Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation by Wei Xu, Hao Lv, Yaxin Xue, Xiaofeng Shi, Shaotian Fu, Xiaojun Li, Chuandong Wang, Danyang Zhao, Dong Han

“…Methods The impact of fraxinellone (FRA) on the proliferation and migration capacity of human hypertrophic scar-derived fibroblasts (HSFs) was assessed by EdU proliferation, wound healing and transwell assays. …”
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Inosine enhances the efficacy of immune‐checkpoint inhibitors in advanced solid tumors: A randomized, controlled, Phase 2 study by Haiqing Zhao, Wei Zhang, Yuting Lu, Yin Dong, Zhihao He, Hongchao Zhen, Qin Li

“…Abstract Background This study aimed to evaluate whether inosine enhances the efficacy of immune‐checkpoint inhibitors in human malignant solid tumors. Methods This single‐center, prospective, randomized, open‐label study was conducted, from January 2021 to December 2022, in Beijing Friendship Hospital, Capital Medical University, and participants were randomly assigned (1:1) to either the inosine (trial) or non‐inosine (control) group that received inosine (dosage: 0.2 g, three times/day) + PD‐1/PD‐L1 inhibitor or only PD‐1/PD‐L1 inhibitor ± targeted ± chemotherapy, respectively. …”
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The Effects of Different Roasting Degrees on Antioxidant of Coffee From West Sumatra by Muhammad Isa Dwijatmoko, R. A. Fadri, S. Syahrul, M. Harni, Y. Muchrida

“…<p><span lang="EN-US">Coffee has several benefits for human health because it contains bioactive components and one of which is polyphenol components. …”
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Role of Dolutegravir/Lamivudine in the Management of Pregnant People Living with HIV-1: A Narrative Review by William R. Short, Parul Patel, Gustavo Verdier, Ana Puga, Vani Vannappagari, Annemiek de Ruiter, Bryn Jones

“…Abstract Lowering viral load during pregnancy is regarded as the most important method of reducing human immunodeficiency virus 1 (HIV-1) vertical transmission risk, and minimizing fetal exposure to drugs is a guiding principle during pregnancy. …”
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MUC1 and glycan probing of CA19-9 captured biomarkers from cyst fluids and serum provides enhanced recognition of ovarian cancer by Shamima Afrin Ruma, Rufus Vinod, Shruti Jain, Kaisa Huhtinen, Johanna Hynninen, Janne Leivo, Kim Pettersson, Karin Sundfeldt, Kamlesh Gidwani

“…Search for assay designs for targets initially captured by a CA19-9 antigen reactive antibody from human body fluids by probing with fluorescent nanoparticles coated with lectins or antibodies to known EOC associated proteins. …”
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DYNLT3 overexpression induces apoptosis and inhibits cell growth and migration via inhibition of the Wnt pathway and EMT in cervical cancer by Jianan Zhang, Qi Shen, Lu Xia, Xueqiong Zhu, Xuejie Zhu

“…Furthermore, the effects of DYNLT3 on the tumorigenicity and metastasis of cervical cancer in nude mice were analyzed by performing immunohistochemistry, and we found that the expression level of the DYNLT3 protein was higher in human normal cervical tissues than in cervical cancer tissues. …”
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Global Occupational Exposure to Blood and Body Fluids among Healthcare Workers: Systematic Review and Meta-Analysis by Dechasa Adare Mengistu, Gebisa Dirirsa, Elsai Mati, Dinku Mekbib Ayele, Kefelegn Bayu, Wegene Deriba, Fekade Ketema Alemu, Yohannes Mulugeta Demmu, Yohanis Alemeshet Asefa, Abraham Geremew

“…Occupational exposure to blood and body fluids has become a serious public health problem for healthcare workers and is a major risk for the transmission of various infections such as human immune-deficiency virus, hepatitis B virus, and hepatitis C virus. …”
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Exploring the genotypic potential of perilla (Perilla frutescens L.) for climate-resilient agriculture in the North Eastern Himalayas by Meraj Alam Ansari, Meraj Alam Ansari, Amit Kumar, T. P. Ahammed Shabeer, Alok Kumar, Subhra Saikat Roy, Subhra Saikat Roy, Majhrool Hak Ansari, Raghavendra Singh, Raghavendra Singh, Moirangthem Sangeeta, Jayanta Layek, Narendra Prakash, Vinay K. Mishra

