Urolithin A increases the natural killer activity of PBMCs in patients with prostate cancer by Vladimir Rogovskii, Vladimir Rogovskii, Vladimir V. Murugin, Vladimir V. Murugin, Nikolay Vorobyev, Nikolay Vorobyev, Sergey Popov, Nikolay Sturov, Alexey Krasheninnikov, Alexander Morozov, Marina Prokhorova

“…We analyzed the ability of PBMCs preincubated with urolithin A, AhR agonist or antagonist to kill K562 (human chronic myelogenous leukemia) target cells.ResultsOur results demonstrate that urolithin A enhances the natural cytotoxicity of PBMCs in a dose-dependent manner. …”
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Willingness of end users to pay for e-waste recycling by H.T.T. Nguyen, C.-H. Lee, R.-J. Hung

“…<strong>BACKGROUND AND OBJECTIVES:</strong> The sheer volume of electrical and electronic waste (e-waste) has presently been generated in Vietnam, posing a growing concern regarding its impact can have on the environment and human health. Therefore, the need for developing policies and regulations towards the environmentally sound management of e-waste is becoming crucial. …”
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DIGITALISATION OF CRISIS MANAGEMENT AND RESOURCE BALANCING FOR EDUCATIONAL QUALITY ASSURANCE AT A DISPLACED UNIVERSITY by Oleksandr Spivakovsky, Daria Malchykova, Viktoria Yatsenko

“…The crisis management strategy at Kherson State University involved seeking a balance of resources (material, financial, human, communicational, managerial, and innovative) to ensure the proper quality of education. …”
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Assessment of degraded lands in the Ile-Balkhash region, Kazakhstan by Sanim Bissenbayeva, Ruslan Salmurzauly, Ruslan Salmurzauly, Aigul Tokbergenova, Nazym Zhengissova, Jialuo Xing

“…The northern part of the region is experiencing the most rapid increase in DDI due to human agricultural activities and landscape features. …”
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REDD1 expression in podocytes facilitates renal inflammation and pyroptosis in streptozotocin-induced diabetic nephropathy by Siddharth Sunilkumar, Sandeep M. Subrahmanian, Esma I. Yerlikaya, Allyson L. Toro, Edward W. Harhaj, Scot R. Kimball, Michael D. Dennis

“…In contrast with diabetic REDD1+/+ mice, diabetic REDD1−/− mice did not exhibit albuminuria, increased pro-inflammatory factors, or renal macrophage infiltration. In cultured human podocytes, exposure to hyperglycemic conditions promoted REDD1-dependent activation of NF-κB signaling. …”
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Multislice B1 Mapping Method Using Magnetic Resonance Composite Spin Echo Sequences and Simultaneous Echo Refocusing by Suchit Kumar, Kyu Chan Lee, Jong-Min Kim, Jeung-Hoon Seo, Chulhyun Lee, Chang-Hyun Oh

“…In addition, the proposed B1 mapping methods were compared to the multislice iterative signal intensity mapping method in both phantom and in vivo human experiments, and there was no remarkable difference between the two methods regarding the flip angle distribution in these experiments. …”
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Simulating the Tone River eastward diversion project in Japan carried out 4 centuries ago by J. Trošelj, J. Trošelj, N. Hanasaki

“…We show that it is possible to bridge two different disciplines, history, and numerical hydrological modeling to obtain a better understanding of human–water interactions. One limitation is that we only reconstructed historical land maps in the present study; the meteorological forcing inputs employed were identical to those of the 20th century. …”
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Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses by Valentina Stock, Rebecca Hofer, Franziska Lochmann, Vera Spanke, Klaus R. Liedl, Jakob Troppmair, Thierry Langer, Hubert Gstach, Christian Dank, Chris A. Mayhew, Sarah Kammerer, Veronika Ruzsanyi

“…For the first time, we identify an isotopically unlabelled CYP3A4 substrate, tolterodine that leads to the formation of a non-toxic volatile metabolite, acetone, which could potentially be applied to monitor CYP3A4 activity in humans. In vitro biotransformation of tolterodine by HepG2 cells overexpressing CYP3A4, CYP2D6 or CYP2C9 was investigated by LC-MS analysis of cell culture supernatant for the non-volatile metabolite, N-dealkylated tolterodine, and PTR-ToF-MS analysis of the headspace for acetone. …”
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Strategies for H-score Normalization of Preanalytical Technical Variables with Potential Utility to Immunohistochemical-Based Biomarker Quantitation in Therapeutic Reponse Diagnost... by William E. Pierceall, Michele Wolfe, Jessica Suschak, Hua Chang, Yan Chen, Kam M. Sprott, Jeffery L. Kutok, Stella Quan, David T. Weaver, Brian E. Ward

“…To examine the effects of preanalytical fixation variation on biomarker quantitation and potential utility of candidate calibrators to address such issues, 6 surgically-resected human breast cancer patient specimens were divided into 6 portions and fixed under distinct conditions (fixation following resection in formalin for 2 hr, 8 hr or 48 hr, or held overnight at 4°C in buffered saline prior to formalin fixation for 2 hr, 8 hr, or 48 hr). …”
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Evaluating cognitive bias in clinical ethics supports: a scoping review by Louise Giaume, Antoine Lamblin, Nathalie Pinol, Frédérique Gignoux-Froment, Marion Trousselard

