Lactobacillus acidophilus alleviate Salmonella enterica Serovar Typhimurium-induced murine inflammatory/oxidative responses via the p62-Keap1-Nrf2 signaling pathway and cecal micro... by Haihua Li, Xinyi Ma, Zhiyuan Shang, Xuejiao Liu, Jiayun Qiao

“…Typhimurium) infection can cause inflammation and oxidative stress in the body, leading to gastroenteritis, fever and other diseases in humans and animals. More and more studies have emphasized the broad prospects of probiotics in improving inflammation and oxidative stress, but the ability and mechanism of Lactobacillus acidophilus (LA) to alleviate the inflammatory/oxidative reaction caused by pathogens are still unclear.Methods and resultsIn this study, we treated the mice with LA for 14 days, infected them with S. …”
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Comparative Effectiveness of Anti-Inflammatory Drug Treatments in Coronary Heart Disease Patients: A Systematic Review and Network Meta-Analysis by Ivan Wudexi, Elica Shokri, Mohamed Abo-Aly, Kazuhiro Shindo, Ahmed Abdel-Latif

“…Research on animal models had shown the potential benefits of targeting specific inflammatory pathways. However, studies on human subjects are limited with small number of patients and no head-to-head comparisons. …”
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A Network Pharmacology-Based Approach for Exploring Key Active Compounds and Pharmacological Mechanisms of Tangshen Formula for Treatment of Diabetic Nephropathy by Weie Zhou, Xuefeng Zhou, Yuan Zhang, Yuyang Wang, Wenjie Wu, Haojun Zhang, Tingting Zhao, Liang Peng, Hailing Zhao, Ping Li

“…The occurrence and development of DN are related to multiple factors in the human body, which makes DN a complex disease, and the pathogeneses of DN have not yet been fully illustrated. …”
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How and why do financial incentives contribute to helping people stop smoking? A realist review protocol by Sarah Parker, Rikke Siersbaek, John Alexander Ford, Sara Burke, Paul Kavanagh

“…Introduction Smoking is harmful to human health and programmes to help people stop smoking are key public health efforts that improve individual and population health outcomes. …”
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Immune response profiling of HERV-W envelope proteins in multiple sclerosis: potential biomarkers for disease progression by Stefano Ruberto, Stefano Ruberto, María I. Domınguez-Mozo, M. Angel Garcıa-Martınez, Davide Cossu, Davide Cossu, Leonardo A. Sechi, Leonardo A. Sechi, Roberto Alvarez-Lafuente

“…IntroductionThe envelope proteins syncytin-1 and pHERV-W from the Human Endogenous Retroviral family ‘W’ (HERV-W) have been identified as potential risk factors in multiple sclerosis (MS). …”
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Management of tuberculosis risk, screening and preventive therapy in patients with chronic autoimmune arthritis undergoing biotechnological and targeted immunosuppressive agents by Andrea Picchianti-Diamanti, Alessandra Aiello, Chiara De Lorenzo, Giovanni Battista Migliori, Delia Goletti

“…Its etiologic agent, the Mycobacterium tuberculosis (Mtb), is a slow-growing bacterium that has coexisted in humans for thousands of years. According to the World Health Organization, 10.6 million new cases of TB and over 1 million deaths were reported in 2022. …”
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Two-Step Transfer Learning Improves Deep Learning–Based Drug Response Prediction in Small Datasets: A Case Study of Glioblastoma by Jie Ju, Ioannis Ntafoulis, Michelle Klein, Marcel JT Reinders, Martine Lamfers, Andrew P Stubbs, Yunlei Li

