An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors by Russell J. Schilder, Drew Rasco, Manish R. Sharma

“…Tyrosine kinase inhibitors (TKIs) targeting ALK have improved disease outcomes, but resistance mechanisms are common. This first-in-human trial evaluates ESK-440, a dual inhibitor of ALK and focal adhesion kinase, as a novel strategy for cancers with resistance to ALK-targeting TKIs. …”
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Host-symbiont-gene phylogenetic reconciliation by Menet, Hugo, Trung, Alexia Nguyen, Daubin, Vincent, Tannier, Eric

“…We finally evaluate different hypotheses on human population histories in the light of their coevolving Helicobacter pylori symbionts, reconciled together with their genes. …”
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Enterococcus and Eggerthella species are enriched in the gut microbiomes of COVID-19 cases in Uganda by Carolina Agudelo, David Patrick Kateete, Emmanuel Nasinghe, Rogers Kamulegeya, Christopher Lubega, Monica Mbabazi, Noah Baker, Kathryn Y. Lin, Chang C. Liu, Arthur Shem Kasambula, Edgar Kigozi, Kevin Komakech, John Mukisa, Kassim Mulumba, Patricia Mwachan, Brenda Sharon Nakalanda, Gloria Patricia Nalubega, Julius Nsubuga, Diana Sitenda, Henry Ssenfuka, Giana T. Cirolia, Jeshua T. Gustafson, Ruohong Wang, Moses Luutu Nsubuga, Fahim Yiga, Sarah A. Stanley, Bernard Ssentalo Bagaya, Alison Elliott, Moses Joloba, Ashley R. Wolf

“…Abstract Background Infection with the COVID-19-causing pathogen SARS-CoV-2 is associated with disruption in the human gut microbiome. The gut microbiome enables protection against diverse pathogens and exhibits dysbiosis during infectious and autoimmune disease. …”
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Cetacean feeding modelling using machine learning: A case study of the Central-Eastern Mediterranean Sea by Carla Cherubini, Giulia Cipriano, Leonardo Saccotelli, Giovanni Dimauro, Giovanni Coppini, Roberto Carlucci, Carmelo Fanizza, Rosalia Maglietta

“…Investigating environmental drivers of cetacean feeding behaviour is essential for effective marine resource management, especially in the Mediterranean Sea, a biodiversity hotspot heavily impacted by human activities and climate change. This study realized a pioneer assessment of feeding activity related to the marine environment for three cetacean species - striped dolphin, common bottlenose dolphin, and Risso's dolphin - in the Gulf of Taranto (Northern Ionian Sea, Central-eastern Mediterranean) using an innovative Machine Learning (ML) approach. …”
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Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy by Diana Peixoto, João M. Ravasco, Barbara Blanco-Fernandez, Francisco Veiga, Angel Concheiro, João Conde, Ana Cláudia Paiva-Santos, Carmen Alvarez-Lorenzo

“…PTX-loaded VD3 micelles also exhibited prominent cell internalization and induced a considerable cytotoxic synergistic effect against human PDAC cells (BxPC-3 cells) in 2D and 3D cell culture models compared with free PTX. …”
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HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO) by Aijaz Zeeshan Khan, Omer Sabir, Adnan Hussain Shahid, Muhammad Bilal Basit, Syeda Arzinda Fatima Shah, Qamar Sajad

“… Background: Dengue Fever, also known as break-bone fever, is a viral illness and transmitted to humans by bites of infected Aedes aegypti and Aedes albopictus mosquitoes. …”
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Association between sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis by Kasra Pirahesh, Ali Zarrinnia, Leila Nikniaz, Zeinab Nikniaz

“…Observational studies were included if they assess the association between sleep duration and NAFLD or compare the mean sleep duration between patients with NAFLD and healthy population. All studies done in humans without restriction on sex, age, and language were included. …”
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Health and Educational Inequalities among the Third Gender Community in Lahore, Pakistan by Ayesha Humayun, Muhammad Hassan, Hira Ashfaq, Zulqarnain Haider, Nauman Naeem, Mubashar Munir

“…Conclusion: The third gender community faces significant barriers in accessing education and healthcare, depriving them of basic human rights. Urgent policy reforms promoting equity, inclusivity, and community sensitization are needed to end their social neglect. …”
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Mediterranean diet improves liver health but does not protect against azoxymethane-induced colon tumorigenesis compared to Western diet in A/J mice by Weimin Guo, Nicholas Crossland, Jimmy W. Crott

“…Conclusion: In this study male mice displayed elevated sensitivity to AOM-induced hepatotoxicity and mortality than females. In agreement with human and preclinical data, livers of MED-diet-fed mice were healthier than those fed WRN diets. …”
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A global Corynebacterium diphtheriae genomic framework sheds light on current diphtheria reemergence by Hennart, Mélanie, Crestani, Chiara, Bridel, Sébastien, Armatys, Nathalie, Brémont, Sylvie, Carmi-Leroy, Annick, Landier, Annie, Passet, Virginie, Fonteneau, Laure, Vaux, Sophie, Toubiana, Julie, Badell, Edgar, Brisse, Sylvain

“…Methods: We developed the bioinformatics pipeline diphtOscan (available at https://gitlab.pasteur.fr/BEBP/diphtoscan) to extract from genomes of Corynebacteria of the diphtheriae species complex, medically relevant features including tox gene presence and disruption. We analyzed 101 human C. diphtheriae isolates collected in 2022 in metropolitan and overseas France (France-2022). …”
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Biological effectiveness of combined exposure to neutrons and gamma radiation applied in two orders of sequence: Relevance for biological dosimetry after nuclear emergencies by Tomas Palmqvist, Milagrosa Lopez-Riego, Martin Bucher, Ursula Oestreicher, Stefan Pojtinger, Ulrich Giesen, Iuliana Toma-Dasu, Andrzej Wojcik