“…Our main result first shows an overview of bias related to the working human environment and to information gathering that concerns different types of CES. …”
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Factors associated with unplanned readmissions for patients with mental and behavioural disorders in China: a quantitative analysis by Sha Lai, Zechen Wang, Chi Shen, Junfei Feng, Yawei Huang, Xiaolong Zhang, Li Lu, Zhongliang Zhou

“…Hospital factors such as facility type and size, human resources, and revenue size were associated with unplanned readmissions only in specific subgroups. …”
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The impact of a weakened AMOC on European heatwaves by Virna L Meccia, Claudia Simolo, Katinka Bellomo, Susanna Corti

“…In our changing climate we expect an increase in the frequency of heatwaves, which are extreme events that can have severe consequences for human health, ecosystems, and economies. In this study, we examine how the weakening of the atlantic meridional overturning circulation (AMOC) may influence the occurrence of extreme warm events in Europe. …”
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Association of high complement and low immunoglobulins with the clinical symptoms of patients with fibromyalgia by Satoshi Izuno, Masako Hosoi, Kozo Anno, Takahiro A. Kato, Nobuyuki Sudo, Kazufumi Yoshihara

“…Although chronic inflammation has been implicated in the immunological abnormalities of FM, there are few human studies on complement and immunoglobulins. …”
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Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophenotypic target for ASD by Seong Mi Lee, Yura Choi, Dayeon Kim, Ha Jin Jeong, Young Ho Do, Sohee Jung, Bomee Lee, Hyung Jun Choi, Suhyeon Kim, Jung-Min Oh, Songhee Jeon, Jinju Han, Yeni Kim

“…Additionally, Sholl analysis revealed a reduction in dendritic branching and neuronal projection length in both mouse and human CLCN4 KD neurons. Finally, the decreased phosphorylation of SYNAPSIN and expression of PSD95 along with dendrite abnormalities were restored after Risperidone treatment. …”
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Efficient method for identification of Escherichia coli strains isolated from various chicken (Gallus gallus domesticus) organs by V. P. Terletskiy, V. I. Tyshchenko, O. B. Novikova, E. D. Dzhavadov, I. Ya. Shakhtamirov, N. L. Adaev

“…Tracing of transmission routes and identification of pathogen sources are important issues in preventive measures aimed at controlling human and animal infectious diseases. A fast and accurate method for bacterial strain identification (genotyping) allows scientifically sound planning of preventive schemes. …”
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Relation Between Quality of Transportation and Nano-Scale Air Pollution by Elif Cicek, Semra Ide, Cem Küçük, Oğuzhan Yorulmaz, Murat Vedat Yurttaş, Özge Zorlu Kaymak, Dilem Ergün

“…Additionally, 5 different filter types were used to analyse traffic behaviour as exhaust gas may affect human health. For this reason, different mask types with different specified parameters, which are using as face masks for health and a new type was prepared by Argiope lobata spider silk membrane, were also investigated in relation to the filtered exhaust gases. …”
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Computational biology assisted exploration of phytochemicals derived natural inhibitors to block BZLF1 gene activation of Epstein–Bar virus in host by Muhammad Naveed, Muzamal Hussain, Tariq Aziz, Nimra Hanif, Nazia Kanwal, Arooj Arshad, Ayaz Ali Khan, Abdulrahman Alshammari, Metab Alharbi

“…The current study performed computer-assisted techniques to analyses the potential drug candidates against Epstein–Barr virus toxin Zta [Human gamma-herpesvirus 4 (Epstein–Barr virus)] from phytochemicals derived natural inhibitors. …”
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The future of flourishing in veterinary medicine: a systems-informed positive psychology approach in veterinary education by Virginia K. Corrigan, Rebecca L. Newman, Philip Richmond, Elizabeth B. Strand, Josh M. Vaisman

“…Wellbeing challenges in veterinary medicine may contribute to negative impacts in animal, human, and environmental health. Veterinary education institutions and systems are also experiencing complex challenges as they adapt to rapidly changing societal, workforce, and professional wellbeing related pressures. …”
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Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms by Mie Suzuki Okutani, Shinya Okamura, Tang Gis, Hitomi Sasaki, Suni Lee, Akiho Kashiwabara, Simon Goto, Mai Matsumoto, Mayuko Yamawaki, Toshiaki Miyazaki, Tatsuya Nakagawa, Masahito Ikawa, Wataru Kamitani, Shiro Takekawa, Koichi Yamanishi, Hirotaka Ebina

“…Furthermore, we confirmed the safety of BK2102 using transgenic (Tg) mice expressing human ACE2 (hACE2) that are highly susceptible to SARS-CoV-2. …”
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Kombucha Versus Vegetal Cellulose for Affordable Mucoadhesive (nano)Formulations by Ioana Popa-Tudor, Naomi Tritean, Ștefan-Ovidiu Dima, Bogdan Trică, Marius Ghiurea, Anisoara Cimpean, Florin Oancea, Diana Constantinescu-Aruxandei

“…The cytocompatibility and in vitro antioxidant activity of the nanocellulose-based hydrogels were investigated using human gingival fibroblasts (HGF-1, ATCC CRL-2014). …”
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