Iron triggers TvPI4P5K proteostasis and Arf-mediated cell membrane trafficking to regulate PIP2 signaling crucial for multiple pathogenic activities of the parasitic protozoan Tric... by Kuan-Yi Wu, Yen-Ju Chen, Shu-Fan Lin, Hong-Ming Hsu

“…Beyond cytoadherence, during host-parasite interactions, TvArf220 influenced both contact-dependent and -independent cytotoxicity, as well as phagocytotic capacity, contributing to the cytopathogenesis of human vaginal epithelial cells. Our findings underscore the key upstream regulation mechanisms of the PIP2 signaling, orchestrating the interplay between TvArf220-PIP2-calcium signaling and downstream actin cytoskeleton-driven pathogenicity in T. vaginalis.IMPORTANCETrichomonas vaginalis actin cytoskeleton-centric pathogenicity is regulated by the phosphatidylinositol 4,5-bisphosphates (PIP2)-triggered calcium signaling cascade in response to environmental iron, though the detailed mechanism by which iron modulates PIP2 signaling remains unclear. …”
Get full text

TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles by Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Konstantina Psatha, Dimitris Kletsas, Michalis Aivaliotis, Carl-Henrik Heldin, Aristidis Moustakas

“…Results We report that TGF-β, by activating its type I receptor and MEK-ERK1/2 signaling, increased the numbers of EVs released by human cancer cells. Upon examining cholesterol as a mediator of EV biogenesis, we delineated a pathway whereby ERK1/2 acted by phosphorylating sterol regulatory element-binding protein-2 that transcriptionally induced 7-dehydrocholesterol reductase expression, thus raising cholesterol abundance at both cellular and EV levels. …”
Get full text

Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-κB/IL-17A Pathway in Mice by Wang J, Li Y, Tan C, Shao J, Tang W, Kong Q, Sheng W, Ding Z, Li F, Piao J, Lv D, Hu L, Wang Q, Jiang X

“…The ICH model was treated with recombinant human IRAK3 (rh-IRAK3) or IRAK3 siRNA via an intracerebroventricular injection. …”
Get full text

Feasibility and Acceptability of Antenatal Hepatitis C Screening: A Pilot Study by Joseph Valamparampil, Jaswant Sira, Maxine Brown, Saket Singhal, Deirdre Kelly

“…Knowledge about blood-borne viruses was limited; 75% of women had some understanding about antenatal hepatitis B (HBV) and human immunodeficiency virus (HIV) testing. Previous awareness about hepatitis C was reported by 55%. …”
Get full text

Klasifikasi Kelas Kata (Part-Of-Speech Tagging) untuk Bahasa Madura Menggunakan Algoritme Viterbi by Ilham Firmansyah, Putra Pandu Adikara, Sigit Adinugroho

“…Abstract Natural language is a form of language used by human, either in writing or speaking form. There is a specific field in computer science that processes natural language, which is called Natural Language Processing. …”
Get full text

Evaluation of primary HPV-based cervical screening among older women: Long-term follow-up of a randomized healthcare policy trial in Sweden. by Qingyun Yao, Jiangrong Wang, K Miriam Elfström, Björn Strander, Joakim Dillner, Karin Sundström

“…<h4>Background</h4>Evidence on invasive cervical cancer prevention among older women is limited, especially with the introduction of human papillomavirus (HPV)-based screening and longer interval. …”
Get full text

Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance by Irena Josephina Johanna Muffels, Hans R. Waterham, Giuseppina D’Alessandro, Guido Zagnoli-Vieira, Michael Sacher, Dirk J. Lefeber, Celine Van der Vinne, Chaim M. Roifman, Koen L. I. Gassen, Holger Rehmann, Desiree Y. Van Haaften-Visser, Edward S. S. Nieuwenhuis, Stephen P. Jackson, Sabine A. Fuchs, Femke Wijk, Peter van Hasselt

Get full text

Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER) by Landon Myer, Amy L Slogrove, Ushma Mehta, Mary-Ann Davies, Max Kroon, Greg Petro, Alexa Heekes, Andrew Boulle, Karen Fieggen, Chantal Stewart, Ayesha Osman, Natasha Rhoda, Emma Kalk, Florence Phelanyane, Jonathan Euvrard, Stefan Gebhardt, Kim Anderson

Get full text

Application of fuzzy logic in decision-making process for relocation of floating net cages in river fish farming by R. Pramana, B.Y. Suprapto, Z. Nawawi

“…Floating net cages are one of the traditional methods commonly used by Indonesian fishermen for river fish farming. Increased human activities along the Musi River and coastline have resulted in pollution and waste in the river waters and fluctuating water quality. …”
Get full text

PATHOLOGICAL CHANGES IN MICE TREATED WITH CYCLOPHOSPHAMIDE AND EXOGENOUS DNA by E. V. Dolgova, V. P. Nikolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Ya. R. Efremov, S. I. Baiborodin, E. R. Chernykh, A. A. Ostanin, S. S. Bogachev, T. S. Gvozdeva, E. M. Malkova, O. S. Taranov, V. A. Rogachev, A. S. Panov, S. N. Zagrebelnyi, M. A. Shurdov

