Addition of PARP1-inhibition enhances chemoradiotherapy and thermoradiotherapy when treating cervical cancer in an in vivo mouse model by Marloes IJff, Xionge Mei, Enzo M. Scutigliani, Hans M. Rodermond, Gregor G. W. van Bochove, Przemek M. Krawczyk, Nicolaas A. P. Franken, Lukas J. A. Stalpers, Johannes Crezee, Arlene L. Oei

“…For the in vivo study, human cervical cancer (SiHa) cells were injected in the right hind leg of athymic nude mice. …”
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Identification and Functional Characterization of P159L Mutation in in a Family with Maturity-Onset Diabetes of the Young 5 (MODY5) by Eun Ky Kim, Ji Seon Lee, Hae Il Cheong, Sung Soo Chung, Soo Heon Kwak, Kyong Soo Park

“…The wild-type and mutant HNF1B constructs were transfected into COS-7 cells in the presence of the promoter sequence of human glucose transporter type 2 (GLUT2). The luciferase reporter assay revealed that P159L HNF1B had decreased transcriptional activity compared to wild-type (p < 0.05). …”
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Hematopoietic stem cell discovery: unveiling the historical and future perspective of colony-forming units assay by Nur Afizah Yusoff, Zariyantey Abd Hamid, Siti Balkis Budin, Izatus Shima Taib

“…In this review, we explore the fundamental discoveries concerning the CFUs assay by covering the following aspects: (i) the historical overview of the CFUs assay for the study of clonal hematopoiesis involving multilineage potential of HSPCs, (ii) its use in various experimental models comprising humans, mice/rodents, zebrafish and induced pluripotent stem cells (iPSCs) and (iii) research gaps and future direction concerning the role of CFUs assay in clinical and basic sciences. …”
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Individual participant data meta-analysis of trials comparing frozen versus fresh embryo transfer strategy (INFORM): a protocol by Lan N Vuong, Rui Wang, Ben W Mol, Rong Li, Karin Hammarberg, Kate Brian, Yun Sun, Pollyanna Hardy, Anja Pinborg, Siladitya Bhattacharya, Sacha Stormlund, David J McLernon, Zi-Jiang Chen, Richard S Legro, Carlos Simon, Shimona Lai, Marian G Showell, Daimin Wei, Ze Wang, Keliang Wu, Xavier Santamaría, Christophe Blockeel, Femke Mol, Anna P Ferraretti, Bruce S Shapiro, Forest C Garner, Christos A Venetis, Abha Maheshwari, Gwenda Burns

“…We will harmonise the IPD and perform a two-stage meta-analysis and examine treatment–covariate interactions for important baseline characteristics.Ethics and dissemination The study ethics have been granted by the Monash University Human Research Ethics Committee (Project ID: 30391). …”
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A systemic analysis of Creutzfeldt Jakob disease cases in Asia by Urwah Rasheed, Sana Khan, Minahil Khalid, Aneeqa Noor, Saima Zafar

“…Sporadic CJD, which occurs for reasons unbeknown to science (85% of known cases), Genetic or Familial CJD which is characterized by the presence of mutations in the human prion protein (PRNP) gene (10–15% cases) and Iatrogenic CJD that occurs via accidental transmission through medical and surgical procedures (1–2% cases). …”
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Metagenomic analysis of DNA viruses from posttransplant lymphoproliferative disorders by Vikas R. Dharnidharka, Marianna B. Ruzinova, Chun‐Cheng Chen, Priyanka Parameswaran, Harry O'Gorman, Charles W. Goss, Hongjie Gu, Gregory A. Storch, Kristine Wylie

“…In univariable analysis, death within 5 years of PTLD diagnosis was associated with anellovirus (P = 0.037) and gammapapillomavirus (P = 0.036) detection by MSS, higher tissue qPCR levels of the predominant human anellovirus species torque teno virus (TTV; P = 0.016), T cell type PTLD, liver, brain or bone marrow location. …”
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Ethnobiological survey on medicinal plants used by gaddi and gujjar tribes of riparian region of Beas River of Himachal Pradesh in North Western Himalayas, India by Neha Thakur, Nitesh Kumar, Sanjeev Kumar, Anju Sharma, Yogesh K. Ahlawat, Anurag Malik, Meraj Ahmed

