the human population and urbanization has significantly increased the demand for animal proteins. …”
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Exposure to high-temperature and high-humidity environments associated with cardiovascular mortality by Yalan Wu, Xiangrong Feng, Jinmei Li, Mengjun Li, Yao Wang, Weihui Lu, Huanhuan Luo

“…These findings suggest that exacerbated dyslipidemia caused by long-term HTH environment exposure may be a key risk factor for CVD-related mortality in middle-aged and elderly individuals and suggest research directions into the effects of HTH environments on human health.…”
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Yiqi Fumai Lyophilized injection protects cardiac contractility in a rat model of heart failure with reduced ejection fraction by modulating SERCA2 by Yongwei Nie, Lu Chen, Yanxin Zhang, Yuqing Yao, Zizhuo Xue, Na Guo, Meixiu Wan, Zhi Li, Chunhua Liu, Dekun Li, Aichun Ju

“…Background: Yiqi Fumai Lyophilized Injection (YQFM) is a plant-derived preparation that shows protective effects against cardiac dysfunction in both human and animal models. In heart failure (HF), proteins involved in Ca2+ regulation, such as sarcoplasmic/endoplasmic reticulum Ca2+ transporting protein 2 (SERCA2) and cardiac ryanodine receptor 2 (RyR2), are dysfunctional. …”
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Physiological and behavioural resistance of malaria vectors in rural West-Africa: a data mining study to address their fine-scale spatiotemporal heterogeneity, drivers, and predict... by Taconet, Paul, Soma, Dieudonné Diloma, Zogo, Barnabas, Mouline, Karine, Simard, Frédéric, Koffi, Alphonsine Amanan, Dabiré, Roch Kounbobr, Pennetier, Cédric, Moiroux, Nicolas

“…The explanatory variables covered a wide range of potential environmental determinants of vector resistance to insecticide or behavioural resistance phenotypes: vector control, human availability and nocturnal behaviour, macro and micro-climatic conditions, landscape, etc. …”
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Longitudinal Survey of Astrovirus infection in different bat species in Zimbabwe: Evidence of high genetic Astrovirus diversity by Chidoti, Vimbiso, De Nys, Hélène, Abdi, Malika, Mashura, Getrude, Pinarello, Valérie, Chiweshe, Ngoni, Matope, Gift, Guerrini, Laure, Pfukenyi, Davies, Cappelle, Julien, Mwandiringana, Ellen, Missé, Dorothée, Gori, Elizabeth, Bourgarel, Mathieu, Liégeois, Florian

“…One group was comprised of sequences isolated from Hipposideros, Rhinolophus and Eidolon helvum spp. clustered with Human Astrovirus strains: HuAstV types1-6, HuAstV-MLB1-3 and HuAstV-VA-1. …”
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Understanding Cognition, Oxytocin, and Pain in Elders (UCOPE): protocol for a double-blinded cross-over trial in chronic knee osteoarthritis pain by Yenisel Cruz-Almeida, Soamy Montesino-Goicolea, Pedro Valdes-Hernandez, Zhiguang Huo, Roland Staud, Natalie C. Ebner

“…A promising treatment is the neuropeptide oxytocin (OT), which has been shown to play a role in endogenous analgesia with human and animal studies demonstrating anti-nociceptive effects. …”
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Disentangling the effects of eutrophication and natural variability on macrobenthic communities across French coastal lagoons by Jones, Auriane G., Schaal, Gauthier, Boyé, Aurélien, Creemers, Marie, Derolez, Valérie, Desroy, Nicolas, Fiandrino, Annie, Mouton, Théophile L., Simier, Monique, Smith, Niamh, Ouisse, Vincent

“…Owing to their position at the interface between land and sea, they are also subject to increasing human impacts, which alter their ecological functioning. …”
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Newer Generation of Scooters: Polychlorinated Dibenzo-p-dioxin and Dibenzofuran and Polychlorinated Biphenyl Reductions by Hung-Hong Chen, Yun-Hwei Shen, Hsi-Hsien Yang, Jau-Huai Lu, Lin-Chi Wang, Yen-Kung Hsieh, Chia-Fon Lee, Sheng-Lun Lin

“…Abstract Scooter emissions have attracted attention in recent years because of human exposure to their direct effects in urban areas. …”
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