“…The 2-step TL framework was built on 3 datasets: (1) the subset of the Genomics of Drug Sensitivity in Cancer (GDSC) dataset, including miscellaneous cell cultures treated by TMZ, cyclophosphamide, bortezomib, and oxaliplatin, as the source dataset; (2) the Human Glioblastoma Cell Culture (HGCC) dataset, for fine-tuning; and (3) a small target dataset GSE232173, for validation. …”
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Assessing subtle changes in arid land river basin ecological quality: A study utilizing the PIE engine platform and RSEI by Aizemaitijiang Maimaitituersun, Han Yang, Nuerbiye Aobuliaisan, Kamuran Maimaitiaili, Ouyang Chenyu

“…The ecological environment in arid regions is fragile, with its quality highly sensitive to human activities. The ecological quality (EQ) of arid land river basins is crucial for the populations living within and the overall societal development. …”
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Comprehensive Analysis of Differentially Expressed miRNAs and mRNAs Reveals That miR-181a-5p Plays a Key Role in Diabetic Dermal Fibroblasts by Peng Liu, Yi Zhu, Qin Li, Biao Cheng

“…A diabetic nonhealing wound causes heavy economic burden and compromised quality of life in patients. The human dermal fibroblast (HDF), which is an important kind of effector cell in the wound healing process, represents different biological behaviors in the normal and diabetic skins. …”
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Fibrosis in PCLS: comparing TGF-β and fibrotic cocktail by Carlos Machahua, Thomas M. Marti, Patrick Dorn, Manuela Funke-Chambour

“…Our aim was to compare the pro-fibrotic effects of TGF-β1 with FC in human precision-cut lung slices (PCLS). Methods PCLS from “healthy” lung tissue of cancer patients undergoing surgery (n = 7) were incubated with TGF-β1, FC or control for 72 h. …”
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Silver (Ag) doped graphitic carbon nitride (g-C3N4)/biochar composite photocatalyst for improved photocatalytic degradation of ciprofloxacin (CIP) by Ijlal Idrees, Muhammad Zafar, Malik Adeel Umer, Fahad Rehman, Abdul Razzaq, Seongwan Kim, Yunsook Yang, Woo Young Kim

“…Dumping pharmaceutical wastewater into aquatic bodies vigorously adds to environmental pollution and amplifies antibiotic-resilient bacteria (ARB), a potential danger to humans and living organisms. Among several wastewater treatment methods, the photocatalysis approach under the umbrella of advanced oxidation processes (AOPs) offers a sustainable, inexpensive, and comprehensive treatment of emerging pharmaceutical pollutants (PEPs). …”
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Serial Paediatrics Omics Tracking in Myalgic Encephalomyelitis (SPOT-ME): protocol paper for a multidisciplinary, observational study of clinical and biological markers of paediatr... by Adam Scheinberg, Natalie Thomas, Katherine Huang, Paul R Gooley, Elisha K Josev, Tracey Chau, Darcy Tantanis, Sarah J Knight, Christopher W Armstrong

“…The outcomes of this research have the potential to identify biomarker signatures, aid in understanding the underlying mechanisms, and ultimately, improve the lives of children with ME/CFS.Ethics and dissemination This project was approved by the Royal Children’s Hospital’s Human Research Ethics Committee (HREC 74175). Findings from this study will be disseminated through peer-reviewed journal publications and presentations at relevant conferences. …”
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Carthamin yellow-loaded glycyrrhetinic acid liposomes alleviate interstitial fibrosis in diabetic nephropathy by Yifei Wang, Wenfang He, Peiyao Ren, Li Zhao, Danna Zheng, Juan Jin

“…In vitro experiments with TGF-β1-stimulated human renal interstitial fibroblasts (hRIFs) examined the effects of CY-loaded GA liposomes on cell proliferation and the expression of fibrotic markers. …”
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Enhanced Interleukin 6 Trans-Signaling Modulates Disease Process in Amyotrophic Lateral Sclerosis Mouse Models by Carol Milligan, Dale O. Cowley, William Stewart, Alyson M. Curry, Elizabeth Forbes, Brian Rector, Annette Hastie, Liang Liu, Gregory A. Hawkins