“…Methods: Whole blood from 3 human donors was exposed to neutrons with an energy spectrum similar to that of the Hiroshima uranium bomb, to gamma radiation from a 60Co source and to a 50:50 combination of both radiations, given in two orders of sequence. …”
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Assessment of Knowledge and Practice of Various Eye Diseases in Sulaimani: A Descriptive Study by Abdulrahman M. Ibrahem, Salah Q. Mahmood, Muhammed Babakir-Mina, Salar Ibrahim Ali, Bakhtyar Kamal Talabany

“…Knowledge and practice of public, especially patients about eye diseases are important to reduce magnitude of human blindness. Vision and sight are very essential because they allow us to connect to each other’s. …”
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Investigating the Effectiveness of Coal-Fired Power Plant Operations: Management, Technical and Air Pollution Aspects by Zamzam T. A. Ramly, Mohd Y. Ishak, Ahmad M. Abdullah, Marzuki Ismail, Samsuri Abdullah, Amalina Abu Mansor

“…The model indicates that verifying the standard operating procedure (SOP) is crucial for improving power generation efficiency and reducing human error (R²=0.914). This study pinpoints issues reducing power plant efficiency, particularly regarding emissions, and shows that the regression model is strong (R² = 0.916–0.647). …”
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Characteristic Fe and Cu Compounds in Particulate Matter from Subway Premises in Japan and their Potential Biological Effects by Takuma Okamoto, Ayumi Iwata, Hiroko Yamanaka, Kako Ogane, Tatsuhiro Mori, Akiko Honda, Hirohisa Takano, Tomoaki Okuda

“…The potential biological effects of these chemical states on humans were also investigated in vitro by assessing cell damage and its pathways in cells after exposure to several compounds. …”
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mtSTAT3 suppresses rheumatoid arthritis by regulating Th17 and synovial fibroblast inflammatory cell death with IL-17-mediated autophagy dysfunction by Seon-Yeong Lee, Jeonghyeon Moon, A Ram Lee, Young-Mee Moon, Jeong Won Choi, Chae Rim Lee, Su Been Jeon, Hee Su Sohn, Jeehee Youn, Dongyun Shin, Sung-Hwan Park, Mi-La Cho

“…The abnormal accumulation of autophagosomes and the expression of inflammatory cell death factors were also decreased in these mice. In mouse and human immune cells, ZnSO4, an inducer of mitochondrial STAT3, decreases the production of reactive oxygen species, the IL-17 concentration, and differentiation into Th17 cells. …”
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Protection of liver sinusoidal endothelial cells using different preservation solutions by Julia H E Houtzager, Anne-Marieke van Stalborch, Charlotte Hofstee, Thomas M van Gulik, Jaap D van Buul

“…Therefore, the present study aimed to determine optimal preservation of LSEC barrier function and integrity using different preservation solutions. Human umbilical vein endothelial cells (HUVECs) and LSECs were incubated in either University of Wisconsin machine perfusion solution (UW-MPS), histidine-tryptophan-ketoglutarate, or endothelial cell growth medium 2 (EGM2) (as a gold standard for cell culturing). …”
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Molecular effects of clinically relevant chemotherapeutic agents on choline phospholipid metabolism in triple negative breast cancer cells by Caitlin M. Tressler, Kanchan Sonkar, Menglin Cheng, Vinay Ayyappan, Ruoqing Cai, Kristine Glunde

“…We sought to further investigate these clinical observations at the molecular level by combining metabolic and transcriptomic studies in two human TNBC cell lines treated with six different chemotherapeutic agents. …”
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Influence of sacroiliac joint variation on clinical features of axial spondyloarthritis: a comparative analysis by Denis Poddubnyy, Torsten Diekhoff, Sevtap Tugce Ulas, Fabian Proft, Valeria Rios Rodriguez, Judith Rademacher, Juliane Greese, Katharina Ziegeler, Carolina Dominguez Aleixo, Maximilian Lindholz

“…Classification of back pain as inflammatory (=IBP), human leucocyte antigen-B27 positivity, family history, disease activity according to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), symptom duration, elevated acute phase reactants, peripheral and extramusculoskeletal manifestations were evaluated. …”
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Mechanism of the blood-brain barrier modulation by cadherin peptides by Elinaz Farokhi, Ahmed L. Alaofi, Vivitri D. Prasasty, Filia Stephanie, Marlyn D. Laksitorini, Krzysztof Kuczera, Teruna J. Siahaan

“…Aim: This study was aimed at finding the binding site on the human E-cadherin for Ala-Asp-Thr Cyclic 5 (ADTC5), ADTC7, and ADTC9 peptides as blood-brain barrier modulator (BBBM) for determining their mechanism of action in modulating the blood-brain barrier (BBB). …”
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The Changes in Biochemical Compositions of Five Different Macroalgae and Seagrass (Halophila stipulacea (Forsskal) Ascherson 1867) Collected from Iskenderun Bay by Eyüp İlker Saygılı, Zafer Çetin, Mehmet Naz, Oktay Söyler, Ergün Taşkın, Selin Sayın

“…In conclusion, the information of the biochemical compositions of five different macroalgae and Angiosperms/Seagrass (Halophila stipulacea) are important for the evaluation of potential sources for commercial and human consumption. In addition, biochemical compositions of tested macroalgae and seagrass could make important contributions to feed formulations and functional foods in future.…”
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