Patients’ acceptability and implementation outcomes of a case management approach to encourage participation in colorectal cancer screening for people with schizophrenia: a qualita... by Tempei Miyaji, Yosuke Uchitomi, Hiroyuki Okada, Masatoshi Inagaki, Maiko Fujimori, Taichi Shimazu, Masaki Fujiwara, Masafumi Kodama, Ryuhei So, Takanori Matsushita, Yusaku Yoshimura, Shigeo Horii, Hirokazu Takahashi, Naoki Nakaya, Shiro Hinotsu, Keita Harada, Norihito Yamada, Yuto Yamada, Tsuyoshi Etoh

“…However, providing the intervention to all patients simultaneously was considered difficult with the current human resources.Conclusions This study showed that the CM intervention was perceived as acceptable by patients and acceptable and appropriate by psychiatric care providers.Trial registration number UMIN000036017.…”
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Exposure to Air Pollution Exacerbates Inflammation in Rats with Preexisting COPD by Jing Wang, Ya Li, Peng Zhao, Yange Tian, Xuefang Liu, Huihui He, Rui Jia, Brian G. Oliver, Jiansheng Li

“…In this study, we aimed to investigate the effect of PM2.5 on lung injury in rats with hallmark features of COPD. Cardinal features of human COPD were induced in a rat model by repeated cigarette smoke inhalation and bacterial infection for 8 weeks. …”
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Comprehensive analysis pinpoints CCNA2 as a prognostic and immunological biomarker in non-small cell lung cancer by Liming Zhang, Shaoqiang Wang, Lina Wang

“…Clinicopathological correlations were assessed via the Human Protein Atlas (HPA) and UALCAN databases. qRT-PCR and immunohistochemistry (IHC) were performed to validate CCNA2 mRNA and protein levels. …”
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Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation by Jan Kassubek, Francesco Roselli, Simon Witzel, Johannes Dorst, Albert C. Ludolph, Volker Rasche, Ina Vernikouskaya, Hans-Peter Müller

“…Recently, we have introduced automatic hypothalamic quantification method based on the use of convolutional neural network (CNN) to reduce human variability and enhance analysis robustness. …”
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Seasonal changes in the fatty acid profile of Cystoseira crinita Duby, 1830, distributed on the Sinop Peninsula Coast of the Black Sea by Melek Ersoy Karaçuha, Gökhan Yıldız, Ali Karaçuha

“…These results of our study showed that the seasons have a significant effect on the fatty acid profile and the fatty acids in C. crinita may have important contributions to human nutrition. For this reasons, it is thought that it is extremely important to reveal the nutritional content of different seaweed species that spread in the seas of Turkey and to observe the seasonal changes in their contents.…”
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Impact of the Clinical Trials Act 2018 on clinical trial activity in Japan from 2018 to 2020: a retrospective database study using new and conventional Japanese registries by Hiroyuki Taruno, Mari S Oba, Osamu Takizawa, Kayoko Kikuchi, Kazuaki Matsui, Mayumi Shikano

“…The temporal trends in clinical trial activity after CTA enactment were examined.Results A total of 577 CTA-compliant specified clinical trials (ie, studies funded by pharmaceutical companies or studies evaluating the efficacy and safety of off-label drugs or devices in humans) were registered in the jRCT. During the same period, 5068 clinical trials were registered in the UMIN-CTR. …”
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Comparison of reverse-transcriptase polymerase chain reaction (rt-pcr) and rapid test for the detection of bovine rotavirus and bovine coronavirus in anatolian water by Oya Bulut, Gülşah Uyunmaz Saklı, Mustafa Hasöksüz, Irmak Dik, Hasan Hüseyin Hadimli, Mustafa Hitit

“…<b>Aim:</b> Coronaviruses and Rotaviruses are important virologic factors for both animal and human health in Turkey and the world. Bovine Rotavirus (BRV) and Bovine Coronavirus (BCoV) in cattle cause significant economic losses. …”
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Review of drug recalls and quality of pharmaceutical products in Nepal by Astha Neupane, Maheshwor Bastakoti, Sabita Tamang, Basant Giri

“…Objectives To evaluate the pattern of substandard and falsified pharmaceutical products recall in Nepal.Setting We analysed drug recall notices issued by the Department of Drug Administration (DDA), Nepal, and systematically reviewed peer-reviewed research articles during January 2010 to December 2020.Participants This study did not include human participants. However, data were collected from 72 drug recall notices issued by DDA and four research papers.Results A total of 346 pharmaceutical products were recalled during the reported period. …”
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Academic Philosophy as a Way of Life by Eli Kramer, Marta Faustino, Hélder Telo

