Determining the incidence, risk factors and biological drivers of irritable bowel syndrome (IBS) as part of the constellation of postacute sequelae of SARS-CoV-2 infection (PASC) o... by Erika Austhof, Kelly M Heslin, Xiaoxiao Sun, Kristen Pogreba Brown, Caitlyn M McFadden, Caroline Scranton, Ivan Vujkovic-Cviji, Dominic Rodriguez, Laura Falk, Gayatri Arani, Victoria Obergh, Kate Bessey, Kerry Cooper

“…All laboratory data will be linked with in-depth epidemiologic data on demographics, symptoms and chronic conditions.Ethics and dissemination This study involves human participants and was approved by the University of Arizona Institutional Review Board (IRB (#00002332) and has been deemed minimal risk. …”
Get full text

富硒生物活性肽的制备、生物活性及构效关系研究进展 "Progress on the preparation, bioactivity and structure-activity relationship of selenium-enriched bioactive peptides"... by 侯春艳，杨趁仙 HOU Chunyan, YANG Chenxian

“…Selenium is an essential trace nutritional element that is very important for human life activities. Aiming to provide a theoretical basis for the research and application of selenium-enriched bioactive peptides, the raw material sources, preparation methods, bioactivities of selenium-enriched bioactive peptides were summarized. …”
Get full text

B7-H3 CAR-T cell therapy combined with irradiation is effective in targeting bulk and radiation-resistant chordoma cancer cells by Kun Wang, Gianpietro Dotti, Soldano Ferrone, Yufeng Wang, Yin P Hung, Tao Ma, Giulia Cattaneo, Xinhui Wang, David O Osei-Hwedieh, Tara A Walhart, Joseph H Schwab

“…Retroviral particles containing either B7-H3 or CD19 CAR-expressing virus were transduced into T cells derived from peripheral blood mononuclear cells isolated from healthy human donor blood to prepare CAR-T cells. Animal bioluminescent imaging was used to evaluate the killing effect of CAR-T cells on chordoma cells in vivo. …”
Get full text

Elucidation of genetic diversity in hawthorn (Crataegus azarolus L.) accessions naturally growing in the Eastern Mediterranean region of Türkiye using morphological, pomological, a... by Yazgan Tunç, Mehmet Yaman, Kadir Uğurtan Yılmaz, Ali Khadivi, Somayeh Goodarzi

“…Hawthorn, which is highly beneficial for human health, is one of these significant fruit species. …”
Get full text

Dynamic stability evaluation method of mine goaf slopes by Yan DU, Hongda ZHANG, Mowen XIE, Yujing JIANG, Ming ZHANG, Beining JIA

“…These hazards are not only highly destructive and widespread but also occur suddenly, endangering mine operations and human safety. Traditional stability evaluation methods often overlook the variations in thrust caused by the settlement of goaf blocks at the leading edge locking section, making it difficult to dynamically evaluate mine slope stability. …”
Get full text

Antifungal activity and mechanism of Phoebe bournei wood essential oil against two dermatophytes by Yan Yang, Qinglin Sun, Yuting Zhang, Junhua Huang, Wenjun Ma, Qi Yang, Zaikang Tong, Junhong Zhang

“…BackgroundDermatophytes are notorious pathogenic fungi that threaten human health and reduce quality of life. Phoebe bournei (Hemsl.) …”
Get full text

Soluble CD14 Enhances the Response of Periodontal Ligament Stem Cells to Toll-Like Receptor 2 Agonists by Christian Behm, Alice Blufstein, Johannes Gahn, Nazanin Noroozkhan, Andreas Moritz, Xiaohui Rausch-Fan, Oleh Andrukhov

“…Human periodontal ligament stem cells (hPDLSCs) do not express membrane-bound CD14, and their responsiveness to bacterial lipopolysaccharide (LPS) is drastically enhanced by soluble CD14 (sCD14), which is due to the facilitation of the interaction between LPS and Toll-like receptor- (TLR-) 4. …”
Get full text

Effectiveness–implementation hybrid-2 randomised trial of a collaborative Shared Care Model for Detecting Neurodevelopmental Impairments after Critical Illness in Young Children (D... by Paula Lister, Kristen Gibbons, Zephanie Tyack, Luregn J Schlapbach, Samudragupta Bora, Maria Isabel Castillo, James Best, Debbie Long, Helen G Liley, Belinda Dow, Kerri-Lyn Webb, Christian Stocker, Debra Thoms, Carolyn Wharton, Lori Matuschka

“…The Children’s Health Queensland Human Research Ethics Committee approved this study. …”
Get full text

Effect of SY009, a novel SGLT1 inhibitor, on the plasma metabolome and bile acids in patients with type 2 diabetes mellitus by Haoyi Yang, Yuwen Zhang, Yuxin Hong, Yuan Wei, Yuning Zhu, Lei Huang, Yuanxun Yang, Runbin Sun, Runbin Sun, Runbin Sun, Juan Li, Juan Li, Juan Li

“…However, the effects of SY-009 on human plasma metabolomics are still unknown.ObjectiveThis study aimed to explore the effects of SY-009 on plasma metabolomics in patients with T2DM and the potential metabolic regulatory mechanism involved.Study designIn the phase Ib study, a total of 50 participants with T2DM were enrolled and randomly assigned to the 0.5 mg BID, 1 mg BID, 2 mg BID, 1 mg QD, and 2 mg QD dose groups, with a 4:1 random allocation within each group to receive either the SY-009 capsule or placebo. …”
Get full text

Increased methane production associated with community shifts towards Methanocella in paddy soils with the presence of nanoplastics by Zhibin He, Yarong Hou, Ying Li, Qicheng Bei, Xin Li, Yong-Guan Zhu, Werner Liesack, Matthias C. Rillig, Jingjing Peng