“…Large-scale cultivation of perilla improves food security and offers numerous health benefits, including cardiovascular support and disease prevention, thereby enhancing human wellbeing. However, the genetic complexity of its fatty acid composition, nutrient content, and yield-associated agronomic traits remains poorly understood. …”
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Comparative analysis of the primary structure and production of recombinant poly(ADP-ribose)polymerase 1 of long-lived Heterocephalus glaber by K. N. Naumenko, A. R. Nurislamov, K. D. Nazarov, V. S. Fishman, A. A. Popov, I. O. Petruseva, A. N. Evdokimov, O. I. Lavrik

“…In the present work, the amino acid sequence of PARP1 of the naked mole rat is compared with the amino acid sequences of orthologous proteins of other mammals. In contrast to human PARP1, 13 evolutionarily conservative amino acid substitutions in various functional domains of the protein have been identified in the amino acid sequence of naked mole rat PARP1. …”
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Epizootiological characteristics of echinococcosis in dogs, sheep and goats and measures to combat it in Caspian Sea region of Russia by S. Sh. Kabardiev, A. M. Bittirov, G. M. Magomedshapiev, Z. G. Musaev, S. A. Aygubova, N. H. Gulakhmedova

“…Since echinococcosis in dogs and other carnivores constitutes a large-scale social problem and is a helminthiasis that is dangerous for humans, seeking state-of-the-art ways and means to combat this parasitic disease of carnivores is an urgent challenge. …”
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Biomarkers of pembrolizumab efficacy in advanced anal squamous cell carcinoma: analysis of a phase II clinical trial and a cohort of long-term responders by Jeffrey A Meyerhardt, Sunil Kumar, Jessica A Zerillo, Aparna Parikh, James M Cleary, Scott Rodig, Benjamin Schlechter, Kimmie Ng, Stephanie K Dougan, Nora Horick, Glenn J Hanna, Andrew L Coveler, Anuj K Patel, Nadine J McCleary, Douglas A Rubinson, Jeffrey W Clark, Kent Mouw, Kathleen Pfaff, Thomas A Abrams, Matthew B Yurgelun, Eliezer M Van Allen, S Jennifer Wang, Leah H Biller, Harshabad Singh, Emma L Welsh, Brandon M Huffman, Lestat R Ali, Megan T Hoffman, Katherine A Metayer, Shayla Murray, Alexandra Bird, Jennifer A Chan, Wolfram Goessling, Jeffrey S Wisch, Brendan Reardon, Robert J Mayer, Catherine Del Vecchio Fitz, Charlotte Kuperwasser

“…Exploratory objectives included analysis of potential predictive biomarkers including assessment of tumor-associated immune cell populations with multichannel immunofluorescence and analysis of circulating tumor tissue modified viral-human papillomavirus DNA (TTMV-HPV DNA) using serially collected blood samples. …”
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Antioxidant, Anti-Tyrosinase, and Wound-Healing Capacities of Soy Protein Hydrolysates Obtained by Hydrolysis with Papaya and Cantaloupe Juices Showing Proteolytic Activity by Thi-Phuong Nguyen, Quang Thai Le, Mai Linh Thi Tran, Kim Nhung Ta, Khoa Thi Nguyen

“…Remarkably, the hydrolysates prepared from the hydrolysis with fruit juices accelerated the wound closure in human fibroblasts by estimately 1.5 times after 24 h of treatment while this property was not observed in the hydrolysate by papain. …”
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Silver-based plasmonic nanoparticles for biosensor organophosphate pesticides using a single film containing acetylcholinesterase/choline oxidase by D. Hermanto, N. Ismillayli, H. Muliasari, R. Wirawan, S.R. Kamali