Get full text

AI prediction model for endovascular treatment of vertebrobasilar occlusion with atrial fibrillation by Zhi-Xin Huang, Andrea M. Alexandre, Alessandro Pedicelli, Xuying He, Quanlong Hong, Yongkun Li, Ping Chen, Qiankun Cai, Aldobrando Broccolini, Luca Scarcia, Serena Abruzzese, Carlo Cirelli, Mauro Bergui, Andrea Romi, Erwah Kalsoum, Giulia Frauenfelder, Grzegorz Meder, Simona Scalise, Maria Porzia Ganimede, Luigi Bellini, Bruno Del Sette, Francesco Arba, Susanna Sammali, Andrea Salcuni, Sergio Lucio Vinci, Giacomo Cester, Luisa Roveri, Xianjun Huang, Wen Sun

Get full text

Applying evidence-based cross-disciplinary concepts helps to explain the heterogeneity in pain, function, and biological measures in individuals with knee pain with/at risk of oste... by Angela M. Mickle, Jared J. Tanner, Udell Holmes, III, Ahmed Rashid, Olivier Barolette, Brittany Addison, Nicola Sambuco, Cynthia Garvan, Song Lai, Christoph Seubert, Siegfried Schmidt, Roland Staud, Jeffrey C. Edberg, David Redden, Burel R. Goodin, Catherine C. Price, Roger B. Fillingim, Kimberly T. Sibille

Get full text

Dissemination of the Russian emigrant literature and the literature of the Book Program in East Europe in 1950-1990 by Alvydas Kazakevičius

“….," Inter-Language Literary Associates, Alexander Herzen Foundation, "Chronika Press," "Chalidze Publications") published works related to the underground, opposition, and dissenter movements, human rights, and their suppression. Publications of Russian émigrés and other foreign publishers made their way to Lithuania, Russia, and other neighboring countries, and were disseminated through various means: mainly by balloons in the 1950s, by mailings and colporteurs from the late 1950s, by diplomatic mailings, colporteurs, and couriers, by foreign correspondents, and by dissidents from the early 1960s. …”
Get full text

Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents by Erivaldo Machado Araújo, Hélio José Coelho-Júnior, Caio Victor Sousa, Thiago dos Santos Rosa, Ivo Vieira Sousa Neto, Emanuele Marzetti, Octávio Luiz Franco, Samuel da Silva Aguiar

Get full text

Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds by Jean Baptiste Niyibizi, Peter G. Kirira, Francis T. Kimani, Fiona Oyatsi, Joseph K. Ng’ang’a

“…Malaria is a disease caused by protozoans transmitted to humans by infected female Anopheles mosquitoes. According to the WHO report of 2015, there were 214 million cases of malaria with 438,000 deaths worldwide. …”
Get full text

Geographic variation in modern contraceptive utilization among women of reproductive age in Mozambique: a multilevel analysis by Habtu Kifle Negash, Destaye Tirite Gelaw, Mihret Getnet, Hiwot Tezera Endale, Tseganesh Asefa, Fethiya Seid Hasen, Yihun Tefera Ayenew, Nebebe Demis Baykemagn, Trualem Zeleke Yehuala, Winta Tesfaye

Get full text

Pemeriksaan Laboratorium Cystatin C Untuk Uji Fungsi Ginjal by Rismawati Yaswir, Afrida Maiyesi

“…Kata kunci: Laju filtrasi glomerulus/LFG, Cystatin C/CysC Abstract Cystatin C is a low molecular weight (13kD) protein is synthesized by all nucleated cells and are found in various human body fluid. Cystatin C is freely filtered by the renal glomerulus and not secreted, reabsorbed, but then suffered a nearly complete catabolized by proximal tubular epithelial cells, so that no one returned into the blood, thus describing GFR level in the blood, so it can be said endogenous CysC is marker close to ideal. …”
Get full text

Call for Papers - Advancing Astropharmacy and Sports Pharmacy by Ashley Anderson, Ahmer Raza, Shireen Aziz, Misbah Noreen

“…Her research interest are on pharmacokinetic and pharmacodynamic (PKPD) changes in space, drug stability under space conditions, and the effects of the space environment on human physiopharmacology. In addition to her clinical pharmacy research, Shireen is actively working on advancing the concept of Astropharmacy, exploring innovative pharmaceutical solutions for long-duration space missions and extraterrestrial environments. …”
Get full text

Protección del Patrimonio en Valparaiso (Chile): Proyecto "MAR VASTO" Heritage protection in Valparaiso (Chile): The "Mar Vasto" project by Maurizio Indirli, Minchel Sotero Apablaza

“…Being the city declared patrimony of the humanity by, UNESCO in 2003, the following main outcomes have been achieved: to evaluate the impact of main hazards (earthquake, tsunami, fire, and landslide); to provide a vulnerability analysis for three historical churches San Francisco, Las Hermanas de la Divina Providencia, La Matriz, comprised of various materials (masonry, concrete, wood, and adobe) and located in different city areas); to carry out an architectural and vulnerability analysis for a pilot building stock in the Cerro Cordillera historic area; to suggest guidelines for future urban planning; and to develop a GIS digital data base (well organized, user-friendly and easy to be implemented in the future), providing hazard maps and scenarios. …”
Get full text

Blood-based epigenome-wide association study and prediction of alcohol consumption by Elena Bernabeu, Aleksandra D. Chybowska, Jacob K. Kresovich, Matthew Suderman, Daniel L. McCartney, Robert F. Hillary, Janie Corley, Maria Del C. Valdés-Hernández, Susana Muñoz Maniega, Mark E. Bastin, Joanna M. Wardlaw, Zongli Xu, Dale P. Sandler, Archie Campbell, Sarah E. Harris, Andrew M. McIntosh, Jack A. Taylor, Paul Yousefi, Simon R. Cox, Kathryn L. Evans, Matthew R. Robinson, Catalina A. Vallejos, Riccardo E. Marioni

Get full text