“…As he comments in the same text: “Such is the lesson of ancient philosophy: an invitation to each human being to transform himself. Philosophy is a conversion, a transformation of one’s way of being and living, and a quest for wisdom.” …”
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H3K4 methylation regulates development, DNA repair, and virulence in Mucorales by Macario Osorio-Concepción, Carlos Lax, Damaris Lorenzo-Gutiérrez, José Tomás Cánovas-Márquez, Ghizlane Tahiri, Eusebio Navarro, Ulrike Binder, Francisco Esteban Nicolás, Victoriano Garre

“…Abstract Mucorales are basal fungi that opportunistically cause a potentially fatal infection known as mucormycosis (black fungus disease), which poses a significant threat to human health due to its high mortality rate and its recent association with SARS-CoV-2 infections. …”
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Runs of homozygosity in spontaneous abortions from families with recurrent pregnancy loss by N. A. Skryabin, S. A. Vasilyev, T. V. Nikitina, D. I. Zhigalina, R. R. Savchenko, N. P. Babushkina, M. E. Lopatkina, A. A. Kashevarova, I. N. Lebedev

“…All embryos had normal karyotypes according to metaphase karyotyping and conventional comparative genomic hybridization. SurePrint G3 Human CGH + SNP 4 × 180K microarrays (Agilent Technologies) were used to search for homozygous regions. …”
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All-Trans Retinoic Acid Inhibits Bone Marrow Mesenchymal Stem Cell Commitment to Adipocytes via Upregulating FRA1 Signaling by Linjun Xie, Liying Zou, Jie Chen, Youxue Liu

“…Obesity, caused by an increased number and volume of adipocytes, is a global epidemic that seriously threatens human health. Bone marrow mesenchymal stem cells (BMSCs) can differentiate into adipocytes. …”
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Therapy of genomic unstable solid tumours (WHO grade 3/4）in clinical stage III/IV using individualised neoantigen tumour peptides-INP trial (individualised neoantigen tumour peptid... by Ling Wang, Xia Chen, Juan Zhao, Jiaxi Tang, Wanyan Tang, Bin Liao, Weiqi Nian

“…Patients will be treated with their own individualised neoantigen polypeptide combined with a polypeptide adjuvant (human granulocyte-macrophage colony-stimulating factor). …”
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Gooseberry Microbiota during Storage by Natalya V. Motovilova, Olga V. Golub, Galina P. Chekryga

“…Berries are a source of biologically active substances in human diet. Gooseberries have attractive sensory properties and high nutritional value. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Bcl-2 (B-cell lymphoma 2), encoded by the human Bcl-2 gene, is a critical anti-apoptotic protein that regulates cell death pathways, primarily by inhibiting apoptosis. …”
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Machine vision-based detection of key traits in shiitake mushroom caps by Jiuxiao Zhao, Jiuxiao Zhao, Wengang Zheng, Wengang Zheng, Yibo Wei, Yibo Wei, Qian Zhao, Qian Zhao, Jing Dong, Jing Dong, Xin Zhang, Xin Zhang, Mingfei Wang, Mingfei Wang

“…In practical applications, this method improves the breeding process by rapidly and non-invasively assessing key traits such as the size and color of shiitake mushroom caps, which helps in efficiently screening strains and reducing human errors. Firstly, an edge detection model was established. …”
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Actinomycete-Derived Pigments: A Path Toward Sustainable Industrial Colorants by Blanca Hey Díez, Cristiana A. V. Torres, Susana P. Gaudêncio

“…The successful commercialization of actinomycete pigments can drive an industry-wide transition to environmentally responsible alternatives, offering substantial benefits for human health, safety, and environmental sustainability.…”
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ZBP1 senses Brucella abortus DNA triggering type I interferon signaling pathway and unfolded protein response activation by Marco Túlio R. Gomes, Erika S. Guimarães, Erika S. Guimarães, Sergio C. Oliveira, Sergio C. Oliveira, Sergio C. Oliveira

“…Brucella abortus is the etiologic agent of brucellosis in livestock and humans, leading to significant economic losses and public health impact. …”
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The Role of Sulfur Emission from the Petroleum Industry on Ultrafine Particle Number Concentration in Singapore by Suyi Hou, Weihan Li, Liudongqing Yang, Guorong Chen, Yilin Zhang, Mikinori Kuwata

“…Abstract Ultrafine particles, defined as particles with a diameter (dp) smaller than 100 nm, serve as an important component of cloud condensation nuclei, in addition to impacting human health. The dominant sources of ultrafine particles include traffic emissions and nucleation. …”
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What makes health systems resilient? An analytical framework drawing on European learnings from the COVID-19 pandemic based on a multitiered approach by Thomas Czypionka, Markus Kraus, Miriam Reiss, Monika Riedel

“…Both sections are further divided into six building blocks that were adapted from the WHO health system framework: governance and leadership, information and research, financing, physical resources, human resources, and service delivery. An overarching component on contextual factors—subdivided into situational, structural, cultural and international factors—represents an important addition to the existing spectrum of resilience frameworks.Conclusions Foundations for a resilient health system must be laid in ‘normal’ times and in all areas of the health system. …”
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