“…<b>Methods:</b> We leveraged unique mouse models of IL6 trans-signaling that we developed that recapitulate the production of active sIL6R in a genotypic and quantitative fashion observed in humans. Given that the SOD1 transgenic mouse is one of the most highly studied and characterized models of ALS, we bred <i>SOD1^G93A</i> mice with IL6R trans-signaling mice to determine how enhanced trans-signaling influenced symptom onset and pathological processes, including neuromuscular junction (NMJ) denervation, glial activation and motoneuron (MN) survival. …”
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Positive Correlation Between Serum Limonene Levels and Muscle Health in a Representative Adult Population in the United States by Chang-Chin Wu, Yu-Wei Fang, Chikang Wang, Chien-Yu Lin

“…However, the impact of monoterpene exposure on muscle strength and mass in humans remains unclear. <b>Methods</b>: To explore this relationship, we analyzed data from 1202 adults (aged ≥ 18 years) who participated in the 2013–2014 National Health and Nutrition Examination Survey (NHANES), focusing on serum levels of three specific monoterpenes—α-pinene, β-pinene, and limonene—and their association with hand grip strength and lean muscle mass. …”
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Exceeding the limits of paediatric heat stress tolerance: the risk of losing a generation to climate inaction by Sulani Nyimbili, Anna Bershteyn, Alexander Azan, Oyinkansola O Babayode

“…Greenhouse gas (GHG) emissions are creating unprecedented climate-driven extreme weather, with levels of heat and humidity surpassing human physiological tolerance for heat stress. These conditions create a risk of mass casualties, with some populations particularly vulnerable due to physiological, behavioural and socioeconomic conditions (eg, lack of adequate shelter, limited healthcare infrastructure, sparse air conditioning access and electrical grid vulnerabilities). …”
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Cytotoxicity and genotoxicity of orthodontic bands after aging: an in-vitro study by Maryam Karandish, Bahar Khademi, Golnaz Ziaei, Nasrollah Erfani, Leila Moezi, Zahra Faghih

“…Abstract Background This investigation sought to evaluate cytotoxic and genotoxic effects of two different types of orthodontic bands after aging in acidic and neutral artificial saliva using human gingival fibroblast-like (HGF1-PI 1) cell lines. …”
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FTO attenuates TNF-α-induced damage of proximal tubular epithelial cells in acute pancreatitis-induced acute kidney injury via targeting AQP3 in an N6-methyladenosine-dependent man... by Xinghui Li, Qi Liang, Lu Liu, Shujun Chen, Yong Li, Yu Pu

“…Therefore, the aim of this study is to explore the association of FTO and AQP3 on proximal tubular epithelial cell damage in SAP-induced AKI.Methods An in-vitro AKI model was established in human proximal tubular epithelial cells (PTECs) HK-2 via tumor necrosis factor-α (TNF-α) induction (20 ng/mL), after which FTO and AQP3 expression was manipulated and quantified by quantitative real-time PCR and Western blotting. …”
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Health impacts and economic costs of residential fires (RESFIRES study): protocol for a population-based cohort study using linked administrative data by Lara A Harvey, Nargess Ghassempour, Mark Whybro, W Kathy Tannous

“…Costing models will be constructed.Ethics and dissemination Ethical approval for this study has been obtained from the NSW Population and Health Service Research Ethics Committee and Western Sydney University Human Research Ethics Committee. The study reference group comprises key stakeholders including Fire and Rescue NSW, policy agencies, health service providers and burns clinicians ensuring wide dissemination of results and translation of data to inform practice and identify areas for targeted prevention. …”
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Impact of Combined Acidic and Hyperosmotic Shock Conditions on the Proteome of Listeria monocytogenes ATCC 19115 in a Time-Course Study by Dong Lai Zhang, Ya Long Bai, John P. Bowman

“…Listeria monocytogenes can cause listeriosis in humans through consumption of contaminated food and can adapt to and grow under a wide array of physiochemical stresses. …”
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