“…This study aimed to record the traditional knowledge of the tribal communities in Himachal Pradesh concerning the use of medicinal plants for treating diseases in humans and livestock. Despite this richness, there is a lack of detailed documentation about the use of therapeutic plants in this area. …”
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Component composition of essential oil in the North American <i>Pinus</i> L. species introduced to the Southern Coast of Crimea by T. M. Sakhno, Y. V. Plugatar, O. M. Shevchuk, S. A. Feskov, I. V. Bulavin

“…Their volatiles play an important role in combating pathogenic microflora and removing harmful microorganisms from the air, thus benefiting human health. Conifers are highly effective as part of parklands and urban landscaping.Materials and methods. …”
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Investigating BLS instructors’ ability to evaluate CPR performance: focus on compression depth, rate, and recoil by Shih-Jhan Lin, Chih-Jan Chang, Shao-Chung Chu, Ying-Hsin Chang, Ming-Yuan Hong, Po-Chang Huang, Chia-Lung Kao, Chih-Hsien Chi

“…Key metrics such as chest compression speed, depth, and recoil were examined to identify the degree of consistency between human and automated evaluations. Results In this study, CPR performance was analyzed using QCPR devices and BLS instructors across metrics like speed, depth, and recoil. …”
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MEG3 Alleviated LPS-Induced Intestinal Injury in Sepsis by Modulating miR-129-5p and Surfactant Protein D by Xianjin Du, Dan Tian, Jie Wei, Chen Yan, Peng Hu, Xu Wu, Wenbin Yang

“…Subsequently, to induce the inflammatory injury of sepsis, human colorectal Caco2 cells were treated with 10 ng/ml LPS. 10 ng/ml LPS significantly inhibited Caco2 cell proliferation and increased the apoptosis. …”
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Lidocaine Shows Significant Antimicrobial Effects Against <i>Staphylococcus</i> Species: An In-Vitro Study Comparing Different Combinations of Lidocaine and Clinically Used Injecta... by Stephan Heller, Ricarda Johanna Seemann, Rainer Burgkart, Andreas Obermeier, Hermann Locher

“…Additional tests were conducted on <i>Staphylococcus epidermidis</i> and methicillin-resistant Staphylococcus aureus (MRSA), as well as on <i>S. aureus</i> in human synovial fluid. Results: Lidocaine showed a concentration-dependent antimicrobial effect, with greater inhibition at higher concentrations and lower bacterial densities. …”
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Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines by Amrita Ulhe, Prerna Raina, Amol Chaudhary, Ruchika Kaul-Ghanekar

“…Cervical cancer, the fourth most common cancer globally and the second most prevalent cancer among women in India, is primarily caused by Human Papilloma Virus (HPV). The association of diet with cancer etiology and prevention has been well established and nutrition has been shown to regulate cancer through modulation of epigenetic markers. …”
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Protocol for the enhanced management of multimorbid patients with COPD and severe asthma: role of indoor air quality by Emili Vela, Isaac Cano, Josep Roca, Antoni Sisó-Almirall, Carme Hernandez, Ebymar Arismendi, Ramon Farré, Alba Gómez-López, María Figols, Antonio Montilla-Ibarra, Núria Sánchez-Ruano, Benigno Sánchez, Marta Sorribes, Jordi Piera-Jiménez, Jaume Benavent, Jose Fermoso, Rubèn González-Colom

“…Each cycle involves a targeted cocreation process following a mixed-methods approach with the active participation of patients, health professionals, managers and digital experts.Ethics and dissemination The Ethics Committee for Human Research at Hospital Clinic de Barcelona approved the protocol on 29 June 2023 (HCB/2023/0126). …”
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Advancements and challenges in agriculture: a comprehensive review of machine learning and IoT applications in vertical farming and controlled environment agriculture by Binoy Sasmal, Gobinda Das, Preeti Mallick, Sneha Dey, Suman Ghorai, Subrata Jana, Chiranjibe Jana

