Analytical Methods for Atmospheric Carbonyl Compounds: A Review by Xiaoshuai Gao, Xin Zhang, Yan Nie, Jiemeng Bao, Junling Li, Rui Gao, Yunfeng Li, Wei Wei, Xiaoyu Yan, Yongxin Yan, Hong Li

“…Atmospheric carbonyl compounds have significant impacts on the atmospheric environment and human health, making the selection of appropriate analytical techniques crucial for accurately detecting these compounds in specific environments. …”
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Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques. by Christopher T Edwards, Kirti A Karunakaran, Elijah Garcia, Nathan Beutler, Matthew Gagne, Nadia Golden, Hadj Aoued, Kathryn L Pellegrini, Matthew R Burnett, Christopher Cole Honeycutt, Stacey A Lapp, Thang Ton, Mark C Lin, Amanda Metz, Andrei Bombin, Kelly Goff, Sarah E Scheuermann, Amelia Wilkes, Jennifer S Wood, Stephanie Ehnert, Stacey Weissman, Elizabeth H Curran, Melissa Roy, Evan Dessasau, Mirko Paiardini, Amit A Upadhyay, Ian N Moore, Nicholas J Maness, Daniel C Douek, Anne Piantadosi, Raiees Andrabi, Thomas R Rogers, Dennis R Burton, Steven E Bosinger

“…As the next step in the pre-clinical testing of S2-directed antibodies as a strategy to protect from SARS-CoV-2 infection, we evaluated the in vivo efficacy of CC40.8 in a clinically relevant non-human primate model by conducting passive antibody transfer to rhesus macaques (RM) followed by SARS-CoV-2 challenge. …”
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Establishment of <i>Echinococcus granulosus EgM123</i> Recombinant Gene Rabies Virus SRV₉ and Identification of Its Biological Characteristics by Yueqi Yang, Mengdan Hou, Guicheng Su, Xiaoyan Ma, Xiaohui Su, Kunlei Li, Songhan Liu, Luheng Xiao, Jingjing Yao, Jiahao Zhai, Xiaoying Wei, Yang Zhou, Qianqian Lai, Yuwei Dong, Jieyu Liu, Shaohua Zhai

“…Canids act as a crucial intermediary in the transmission of rabies and <i>Echinococcus granulosus</i>, serving as co-infection hosts and pathogen carriers for both rabies and hydatid disease (HD) transmitted from animals to humans. Therefore, an effective and efficient bivalent oral vaccine for preventing HD and rabies is urgently required to reduce economic losses in husbandry resulting from rabies and HD. …”
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A novel cryopreservation solution for adipose tissue based on metformin by Yaping Deng, Xin Liu, Xichao Jian, Yan Zhang, Yinchi Hou, Suyun Hou, Fang Qi, Shune Xiao, Chengliang Deng

“…Subsequently, 1.5 mL of fresh human adipose tissue was subjected to freezing using trehalose + glycerol (TG group), trehalose + glycerol + metformin (TGM group), and the common cryoprotectant dimethyl sulfoxide (DMSO) + fetal bovine serum (FBS) (DF group). …”
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Decreased expression of LEF1 caused defective decidualization by inhibiting IL-11 expression in patients with adenomyosis by Jingru Duan, Xiaowei Zhou, Hanfei Zhu, Mingjuan Zhou, Mengyu Liu, Yan Zhou, Wenzhu Li, Bufang Xu, Aijun Zhang

“…Functional experiments were conducted using human endometrial stromal cells (HESCs) and TERT-immortalized HESCs(T-HESCs), with final validation performed using a mouse model. …”
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Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review by Michele Lanza, Giuditta Benincasa, Dario Costa, Claudio Napoli

“…Network medicine is a molecular-bioinformatic approach analyzing gene-gene interactions that can perturb the human interactome. This review focuses on epigenetic changes involved in several ocular diseases, such as DNA methylation, histone and nonhistone post-translational modifications, and noncoding RNA regulators. …”
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Effect of amisulpride on the expression of serotonin receptors, neurotrophic factor BDNF and its receptors in mice with overexpression of the aggregation-prone [R406W] mutant tau p... by E. M. Kondaurova, A. A. Komarova, T. V. Ilchibaeva, A. Ya. Rodnyy, E. A. Zalivina, V. S. Naumenko