“…Therefore, this study aimed to develop a biosensor that can detect organophosphate pesticides highly toxic to humans and the environment. METHODS: Biosensor organophosphate pesticides using a single film containing acetylcholinesterase/choline oxidase have been designed using silver-based plasmonic nanoparticles as a colorimetric indicator. …”
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Increasing the uptake of long-acting reversible contraception in general practice: the Australian Contraceptive ChOice pRoject (ACCORd) cluster randomised controlled trial longitud... by Danielle Mazza, Angela Taft, Kevin McGeechan, Kathleen Mcnamee, Natalie Amos, Kirsten I Black, Cathy J Watson, Marion Haas, Jeffrey F Peipert, Jayne Lucke

“…We will analyse data using binary regression models with generalised estimating equations and robust standard errors to account for clustering.Discussion Demonstration of sustained use, effectiveness at reducing unwanted pregnancies and cost-effectiveness of this strategy among this cohort of Australian primary care patients, will strengthen the policy and programme urgency of addressing wider dissemination of these strategies and replicating the study elsewhere.Ethics and dissemination The ACCORd Study received approval from the Monash University Human Research Ethics Committee: CF16/188-201000080. …”
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Characterization, Molecular Identification and Antimicrobial Susceptibility Testing of Diarrheagenic Escherichia coli Isolated from Diarrhea Infected Patients Around Dhaka City by Fahima Akter, Md. Shamimuzzaman, Susmita Roy Chowdhury, Faria Islam, Rajib Kanti Roy

“…Nevertheless, Shiga toxigenic Escherichia coli (STEC) is one of the few strains that causes severe diarrheal disease in humans all over the world, where tropical and developing countries have a higher incident rate. …”
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Effect of partial oocyte maturation before ovum pick up on developmental competence of buffalo oocytes by Amjad Riaz, Muhammad K. Ashraf, Talha Ashraf, Ali Husnain, Muhammad Yaseen, Muhammad H. Mushtaq, Burhan E. Azam

“…On Day 5 of the experiment, buffaloes were blocked by parity, and within the block, they were assigned randomly to receive 1500 IU of human chorionic gonadotropin i.m., (hCG, LG Chem, Seoul, South Korea; n = 6) or to remain untreated control (CON; n = 4). …”
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Ex Vivo Expansion of Murine MSC Impairs Transcription Factor-Induced Differentiation into Pancreatic β-Cells by Dario Gerace, Rosetta Martiniello-Wilks, Rosaline Habib, Binhai Ren, Najah Therese Nassif, Bronwyn Anne O’Brien, Ann Margaret Simpson

“…Ex vivo expanded MSCs were transduced with the HMD lentiviral vector (MOI = 10) to express furin-cleavable human insulin (INS-FUR) and murine NeuroD1 and Pdx1. …”
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PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration by Weixing Xu, Rana Dhar, Danyang Zheng, Qi Peng, Yue Li, Sheng Mei, Huifang Tang

“…The findings suggested that the expressions of PDE4B, ASCL4, and TRFC were significantly upregulated, and the expression of Nrf2 was significantly downregulated in nucleus pulposus (NP) tissues from human IDD patients dependent on IDD degeneration. …”
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Real‐World Prevalence, Treatment Patterns, and Outcomes for Patients With HER2 (ERBB2)‐Mutant Metastatic Non‐Small Cell Lung Cancer, From a US‐Based Clinico‐Genomic Database... by Sarah Waliany, Misako Nagasaka, Leah Park, Clara Lam, Zoe Jiang, Feng Lin, Joel W. Neal

“…We evaluated the real‐world prevalence of human epidermal growth factor receptor 2 (HER2; ERBB2) tumor gene mutations among patients with mNSCLC and described historical treatments and outcomes in patients with HER2‐mutant mNSCLC, during a period when there was no approved targeted therapy for HER2‐mutant mNSCLC. …”
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Characterization, Molecular Identification and Antimicrobial Susceptibility Testing of Diarrheagenic Escherichia coli Isolated from Diarrhea Infected Patients Around Dhaka City by Fahima Akter, Md. Shamimuzzaman, Susmita Roy Chowdhury, Faria Islam, Rajib Kanti Roy

“…Nevertheless, Shiga toxigenic Escherichia coli (STEC) is one of the few strains that causes severe diarrheal disease in humans all over the world, where tropical and developing countries have a higher incident rate. …”
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