“…In VF, aeroponics consumes 98% less water than conventional farming. Human health, comfort, and productivity directly correlate with the indoor climate. …”
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Integrated communication support program for oncologists, caregivers and patients with rapidly progressing advanced cancer to promote patient-centered communication: J-SUPPORT 1904... by Makoto Ueno, Takuhiro Yamaguchi, Tempei Miyaji, Yosuke Uchitomi, Takuji Okusaka, Masafumi Ikeda, Maiko Fujimori, Ayako Sato, Sayaka Jinno, Masato Ozaka, Yukiko Takayama, Yoshiyuki Majima

“…The primary endpoint is the intergroup difference between before-intervention and after-intervention patient-centred communication behaviours during oncology visits.Ethics and dissemination This study is conducted in accordance with the ethical guidelines for clinical studies published by Japan’s Ministry of Education, Cultural, Sports, Science and Technology, the Ministry of Health, Labour and Welfare, and the ethical principles established for research on humans stipulated in the Declaration of Helsinki and further amendments thereto. …”
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What can qualitative research do for randomised controlled trials? A systematic mapping review by J Hewison, A O'Cathain, A Rudolph, K J THOMAS, S J Drabble

“…The potential value included optimising the intervention and trial conduct, facilitating interpretation of the trial findings, helping trialists to be sensitive to the human beings involved in trials, and saving money by steering researchers towards interventions more likely to be effective in future trials.Conclusions A large amount of qualitative research undertaken with specific trials has been published, addressing a wide range of aspects of trials, with the potential to improve the endeavour of generating evidence of effectiveness of health interventions. …”
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Assessment of technogenic pollution by silver compounds on the biological properties of the soil (model experiment) by Tatiana Minnikova, Natalia Tsepina, Sergey Kolesnikov, Natalia Evstegneeva, Anna Kusina

“… Introduction: Silver (Ag) has increasingly become one of the priority pollutants of soils, which is accompanied by a number of consequences for humans and soil biota. To fully assess the effects of the entry of different chemical forms of Ag into soils, it is necessary to conduct experiments with different types of soils, different exposure periods, as well as a wide range of biological indicators. …”
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Investigating the role of cathepsins in breast cancer progression: a Mendelian randomization study by Shengyi Zhou, Shengyi Zhou, Shengyi Zhou, Yizhou Sun, Yizhou Sun, Wenzhang Zha, Wenzhang Zha, Guangjun Zhou, Guangjun Zhou

“…BackgroundBreast cancer, a major threat to women’s health worldwide, has mechanisms of onset that remain unclear. Within the human lysosomal system, a class of enzymes known as cathepsins exhibit elevated expression levels in various malignant tumors, suggesting that they may play key roles in cancer progression.MethodsThis study employed the two-sample Mendelian randomization (MR) approach to investigate the potential causal relationship between cathepsin levels and the risk of developing breast cancer. …”
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Mapping the landscape and evidence of cross-sectoral collaboration models targeting individuals referred for assessment of attention-deficit hyperactivity disorder or autism spectr... by Niels Bilenberg, Pernille Tanggaard Andersen, Rikke Kirstine Kristensen, Emilie Dalsgaard Milling, Julie Dalgaard Guldager

“…Results will be synthesised into descriptive tables, providing a comprehensive mapping of existing models and emphasising implementation feasibility.Ethics and dissemination Ethical approval is not required for this protocol since it involves the review of existing literature without the involvement of human participants or personal data. Findings will be disseminated at national and international conferences and will be integrated into future efforts to develop cross-sectoral collaboration models in Denmark.…”
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Therapeutic effects of cyclophosphamide, dsDNA preparations and combinations thereof against Krebs-2 ascites cancer cells and various cancer transplants by E. A. Potter, E. V. Dolgova, A. M. Minkevich, Ya. R. Efremov, O. S. Taranov, V. V. Omigov, V. P. Nikolin, N. A. Popova, A. S. Proskurina, E. I. Vereschagin, A. V. Kozel, V. A. Rogachev, D. B. Petrov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…When Krebs-2 ascites are treated with human DNA 1-12 hours post CP injection, this results in either elimination of cells that internalize TAMRA-labeled DNA (TISCs) or alters their phenotype, which is accompanied with the loss of surface expression of CD34. …”
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