“…In this study, we investigated the effects of amisulpride (5-HT7R inverse agonist) in C57BL/6J mice with experimentally induced expression of the gene encoding the aggregation-prone human Tau[R406W] protein in the prefrontal cortex. …”
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Examining the effect of direct-from-blood bacterial testing on antibiotic administration and clinical outcomes: a protocol and statistical analysis plan for a pragmatic randomised... by Li Wang, Wesley H Self, Todd W Rice, Matthew W Semler, Karen F Miller, Cheryl L Gatto, Andrea Fletcher, Romney M Humphries, Joanna L Stollings, Adrienne Baughman, Jakea Johnson, Edward T Qian, Mary Lynn Dear, David C Gaston, Ariel A Lewis, George E Nelson, Benjamin J Ereshefsky, Matthew A Christensen, Ritu Banerjee, Dan Albert, Alison Benton, Laura Bobbitt, Carleigh Burns, Timothy Duff, David C. Gaston, MLS Sharon Glover, Allyson Hobbie, Austin Ing, Gabriel Kemp, Sheryl Mangrum, Geoff Mavrak, Kelly Moser, David Mulherin, Shannon Pugh, Matthew Rodgers, Chrissie Schaeffer, Adam Turner, Sabrina Shipman, Halden Z VanCleave, Hamilton Wen Li Wang, LaKeysha Wiggins

“…Enrolment began on 13 December 2023.Ethics and dissemination The trial involves human participants and was approved by the Vanderbilt University Medical Center institutional review board with a waiver of informed consent (IRB#231229). …”
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Phase Ib study of pembrolizumab in combination with trastuzumab emtansine for metastatic HER2-positive breast cancer by Sara M Tolaney, Tianyu Li, Edward T Richardson, Judith Agudo, Elizabeth A Mittendorf, Beth Overmoyer, Eric P Winer, Adrienne G Waks, Tanya E Keenan, Nabihah Tayob, Gerburg M Wulf, Victoria Attaya, Leilani Anderson, Ian E Krop, Eliezer M Van Allen

“…The safety and tolerability of trastuzumab emtansine (T-DM1) combined with pembrolizumab is unknown.Methods This was a single-arm phase Ib trial (registration date January 26, 2017) of T-DM1 plus pembrolizumab in metastatic, human epidermal growth factor receptor 2 (HER2)-positive breast cancer. …”
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miR-199a-5p Exacerbated Intestinal Barrier Dysfunction through Inhibiting Surfactant Protein D and Activating NF-κB Pathway in Sepsis by Xianjin Du, Dan Tian, Jie Wei, Chen Yan, Peng Hu, Xu Wu, Wenbin Yang, Zhanyong Zhu

“…Multiple investigations indicate that miR-199a-5p participates in different human diseases. Nevertheless, little is known on the roles of miR-199a-5p in sepsis. …”
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Determination of Carbapenemase-Producing OXA- 48 and KPC Genes in Antibiotic-Resistant Gram-Negative Bacilli Isolated from Infectious Samples of Cardiovascular Patients Hospitalize... by Mina Owrang, Ebrahim Taheri Hossein Abad, Shakiba Shafaie

“…Background and purpose: Antibiotic resistance remains a serious problem for human health and continues to impact patients in hospitals worldwide. …”
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Comprehensive Cervical Cancer Prevention in Tanzania (CONCEPT) study: Cohort profile by Ditte Søndergaard Linde, Vibeke Rasch, Julius D Mwaiselage, Rachel Manongi, Patricia Swai, Chunsen Wu, Bariki Mchome, Johnson Katanga, Crispin Kahesa, Susanne Kjaer

“…Purpose Cervical cancer is a major cause of death among women in Eastern Africa, and the distribution of human papillomavirus (HPV) according to HIV status is inadequately characterised in this region. …”
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Deficiency of ATF3 facilitates both angiotensin II‐induced and spontaneously formed aortic aneurysm and dissection development by activating cGAS–STING pathway by Yifan Du, Poyi Hu, Xiangchao Ding, Dashuai Wang, Jingjing Luo, Sheng Le, Lingyun Ren, Manhua Chen, Ping Ye, Jiahong Xia