“…Abstract Background Planetary plastic pollution poses a major threat to ecosystems and human health in the Anthropocene, yet its impact on biogeochemical cycling remains poorly understood. …”
Get full text

Prevalence of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Ethiopia: A Systematic Review and Meta-Analysis by Teklehaimanot Kiros, Lema Workineh, Tegenaw Tiruneh, Tahir Eyayu, Shewaneh Damtie, Debaka Belete

“…For this reason, we systematically reviewed laboratory-based studies to summarize the overall pooled prevalence of the isolates recovered from various human specimens. Methods. An exhaustive literature search was carried out using the major electronic databases including PubMed, Web of Science, MEDLINE, EMBASE, CINAHL, Google Scholar, Cochrane Library, Scopus, and Wiley Online Library to identify potentially relevant studies without date restriction. …”
Get full text

Integrated analysis of cell cycle and p53 signaling pathways related genes in breast, colorectal, lung, and pancreatic cancers: implications for prognosis and drug sensitivity for... by Jiyauddin Khan, Priyanjana Ghosh, Urmi Bajpai, Kountay Dwivedi, Daman Saluja

“…Validation of hub genes at mRNA and protein levels was done via GEPIA2 and Human Protein Atlas. Survival analysis was conducted using TCGA data by GEPIA2 and LASSO, and drug sensitivity was analyzed with the GSCA drug bank database, highlighting potential therapeutic targets. …”
Get full text

Evaluation of choices and time spent on an open online elective course by undergraduate medical students during the COVID-19 pandemic by Z Mfeka, A Turner, J E Wolvaardt, D Muganhiri

“…The most popular courses related to the Leader and Manager role were around decision-making in human resources, problem-solving, and managing healthcare teams. …”
Get full text

The Influence of Posterior Class II Composite Restoration Location and Techniques on Marginal Sealing by Mishel Haddad, Diva Lugassy, Mohana Barhum, Tamar Brosh, Shlomo Matalon

“…<b>Methods</b>: Sixty extracted human teeth that had been indicated for orthodontic extraction were collected and embedded into a custom-made holder that was located in one of the four quadrants of a laboratory phantom head. …”
Get full text

Ontologies in modelling and analysing of big genetic data by N. L. Podkolodnyy, O. A. Podkolodnaya, V. A. Ivanisenko, M. A. Marchenko

“…ONN4MST can distinguish samples from ontologically similar biomes, thus offering a quantitative way to characterize the evolution of the human gut microbial community. Both examples demonstrate high performance and interpretability, making them valuable tools for analyzing and interpreting big data in biology.…”
Get full text

The antiarthritic effect of CBR‐470‐1 in hypoxic environment is to increase the level of NOD‐like receptor family pyrin domain containing 3 ubiquitination by decreasing phosphoglyc... by Ao Duan, Zemeng Ma, Xiaolong Shao, Zhencheng Xiong, Chaoyi Zhang, Wenzheng Liu, Guanglin Wang, Shouye Hu, Wei Lin

“…Abstract Background Hypoxia can affect the occurrence and development of inflammation in humans, but its effects on the disease progression of osteoarthritis (OA) remain unclear. …”
Get full text

Modulating tumor-associated macrophages through CSF1R inhibition: a potential therapeutic strategy for HNSCC by Kaiting Chen, Xiaochen Li, Shuyi Dong, Yu Guo, Ziyin Luo, Shi-Min Zhuang, Jie Liu, Tianrun Liu, Jing Liao, Weiping Wen

“…High TAMs infiltration was associated with poorer overall survival (OS), disease-free survival (DFS), human papillomavirus (HPV) infection status, and advanced disease stages. …”
Get full text

Mechanistic investigation and the optimal dose based on baicalin in the treatment of ulcerative colitis–A preclinical systematic review and meta-analysis by Jinchen Chong, Zepeng Chen, Jiaze Ma, Linhai He, Yijia Zhu, Zhihua Lu, Zhengxi Qiu, Chen Chen, Yugen Chen, Feng Jiang

“…While higher doses and longer treatments appear beneficial, further research, particularly human clinical trials, is necessary to verify its effectiveness and safety in people.…”
Get full text

Construction and function validation of inducible immortalized gene integration vectors by YUE Wei, YANG Yue, QIAN Baohua, LI Yanxin, GU Haihui

“…[Methods] Using gene homologous recombination technology, the coding sequences (CDS) of immortalization genes-including human telomerase reverse transcriptase (hTERT), simian virus 40 large T antigen (SV40LT), acute myeloid leukemia fusion genes NUP98-KDM5A (N/K) and CBFA2T3-GLIS2 (C/G), as well as the proto-oncogene KRAS were precisely inserted into the tetracycline (Tet)-inducible eukaryotic expression lentiviral vector pLV2-TRE3GS-EGFP-MCS-3×FLAG-hPGK-Tet-On-SV40-Neo and the transposon PB-TRE3G-3×FLAG-T2A-Puro-SV40-PA. …”
Get full text

Efficacy and safety of Janus kinase inhibitors in the treatment of psoriasis and psoriatic arthritis: An analysis of evidence from 2014 to 2022 by Jiao Wang, Tian Ma, Xiaoying Sun, Liu Liu, Seokgyeong Hong, Huijung Cha, Miao Zhang, Jiale Chen, Naixuan Lin, Bin Li, Xin Li

“…Adverse events (AEs) were classified according to eight systems of the human body. Results: We included 16 relevant RCTs involving 4,936 patients with psoriasis, with interventions performed using different doses of JAK inhibitors. …”
Get full text