“…We identified elevated expression of ATF3 in both human sporadic AAD tissues and mouse AAD models. …”
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Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes by Laura J. Andreasen, Rikke K. Kirk, Christian Fledelius, Mark A. Yorek, Jens Lykkesfeldt, Thorbjorn Akerstrom

“…Consequently, this rat model of T2D seems to fit well with progression of DPN in humans and could be a relevant preclinical model to use in relation to research investigating treatment opportunities for DPN.…”
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STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer by Changli Qian, Gordon J Freeman, Tao Jiang, Ursula Matulonis, Ziying Lin, Hye-Jung Kim, Anniina Färkkilä, Hua Yu, Xin Cheng, Panagiotis A Konstantinopoulos, Antons Martincuks, Joyce F Liu, Qiwei Wang, Liya Ding, Michael J Kearns, Shaozhen Xie, Inga-Maria Launonen, Thomas M Roberts, Jean J Zhao

“…Signal transducer and activator of transcription 3 (STAT3)-mediated immunosuppression was investigated in vitro by co-culture experiments and in vivo by analysis of immune cells in the tumor microenvironment (TME) of human and mouse PARPi-resistant tumors. Whole genome transcriptome analysis was performed to assess the antitumor immunomodulatory effect of STING (stimulator of interferon genes) agonists on myeloid cells in the TME of PARPi-resistant ovarian tumors. …”
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Virulence-associated variants in Cryptococcus neoformans sequence type 93 are less likely to be associated with population structure compared to independent rare mutations by Katrina M. Jackson, Kisakye Diana Kabbale, Marissa Macchietto, David Meya, Peter Tiffin, Kirsten Nielsen

“…We additionally found that recurrent SNPs associated with virulence were less frequently evolutionarily linked and were two times more likely to be independent, congruent mutations rather than tied to phylogeny.IMPORTANCECryptococcus neoformans is an important pathogen that is widely distributed and ubiquitous in the environment. The majority of the human population has a latent, controlled infection suggesting that C. neoformans is uniquely adapted to cause infection. …”
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Adaptive Neuro-Fuzzy Inference System guided objective function parameter optimization for inverse treatment planning by Eduardo Cisternas Jiménez, Fang-Fang Yin, Fang-Fang Yin, Fang-Fang Yin

“…We developed an in-house ANFIS-AI system utilizing Prescription Dose (PD) constraints to guide the optimization process toward achievable prescriptions. Mimicking human planning behavior, the AI system adjusts TPPs, represented as dose-volume constraints, to meet the prescribed dose goals. …”
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Development of a Recombinant Fusion Vaccine Candidate Against Lethal <i>Clostridium botulinum</i> Neurotoxin Types A and B by Eun-Sun Choi, Seong-Wook Pyo, So-Hyeon Kim, Jun-Ho Jeon, Gi-Eun Rhie, Mi-Ran Yun, Hwajung Yi, Yoon-Seok Chung

“…Background: Botulinum neurotoxins (BoNTs), produced by <i>Clostridium botulinum</i>, are potent protein toxins that can cause botulism, which leads to death or neuroparalysis in humans by targeting the nervous system. BoNTs comprise three functional domains: a light-chain enzymatic domain (LC), a heavy-chain translocation domain (HC_N), and a heavy-chain receptor-binding domain (HC_C). …”
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Symptomatic neurosyphilis in HIV-negative patients: a retrospective cohort study by Qiaoer Chen, Qiaoer Chen, Weiqi Wu, Lu Wang, Honghong Huang, Lingxing Wang

“…Few studies have focused on human immunodeficiency virus (HIV)-negative patients with symptomatic neurosyphilis, and the clinical outcomes and factors influencing the outcomes are unclear. …”
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Identification of mesenchymal stem cell populations with high osteogenic potential using difference in cell division rate by Maya Watanabe, Yukiyo Asawa, Dan Riu, Tomoaki Sakamoto, Kazuto Hoshi, Atsuhiko Hikita

“…Our group previously reported that by selecting rapidly dividing human auricular chondrocytes, it was possible to enrich for more chondrogenic cells. …”
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